isocitrate dehydrogenase 1 (NADP+), soluble (IDH1) - coding DNA reference sequence

(used for variant description)

(last modified May 11, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_005896.2 in the IDH1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_023319.2, covering IDH1 transcript NM_005896.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5054
       cctgtggtcccgggtttctgcagagtctacttcagaagcggaggcactgggagt       c.-181

 .         .         .         .         .         .                g.5114
 ccggtttgggattgccaggctgtggttgtgagtctgagcttgtgagcggctgtggcgccc       c.-121

 .         .         .          | 02        .         .             g.6153
 caactcttcgccagcatatcatcccggcag | gcgataaactacattcagttgagtctgcaa    c.-61

 .         .         .         .         .    | 03    .             g.8531
 gactgggaggaactggggtgataagaaatctattcactgtcaag | gtttattgaagtcaaa    c.-1

          .         .         .         .         .         .       g.8591
 ATGTCCAAAAAAATCAGTGGCGGTTCTGTGGTAGAGATGCAAGGAGATGAAATGACACGA       c.60
 M  S  K  K  I  S  G  G  S  V  V  E  M  Q  G  D  E  M  T  R         p.20

          .         .         .         .         .         .       g.8651
 ATCATTTGGGAATTGATTAAAGAGAAACTCATTTTTCCCTACGTGGAATTGGATCTACAT       c.120
 I  I  W  E  L  I  K  E  K  L  I  F  P  Y  V  E  L  D  L  H         p.40

    | 04     .         .         .         .         .         .    g.11480
 AG | CTATGATTTAGGCATAGAGAATCGTGATGCCACCAACGACCAAGTCACCAAGGATGCT    c.180
 S  |  Y  D  L  G  I  E  N  R  D  A  T  N  D  Q  V  T  K  D  A      p.60

          .         .         .         .         .         .       g.11540
 GCAGAAGCTATAAAGAAGCATAATGTTGGCGTCAAATGTGCCACTATCACTCCTGATGAG       c.240
 A  E  A  I  K  K  H  N  V  G  V  K  C  A  T  I  T  P  D  E         p.80

          .         .         .         .         .         .       g.11600
 AAGAGGGTTGAGGAGTTCAAGTTGAAACAAATGTGGAAATCACCAAATGGCACCATACGA       c.300
 K  R  V  E  E  F  K  L  K  Q  M  W  K  S  P  N  G  T  I  R         p.100

          .         .         .         .         .         .       g.11660
 AATATTCTGGGTGGCACGGTCTTCAGAGAAGCCATTATCTGCAAAAATATCCCCCGGCTT       c.360
 N  I  L  G  G  T  V  F  R  E  A  I  I  C  K  N  I  P  R  L         p.120

          .         .         .         .         .     | 05   .    g.14664
 GTGAGTGGATGGGTAAAACCTATCATCATAGGTCGTCATGCTTATGGGGATCAA | TACAGA    c.420
 V  S  G  W  V  K  P  I  I  I  G  R  H  A  Y  G  D  Q   | Y  R      p.140

          .         .         .         .         .         .       g.14724
 GCAACTGATTTTGTTGTTCCTGGGCCTGGAAAAGTAGAGATAACCTACACACCAAGTGAC       c.480
 A  T  D  F  V  V  P  G  P  G  K  V  E  I  T  Y  T  P  S  D         p.160

          .         .         .         . | 06       .         .    g.16498
 GGAACCCAAAAGGTGACATACCTGGTACATAACTTTGAAG | AAGGTGGTGGTGTTGCCATG    c.540
 G  T  Q  K  V  T  Y  L  V  H  N  F  E  E |   G  G  G  V  A  M      p.180

          .         .         .         .         .         .       g.16558
 GGGATGTATAATCAAGATAAGTCAATTGAAGATTTTGCACACAGTTCCTTCCAAATGGCT       c.600
 G  M  Y  N  Q  D  K  S  I  E  D  F  A  H  S  S  F  Q  M  A         p.200

          .         .         .         .         .         .       g.16618
 CTGTCTAAGGGTTGGCCTTTGTATCTGAGCACCAAAAACACTATTCTGAAGAAATATGAT       c.660
 L  S  K  G  W  P  L  Y  L  S  T  K  N  T  I  L  K  K  Y  D         p.220

          .         .         .         | 07         .         .    g.17959
 GGGCGTTTTAAAGACATCTTTCAGGAGATATATGACAA | GCAGTACAAGTCCCAGTTTGAA    c.720
 G  R  F  K  D  I  F  Q  E  I  Y  D  K  |  Q  Y  K  S  Q  F  E      p.240

          .         .         .         .         .         .       g.18019
 GCTCAAAAGATCTGGTATGAGCATAGGCTCATCGACGACATGGTGGCCCAAGCTATGAAA       c.780
 A  Q  K  I  W  Y  E  H  R  L  I  D  D  M  V  A  Q  A  M  K         p.260

