interleukin 11 receptor, alpha (IL11RA) - coding DNA reference sequence

(used for variant description)

(last modified September 12, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_001142784.2 in the IL11RA gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_028966.1, covering IL11RA transcript NM_001142784.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5049
            agagggcgagggcgagggcagagggcgctggcggcagcggccgcggaag       c.-1

  | 02       .         .         .         .         .         .    g.8093
  | ATGAGCAGCAGCTGCTCAGGGCTGAGCAGGGTCCTGGTGGCCGTGGCTACAGCCCTGGTG    c.60
  | M  S  S  S  C  S  G  L  S  R  V  L  V  A  V  A  T  A  L  V      p.20

          .         .         .         . | 03       .         .    g.8440
 TCTGCCTCCTCCCCCTGCCCCCAGGCCTGGGGCCCCCCAG | GGGTCCAGTATGGGCAGCCA    c.120
 S  A  S  S  P  C  P  Q  A  W  G  P  P  G |   V  Q  Y  G  Q  P      p.40

          .         .         .         .  | 04      .         .    g.9573
 GGCAGGTCCGTGAAGCTGTGTTGTCCTGGAGTGACTGCCGG | GGACCCAGTGTCCTGGTTT    c.180
 G  R  S  V  K  L  C  C  P  G  V  T  A  G  |  D  P  V  S  W  F      p.60

          .         .         .         .         .         .       g.9633
 CGGGATGGGGAGCCAAAGCTGCTCCAGGGACCTGACTCTGGGCTAGGGCATGAACTGGTC       c.240
 R  D  G  E  P  K  L  L  Q  G  P  D  S  G  L  G  H  E  L  V         p.80

          .         .         .         .         .         .       g.9693
 CTGGCCCAGGCAGACAGCACTGATGAGGGCACCTACATCTGCCAGACCCTGGATGGTGCA       c.300
 L  A  Q  A  D  S  T  D  E  G  T  Y  I  C  Q  T  L  D  G  A         p.100

          .         .         .  | 05      .         .         .    g.9879
 CTTGGGGGCACAGTGACCCTGCAGCTGGGCT | ACCCTCCAGCCCGCCCTGTTGTCTCCTGC    c.360
 L  G  G  T  V  T  L  Q  L  G  Y |   P  P  A  R  P  V  V  S  C      p.120

          .         .         .         .         .         .       g.9939
 CAAGCAGCCGACTATGAGAACTTCTCTTGCACTTGGAGTCCCAGCCAGATCAGCGGTTTA       c.420
 Q  A  A  D  Y  E  N  F  S  C  T  W  S  P  S  Q  I  S  G  L         p.140

          .         .       | 06 .         .         .          | 07 g.10237
 CCCACCCGCTACCTCACCTCCTACAG | GAAGAAGACAGTCCTAGGAGCTGATAGCCAGAG | G c.480
 P  T  R  Y  L  T  S  Y  R  |  K  K  T  V  L  G  A  D  S  Q  R  |   p.160

          .         .         .         .         .         .       g.10297
 AGGAGTCCATCCACAGGGCCCTGGCCATGCCCACAGGATCCCCTAGGGGCTGCCCGCTGT       c.540
 R  S  P  S  T  G  P  W  P  C  P  Q  D  P  L  G  A  A  R  C         p.180

          .         .         .         .         .         .       g.10357
 GTTGTCCACGGGGCTGAGTTCTGGAGCCAGTACCGGATTAATGTGACTGAGGTGAACCCA       c.600
 V  V  H  G  A  E  F  W  S  Q  Y  R  I  N  V  T  E  V  N  P         p.200

          .         .         .         .       | 08 .         .    g.11349
 CTGGGTGCCAGCACACGCCTGCTGGATGTGAGCTTGCAGAGCATCT | TGCGCCCTGACCCA    c.660
 L  G  A  S  T  R  L  L  D  V  S  L  Q  S  I  L |   R  P  D  P      p.220

          .         .         .         .         .         .       g.11409
 CCCCAGGGCCTGCGGGTAGAGTCAGTACCAGGTTACCCCCGACGCCTGCGAGCCAGCTGG       c.720
 P  Q  G  L  R  V  E  S  V  P  G  Y  P  R  R  L  R  A  S  W         p.240

