inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (IKBKB) - coding DNA reference sequence

(used for variant description)

(last modified April 23, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001556.2 in the IKBKB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_041793.1, covering IKBKB transcript NM_001556.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5006
                                                       gtgacg       c.-181

 .         .         .         .         .         .                g.5066
 tcagagcaggaagtgtttgaggaagtcgcgccgcgctgcccgcgttaagattcccgcatt       c.-121

 .         .         .         .         .         .                g.5126
 ttaatgttttcaggggggtgtcatagccccgggtttggccgccccagccccgccttcccc       c.-61

 .         .         .         .         .  | 02      .             g.5799
 gccccggggagcccgccccctgccccgcgtccctgccgacag | agttagcacgacatcagt    c.-1

          .         .         .         .         .         .       g.5859
 ATGAGCTGGTCACCTTCCCTGACAACGCAGACATGTGGGGCCTGGGAAATGAAAGAGCGC       c.60
 M  S  W  S  P  S  L  T  T  Q  T  C  G  A  W  E  M  K  E  R         p.20

          .         .         .         .      | 03  .         .    g.22347
 CTTGGGACAGGGGGATTTGGAAATGTCATCCGATGGCACAATCAG | GAAACAGGTGAGCAG    c.120
 L  G  T  G  G  F  G  N  V  I  R  W  H  N  Q   | E  T  G  E  Q      p.40

          .         .         .         .         .         .       g.22407
 ATTGCCATCAAGCAGTGCCGGCAGGAGCTCAGCCCCCGGAACCGAGAGCGGTGGTGCCTG       c.180
 I  A  I  K  Q  C  R  Q  E  L  S  P  R  N  R  E  R  W  C  L         p.60

          .         . | 04       .         .         .         .    g.23894
 GAGATCCAGATCATGAGAAG | GCTGACCCACCCCAATGTGGTGGCTGCCCGAGATGTCCCT    c.240
 E  I  Q  I  M  R  R  |  L  T  H  P  N  V  V  A  A  R  D  V  P      p.80

          .         .         .         .         .         .       g.23954
 GAGGGGATGCAGAACTTGGCGCCCAATGACCTGCCCCTGCTGGCCATGGAGTACTGCCAA       c.300
 E  G  M  Q  N  L  A  P  N  D  L  P  L  L  A  M  E  Y  C  Q         p.100

          .         | 05         .         .         .         .    g.27183
 GGAGGAGATCTCCGGAAG | TACCTGAACCAGTTTGAGAACTGCTGTGGTCTGCGGGAAGGT    c.360
 G  G  D  L  R  K   | Y  L  N  Q  F  E  N  C  C  G  L  R  E  G      p.120

          .         .         | 06         .         .         .    g.38917
 GCCATCCTCACCTTGCTGAGTGACATTG | CCTCTGCGCTTAGATACCTTCATGAAAACAGA    c.420
 A  I  L  T  L  L  S  D  I  A |   S  A  L  R  Y  L  H  E  N  R      p.140

          .         .         .         .         .        | 07.    g.40044
 ATCATCCATCGGGATCTAAAGCCAGAAAACATCGTCCTGCAGCAAGGAGAACAGAGG | TTA    c.480
 I  I  H  R  D  L  K  P  E  N  I  V  L  Q  Q  G  E  Q  R   | L      p.160

          .         .         .         .         .         .       g.40104
 ATACACAAAATTATTGACCTAGGATATGCCAAGGAGCTGGATCAGGGCAGTCTTTGCACA       c.540
 I  H  K  I  I  D  L  G  Y  A  K  E  L  D  Q  G  S  L  C  T         p.180

          .         .        | 08.         .         .         .    g.42632
 TCATTCGTGGGGACCCTGCAGTACCTG | GCCCCAGAGCTACTGGAGCAGCAGAAGTACACA    c.600
 S  F  V  G  T  L  Q  Y  L   | A  P  E  L  L  E  Q  Q  K  Y  T      p.200

          .         .         .         .         .         .       g.42692
 GTGACCGTCGACTACTGGAGCTTCGGCACCCTGGCCTTTGAGTGCATCACGGGCTTCCGG       c.660
 V  T  V  D  Y  W  S  F  G  T  L  A  F  E  C  I  T  G  F  R         p.220

