interferon induced with helicase C domain 1 (IFIH1) - coding DNA reference sequence

(used for variant description)

(last modified February 15, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_022168.3 in the IFIH1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011495.1, covering IFIH1 transcript NM_022168.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.4862
                    atcgaaacagaaaccaaagtcaggcaaactctgtaagaact       c.-361

 .         .         .         .         .         .                g.4922
 gcctgacagaaagctggactcaaagctcctacccgagtgtgcagcaggatcgccccggtc       c.-301

 .         .         .         .         .         .                g.4982
 cgggaccccaggcgcacaccgcagagtccaaagtgccgcgcctgccggccgcacctgcct       c.-241

 .         .         .         .         .         .                g.5042
 gccgcggccccgcgcgccgccccgctgcccacctgcccgcctgcccacctgcccaggtgc       c.-181

 .         .         .         .         .         .                g.5102
 gagtgcagccccgcgcgccggcctgagagccctgtggacaacctcgtcattgtcaggcac       c.-121

 .         .         .         .         .         .                g.5162
 agagcggtagaccctgcttctctaagtgggcagcggacagcggcacgcacatttcacctg       c.-61

 .         .         .         .         .         .                g.5222
 tcccgcagacaacagcaccatctgcttgggagaaccctctcccttctctgagaaagaaag       c.-1

          .         .         .         .         .         .       g.5282
 ATGTCGAATGGGTATTCCACAGACGAGAATTTCCGCTATCTCATCTCGTGCTTCAGGGCC       c.60
 M  S  N  G  Y  S  T  D  E  N  F  R  Y  L  I  S  C  F  R  A         p.20

          .         .         .         .         .         .       g.5342
 AGGGTGAAAATGTACATCCAGGTGGAGCCTGTGCTGGACTACCTGACCTTTCTGCCTGCA       c.120
 R  V  K  M  Y  I  Q  V  E  P  V  L  D  Y  L  T  F  L  P  A         p.40

          .         .         .         .         .         .       g.5402
 GAGGTGAAGGAGCAGATTCAGAGGACAGTCGCCACCTCCGGGAACATGCAGGCAGTTGAA       c.180
 E  V  K  E  Q  I  Q  R  T  V  A  T  S  G  N  M  Q  A  V  E         p.60

          .         .         .         .         .         .       g.5462
 CTGCTGCTGAGCACCTTGGAGAAGGGAGTCTGGCACCTTGGTTGGACTCGGGAATTCGTG       c.240
 L  L  L  S  T  L  E  K  G  V  W  H  L  G  W  T  R  E  F  V         p.80

          .         .         .         .         .         .       g.5522
 GAGGCCCTCCGGAGAACCGGCAGCCCTCTGGCCGCCCGCTACATGAACCCTGAGCTCACG       c.300
 E  A  L  R  R  T  G  S  P  L  A  A  R  Y  M  N  P  E  L  T         p.100

          .         .         .         .         .         .       g.5582
 GACTTGCCCTCTCCATCGTTTGAGAACGCTCATGATGAATATCTCCAACTGCTGAACCTC       c.360
 D  L  P  S  P  S  F  E  N  A  H  D  E  Y  L  Q  L  L  N  L         p.120

          .         .         .         .         .         .       g.5642
 CTTCAGCCCACTCTGGTGGACAAGCTTCTAGTTAGAGACGTCTTGGATAAGTGCATGGAG       c.420
 L  Q  P  T  L  V  D  K  L  L  V  R  D  V  L  D  K  C  M  E         p.140

          .         .         .    | 02    .         .         .    g.12623
 GAGGAACTGTTGACAATTGAAGACAGAAACCGG | ATTGCTGCTGCAGAAAACAATGGAAAT    c.480
 E  E  L  L  T  I  E  D  R  N  R   | I  A  A  A  E  N  N  G  N      p.160

          .         .         .         .         .         .       g.12683
 GAATCAGGTGTAAGAGAGCTACTAAAAAGGATTGTGCAGAAAGAAAACTGGTTCTCTGCA       c.540
 E  S  G  V  R  E  L  L  K  R  I  V  Q  K  E  N  W  F  S  A         p.180

          .         .         .         .         .         .       g.12743
 TTTCTGAATGTTCTTCGTCAAACAGGAAACAATGAACTTGTCCAAGAGTTAACAGGCTCT       c.600
 F  L  N  V  L  R  Q  T  G  N  N  E  L  V  Q  E  L  T  G  S         p.200

