interleukin 7 receptor (IL7R) - coding DNA reference sequence

(used for variant description)

(last modified October 17, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_002185.3 in the IL7R gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000005.9, covering IL7R transcript NM_002185.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5043
                  atctaagcttctctgtcttcctccctccctcccttcctcttac       c.-61

 .         .         .         .         .         .                g.5103
 tctcattcatttcatacacactggctcacacatctactctctctctctatctctctcaga       c.-1

          .         .         .         .         .         .       g.5163
 ATGACAATTCTAGGTACAACTTTTGGCATGGTTTTTTCTTTACTTCAAGTCGTTTCTGGA       c.60
 M  T  I  L  G  T  T  F  G  M  V  F  S  L  L  Q  V  V  S  G         p.20

          .         .   | 02     .         .         .         .    g.9015
 GAAAGTGGCTATGCTCAAAATG | GAGACTTGGAAGATGCAGAACTGGATGACTACTCATTC    c.120
 E  S  G  Y  A  Q  N  G |   D  L  E  D  A  E  L  D  D  Y  S  F      p.40

          .         .         .         .         .         .       g.9075
 TCATGCTATAGCCAGTTGGAAGTGAATGGATCGCAGCACTCACTGACCTGTGCTTTTGAG       c.180
 S  C  Y  S  Q  L  E  V  N  G  S  Q  H  S  L  T  C  A  F  E         p.60

          .         .         .         .  | 03      .         .    g.15450
 GACCCAGATGTCAACATCACCAATCTGGAATTTGAAATATG | TGGGGCCCTCGTGGAGGTA    c.240
 D  P  D  V  N  I  T  N  L  E  F  E  I  C  |  G  A  L  V  E  V      p.80

          .         .         .         .         .         .       g.15510
 AAGTGCCTGAATTTCAGGAAACTACAAGAGATATATTTCATCGAGACAAAGAAATTCTTA       c.300
 K  C  L  N  F  R  K  L  Q  E  I  Y  F  I  E  T  K  K  F  L         p.100

          .         .         .         .         .         .       g.15570
 CTGATTGGAAAGAGCAATATATGTGTGAAGGTTGGAGAAAAGAGTCTAACCTGCAAAAAA       c.360
 L  I  G  K  S  N  I  C  V  K  V  G  E  K  S  L  T  C  K  K         p.120

          .          | 04        .         .         .         .    g.19222
 ATAGACCTAACCACTATAG | TTAAACCTGAGGCTCCTTTTGACCTGAGTGTCGTCTATCGG    c.420
 I  D  L  T  T  I  V |   K  P  E  A  P  F  D  L  S  V  V  Y  R      p.140

          .         .         .         .         .         .       g.19282
 GAAGGAGCCAATGACTTTGTGGTGACATTTAATACATCACACTTGCAAAAGAAGTATGTA       c.480
 E  G  A  N  D  F  V  V  T  F  N  T  S  H  L  Q  K  K  Y  V         p.160

          .         .         .         .         .        | 05.    g.21608
 AAAGTTTTAATGCACGATGTAGCTTACCGCCAGGAAAAGGATGAAAACAAATGGACG | CAT    c.540
 K  V  L  M  H  D  V  A  Y  R  Q  E  K  D  E  N  K  W  T   | H      p.180

          .         .         .         .         .         .       g.21668
 GTGAATTTATCCAGCACAAAGCTGACACTCCTGCAGAGAAAGCTCCAACCGGCAGCAATG       c.600
 V  N  L  S  S  T  K  L  T  L  L  Q  R  K  L  Q  P  A  A  M         p.200

          .         .         .         .         .         .       g.21728
 TATGAGATTAAAGTTCGATCCATCCCTGATCACTATTTTAAAGGCTTCTGGAGTGAATGG       c.660
 Y  E  I  K  V  R  S  I  P  D  H  Y  F  K  G  F  W  S  E  W         p.220