          .         .         .   | 09     .         .         .    g.48048
 CCCTTCCTCCCCAACTGGCAGCCCGTGCAGTG | GCATTCAAAAGTGCGGCAGAAGAGTGAG    c.720
 P  F  L  P  N  W  Q  P  V  Q  W  |  H  S  K  V  R  Q  K  S  E      p.240

          .         .         .         .         .         .       g.48108
 GTGGACATTGTTGTTAGCGAAGACTTGAATGGAACGGTGAAGTTTTCAAGCTCTTTACCC       c.780
 V  D  I  V  V  S  E  D  L  N  G  T  V  K  F  S  S  S  L  P         p.260

          .         . | 10       .         .         .         .    g.49948
 TACCCCAATAATCTTAACAG | TGTCCTGGCTGAGCGACTGGAGAAGTGGCTGCAACTGATG    c.840
 Y  P  N  N  L  N  S  |  V  L  A  E  R  L  E  K  W  L  Q  L  M      p.280

          .         .         .         .         .         .       g.50008
 CTGATGTGGCACCCCCGACAGAGGGGCACGGATCCCACGTATGGGCCCAATGGCTGCTTC       c.900
 L  M  W  H  P  R  Q  R  G  T  D  P  T  Y  G  P  N  G  C  F         p.300

          .         .         . | 11       .         .         .    g.50438
 AAGGCCCTGGATGACATCTTAAACTTAAAG | CTGGTTCATATCTTGAACATGGTCACGGGC    c.960
 K  A  L  D  D  I  L  N  L  K   | L  V  H  I  L  N  M  V  T  G      p.320

          .         .         .         .         .         .       g.50498
 ACCATCCACACCTACCCTGTGACAGAGGATGAGAGTCTGCAGAGCTTGAAGGCCAGAATC       c.1020
 T  I  H  T  Y  P  V  T  E  D  E  S  L  Q  S  L  K  A  R  I         p.340

          .         .         .         .         .         .       g.50558
 CAACAGGACACGGGCATCCCAGAGGAGGACCAGGAGCTGCTGCAGGAAGCGGGCCTGGCG       c.1080
 Q  Q  D  T  G  I  P  E  E  D  Q  E  L  L  Q  E  A  G  L  A         p.360

          .         .         .         .      | 12  .         .    g.51370
 TTGATCCCCGATAAGCCTGCCACTCAGTGTATTTCAGACGGCAAG | TTAAATGAGGGCCAC    c.1140
 L  I  P  D  K  P  A  T  Q  C  I  S  D  G  K   | L  N  E  G  H      p.380

          .         .         .         .         .         .       g.51430
 ACATTGGACATGGATCTTGTTTTTCTCTTTGACAACAGTAAAATCACCTATGAGACTCAG       c.1200
 T  L  D  M  D  L  V  F  L  F  D  N  S  K  I  T  Y  E  T  Q         p.400

          .         .         .         . | 13       .         .    g.52270
 ATCTCCCCACGGCCCCAACCTGAAAGTGTCAGCTGTATCC | TTCAAGAGCCCAAGAGGAAT    c.1260
 I  S  P  R  P  Q  P  E  S  V  S  C  I  L |   Q  E  P  K  R  N      p.420

          .         .         .         .         .         .       g.52330
 CTCGCCTTCTTCCAGCTGAGGAAGGTGTGGGGCCAGGTCTGGCACAGCATCCAGACCCTG       c.1320
 L  A  F  F  Q  L  R  K  V  W  G  Q  V  W  H  S  I  Q  T  L         p.440

          .         .         .         .     | 14   .         .    g.52984
 AAGGAAGATTGCAACCGGCTGCAGCAGGGACAGCGAGCCGCCAT | GATGAATCTCCTCCGA    c.1380
 K  E  D  C  N  R  L  Q  Q  G  Q  R  A  A  M  |  M  N  L  L  R      p.460

          .         .         .         .         .         .       g.53044
 AACAACAGCTGCCTCTCCAAAATGAAGAATTCCATGGCTTCCATGTCTCAGCAGCTCAAG       c.1440
 N  N  S  C  L  S  K  M  K  N  S  M  A  S  M  S  Q  Q  L  K         p.480

          .         .         .         .         .         .       g.53104
 GCCAAGTTGGATTTCTTCAAAACCAGCATCCAGATTGACCTGGAGAAGTACAGCGAGCAA       c.1500
 A  K  L  D  F  F  K  T  S  I  Q  I  D  L  E  K  Y  S  E  Q         p.500