          .         .   | 03     .         .         .         .    g.16712
 GATTGCTCAGAAAGCAATGCAG | AGATTGAGAATTTATCACAAGTTGATGGTCCTCAAGTG    c.660
 D  C  S  E  S  N  A  E |   I  E  N  L  S  Q  V  D  G  P  Q  V      p.220

          .         .         .         .         .         .       g.16772
 GAAGAGCAACTTCTTTCAACCACAGTTCAGCCAAATCTGGAGAAGGAGGTCTGGGGCATG       c.720
 E  E  Q  L  L  S  T  T  V  Q  P  N  L  E  K  E  V  W  G  M         p.240

          .         .         .         .          | 04        .    g.29872
 GAGAATAACTCATCAGAATCATCTTTTGCAGATTCTTCTGTAGTTTCAG | AATCAGACACA    c.780
 E  N  N  S  S  E  S  S  F  A  D  S  S  V  V  S  E |   S  D  T      p.260

          .         .         .         .         .         .       g.29932
 AGTTTGGCAGAAGGAAGTGTCAGCTGCTTAGATGAAAGTCTTGGACATAACAGCAACATG       c.840
 S  L  A  E  G  S  V  S  C  L  D  E  S  L  G  H  N  S  N  M         p.280

          .         .         .     | 05   .         .         .    g.35200
 GGCAGTGATTCAGGCACCATGGGAAGTGATTCAG | ATGAAGAGAATGTGGCAGCAAGAGCA    c.900
 G  S  D  S  G  T  M  G  S  D  S  D |   E  E  N  V  A  A  R  A      p.300

          .         .         .         .         .         .       g.35260
 TCCCCGGAGCCAGAACTCCAGCTCAGGCCTTACCAAATGGAAGTTGCCCAGCCAGCCTTG       c.960
 S  P  E  P  E  L  Q  L  R  P  Y  Q  M  E  V  A  Q  P  A  L         p.320

          .         .         .         .         .         .       g.35320
 GAAGGGAAGAATATCATCATCTGCCTCCCTACAGGGAGTGGAAAAACCAGAGTGGCTGTT       c.1020
 E  G  K  N  I  I  I  C  L  P  T  G  S  G  K  T  R  V  A  V         p.340

          .         .         .         .         .         .       g.35380
 TACATTGCCAAGGATCACTTAGACAAGAAGAAAAAAGCATCTGAGCCTGGAAAAGTTATA       c.1080
 Y  I  A  K  D  H  L  D  K  K  K  K  A  S  E  P  G  K  V  I         p.360

          .      | 06  .         .         .         .         .    g.40998
 GTTCTTGTCAATAAG | GTACTGCTAGTTGAACAGCTCTTCCGCAAGGAGTTCCAACCATTT    c.1140
 V  L  V  N  K   | V  L  L  V  E  Q  L  F  R  K  E  F  Q  P  F      p.380

          .         .         .         .         .         .       g.41058
 TTGAAGAAATGGTATCGTGTTATTGGATTAAGTGGTGATACCCAACTGAAAATATCATTT       c.1200
 L  K  K  W  Y  R  V  I  G  L  S  G  D  T  Q  L  K  I  S  F         p.400

          .         .         .         .         .         .       g.41118
 CCAGAAGTTGTCAAGTCCTGTGATATTATTATCAGTACAGCTCAAATCCTTGAAAACTCC       c.1260
 P  E  V  V  K  S  C  D  I  I  I  S  T  A  Q  I  L  E  N  S         p.420

          .         .         .         .       | 07 .         .    g.41998
 CTCTTAAACTTGGAAAATGGAGAAGATGCTGGTGTTCAATTGTCAG | ACTTTTCCCTCATT    c.1320
 L  L  N  L  E  N  G  E  D  A  G  V  Q  L  S  D |   F  S  L  I      p.440

          .         .         .         .         .         .       g.42058
 ATCATTGATGAATGTCATCACACCAACAAAGAAGCAGTGTATAATAACATCATGAGGCAT       c.1380
 I  I  D  E  C  H  H  T  N  K  E  A  V  Y  N  N  I  M  R  H         p.460

          .         .         .         .         .         .       g.42118
 TATTTGATGCAGAAGTTGAAAAACAATAGACTCAAGAAAGAAAACAAACCAGTGATTCCC       c.1440
 Y  L  M  Q  K  L  K  N  N  R  L  K  K  E  N  K  P  V  I  P         p.480