          .         .         .         .       | 06 .         .    g.22588
 AGTCCAAGTTATTACTTCAGAACTCCAGAGATCAATAATAGCTCAG | GGGAGATGGATCCT    c.720
 S  P  S  Y  Y  F  R  T  P  E  I  N  N  S  S  G |   E  M  D  P      p.240

          .         .         .         .         .         .       g.22648
 ATCTTACTAACCATCAGCATTTTGAGTTTTTTCTCTGTCGCTCTGTTGGTCATCTTGGCC       c.780
 I  L  L  T  I  S  I  L  S  F  F  S  V  A  L  L  V  I  L  A         p.260

          .         . | 07       .         .         .         .    g.23677
 TGTGTGTTATGGAAAAAAAG | GATTAAGCCTATCGTATGGCCCAGTCTCCCCGATCATAAG    c.840
 C  V  L  W  K  K  R  |  I  K  P  I  V  W  P  S  L  P  D  H  K      p.280

          .         .         .       | 08 .         .         .    g.24132
 AAGACTCTGGAACATCTTTGTAAGAAACCAAGAAAA | AATTTAAATGTGAGTTTCAATCCT    c.900
 K  T  L  E  H  L  C  K  K  P  R  K   | N  L  N  V  S  F  N  P      p.300

          .         .         .         .         .         .       g.24192
 GAAAGTTTCCTGGACTGCCAGATTCATAGGGTGGATGACATTCAAGCTAGAGATGAAGTG       c.960
 E  S  F  L  D  C  Q  I  H  R  V  D  D  I  Q  A  R  D  E  V         p.320

          .         .         .         .         .         .       g.24252
 GAAGGTTTTCTGCAAGATACGTTTCCTCAGCAACTAGAAGAATCTGAGAAGCAGAGGCTT       c.1020
 E  G  F  L  Q  D  T  F  P  Q  Q  L  E  E  S  E  K  Q  R  L         p.340

          .         .         .         .         .         .       g.24312
 GGAGGGGATGTGCAGAGCCCCAACTGCCCATCTGAGGATGTAGTCATCACTCCAGAAAGC       c.1080
 G  G  D  V  Q  S  P  N  C  P  S  E  D  V  V  I  T  P  E  S         p.360

          .         .         .         .         .         .       g.24372
 TTTGGAAGAGATTCATCCCTCACATGCCTGGCTGGGAATGTCAGTGCATGTGACGCCCCT       c.1140
 F  G  R  D  S  S  L  T  C  L  A  G  N  V  S  A  C  D  A  P         p.380

          .         .         .         .         .         .       g.24432
 ATTCTCTCCTCTTCCAGGTCCCTAGACTGCAGGGAGAGTGGCAAGAATGGGCCTCATGTG       c.1200
 I  L  S  S  S  R  S  L  D  C  R  E  S  G  K  N  G  P  H  V         p.400

          .         .         .         .         .         .       g.24492
 TACCAGGACCTCCTGCTTAGCCTTGGGACTACAAACAGCACGCTGCCCCCTCCATTTTCT       c.1260
 Y  Q  D  L  L  L  S  L  G  T  T  N  S  T  L  P  P  P  F  S         p.420

          .         .         .         .         .         .       g.24552
 CTCCAATCTGGAATCCTGACATTGAACCCAGTTGCTCAGGGTCAGCCCATTCTTACTTCC       c.1320
 L  Q  S  G  I  L  T  L  N  P  V  A  Q  G  Q  P  I  L  T  S         p.440

          .         .         .         .         .         .       g.24612
 CTGGGATCAAATCAAGAAGAAGCATATGTCACCATGTCCAGCTTCTACCAAAACCAGTGA       c.1380
 L  G  S  N  Q  E  E  A  Y  V  T  M  S  S  F  Y  Q  N  Q  X         p.459

          .         .         .         .         .         .       g.24672
 agtgtaagaaacccagactgaacttaccgtgagcgacaaagatgatttaaaagggaagtc       c.*60

          .         .         .         .         .         .       g.24732
 tagagttcctagtctccctcacagcacagagaagacaaaattagcaaaaccccactacac       c.*120