          .       | 15 .         .         .         .         .    g.53327
 ACCGAGTTTGGGATCA | CATCAGATAAACTGCTGCTGGCCTGGAGGGAAATGGAGCAGGCT    c.1560
 T  E  F  G  I  T |   S  D  K  L  L  L  A  W  R  E  M  E  Q  A      p.520

          .         | 16         .         .         .         .    g.54475
 GTGGAGCTCTGTGGGCGG | GAGAACGAAGTGAAACTCCTGGTAGAACGGATGATGGCTCTG    c.1620
 V  E  L  C  G  R   | E  N  E  V  K  L  L  V  E  R  M  M  A  L      p.540

          .         .         .         .         .         .       g.54535
 CAGACCGACATTGTGGACTTACAGAGGAGCCCCATGGGCCGGAAGCAGGGGGGAACGCTG       c.1680
 Q  T  D  I  V  D  L  Q  R  S  P  M  G  R  K  Q  G  G  T  L         p.560

          | 17         .         .         .         .         | 18 g.55754
 GACGACCT | AGAGGAGCAAGCAAGGGAGCTGTACAGGAGACTAAGGGAAAAACCTCGAG | AC c.1740
 D  D  L  |  E  E  Q  A  R  E  L  Y  R  R  L  R  E  K  P  R  D |    p.580

          .         .         .         .         .         .       g.55814
 CAGCGAACTGAGGGTGACAGTCAGGAAATGGTACGGCTGCTGCTTCAGGCAATTCAGAGC       c.1800
 Q  R  T  E  G  D  S  Q  E  M  V  R  L  L  L  Q  A  I  Q  S         p.600

          .         .         .         | 19         .         .    g.56067
 TTCGAGAAGAAAGTGCGAGTGATCTATACGCAGCTCAG | TAAAACTGTGGTTTGCAAGCAG    c.1860
 F  E  K  K  V  R  V  I  Y  T  Q  L  S  |  K  T  V  V  C  K  Q      p.620

          .         .         .         .         .         .       g.56127
 AAGGCGCTGGAACTGTTGCCCAAGGTGGAAGAGGTGGTGAGCTTAATGAATGAGGATGAG       c.1920
 K  A  L  E  L  L  P  K  V  E  E  V  V  S  L  M  N  E  D  E         p.640

          .         .         .         .         .         .       g.56187
 AAGACTGTTGTCCGGCTGCAGGAGAAGCGGCAGAAGGAGCTCTGGAATCTCCTGAAGATT       c.1980
 K  T  V  V  R  L  Q  E  K  R  Q  K  E  L  W  N  L  L  K  I         p.660

        | 20 .         .         .         .         .         .    g.59722
 GCTTGT | AGCAAGGTCCGTGGTCCTGTCAGTGGAAGCCCGGATAGCATGAATGCCTCTCGA    c.2040
 A  C   | S  K  V  R  G  P  V  S  G  S  P  D  S  M  N  A  S  R      p.680

          .         .         .         .         .         .       g.59782
 CTTAGCCAGCCTGGGCAGCTGATGTCTCAGCCCTCCACGGCCTCCAACAGCTTACCTGAG       c.2100
 L  S  Q  P  G  Q  L  M  S  Q  P  S  T  A  S  N  S  L  P  E         p.700

          .     | 21   .         .         .         .         .    g.62868
 CCAGCCAAGAAGAG | TGAAGAACTGGTGGCTGAAGCACATAACCTCTGCACCCTGCTAGAA    c.2160
 P  A  K  K  S  |  E  E  L  V  A  E  A  H  N  L  C  T  L  L  E      p.720

          .         .         .         .      | 22  .         .    g.64627
 AATGCCATACAGGACACTGTGAGGGAACAAGACCAGAGTTTCACG | GCCCTAGACTGGAGC    c.2220
 N  A  I  Q  D  T  V  R  E  Q  D  Q  S  F  T   | A  L  D  W  S      p.740

          .         .         .         .         .                 g.64678
 TGGTTACAGACGGAAGAAGAAGAGCACAGCTGCCTGGAGCAGGCCTCATGA                c.2271
 W  L  Q  T  E  E  E  E  H  S  C  L  E  Q  A  S  X                  p.756

          .         .         .         .         .         .       g.64738
 tgtggggggactcgaccccctgacatggggcagcccatagcaggccttgtgcagtggggg       c.*60

