interphotoreceptor matrix proteoglycan 1 (IMPG1) - coding DNA reference sequence

(used for variant description)

(last modified July 6, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_001563.2 in the IMPG1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_041812.1, covering IMPG1 transcript NM_001563.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5010
                                                   taaaccaaga       c.-121

 .         .         .         .         .         .                g.5070
 aggttatcctcaatcatctggtatcaatatataattatttttcacatttctgttactttt       c.-61

 .         .         .         .         .         .                g.5130
 taatgagatttgaggttgttctgtgattgttatcagaattaccaatgcacaaaagccaga       c.-1

          .         .         .         .         .         .       g.5190
 ATGTATTTGGAAACTAGAAGAGCTATTTTTGTTTTTTGGATTTTTCTCCAAGTTCAAGGA       c.60
 M  Y  L  E  T  R  R  A  I  F  V  F  W  I  F  L  Q  V  Q  G         p.20

         | 02.         .         .         .         .         .    g.35545
 ACCAAAG | ATATCTCCATTAACATATACCATTCTGAAACTAAAGACATAGACAATCCCCCA    c.120
 T  K  D |   I  S  I  N  I  Y  H  S  E  T  K  D  I  D  N  P  P      p.40

          .         .         .         .         .         .       g.35605
 AGAAATGAAACAACTGAAAGTACTGAAAAAATGTACAAAATGTCAACTATGAGACGAATA       c.180
 R  N  E  T  T  E  S  T  E  K  M  Y  K  M  S  T  M  R  R  I         p.60

          .         .         .         .         .         .       g.35665
 TTCGATTTGGCAAAGCATCGAACAAAAAGATCCGCATTTTTCCCAACGGGGGTTAAAGTC       c.240
 F  D  L  A  K  H  R  T  K  R  S  A  F  F  P  T  G  V  K  V         p.80

          .         .         .         .         .         .       g.35725
 TGTCCACAGGAATCCATGAAACAGATTTTAGACAGTCTTCAAGCTTATTATAGATTGAGA       c.300
 C  P  Q  E  S  M  K  Q  I  L  D  S  L  Q  A  Y  Y  R  L  R         p.100

   | 03      .         .         .         .         .         .    g.42890
 G | TGTGTCAGGAAGCAGTATGGGAAGCATATCGGATCTTTCTGGATCGCATCCCTGACACA    c.360
 V |   C  Q  E  A  V  W  E  A  Y  R  I  F  L  D  R  I  P  D  T      p.120

          .         .         .         .         .         .       g.42950
 GGGGAATATCAGGACTGGGTCAGCATCTGCCAGCAGGAGACCTTCTGCCTCTTTGACATT       c.420
 G  E  Y  Q  D  W  V  S  I  C  Q  Q  E  T  F  C  L  F  D  I         p.140

          .         .         .         .         | 04         .    g.43287
 GGAAAAAACTTCAGCAATTCCCAGGAGCACCTGGATCTTCTCCAGCAG | AGAATAAAACAG    c.480
 G  K  N  F  S  N  S  Q  E  H  L  D  L  L  Q  Q   | R  I  K  Q      p.160

          .        | 05.         .         .         .         .    g.52403
 AGAAGTTTCCCTGACAG | AAAAGATGAAATATCTGCAGAGAAGACATTGGGAGAGCCTGGT    c.540
 R  S  F  P  D  R  |  K  D  E  I  S  A  E  K  T  L  G  E  P  G      p.180

          .         .   | 06     .         .         .         .    g.55437
 GAAACCATTGTCATTTCAACAG | ATGTTGCCAACGTCTCACTTGGGCCTTTCCCTCTCACT    c.600
 E  T  I  V  I  S  T  D |   V  A  N  V  S  L  G  P  F  P  L  T      p.200

          .         .         .         .         .         .       g.55497
 CCTGATGACACCCTCCTCAATGAAATTCTCGATAATACACTCAACGACACCAAGATGCCT       c.660
 P  D  D  T  L  L  N  E  I  L  D  N  T  L  N  D  T  K  M  P         p.220

        | 07 .         .         .         .         .         .    g.58814
 ACAACA | GAAAGAGAAACAGAATTCGCTGTGTTGGAGGAGCAGAGGGTGGAGCTCAGCGTC    c.720
 T  T   | E  R  E  T  E  F  A  V  L  E  E  Q  R  V  E  L  S  V      p.240

          .         .         .         .         .         .       g.58874
 TCTCTGGTAAACCAGAAGTTCAAGGCAGAGCTCGCTGACTCCCAGTCCCCATATTACCAG       c.780
 S  L  V  N  Q  K  F  K  A  E  L  A  D  S  Q  S  P  Y  Y  Q         p.260

          .         .        | 08.         .         .         .    g.66427
 GAGCTAGCAGGAAAGTCCCAACTTCAG | ATGCAAAAGATATTTAAGAAACTTCCAGGATTC    c.840
 E  L  A  G  K  S  Q  L  Q   | M  Q  K  I  F  K  K  L  P  G  F      p.280

