intraflagellar transport 74 homolog (Chlamydomonas) (IFT74) - coding DNA reference sequence

(used for variant description)

(last modified November 30, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_025103.2 in the IFT74 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_053083.1, covering IFT74 transcript NM_025103.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.14377
                  atcccgcccccgttgccgggatacgccgcggcgcacggcagtt       c.-121

 .         .         .         .         .         .                g.14437
 agtgggtaggcctgagagccgaggaaaactgagcgtgggcctcagaaagaagttaaggca       c.-61

 .         .         .         .         . | 02       .             g.19929
 cccgcgagccgggcaactgccctccttccgcgccggcggag | cgattaaagtgaagaaaca    c.-1

          .         .         .         .         .         .       g.19989
 ATGGCCAGCAATCACAAATCTTCAGCAGCTCGCCCTGTTTCAAGAGGTGGAGTTGGGTTA       c.60
 M  A  S  N  H  K  S  S  A  A  R  P  V  S  R  G  G  V  G  L         p.20

          .         .         .         .         .         .       g.20049
 ACAGGAAGGCCTCCTTCTGGGATACGACCCCTATCAGGAAATATTCGAGTGGCAACTGCA       c.120
 T  G  R  P  P  S  G  I  R  P  L  S  G  N  I  R  V  A  T  A         p.40

  | 03       .         .         .         .         .         .    g.36149
  | ATGCCACCTGGGACAGCAAGACCAGGTTCTCGTGGTTGTCCCATAGGGACTGGTGGAGTT    c.180
  | M  P  P  G  T  A  R  P  G  S  R  G  C  P  I  G  T  G  G  V      p.60

          .         .         .         .         .         .       g.36209
 CTGTCTTCTCAAATCAAAGTTGCCCATCGCCCTGTAACACAACAAGGTTTGACTGGAATG       c.240
 L  S  S  Q  I  K  V  A  H  R  P  V  T  Q  Q  G  L  T  G  M         p.80

          .       | 04 .         .         .         .         .    g.38576
 AAAACTGGGACGAAAG | GTCCCCAGAGGCAAATTTTAGACAAATCTTACTATCTTGGGCTT    c.300
 K  T  G  T  K  G |   P  Q  R  Q  I  L  D  K  S  Y  Y  L  G  L      p.100

       | 05  .         .         .         .         .         .    g.42273
 CTTAG | AAGTAAAATAAGTGAACTTACAACTGAAGTTAATAAACTTCAGAAGGGAATAGAA    c.360
 L  R  |  S  K  I  S  E  L  T  T  E  V  N  K  L  Q  K  G  I  E      p.120

          .         .         .         .     | 06   .         .    g.42476
 ATGTACAATCAAGAGAATTCAGTATATTTGTCATATGAAAAGAG | GGCTGAGACTTTAGCT    c.420
 M  Y  N  Q  E  N  S  V  Y  L  S  Y  E  K  R  |  A  E  T  L  A      p.140

          .         .         .         .      | 07  .         .    g.46645
 GTTGAGATAAAAGAGCTTCAAGGACAACTAGCAGACTACAACATG | TTGGTAGATAAACTT    c.480
 V  E  I  K  E  L  Q  G  Q  L  A  D  Y  N  M   | L  V  D  K  L      p.160

          .         .         .         .      | 08  .         .    g.48110
 AATACCAACACTGAAATGGAAGAAGTAATGAATGATTACAATATG | CTTAAAGCTCAAAAT    c.540
 N  T  N  T  E  M  E  E  V  M  N  D  Y  N  M   | L  K  A  Q  N      p.180

          .         .         .         .        | 09.         .    g.66994
 GATCGAGAAACACAAAGTTTGGATGTCATATTTACTGAAAGACAAGC | GAAAGAAAAACAA    c.600
 D  R  E  T  Q  S  L  D  V  I  F  T  E  R  Q  A  |  K  E  K  Q      p.200

          .         .         .         .         .         .       g.67054
 ATCAGAAGTGTCGAAGAAGAAATTGAACAGGAAAAACAAGCAACAGATGACATTATCAAA       c.660
 I  R  S  V  E  E  E  I  E  Q  E  K  Q  A  T  D  D  I  I  K         p.220

          .         .         .         .         .         .       g.67114
 AATATGTCTTTTGAAAACCAAGTCAAGTACCTAGAGATGAAAACCACAAATGAGAAACTG       c.720
 N  M  S  F  E  N  Q  V  K  Y  L  E  M  K  T  T  N  E  K  L         p.240

        | 10 .         .         .         .         .         .    g.69921
 TTACAG | GAATTAGATACACTTCAACAACAATTGGATTCACAGAACATGAAAAAAGAGAGC    c.780
 L  Q   | E  L  D  T  L  Q  Q  Q  L  D  S  Q  N  M  K  K  E  S      p.260

           | 11        .         .         .         .         .    g.74919
 CTGGAAGCA | GAAATAGCTCACTCCCAGGTGAAACAGGAGGCGGTATTGCTGCATGAAAAA    c.840
 L  E  A   | E  I  A  H  S  Q  V  K  Q  E  A  V  L  L  H  E  K      p.280

          .         .         .         .         .         .       g.74979
 CTTTATGAGTTGGAGTCCCATCGAGATCAAATGATTGCAGAAGACAAAAGCATAGGATCT       c.900
 L  Y  E  L  E  S  H  R  D  Q  M  I  A  E  D  K  S  I  G  S         p.300