          .         .         .         .         .         .       g.64798
 gactcgaccccctgacatggggctgcctggagcaggccgcgtgacgtggggctgcctggc       c.*120

          .         .         .         .         .         .       g.64858
 cgcggctctcacatggtggttcctgctgcactgatggcccaggggtctctggtatccaga       c.*180

          .         .         .         .         .         .       g.64918
 tggagctctcgcttcctcagcagctgtgactttcacccaggacccaggacgcagccctcc       c.*240

          .         .         .         .         .         .       g.64978
 gtgggcactgccggcgccttgtctgcacactggaggtcctccattacagaggcccagcgc       c.*300

          .         .         .         .         .         .       g.65038
 acatcgctggccccacaaacgttcaggggtacagccatggcagctccttcctctgccgtg       c.*360

          .         .         .         .         .         .       g.65098
 agaaaagtgcttggagtacggtttgccacacacgtgactggacagtgtccaattcaaatc       c.*420

          .         .         .         .         .         .       g.65158
 tttcagggcagagtccgagcagcgcttggtgacagcctgtcctctcctgctctccaaagg       c.*480

          .         .         .         .         .         .       g.65218
 ccctgctccctgtcctctctcactttacagcttgtgtttcttctggattcagcttctcct       c.*540

          .         .         .         .         .         .       g.65278
 aaacagacagtttaattatagttgcggcctggccccatcctcacttcctctttttatttc       c.*600

          .         .         .         .         .         .       g.65338
 actgctgctaaaattgtgtttttacctactactttggtggttgtcctcttttcggcaaag       c.*660

          .         .         .         .         .         .       g.65398
 ttggagcgagtgccaagctctccatctgtggtcctttctgccaagagcgactcatagtaa       c.*720

          .         .         .         .         .         .       g.65458
 ccaggatgggagagcagctgccttattctgaatcccaaaaattacttgggggtgattgtc       c.*780

          .         .         .         .         .         .       g.65518
 acagaggagggacagaaagggtatctgctgaccaccagcctgcctacccatgcccatgtc       c.*840

          .         .         .         .         .         .       g.65578
 tccattcctgctcaagcgtgtgtgctgggccggggagtccctgtctctcacagcatctag       c.*900

          .         .         .         .         .         .       g.65638
 cagtattattaaatggattcattttaaaaatagctcctatattttgtaacatgtctcaaa       c.*960

          .         .         .         .         .         .       g.65698
 cactcatactgggttccacaatccactgttagaatacctatggttagggcttctgaacta       c.*1020

          .         .         .         .         .         .       g.65758
 aaataatggaaaattttaacaatttgtatagtgcctggatcattactagtgccataaccc       c.*1080

          .         .         .         .         .         .       g.65818
 tgcttcttcaacatttcacagaacttctcttttatataaaggcaagagcacaaaatgagt       c.*1140

          .         .         .         .         .         .       g.65878
 tcagatgatcacaaacaggtgagttttgttggagaagaaagttggagtaggagactttca       c.*1200

          .         .         .         .         .         .       g.65938
 caagtggtttccatggagatagaatgaagcattctgtggtcaagtaagtttagggagcta       c.*1260

          .         .         .         .         .         .       g.65998
 ttcatgtttcacttgctttgtggagattcacactatgcactgggaaagtatctgaaaagt       c.*1320

          .         .         .         .         .         .       g.66058
 cttataataaagaaacaggcttaactttgtgtaagaacactgtttatcaatgtcatttgg       c.*1380

          .         .         .         .         .         .       g.66118
 ctatagaaacattttctcctgctgattgtgtgtgtgaaacatgtattaacattccaatga       c.*1440

          .         .         .         .         .         .       g.66178
 actagcatttaataaagcacaattttggaaaccctggtaaatgacagtgggaaataacac       c.*1500

          .         .         .         .         .         .       g.66238
 ccgaaaggcaaggacgggcagattggggagggaaaggatgttgggctaagggctgtgagc       c.*1560

          .         .         .         .         .         .       g.66298
 ttatgttacaggcaactgagccactgaagaattttgacgaagaaaatgccaaccaaagca       c.*1620

          .         .         .         .         .                 g.66352
 gtcattttaaaagtttatggctgttcagttacaggacaagttgtgaaaagaaag             c.*1674

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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