isocitrate dehydrogenase 3 (NAD+) alpha (IDH3A) - coding DNA reference sequence

(used for variant description)

(last modified February 25, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_005530.2 in the IDH3A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000015.9, covering IDH3A transcript NM_005530.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5027
                                  gttgctgcggagccaggaggggaagcg       c.-1

          .         .        | 02.         .         .         .    g.10869
 ATGGCTGGGCCCGCGTGGATCTCTAAG | GTCTCTCGGCTGCTGGGGGCATTCCACAACCCA    c.60
 M  A  G  P  A  W  I  S  K   | V  S  R  L  L  G  A  F  H  N  P      p.20

          .         .         . | 03       .         .         .    g.13201
 AAACAGGTGACCAGAGGTTTTACTGGTGGT | GTTCAGACAGTAACTTTAATTCCAGGAGAT    c.120
 K  Q  V  T  R  G  F  T  G  G   | V  Q  T  V  T  L  I  P  G  D      p.40

          .         .         .         .         .     | 04   .    g.15721
 GGTATTGGCCCAGAAATTTCAGCTGCAGTTATGAAGATTTTTGATGCTGCCAAA | GCACCT    c.180
 G  I  G  P  E  I  S  A  A  V  M  K  I  F  D  A  A  K   | A  P      p.60

          .         .         .         .         .         .       g.15781
 ATTCAGTGGGAGGAGCGGAACGTCACTGCCATTCAAGGACCTGGAGGAAAGTGGATGATC       c.240
 I  Q  W  E  E  R  N  V  T  A  I  Q  G  P  G  G  K  W  M  I         p.80

          .         .         .         .          | 05        .    g.17215
 CCTTCAGAGGCTAAAGAGTCCATGGATAAGAACAAGATGGGCTTGAAAG | GCCCTTTGAAG    c.300
 P  S  E  A  K  E  S  M  D  K  N  K  M  G  L  K  G |   P  L  K      p.100

          .         .         .         .         .         .       g.17275
 ACCCCAATAGCAGCCGGTCACCCATCTATGAATTTACTGCTGCGCAAAACATTTGACCTT       c.360
 T  P  I  A  A  G  H  P  S  M  N  L  L  L  R  K  T  F  D  L         p.120

          .         .         .         .         .         .       g.17335
 TACGCGAATGTCCGACCATGTGTCTCTATCGAAGGCTATAAAACCCCTTACACCGATGTA       c.420
 Y  A  N  V  R  P  C  V  S  I  E  G  Y  K  T  P  Y  T  D  V         p.140

          .         .         .         .         .        | 06.    g.17860
 AATATTGTGACCATTCGAGAGAACACAGAAGGAGAATACAGTGGAATTGAGCATGTG | ATT    c.480
 N  I  V  T  I  R  E  N  T  E  G  E  Y  S  G  I  E  H  V   | I      p.160

          .         .         .         .         .         .       g.17920
 GTTGATGGAGTCGTGCAGAGTATCAAGCTCATCACCGAGGGGGCGAGCAAGCGCATTGCT       c.540
 V  D  G  V  V  Q  S  I  K  L  I  T  E  G  A  S  K  R  I  A         p.180

          .         .         .         .         .         .       g.17980
 GAGTTTGCCTTTGAGTATGCCCGGAACAACCACCGGAGCAACGTCACGGCGGTGCACAAA       c.600
 E  F  A  F  E  Y  A  R  N  N  H  R  S  N  V  T  A  V  H  K         p.200

          .  | 07      .         .         .         .         .    g.19179
 GCCAACATCAT | GCGGATGTCAGATGGGCTTTTTCTACAAAAATGCAGGGAAGTTGCAGAA    c.660
 A  N  I  M  |  R  M  S  D  G  L  F  L  Q  K  C  R  E  V  A  E      p.220

          .         .         .         .         .     | 08   .    g.19345
 AGCTGTAAAGATATTAAATTTAATGAGATGTACCTTGATACAGTATGTTTGAAT | ATGGTA    c.720
 S  C  K  D  I  K  F  N  E  M  Y  L  D  T  V  C  L  N   | M  V      p.240

          .         .         .         .         .          | 09    g.20616
 CAAGATCCTTCCCAATTTGATGTTCTTGTTATGCCAAATTTGTATGGAGACATCCTTAG | T    c.780
 Q  D  P  S  Q  F  D  V  L  V  M  P  N  L  Y  G  D  I  L  S  |      p.260

          .         .         .         .         .         .       g.20676
 GACTTGTGTGCAGGATTGATCGGAGGTCTCGGTGTGACACCAAGTGGCAACATTGGAGCC       c.840
 D  L  C  A  G  L  I  G  G  L  G  V  T  P  S  G  N  I  G  A         p.280

          .         .     | 10   .         .         .         .    g.21809
 AATGGGGTTGCAATTTTTGAGTCG | GTTCATGGGACGGCTCCAGACATTGCAGGCAAGGAC    c.900
 N  G  V  A  I  F  E  S   | V  H  G  T  A  P  D  I  A  G  K  D      p.300