          .         .         .         .         .         .       g.11469
 ACATACCCTGCCTCCTGGCCGTGCCAGCCCCACTTCCTGCTCAAGTTCCGTTTGCAGTAC       c.780
 T  Y  P  A  S  W  P  C  Q  P  H  F  L  L  K  F  R  L  Q  Y         p.260

          .         .         . | 09       .         .         .    g.12604
 CGTCCGGCGCAGCATCCAGCCTGGTCCACG | GTGGAGCCAGCTGGACTGGAGGAGGTGATC    c.840
 R  P  A  Q  H  P  A  W  S  T   | V  E  P  A  G  L  E  E  V  I      p.280

          .         .         .         .         .         .       g.12664
 ACAGATGCTGTGGCTGGGCTGCCCCATGCTGTACGAGTCAGTGCCCGGGACTTTCTAGAT       c.900
 T  D  A  V  A  G  L  P  H  A  V  R  V  S  A  R  D  F  L  D         p.300

          .         .         .         .         .   | 10     .    g.13097
 GCTGGCACCTGGAGCACCTGGAGCCCGGAGGCCTGGGGAACTCCGAGCACTG | GGACCATA    c.960
 A  G  T  W  S  T  W  S  P  E  A  W  G  T  P  S  T  G |   T  I      p.320

          .         .         .         .         .         .       g.13157
 CCAAAGGAGATACCAGCATGGGGCCAGCTACACACGCAGCCAGAGGTGGAGCCTCAGGTG       c.1020
 P  K  E  I  P  A  W  G  Q  L  H  T  Q  P  E  V  E  P  Q  V         p.340

          .         .         .         .         .   | 11     .    g.13327
 GACAGCCCTGCTCCTCCAAGGCCCTCCCTCCAACCACACCCTCGGCTACTTG | ATCACAGG    c.1080
 D  S  P  A  P  P  R  P  S  L  Q  P  H  P  R  L  L  D |   H  R      p.360

          .         .         .         .         .         .       g.13387
 GACTCTGTGGAGCAGGTAGCTGTGCTGGCGTCTTTGGGAATCCTTTCTTTCCTGGGACTG       c.1140
 D  S  V  E  Q  V  A  V  L  A  S  L  G  I  L  S  F  L  G  L         p.380

          .         .          | 12        .         .         .    g.13700
 GTGGCTGGGGCCCTGGCACTGGGGCTCTG | GCTGAGGCTGAGACGGGGTGGGAAGGATGGA    c.1200
 V  A  G  A  L  A  L  G  L  W  |  L  R  L  R  R  G  G  K  D  G      p.400

          .         .         .         .         .   | 13     .    g.14305
 TCCCCAAAGCCTGGGTTCTTGGCCTCAGTGATTCCAGTGGACAGGCGTCCAG | GAGCTCCA    c.1260
 S  P  K  P  G  F  L  A  S  V  I  P  V  D  R  R  P  G |   A  P      p.420

                                                                    g.14314
 AACCTGTAG                                                          c.1269
 N  L  X                                                            p.422

          .         .         .         .         .         .       g.14374
 aggacccaggagggcttcggcagattccacctataattctgtcttgctggtgtggataga       c.*60

          .         .         .         .         .         .       g.14434
 aaccaggcaggacagtagatccctatggttggatctcagctggaagttctgtttggagcc       c.*120

          .         .         .         .         .         .       g.14494
 catttctgtgagaccctgtatttcaaatttgcagctgaaaggtgcttgtacctctgattt       c.*180

          .         .         .         .         .         .       g.14554
 caccccagagttggagttctgctcaaggaacgtgtgtaatgtgtacatctgtgtccatgt       c.*240

          .         .         .         .         .         .       g.14614
 gtgaccatgtgtctgtgaggcagggaacatgtattctctgcatgcatgtatgtaggtgcc       c.*300

          .         .         .         .         .         .       g.14674
 tggggagtgtgtgtgggtccttggctcttggcctttccccttgcaggggttgtgcaggtg       c.*360

          .         .         .         .                           g.14718
 tgaataaagagaataaggaagttcttggagattatactcagaaa                       c.*404

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Interleukin 11 receptor, alpha protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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