          .         .         .         .         .         .       g.24792
 agtctgcaagattctgaaacattgctttgaccactcttcctgagttcagtggcactcaac       c.*180

          .         .         .         .         .         .       g.24852
 atgagtcaagagcatcctgcttctaccatgtggatttggtcacaaggtttaaggtgaccc       c.*240

          .         .         .         .         .         .       g.24912
 aatgattcagctatttaaaaaaaaaagaggaaagaatgaaagagtaaaggaaatgattga       c.*300

          .         .         .         .         .         .       g.24972
 ggagtgaggaaggcaggaagagagcatgagaggaaagaaagaaaggaaaataaaaaatga       c.*360

          .         .         .         .         .         .       g.25032
 tagttgccattattaggatttaatatatatccagtgctttgcaagtgctctgcgcacctt       c.*420

          .         .         .         .         .         .       g.25092
 gtctcactccatcctgacaataatcctgggaggtgtgtgcaattactacgactactctct       c.*480

          .         .         .         .         .         .       g.25152
 tttttatagatcattaaattcagaactaaggagttaagtaacttgtccaagttgttcaca       c.*540

          .         .         .         .         .         .       g.25212
 cagtgaagggaggggccaagatatgatggctgggagtctaattgcagttccctgagccat       c.*600

          .         .         .         .         .         .       g.25272
 gtgcctttctcttcactgaggactgccccattcttgagtgccaaacgtcactagtaacag       c.*660

          .         .         .         .         .         .       g.25332
 ggtgtgcctagataatttatgatccaaactgagtcagtttggaaagtgaaagggaaactt       c.*720

          .         .         .         .         .         .       g.25392
 acatataatccctccgggacaatgagcaaaaactaggactgtccccagacaaatgtgaac       c.*780

          .         .         .         .         .         .       g.25452
 atacatatcatcacttaaattaaaatggctatgagaaagaaagagggggagaaacagtct       c.*840

          .         .         .         .         .         .       g.25512
 tgcgggtgtgaagtcccatgaccagccatgtcaaaagaaggtaaagaagtcaagaaaaag       c.*900

          .         .         .         .         .         .       g.25572
 ccatgaagcccatttggtttcatttttctgaaaataggctcaagagggaataaattagaa       c.*960

          .         .         .         .         .         .       g.25632
 actcacaatttctcttgtttgttaccaagacagtgattctcttgctgctaccacccaact       c.*1020

          .         .         .         .         .         .       g.25692
 gcatccgtccatgatctcagaggaaactgtcgctgaccctggacatgggtacgtttgacg       c.*1080

          .         .         .         .         .         .       g.25752
 agtgagaggaggcatgacccctcccatgtgtatagacactaccccaacctaaattcatcc       c.*1140

          .         .         .         .         .         .       g.25812
 ctaaattgtcccaagttctccagcaatagaggctgccacaaacttcagggagaaagagtt       c.*1200

          .         .         .         .         .         .       g.25872
 acaagtacatgcaatgagtgaactgactgtggctacaatcttgaagatatacggaagaga       c.*1260

          .         .         .         .         .         .       g.25932
 cgtattattaatgcttgacatatatcatcttgcctttcttggtctagactgacttctaat       c.*1320

          .         .         .         .         .         .       g.25992
 gactaactcaaagtcaaggcaactgagtaatgtcagctcagcaaagtgcagcaaacccat       c.*1380

          .         .         .         .         .         .       g.26052
 ctcccacaggcctccaaaccctggctgttcacagaaccacaaagggcagatgctgcacag       c.*1440

          .         .         .         .         .         .       g.26112
 aaaactagagaaggggtcataggttcatggttttgtttgagatttgttgctactgttttt       c.*1500

          .         .         .         .         .         .       g.26172
 ctgttttgaattttcttctttgttctgtttttactttatttagggggactaggtgtttct       c.*1560

          .         .         .         .         .         .       g.26232
 gatattttagttttcttgtttgttttgttttgtgttgtctgtgaatggggttttaactgt       c.*1620