          .         .       | 09 .         .        | 10.         . g.72097
 AAAAAAATCCATGTGTTAGGATTTAG | ACCAAAGAAAGAAAAAGATGG | CTCAAGCTCCACA c.900
 K  K  I  H  V  L  G  F  R  |  P  K  K  E  K  D  G  |  S  S  S  T   p.300

          .         .         .         .         .         .       g.72157
 GAGATGCAACTTACGGCCATCTTTAAGAGACACAGTGCAGAAGCAAAAAGCCCTGCAAGT       c.960
 E  M  Q  L  T  A  I  F  K  R  H  S  A  E  A  K  S  P  A  S         p.320

          .         .         .         .         .         .       g.72217
 GACCTCCTGTCTTTTGATTCCAACAAAATTGAAAGTGAGGAAGTCTATCATGGAACCATG       c.1020
 D  L  L  S  F  D  S  N  K  I  E  S  E  E  V  Y  H  G  T  M         p.340

          .         .         .         .         .         .       g.72277
 GAGGAGGACAAGCAACCAGAAATCTATCTCACAGCTACAGACCTCAAAAGGCTGATCAGC       c.1080
 E  E  D  K  Q  P  E  I  Y  L  T  A  T  D  L  K  R  L  I  S         p.360

          .         .         .         .         .      | 11  .    g.73673
 AAAGCACTAGAGGAAGAACAATCTTTGGATGTGGGGACAATTCAGTTCACTGATG | AAATT    c.1140
 K  A  L  E  E  E  Q  S  L  D  V  G  T  I  Q  F  T  D  E |   I      p.380

          .         .         .         .         .         .       g.73733
 GCTGGATCACTGCCAGCCTTTGGTCCTGACACCCAATCAGAGCTGCCCACATCTTTTGCT       c.1200
 A  G  S  L  P  A  F  G  P  D  T  Q  S  E  L  P  T  S  F  A         p.400

          .   | 12     .         .         .         .         .    g.74670
 GTTATAACAGAG | GATGCTACTTTGAGTCCAGAACTTCCTCCTGTTGAACCCCAGCTTGAG    c.1260
 V  I  T  E   | D  A  T  L  S  P  E  L  P  P  V  E  P  Q  L  E      p.420

          .         .         .  | 13      .         .         .    g.126553
 ACAGTGGACGGAGCAGAGCATGGTCTACCTG | ACACTTCTTGGTCTCCACCTGCTATGGCC    c.1320
 T  V  D  G  A  E  H  G  L  P  D |   T  S  W  S  P  P  A  M  A      p.440

          .         .         .         .         .         .       g.126613
 TCTACCTCCCTGTCAGAAGCTCCACCTTTCTTTATGGCATCAAGCATCTTCTCTCTGACT       c.1380
 S  T  S  L  S  E  A  P  P  F  F  M  A  S  S  I  F  S  L  T         p.460

          .         .         .         .         .         .       g.126673
 GATCAAGGCACCACAGATACAATGGCCACTGACCAGACAATGCTAGTACCAGGGCTCACC       c.1440
 D  Q  G  T  T  D  T  M  A  T  D  Q  T  M  L  V  P  G  L  T         p.480

          .         .         .         .         .         .       g.126733
 ATCCCCACCAGTGATTATTCTGCAATCAGCCAACTGGCTCTGGGAATTTCACATCCACCT       c.1500
 I  P  T  S  D  Y  S  A  I  S  Q  L  A  L  G  I  S  H  P  P         p.500

          .         .         .         .         .         .       g.126793
 GCATCTTCAGATGACAGCCGATCAAGTGCAGGTGGCGAAGATATGGTCAGACACCTAGAT       c.1560
 A  S  S  D  D  S  R  S  S  A  G  G  E  D  M  V  R  H  L  D         p.520

          .         .         .         .         .         .       g.126853
 GAAATGGATCTGTCTGACACTCCTGCCCCATCTGAGGTACCAGAGCTCAGCGAATATGTT       c.1620
 E  M  D  L  S  D  T  P  A  P  S  E  V  P  E  L  S  E  Y  V         p.540

          .         .         .         .         .         .       g.126913
 TCTGTCCCAGATCATTTCTTGGAGGATACCACTCCTGTCTCAGCTTTACAGTATATCACC       c.1680
 S  V  P  D  H  F  L  E  D  T  T  P  V  S  A  L  Q  Y  I  T         p.560

          .         .         .         .         .         .       g.126973
 ACTAGTTCTATGACCATTGCCCCCAAGGGCCGAGAGCTGGTAGTGTTCTTCAGTCTGCGT       c.1740
 T  S  S  M  T  I  A  P  K  G  R  E  L  V  V  F  F  S  L  R         p.580

          .         .         .         .         .         .       g.127033
 GTTGCTAACATGGCCTTCTCCAACGACCTGTTCAACAAGAGCTCTCTGGAGTACCGAGCT       c.1800
 V  A  N  M  A  F  S  N  D  L  F  N  K  S  S  L  E  Y  R  A         p.600