          .         .         .         .         .         .       g.42178
 CTTCCTCAGATACTGGGACTAACAGCTTCACCTGGTGTTGGAGGGGCCACGAAGCAAGCC       c.1500
 L  P  Q  I  L  G  L  T  A  S  P  G  V  G  G  A  T  K  Q  A         p.500

          .         .     | 08   .         .         .         .    g.43453
 AAAGCTGAAGAACACATTTTAAAA | CTATGTGCCAATCTTGATGCATTTACTATTAAAACT    c.1560
 K  A  E  E  H  I  L  K   | L  C  A  N  L  D  A  F  T  I  K  T      p.520

          .         .         .         .         .         .       g.43513
 GTTAAAGAAAACCTTGATCAACTGAAAAACCAAATACAGGAGCCATGCAAGAAGTTTGCC       c.1620
 V  K  E  N  L  D  Q  L  K  N  Q  I  Q  E  P  C  K  K  F  A         p.540

          .         .  | 09      .         .         .         .    g.45240
 ATTGCAGATGCAACCAGAGAA | GATCCATTTAAAGAGAAACTTCTAGAAATAATGACAAGG    c.1680
 I  A  D  A  T  R  E   | D  P  F  K  E  K  L  L  E  I  M  T  R      p.560

          .         .         .         .         .         .       g.45300
 ATTCAAACTTATTGTCAAATGAGTCCAATGTCAGATTTTGGAACTCAACCCTATGAACAA       c.1740
 I  Q  T  Y  C  Q  M  S  P  M  S  D  F  G  T  Q  P  Y  E  Q         p.580

          .         .      | 10  .         .         .         .    g.45871
 TGGGCCATTCAAATGGAAAAAAAAG | CTGCAAAAGAAGGAAATCGCAAAGAACGTGTTTGT    c.1800
 W  A  I  Q  M  E  K  K  A |   A  K  E  G  N  R  K  E  R  V  C      p.600

          .         .         .         .         .         .       g.45931
 GCAGAACATTTGAGGAAGTACAATGAGGCCCTACAAATTAATGACACAATTCGAATGATA       c.1860
 A  E  H  L  R  K  Y  N  E  A  L  Q  I  N  D  T  I  R  M  I         p.620

          .         .         .         .         .         .       g.45991
 GATGCGTATACTCATCTTGAAACTTTCTATAATGAAGAGAAAGATAAGAAGTTTGCAGTC       c.1920
 D  A  Y  T  H  L  E  T  F  Y  N  E  E  K  D  K  K  F  A  V         p.640

          .         .         .         .         .         .       g.46051
 ATAGAAGATGATAGTGATGAGGGTGGTGATGATGAGTATTGTGATGGTGATGAAGATGAG       c.1980
 I  E  D  D  S  D  E  G  G  D  D  E  Y  C  D  G  D  E  D  E         p.660

          .         .         .         .         .         .       g.46111
 GATGATTTAAAGAAACCTTTGAAACTGGATGAAACAGATAGATTTCTCATGACTTTATTT       c.2040
 D  D  L  K  K  P  L  K  L  D  E  T  D  R  F  L  M  T  L  F         p.680

      | 11   .         .         .         .         .         .    g.46639
 TTTG | AAAACAATAAAATGTTGAAAAGGCTGGCTGAAAACCCAGAATATGAAAATGAAAAG    c.2100
 F  E |   N  N  K  M  L  K  R  L  A  E  N  P  E  Y  E  N  E  K      p.700

          .         .         .         .         .         .       g.46699
 CTGACCAAATTAAGAAATACCATAATGGAGCAATATACTAGGACTGAGGAATCAGCACGA       c.2160
 L  T  K  L  R  N  T  I  M  E  Q  Y  T  R  T  E  E  S  A  R         p.720

          .         .         .         .         .         .       g.46759
 GGAATAATCTTTACAAAAACACGACAGAGTGCATATGCGCTTTCCCAGTGGATTACTGAA       c.2220
 G  I  I  F  T  K  T  R  Q  S  A  Y  A  L  S  Q  W  I  T  E         p.740

          .         .         .         .         .         .       g.46819
 AATGAAAAATTTGCTGAAGTAGGAGTCAAAGCCCACCATCTGATTGGAGCTGGACACAGC       c.2280
 N  E  K  F  A  E  V  G  V  K  A  H  H  L  I  G  A  G  H  S         p.760

          .         .     | 12   .         .         .         .    g.49621
 AGTGAGTTCAAACCCATGACACAG | AATGAACAAAAAGAAGTCATTAGTAAATTTCGCACT    c.2340
 S  E  F  K  P  M  T  Q   | N  E  Q  K  E  V  I  S  K  F  R  T      p.780

