isocitrate dehydrogenase 3 (NAD+) beta (IDH3B) - coding DNA reference sequence

(used for variant description)

(last modified November 25, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_006899.3 in the IDH3B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012149.1, covering IDH3B transcript NM_006899.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5031
                              gtcacttcccacgcgacttcctgcgggaaac       c.-1

          .         .         .       | 02 .         .         .    g.5238
 ATGGCGGCATTGAGCGGAGTCCGCTGGCTGACCCGA | GCGCTGGTCTCCGCCGGGAACCCT    c.60
 M  A  A  L  S  G  V  R  W  L  T  R   | A  L  V  S  A  G  N  P      p.20

          .         .         .         .         .        | 03.    g.5464
 GGGGCATGGAGAGGTCTGAGTACCTCGGCCGCGGCGCACGCTGCATCGCGGAGCCAG | GCC    c.120
 G  A  W  R  G  L  S  T  S  A  A  A  H  A  A  S  R  S  Q   | A      p.40

          .         .         .         .         .         .       g.5524
 GAGGACGTGAGGGTGGAGGGCTCCTTTCCCGTGACCATGCTTCCGGGAGACGGTGTGGGG       c.180
 E  D  V  R  V  E  G  S  F  P  V  T  M  L  P  G  D  G  V  G         p.60

          .         .         .       | 04 .         .         .    g.5677
 CCTGAGCTGATGCACGCCGTCAAGGAGGTGTTCAAG | GCTGCCGCTGTCCCAGTGGAGTTC    c.240
 P  E  L  M  H  A  V  K  E  V  F  K   | A  A  A  V  P  V  E  F      p.80

          .         .         .         .         .         .       g.5737
 CAGGAGCACCACCTGAGTGAGGTGCAGAATATGGCATCTGAGGAGAAGCTGGAGCAGGTG       c.300
 Q  E  H  H  L  S  E  V  Q  N  M  A  S  E  E  K  L  E  Q  V         p.100

          .         .         .        | 05.         .         .    g.8273
 CTGAGTTCCATGAAGGAGAACAAAGTGGCCATCATTG | GAAAGATTCATACCCCGATGGAG    c.360
 L  S  S  M  K  E  N  K  V  A  I  I  G |   K  I  H  T  P  M  E      p.120

          .         .         .         | 06         .         .    g.8412
 TATAAGGGGGAGCTAGCCTCCTATGATATGCGGCTGAG | GCGTAAGTTGGACTTATTTGCC    c.420
 Y  K  G  E  L  A  S  Y  D  M  R  L  R  |  R  K  L  D  L  F  A      p.140

          .         .         .         .         .         .       g.8472
 AACGTAGTCCATGTGAAGTCACTTCCTGGGTATATGACTCGGCACAACAATCTAGACCTG       c.480
 N  V  V  H  V  K  S  L  P  G  Y  M  T  R  H  N  N  L  D  L         p.160

          .         .         .         .         .  | 07      .    g.8638
 GTGATCATTCGAGAGCAGACAGAAGGGGAGTACAGCTCTCTGGAACATGAG | AGTGCAAGG    c.540
 V  I  I  R  E  Q  T  E  G  E  Y  S  S  L  E  H  E   | S  A  R      p.180

          .         .         .         .         .         .       g.8698
 GGTGTGATTGAGTGTTTGAAGATTGTCACACGAGCCAAGTCTCAGCGGATTGCAAAGTTC       c.600
 G  V  I  E  C  L  K  I  V  T  R  A  K  S  Q  R  I  A  K  F         p.200

          .         .         .         .         .         .       g.8758
 GCCTTTGACTATGCCACCAAGAAGGGGCGGGGCAAGGTCACTGCTGTCCACAAGGCCAAC       c.660
 A  F  D  Y  A  T  K  K  G  R  G  K  V  T  A  V  H  K  A  N         p.220

       | 08  .         .         .         .         .         .    g.8909
 ATCAT | GAAACTTGGGGATGGGTTGTTCCTGCAGTGCTGTGAGGAAGTTGCTGAACTGTAC    c.720
 I  M  |  K  L  G  D  G  L  F  L  Q  C  C  E  E  V  A  E  L  Y      p.240

          .         .         .         .         | 09         .    g.9055
 CCCAAAATCAAATTTGAGACAATGATCATAGACAACTGCTGCATGCAG | CTGGTGCAGAAT    c.780
 P  K  I  K  F  E  T  M  I  I  D  N  C  C  M  Q   | L  V  Q  N      p.260

          .         .         .         .         .         .       g.9115
 CCTTACCAGTTTGATGTGCTTGTGATGCCCAATCTCTATGGGAACATTATTGACAATCTG       c.840
 P  Y  Q  F  D  V  L  V  M  P  N  L  Y  G  N  I  I  D  N  L         p.280

          .         .         .         .         .         .       g.9175
 GCTGCTGGCCTGGTTGGGGGAGCTGGTGTGGTCCCTGGTGAGAGCTATAGTGCAGAATAC       c.900
 A  A  G  L  V  G  G  A  G  V  V  P  G  E  S  Y  S  A  E  Y         p.300

          .      | 10  .         .         .         .         .    g.9471
 GCAGTCTTTGAGACG | GGTGCCCGGCACCCATTTGCCCAGGCAGTGGGCAGGAATATAGCC    c.960
 A  V  F  E  T   | G  A  R  H  P  F  A  Q  A  V  G  R  N  I  A      p.320

          .         .         .         .         . | 11       .    g.9644
 AATCCCACGGCCATGCTGCTGTCGGCTTCCAACATGCTGCGGCATCTTAA | TCTTGAGTAT    c.1020
 N  P  T  A  M  L  L  S  A  S  N  M  L  R  H  L  N  |  L  E  Y      p.340

          .         .         .         .         .  | 12      .    g.10391
 CACTCCAGCATGATCGCAGATGCGGTGAAGAAGGTGATCAAAGTTGGCAAG | GTGCGGACT    c.1080
 H  S  S  M  I  A  D  A  V  K  K  V  I  K  V  G  K   | V  R  T      p.360

          .         .         .         .         .         .       g.10451
 CGAGACATGGGCGGCTACAGCACCACAACCGACTTCATCAAGTCTGTCATCGGTCACCTG       c.1140
 R  D  M  G  G  Y  S  T  T  T  D  F  I  K  S  V  I  G  H  L         p.380

          .                                                         g.10469
 CAGACTAAAGGGAGCTAG                                                 c.1158
 Q  T  K  G  S  X                                                   p.385

          .         .         .         .         .         .       g.10529
 agccctttatttcttccaaccttgcaaggaccacactccccatacccttcagtgcagtgt       c.*60

          .         .         .         .         .         .       g.10589
 accagggaagagaccttgtgcctctaagcagtggaccatggtcaccttgctgggtagagc       c.*120

          .         .         .         .         .         .       g.10649
 ctaggttgtccttgggccggcttccttaggggacagactgttgggtggtgatggggattg       c.*180

          .         .         .         .         .         .       g.10709
 ttaggatggagcccaggccacatggatgatgatgattctcccccacaggttcgaacctct       c.*240

          .         .         .         .         .         .       g.10769
 gacatgggtggctatgctacttgccatgacttcactgaggctgtcattgctgccttgccc       c.*300

          .         .         .         .         .                 g.10825
 cacccataggccctgtccatacccatgtaaggtgttcaataaagaacatgaaccaa           c.*356

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Isocitrate dehydrogenase 3 (NAD+) beta protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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