          .         .     | 14   .         .         .         .    g.130121
 CTGGAGCAACAATTCACACAGCTG | CTGGTTCCATATCTACGATCCAATCTTACAGGATTT    c.1860
 L  E  Q  Q  F  T  Q  L   | L  V  P  Y  L  R  S  N  L  T  G  F      p.620

          .         .         .         .         .         .       g.130181
 AAGCAACTTGAAATACTTAACTTCAGAAACGGGAGTGTGATTGTGAATAGCAAAATGAAG       c.1920
 K  Q  L  E  I  L  N  F  R  N  G  S  V  I  V  N  S  K  M  K         p.640

          .         .         .         .         .         .       g.130241
 TTTGCTAAGTCAGTGCCGTATAACCTCACCAAGGCTGTGCACGGGGTCTTGGAGGATTTT       c.1980
 F  A  K  S  V  P  Y  N  L  T  K  A  V  H  G  V  L  E  D  F         p.660

          .         .         .         .         .         .       g.130301
 CGTTCTGCTGCAGCCCAACAACTCCATCTGGAAATAGACAGCTACTCTCTCAACATTGAA       c.2040
 R  S  A  A  A  Q  Q  L  H  L  E  I  D  S  Y  S  L  N  I  E         p.680

      | 15   .         .         .         .         .         .    g.146523
 CCAG | CTGATCAAGCAGATCCCTGCAAGTTCCTGGCCTGCGGCGAATTTGCCCAATGTGTA    c.2100
 P  A |   D  Q  A  D  P  C  K  F  L  A  C  G  E  F  A  Q  C  V      p.700

          .         .         .         .         .         .       g.146583
 AAGAACGAACGGACTGAGGAAGCGGAGTGTCGCTGCAAACCAGGATATGACAGCCAGGGG       c.2160
 K  N  E  R  T  E  E  A  E  C  R  C  K  P  G  Y  D  S  Q  G         p.720

          .         .         .         .         .         .       g.146643
 AGCCTGGACGGTCTGGAACCAGGCCTCTGTGGCCCTGGCACAAAGGAATGCGAGGTCCTC       c.2220
 S  L  D  G  L  E  P  G  L  C  G  P  G  T  K  E  C  E  V  L         p.740

          .         .    | 16    .         .         .         .    g.153949
 CAGGGAAAGGGAGCTCCATGCAG | GTTGCCAGATCACTCTGAAAATCAAGCATACAAAACT    c.2280
 Q  G  K  G  A  P  C  R  |  L  P  D  H  S  E  N  Q  A  Y  K  T      p.760

          .         .         .       | 17 .         .         .    g.155476
 AGTGTTAAAAAGTTCCAAAATCAACAAAATAACAAG | GTAATCAGTAAAAGAAATTCTGAA    c.2340
 S  V  K  K  F  Q  N  Q  Q  N  N  K   | V  I  S  K  R  N  S  E      p.780

          .         .         .         .         .                 g.155530
 TTACTGACCGTAGAATATGAAGAATTTAACCATCAAGATTGGGAAGGAAATTAA             c.2394
 L  L  T  V  E  Y  E  E  F  N  H  Q  D  W  E  G  N  X               p.797

          .         .         .         .         .         .       g.155590
 aaactgaaaatgtacaattatcatttaggctatctcaagagagatgatttgccttctcaa       c.*60

          .         .         .         .         .         .       g.155650
 ggaaaatggagacaggcatattcatgggtcatcaaaatccagacatacagtcaacactga       c.*120

          .         .         .         .         .         .       g.155710
 gaatcagcacacaccatatttcaaatatagaagagtcatgtacttggcaaccagtaaatt       c.*180

          .         .         .         .         .         .       g.155770
 ctgaagaaaaagacacttacttattattaaaaccccaaatgcaatcagcgaaacatattt       c.*240

          .         .         .         .         .         .       g.155830
 ttactattcttggatgatagtcaaaatgatcataagccaggtttgcttccaccttccctg       c.*300

          .         .         .         .         .         .       g.155890
 aaaattttactcacagatcatttgcaacaagcatagcttacttattgtttagggactgaa       c.*360

          .         .         .         .         .         .       g.155950
 caatttattgggaagcaaactctttatatgctagaaagtacatttaaaagatgactactt       c.*420

          .         .         .         .         .         .       g.156010
 acgcagggagatgcaggtctctctaaacgcatgaatgtatgtagtgtgtaggcactgtag       c.*480

          .         .         .         .         .         .       g.156070
 tgagtgtatatatgctccacactacgtctgataaacacaaacctcagtattcagttatta       c.*540

          .         .         .         .         .         .       g.156130
 ggcacactagttttatacgcaactactgcttacatagtagactgttttgttgccaataat       c.*600

          .         .         .         .         .         .       g.156190
 ctttgaattgttctttaaaagaaactgaggttcagatacacataccatggaaaaatctta       c.*660

          .         .         .         .         .         .       g.156250
 cttttcttgttactacacaaagctattttaaagaagatgctatgttgggagaagggcgaa       c.*720

          .         .                                               g.156274
 gttgtactatatgacataatcaat                                           c.*744

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Interphotoreceptor matrix proteoglycan 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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