interleukin 10 (IL10) - coding DNA reference sequence

(used for variant description)

(last modified October 27, 2021)

This file was created to facilitate the description of sequence variants on transcript NM_000572.2 in the IL10 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering IL10 transcript NM_000572.2.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
           .         .         .         .         .                g.5059
  acacatcaggggcttgctcttgcaaaaccaaaccacaagacagacttgcaaaagaaggc       c.-1

          .         .         .         .         .         .       g.5119
 ATGCACAGCTCAGCACTGCTCTGTTGCCTGGTCCTCCTGACTGGGGTGAGGGCCAGCCCA       c.60
 M  H  S  S  A  L  L  C  C  L  V  L  L  T  G  V  R  A  S  P         p.20

          .         .         .         .         .         .       g.5179
 GGCCAGGGCACCCAGTCTGAGAACAGCTGCACCCACTTCCCAGGCAACCTGCCTAACATG       c.120
 G  Q  G  T  Q  S  E  N  S  C  T  H  F  P  G  N  L  P  N  M         p.40

          .         .         .         .      | 02  .         .    g.6094
 CTTCGAGATCTCCGAGATGCCTTCAGCAGAGTGAAGACTTTCTTT | CAAATGAAGGATCAG    c.180
 L  R  D  L  R  D  A  F  S  R  V  K  T  F  F   | Q  M  K  D  Q      p.60

          .         .         .         .      | 03  .         .    g.6450
 CTGGACAACTTGTTGTTAAAGGAGTCCTTGCTGGAGGACTTTAAG | GGTTACCTGGGTTGC    c.240
 L  D  N  L  L  L  K  E  S  L  L  E  D  F  K   | G  Y  L  G  C      p.80

          .         .         .         .         .         .       g.6510
 CAAGCCTTGTCTGAGATGATCCAGTTTTACCTGGAGGAGGTGATGCCCCAAGCTGAGAAC       c.300
 Q  A  L  S  E  M  I  Q  F  Y  L  E  E  V  M  P  Q  A  E  N         p.100

          .         .         .         .         .         .       g.6570
 CAAGACCCAGACATCAAGGCGCATGTGAACTCCCTGGGGGAGAACCTGAAGACCCTCAGG       c.360
 Q  D  P  D  I  K  A  H  V  N  S  L  G  E  N  L  K  T  L  R         p.120

          .         | 04         .         .         .         .    g.7642
 CTGAGGCTACGGCGCTGT | CATCGATTTCTTCCCTGTGAAAACAAGAGCAAGGCCGTGGAG    c.420
 L  R  L  R  R  C   | H  R  F  L  P  C  E  N  K  S  K  A  V  E      p.140

          .         .     | 05   .         .         .         .    g.8802
 CAGGTGAAGAATGCCTTTAATAAG | CTCCAAGAGAAAGGCATCTACAAAGCCATGAGTGAG    c.480
 Q  V  K  N  A  F  N  K   | L  Q  E  K  G  I  Y  K  A  M  S  E      p.160

          .         .         .         .         .                 g.8859
 TTTGACATCTTCATCAACTACATAGAAGCCTACATGACAATGAAGATACGAAACTGA          c.537
 F  D  I  F  I  N  Y  I  E  A  Y  M  T  M  K  I  R  N  X            p.178

          .         .         .         .         .         .       g.8919
 gacatcagggtggcgactctatagactctaggacataaattagaggtctccaaaatcgga       c.*60

          .         .         .         .         .         .       g.8979
 tctggggctctgggatagctgacccagccccttgagaaaccttattgtacctctcttata       c.*120

          .         .         .         .         .         .       g.9039
 gaatatttattacctctgatacctcaacccccatttctatttatttactgagcttctctg       c.*180

          .         .         .         .         .         .       g.9099
 tgaacgatttagaaagaagcccaatattataatttttttcaatatttattattttcacct       c.*240

          .         .         .         .         .         .       g.9159
 gtttttaagctgtttccatagggtgacacactatggtatttgagtgttttaagataaatt       c.*300

          .         .         .         .         .         .       g.9219
 ataagttacataagggaggaaaaaaaatgttctttggggagccaacagaagcttccattc       c.*360

          .         .         .         .         .         .       g.9279
 caagcctgaccacgctttctagctgttgagctgttttccctgacctccctctaatttatc       c.*420

          .         .         .         .         .         .       g.9339
 ttgtctctgggcttggggcttcctaactgctacaaatactcttaggaagagaaaccaggg       c.*480

          .         .         .         .         .         .       g.9399
 agcccctttgatgattaattcaccttccagtgtctcggagggattcccctaacctcattc       c.*540

          .         .         .         .         .         .       g.9459
 cccaaccacttcattcttgaaagctgtggccagcttgttatttataacaacctaaatttg       c.*600

          .         .         .         .         .         .       g.9519
 gttctaggccgggcgcggtggctcacgcctgtaatcccagcactttgggaggctgaggcg       c.*660

          .         .         .         .         .         .       g.9579
 ggtggatcacttgaggtcaggagttcctaaccagcctggtcaacatggtgaaaccccgtc       c.*720

          .         .         .         .         .         .       g.9639
 tctactaaaaatacaaaaattagccgggcatggtggcgcgcacctgtaatcccagctact       c.*780

          .         .         .         .         .         .       g.9699
 tgggaggctgaggcaagagaattgcttgaacccaggagatggaagttgcagtgagctgat       c.*840

          .         .         .         .         .         .       g.9759
 atcatgcccctgtactccagcctgggtgacagagcaagactctgtctcaaaaaataaaaa       c.*900

          .         .         .         .         .         .       g.9819
 taaaaataaatttggttctaatagaactcagttttaactagaatttattcaattcctctg       c.*960

          .         .         .         .         .         .       g.9879
 ggaatgttacattgtttgtctgtcttcatagcagattttaattttgaataaataaatgta       c.*1020

          .                                                         g.9892
 tcttattcacatc                                                      c.*1033

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Interleukin 10 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.