          .         .         .         .         .         .       g.26292
 ggatgaatggaccttatctgttggcttaaaggactggtaagatcagaccatcttattctt       c.*1680

          .         .         .         .         .         .       g.26352
 caggtgaatgttttactttccaaagtgctctcctctgcaccagcagtaataaatacaatg       c.*1740

          .         .         .         .         .         .       g.26412
 ccataatcccttaggtttgcctagtgcttttgcaattttcaaagcacttccataagcatt       c.*1800

          .         .         .         .         .         .       g.26472
 ccttccacctccttgataggcatttatggaaagcctgctacatgtcaatcatactgttag       c.*1860

          .         .         .         .         .         .       g.26532
 gcacaggggacctaaagacacataaaaggatggcattctgcctcataaattgcaaaacct       c.*1920

          .         .         .         .         .         .       g.26592
 aatgaaagtgactgcttggtaaacaaattattattatattataaaatgctataaaagagc       c.*1980

          .         .         .         .         .         .       g.26652
 catattgaaagtgccctgttggagacagggcaaatgccacaaaaatgatgtaaatttaca       c.*2040

          .         .         .         .         .         .       g.26712
 tggaggaaaagtagaatctgcctggtttgtaggcagcagaagacatttttcatcagtggg       c.*2100

          .         .         .         .         .         .       g.26772
 caggtgttctttaccttttgtagaaatgggagtcaagtctcaaataggaggctccacaaa       c.*2160

          .         .         .         .         .         .       g.26832
 atctcatgccaggtctctgataccttattcacagaagttctttgaagtatttattgttat       c.*2220

          .         .         .         .         .         .       g.26892
 tttctttgacttatgggaaaactgggacacaggaagacaggtaaattacccaacctcaca       c.*2280

          .         .         .         .         .         .       g.26952
 cgttaagtcagaactgggagccataattttgtatccctggtataaatagacaatctcttg       c.*2340

          .         .         .         .         .         .       g.27012
 aagaaatgaagagatgaccatagaaaaacatcgagatatctccagctctaaaatcctttg       c.*2400

          .         .         .         .         .         .       g.27072
 tttcaatgttgtttggcatatgttatctttggaatttagtgtctgagcctctgtctgtta       c.*2460

          .         .         .         .         .         .       g.27132
 ctgtagtatttaaaatgcatgtattataatcatataatcataactgctgttaattcttga       c.*2520

          .         .         .         .         .         .       g.27192
 ttatatacctagggacaatgtgtaatgtaagattactaattggttctgcccaatctcctt       c.*2580

          .         .         .         .         .         .       g.27252
 tcagattttattaggaaaaaaaaataaacctcctgatcggagacaatgtattaatcagaa       c.*2640

          .         .         .         .         .         .       g.27312
 gtgtaaactgccagttctatatagcatgaaatgaaaagacagctaatttggtccaacaaa       c.*2700

          .         .         .         .         .         .       g.27372
 catgactgggtctagggcacccaggctgattcagctgatttcctaccagcctttgcctct       c.*2760

          .         .         .         .         .         .       g.27432
 tccttcaatgtggtttccatgggaatttgcttcagaaaagccaagtatgggctgttcaga       c.*2820

          .         .         .         .         .         .       g.27492
 ggtgcacacctgcattttcttagctcttctagaggggctaagagacttggtacgggccag       c.*2880

          .         .         .         .         .         .       g.27552
 gaagaatatgtggcagagctcctggaaatgatgcagattaggtggcatttttgtcagctc       c.*2940

          .         .         .         .         .         .       g.27612
 tgtggtttattgttgggactattctttaaaatatccattgttcactacagtgaagatctc       c.*3000

          .         .         .         .         .         .       g.27672
 tgatttaaccgtgtactatccacatgcattacaaacatttcgcagagctgcttagtatat       c.*3060

          .         .         .         .         .                 g.27729
 aagcgtacaatgtatgtaataaccatctcatatttaattaaatggtatagaagaaca          c.*3117

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Interleukin 7 receptor protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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