          .         .         .    | 12    .         .         .    g.76635
 CCAATGGAAGAGAGAGAGAAATTACTTAAGCAG | ATTAAAGATGATAATCAGGAAATAGCC    c.960
 P  M  E  E  R  E  K  L  L  K  Q   | I  K  D  D  N  Q  E  I  A      p.320

          .     | 13   .         .         .         .         .    g.87032
 AGCATGGAAAGACA | GTTAACAGATACAAAAGAAAAGATAAATCAGTTTATTGAAGAAATT    c.1020
 S  M  E  R  Q  |  L  T  D  T  K  E  K  I  N  Q  F  I  E  E  I      p.340

          .         .         .     | 14   .         .         .    g.102729
 AGACAACTTGACATGGATTTAGAGGAACACCAAG | GTGAAATGAACCAGAAATACAAGGAG    c.1080
 R  Q  L  D  M  D  L  E  E  H  Q  G |   E  M  N  Q  K  Y  K  E      p.360

          .         .         | 15         .         .         .    g.105267
 CTAAAGAAAAGGGAGGAACATATGGACA | CTTTTATTGAGACTTTTGAGGAAACAAAGAAT    c.1140
 L  K  K  R  E  E  H  M  D  T |   F  I  E  T  F  E  E  T  K  N      p.380

          .         .         .         .         .         .       g.105327
 CAGGAACTGAAACGAAAGGCACAGATAGAAGCCAACATTGTTGCACTCTTGGAGCACTGC       c.1200
 Q  E  L  K  R  K  A  Q  I  E  A  N  I  V  A  L  L  E  H  C         p.400

        | 16 .         .         .         .         .         .    g.106163
 AGTCGA | AATATAAATCGTATAGAACAGATATCCTCTATCACCAATCAAGAGCTAAAGATG    c.1260
 S  R   | N  I  N  R  I  E  Q  I  S  S  I  T  N  Q  E  L  K  M      p.420

          .         .         .         .         .         .       g.106223
 ATGCAGGATGACCTCAATTTTAAATCTACTGAAGTGCAGAAATCACAAAGTACAGCTCAG       c.1320
 M  Q  D  D  L  N  F  K  S  T  E  V  Q  K  S  Q  S  T  A  Q         p.440

          .    | 17    .         .         .         .         .    g.113617
 AATTTGACTTCAG | ACATTCAACGTCTGCAGTTGGATCTGCAGAAAATGGAGCTTCTAGAA    c.1380
 N  L  T  S  D |   I  Q  R  L  Q  L  D  L  Q  K  M  E  L  L  E      p.460

          .         .         .         .         .         .       g.113677
 AGTAAGATGACTGAAGAACAGCATTCTCTAAAAAGCAAAATTAAGCAAATGACAACTGAT       c.1440
 S  K  M  T  E  E  Q  H  S  L  K  S  K  I  K  Q  M  T  T  D         p.480

          .         .         .         .         .        | 18.    g.114298
 CTGGAGATATATAATGATTTGCCAGCTTTAAAATCATCAGGTGAAGAAAAGATAAAG | AAA    c.1500
 L  E  I  Y  N  D  L  P  A  L  K  S  S  G  E  E  K  I  K   | K      p.500

          .         .         .         .         .         .       g.114358
 TTACATCAGGAGAGAATGATATTATCAACCCACAGAAATGCCTTTAAGAAAATAATGGAG       c.1560
 L  H  Q  E  R  M  I  L  S  T  H  R  N  A  F  K  K  I  M  E         p.520

          .         .         .         .         .         .       g.114418
 AAGCAAAACATAGAGTATGAGGCACTAAAAACACAATTGCAAGAAAATGAGACACATTCT       c.1620
 K  Q  N  I  E  Y  E  A  L  K  T  Q  L  Q  E  N  E  T  H  S         p.540

     | 19    .         .         .         .         .         .    g.118609
 CAG | CTTACAAATTTGGAGAGAAAGTGGCAACACCTTGAGCAAAATAATTTTGCGATGAAA    c.1680
 Q   | L  T  N  L  E  R  K  W  Q  H  L  E  Q  N  N  F  A  M  K      p.560

      | 20   .         .         .         .         .         .    g.120635
 GAAT | TCATAGCAACCAAGAGTCAAGAGAGTGATTACCAGCCAATTAAGAAAAATGTGACC    c.1740
 E  F |   I  A  T  K  S  Q  E  S  D  Y  Q  P  I  K  K  N  V  T      p.580

          .         .         .         .         .         .       g.120695
 AAGCAGATTGCAGAGTACAATAAAACCATCGTGGATGCTTTACATAGCACCAGCGGAAAC       c.1800
 K  Q  I  A  E  Y  N  K  T  I  V  D  A  L  H  S  T  S  G  N         p.600

                                                                    g.120698
 TGA                                                                c.1803
 X                                                                  p.600

          .         .         .         .         .         .       g.120758
 gtttaagtccactgaaagtctctaaggaagtatcctcttgctgctaaacttggtacaagt       c.*60

          .         .         .         .         .         .       g.120818
 tgactaccaaaaaaaaaaaaagcttacttttggagtttacctaaaatttctgaatgttat       c.*120

          .         .         .         .         .         .       g.120878
 aatttttgtggcctcttttaagaatgatattttaaaatagtaaatagttcaataaatggt       c.*180

          .                                                         g.120895
 ttgcatattaaaaagta                                                  c.*197

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Intraflagellar transport 74 homolog (Chlamydomonas) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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