          .         .         .         .         .         .       g.49681
 GGAAAAATAAATCTGCTTATCGCTACCACAGTGGCAGAAGAAGGTCTGGATATTAAAGAA       c.2400
 G  K  I  N  L  L  I  A  T  T  V  A  E  E  G  L  D  I  K  E         p.800

          .         .         .         .         .     | 13   .    g.51148
 TGTAACATTGTTATCCGTTATGGTCTCGTCACCAATGAAATAGCCATGGTCCAG | GCCCGT    c.2460
 C  N  I  V  I  R  Y  G  L  V  T  N  E  I  A  M  V  Q   | A  R      p.820

          .         .         .         .         .         .       g.51208
 GGTCGAGCCAGAGCTGATGAGAGCACCTACGTCCTGGTTGCTCACAGTGGTTCAGGAGTT       c.2520
 G  R  A  R  A  D  E  S  T  Y  V  L  V  A  H  S  G  S  G  V         p.840

          .         .         .         .         .         .       g.51268
 ATCGAACATGAGACAGTTAATGATTTCCGAGAGAAGATGATGTATAAAGCTATACATTGT       c.2580
 I  E  H  E  T  V  N  D  F  R  E  K  M  M  Y  K  A  I  H  C         p.860

          .         .         .       | 14 .         .         .    g.55276
 GTTCAAAATATGAAACCAGAGGAGTATGCTCATAAG | ATTTTGGAATTACAGATGCAAAGT    c.2640
 V  Q  N  M  K  P  E  E  Y  A  H  K   | I  L  E  L  Q  M  Q  S      p.880

          .         .         .         .         .         .       g.55336
 ATAATGGAAAAGAAAATGAAAACCAAGAGAAATATTGCCAAGCATTACAAGAATAACCCA       c.2700
 I  M  E  K  K  M  K  T  K  R  N  I  A  K  H  Y  K  N  N  P         p.900

          .         .         .         .         .         .       g.55396
 TCACTAATAACTTTCCTTTGCAAAAACTGCAGTGTGCTAGCCTGTTCTGGGGAAGATATC       c.2760
 S  L  I  T  F  L  C  K  N  C  S  V  L  A  C  S  G  E  D  I         p.920

          .         .         .         .        | 15.         .    g.55973
 CATGTAATTGAGAAAATGCATCACGTCAATATGACCCCAGAATTCAA | GGAACTTTACATT    c.2820
 H  V  I  E  K  M  H  H  V  N  M  T  P  E  F  K  |  E  L  Y  I      p.940

          .         .         .         .         .         .       g.56033
 GTAAGAGAAAACAAAGCACTGCAAAAGAAGTGTGCCGACTATCAAATAAATGGTGAAATC       c.2880
 V  R  E  N  K  A  L  Q  K  K  C  A  D  Y  Q  I  N  G  E  I         p.960

          .         | 16         .         .         .         .    g.56192
 ATCTGCAAATGTGGCCAG | GCTTGGGGAACAATGATGGTGCACAAAGGCTTAGATTTGCCT    c.2940
 I  C  K  C  G  Q   | A  W  G  T  M  M  V  H  K  G  L  D  L  P      p.980

          .         .         .         .         .         .       g.56252
 TGTCTCAAAATAAGGAATTTTGTAGTGGTTTTCAAAAATAATTCAACAAAGAAACAATAC       c.3000
 C  L  K  I  R  N  F  V  V  V  F  K  N  N  S  T  K  K  Q  Y         p.1000

          .         .         .         .         .         .       g.56312
 AAAAAGTGGGTAGAATTACCTATCACATTTCCCAATCTTGACTATTCAGAATGCTGTTTA       c.3060
 K  K  W  V  E  L  P  I  T  F  P  N  L  D  Y  S  E  C  C  L         p.1020

          .                                                         g.56330
 TTTAGTGATGAGGATTAG                                                 c.3078
 F  S  D  E  D  X                                                   p.1025

          .         .         .         .         .         .       g.56390
 cacttgattgaagattcttttaaaatactatcagttaaacatttaatatgattatgatta       c.*60

          .         .         .         .         .         .       g.56450
 atgtattcattatgctacagaactgacataagaatcaataaaatgattgttttactctgc       c.*120

                                                                    g.56451
 a                                                                  c.*121

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Interferon induced with helicase C domain 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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