          .         .         .         .         .         .       g.21869
 ATGGCGAATCCCACAGCCCTCCTGCTCAGTGCCGTGATGATGCTGCGCCACATGGGACTT       c.960
 M  A  N  P  T  A  L  L  L  S  A  V  M  M  L  R  H  M  G  L         p.320

          .         .         .         .         .        | 11.    g.24548
 TTTGACCATGCTGCAAGAATTGAGGCTGCGTGTTTTGCTACAATTAAGGACGGAAAG | AGC    c.1020
 F  D  H  A  A  R  I  E  A  A  C  F  A  T  I  K  D  G  K   | S      p.340

          .         .         .         .         .         .       g.24608
 TTGACAAAAGATTTGGGAGGCAATGCAAAATGCTCAGACTTCACAGAGGAAATCTGTCGC       c.1080
 L  T  K  D  L  G  G  N  A  K  C  S  D  F  T  E  E  I  C  R         p.360

          .         .                                               g.24629
 CGAGTAAAAGATTTAGATTAA                                              c.1101
 R  V  K  D  L  D  X                                                p.366

          .         .         .         .         .         .       g.24689
 cacttctacaactggcatttacatcagtcactctaaatggacaccacatgaacctctgtt       c.*60

          .         .         .         .         .         .       g.24749
 tagaatacctacgtatgtatgcattggtttgcttgtttcttgacagtacatttttagatc       c.*120

          .         .         .         .         .         .       g.24809
 tggccttttcttaacaaaatctgtgcaaaagatgcaggtggatgtccctaggtctgtttt       c.*180

          .         .         .         .         .         .       g.24869
 caaagaactttttccaagtgcttgttttatttattaagtgtctacctggtaaatgttttt       c.*240

          .         .         .         .         .         .       g.24929
 tttgtaaactctgagtggactgtatcatttgctattctaaaccattttacacttaagtta       c.*300

          .         .         .         .         .         .       g.24989
 aaatagtttctcttcagctgtaaataacaggatacagaattaacaagagaaaatgtctaa       c.*360

          .         .         .         .         .         .       g.25049
 ctttttaagaaaaaccttattttcttcggtttttgaaaaacataatggaaataaaacagg       c.*420

          .         .         .         .         .         .       g.25109
 atattgacataatagcacaaaatgacactcttctaaaactaaatgggcacaagagaattt       c.*480

          .         .         .         .         .         .       g.25169
 tcctgggaaagttcacatcaaaaagagtgaatgtggtatatttctaaatgatatggaaaa       c.*540

          .         .         .         .         .         .       g.25229
 tagagacagatttgtcctttacagaaattactgagtgtgaataaaaacttcagatccaag       c.*600

          .         .         .         .         .         .       g.25289
 aaatatataatgagagatataatttttgttaataagacaaaggtaatatattggatacaa       c.*660

          .         .         .         .         .         .       g.25349
 agacacaaatgtattgtgtgttcaattattttgttgtcttgagatttaatattctttcca       c.*720

          .         .         .         .         .         .       g.25409
 agagcttttaatgaagcagagagctagtacttcattttcactggatacattttcagcatc       c.*780

          .         .         .         .         .         .       g.25469
 atgagttgtcacagcctctgagcccctgatctgaagccagaagggctgagtgtattgtaa       c.*840

          .         .         .         .         .         .       g.25529
 acttattcttgcatgttgctgtctgggaatggaccacactacagcaggtagttctggggg       c.*900

          .         .         .         .         .         .       g.25589
 cgatactgccgaaaggcccgaacacatgtattttggctgcaattgaggaacttgggatgc       c.*960

          .         .         .         .         .         .       g.25649
 tattaattttgtatttcagcaactgccccttctcctatcccaaagcaccaattactgccc       c.*1020

          .         .         .         .         .         .       g.25709
 tctgcctcagcagtaccagtataagatgacattccaaagactggaggcaactcagcctga       c.*1080

          .         .         .         .         .         .       g.25769
 gttaattcacaaaattatgccatgctggggcttgagcttgagcttgggcttaggcttggg       c.*1140

          .         .         .         .         .         .       g.25829
 ctcagcttttgaccctcaggcatctcctttcccttcctgtcttcctctcccttctcctct       c.*1200

          .         .         .         .         .         .       g.25889
 gctgcagcatgattttcttaatcttcagacactcactattttcatgaacagttaccctct       c.*1260

          .         .         .         .         .         .       g.25949
 gtccccacaaccaaagacaactcatggcctcctttggcccttgtgtaacattgcaaacct       c.*1320

          .         .         .         .         .         .       g.26009
 gtggctttgcaaaatgtacccaggtcacaaggggatttttttttttttagcaatgatatc       c.*1380

          .         .         .         .         .         .       g.26069
 cctgtctgggtcactttttaagcttgtaaccgcccccccagacttataatcttaaatgta       c.*1440

          .         .         .         .         .         .       g.26129
 ttttcctttgtttaagctgctgcttcctctgtttcattggattgtgccagttatcagtgg       c.*1500

          .         .         .                                     g.26166
 ctcttgggttcaaagtaataaagaattccaaaactga                              c.*1537

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Isocitrate dehydrogenase 3 (NAD+) alpha protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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