          .         .         .         .         .         .       g.18079
 TCAGAGGGAGGCTTCATCTGGGCCTGTAAAAACTATGATGGTGACGTGCAGTCGGACTCT       c.840
 S  E  G  G  F  I  W  A  C  K  N  Y  D  G  D  V  Q  S  D  S         p.280

          . | 08       .         .         .         .         .    g.20129
 GTGGCCCAAG | GGTATGGCTCTCTCGGCATGATGACCAGCGTGCTGGTTTGTCCAGATGGC    c.900
 V  A  Q  G |   Y  G  S  L  G  M  M  T  S  V  L  V  C  P  D  G      p.300

          .         .         .         .         .         .       g.20189
 AAGACAGTAGAAGCAGAGGCTGCCCACGGGACTGTAACCCGTCACTACCGCATGTACCAG       c.960
 K  T  V  E  A  E  A  A  H  G  T  V  T  R  H  Y  R  M  Y  Q         p.320

          .         .         .  | 09      .         .         .    g.20878
 AAAGGACAGGAGACGTCCACCAATCCCATTG | CTTCCATTTTTGCCTGGACCAGAGGGTTA    c.1020
 K  G  Q  E  T  S  T  N  P  I  A |   S  I  F  A  W  T  R  G  L      p.340

          .         .         .         .         .         .       g.20938
 GCCCACAGAGCAAAGCTTGATAACAATAAAGAGCTTGCCTTCTTTGCAAATGCTTTGGAA       c.1080
 A  H  R  A  K  L  D  N  N  K  E  L  A  F  F  A  N  A  L  E         p.360

          .         .         .         .         .         .       g.20998
 GAAGTCTCTATTGAGACAATTGAGGCTGGCTTCATGACCAAGGACTTGGCTGCTTGCATT       c.1140
 E  V  S  I  E  T  I  E  A  G  F  M  T  K  D  L  A  A  C  I         p.380

          .     | 10   .         .         .         .         .    g.22959
 AAAGGTTTACCCAA | TGTGCAACGTTCTGACTACTTGAATACATTTGAGTTCATGGATAAA    c.1200
 K  G  L  P  N  |  V  Q  R  S  D  Y  L  N  T  F  E  F  M  D  K      p.400

          .         .         .         .                           g.23004
 CTTGGAGAAAACTTGAAGATCAAACTAGCTCAGGCCAAACTTTAA                      c.1245
 L  G  E  N  L  K  I  K  L  A  Q  A  K  L  X                        p.414

          .         .         .         .         .         .       g.23064
 gttcatacctgagctaagaaggataattgtcttttggtaactaggtctacaggtttacat       c.*60

          .         .         .         .         .         .       g.23124
 ttttctgtgttacactcaaggataaaggcaaaatcaattttgtaatttgtttagaagcca       c.*120

          .         .         .         .         .         .       g.23184
 gagtttatcttttctataagtttacagcctttttcttatatatacagttattgccacctt       c.*180

          .         .         .         .         .         .       g.23244
 tgtgaacatggcaagggacttttttacaatttttattttattttctagtaccagcctagg       c.*240

          .         .         .         .         .         .       g.23304
 aattcggttagtactcatttgtattcactgtcactttttctcatgttctaattataaatg       c.*300

          .         .         .         .         .         .       g.23364
 accaaaatcaagattgctcaaaagggtaaatgatagccacagtattgctccctaaaatat       c.*360

          .         .         .         .         .         .       g.23424
 gcataaagtagaaattcactgccttcccctcctgtccatgaccttgggcacagggaagtt       c.*420

          .         .         .         .         .         .       g.23484
 ctggtgtcatagatatcccgttttgtgaggtagagctgtgcattaaacttgcacatgact       c.*480

          .         .         .         .         .         .       g.23544
 ggaacgaagtaggagtgcaactcaaatgtgttgaagatactgcagtcatttttgtaaaga       c.*540

          .         .         .         .         .         .       g.23604
 ccttgctgaatgtttccaatagactaaatactgtttaggccgcaggagagtttggaatcc       c.*600

          .         .         .         .         .         .       g.23664
 ggaataaatactacctggaggtttgtcctctccatttttctctttctcctcctggcctgg       c.*660

          .         .         .         .         .         .       g.23724
 cctgaatattatactactctaaatagcatatttcatccaagtgcaataatgtaagctgaa       c.*720

          .         .         .         .         .         .       g.23784
 tcttttttggacttctgctggcctgttttatttcttttatataaatgtgatttctcagaa       c.*780

          .         .         .         .         .         .       g.23844
 attgatattaaacactatcttatcttctcctgaactgttgattttaattaaaattaagtg       c.*840

          .                                                         g.23854
 ctaattacca                                                         c.*850

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Isocitrate dehydrogenase 1 (NADP+), soluble protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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