inositol polyphosphate-5-phosphatase, 72 kDa (INPP5E) - coding DNA reference sequence

(used for variant description)

(last modified November 25, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_019892.4 in the INPP5E gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016126.1, covering INPP5E transcript NM_019892.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5025
                                    ctgggcggccgggcctccgcgagta       c.-361

 .         .         .         .         .         .                g.5085
 ccgggtcgacttcggagtctgcgagcccagccaggggtgcccgcttcccacccctctccc       c.-301

 .         .         .         .         .         .                g.5145
 cgagcggcgtccccgtcggggtcgaacctcccccgcgacaggcgcccagccgcctgttcc       c.-241

 .         .         .         .         .         .                g.5205
 cccaggccttgcctgcggaccgccctgggaacggcgtctgggagccccgaggggctggcg       c.-181

 .         .         .         .         .         .                g.5265
 ggactcggggcccgggccatgcggcagccgcccccgcccctccgcgaccatccccggccc       c.-121

 .         .         .         .         .         .                g.5325
 aagcgggagccgcagcggcgtttctgctcctcgctgcgccggcgaccccggacccggcac       c.-61

 .         .         .         .         .         .                g.5385
 ccgtgacccctcgcgctgcctgcggcctcgcgccgaggcctgccccgggagagaccgtcc       c.-1

          .         .         .         .         .         .       g.5445
 ATGCCGTCCAAGGCGGAGAATCTGCGGCCCTCCGAGCCGGCCCCGCAGCCGCCGGAAGGG       c.60
 M  P  S  K  A  E  N  L  R  P  S  E  P  A  P  Q  P  P  E  G         p.20

          .         .         .         .         .         .       g.5505
 AGGACGCTCCAAGGACAGCTTCCCGGCGCTCCGCCGGCCCAGCGCGCGGGGTCCCCACCC       c.120
 R  T  L  Q  G  Q  L  P  G  A  P  P  A  Q  R  A  G  S  P  P         p.40

          .         .         .         .         .         .       g.5565
 GATGCTCCGGGCTCCGAGAGCCCCGCGCTTGCCTGCAGCACTCCGGCCACGCCCAGCGGC       c.180
 D  A  P  G  S  E  S  P  A  L  A  C  S  T  P  A  T  P  S  G         p.60

          .         .         .         .         .         .       g.5625
 GAGGACCCGCCAGCCCGAGCAGCACCCATCGCCCCGCGGCCCCCCGCCAGGCCTCGACTG       c.240
 E  D  P  P  A  R  A  A  P  I  A  P  R  P  P  A  R  P  R  L         p.80

          .         .         .         .         .         .       g.5685
 GAGCGAGCCCTGTCCCTGGACGACAAGGGCTGGAGGAGGAGGCGTTTTCGAGGCAGCCAG       c.300
 E  R  A  L  S  L  D  D  K  G  W  R  R  R  R  F  R  G  S  Q         p.100

          .         .         .         .         .         .       g.5745
 GAGGACCTGGAAGCCCGGAATGGGACCAGTCCCTCCAGGGGCTCAGTGCAGAGCGAGGGC       c.360
 E  D  L  E  A  R  N  G  T  S  P  S  R  G  S  V  Q  S  E  G         p.120

          .         .         .         .         .         .       g.5805
 CCCGGGGCCCCCGCCCACAGCTGCTCCCCGCCCTGCCTGAGCACCTCCTTGCAGGAAATC       c.420
 P  G  A  P  A  H  S  C  S  P  P  C  L  S  T  S  L  Q  E  I         p.140

          .         .         .         .         .         .       g.5865
 CCCAAGTCCCGCGGGGTCCTGAGCAGTGAGAGAGGGAGCCCGTCCTCGGGGGGTAACCCT       c.480
 P  K  S  R  G  V  L  S  S  E  R  G  S  P  S  S  G  G  N  P         p.160

          .         .         .         .         .         .       g.5925
 CTCTCTGGGGTGGCCAGCAGCTCCCCGAACCTCCCGCACAGAGACGCCGCCGTGGCGGGG       c.540
 L  S  G  V  A  S  S  S  P  N  L  P  H  R  D  A  A  V  A  G         p.180

          .         .         .         .         .         .       g.5985
 AGCTCGCCCAGGCTGCCCAGCCTGCTGCCCCCGCGCCCACCGCCTGCCCTGAGCCTGGAC       c.600
 S  S  P  R  L  P  S  L  L  P  P  R  P  P  P  A  L  S  L  D         p.200

          .         .         .         .         .         .       g.6045
 ATCGCCTCCGACTCCCTGAGGACAGCAAACAAGGTCGACTCGGATCTTGCAGACTACAAG       c.660
 I  A  S  D  S  L  R  T  A  N  K  V  D  S  D  L  A  D  Y  K         p.220

          .         .         .         .         .         .       g.6105
 CTCCGCGCGCAGCCGCTCCTGGTGCGGGCCCACAGCAGCCTGGGCCCCGGCCGGCCGCGG       c.720
 L  R  A  Q  P  L  L  V  R  A  H  S  S  L  G  P  G  R  P  R         p.240

          .         .         .         .         .         .       g.6165
 AGCCCCCTGGCCTGCGACGACTGTTCCCTTCGCTCGGCCAAATCCTCCTTCAGCCTCCTG       c.780
 S  P  L  A  C  D  D  C  S  L  R  S  A  K  S  S  F  S  L  L         p.260

          .         .         .   | 02     .         .         .    g.9969
 GCGCCCATCCGCAGCAAGGACGTCCGCAGCAG | GAGTTACCTGGAGGGCAGCCTCCTGGCC    c.840
 A  P  I  R  S  K  D  V  R  S  R  |  S  Y  L  E  G  S  L  L  A      p.280

          .         .         .         .         .         .       g.10029
 AGCGGGGCCCTGTTGGGGGCGGATGAGCTGGCCCGCTACTTCCCAGACCGGAACGTGGCA       c.900
 S  G  A  L  L  G  A  D  E  L  A  R  Y  F  P  D  R  N  V  A         p.300

          .         .         .       | 03 .         .         .    g.10694
 CTCTTCGTGGCCACCTGGAACATGCAGGGCCAGAAG | GAGCTCCCGCCCAGCCTGGACGAG    c.960
 L  F  V  A  T  W  N  M  Q  G  Q  K   | E  L  P  P  S  L  D  E      p.320

          .         .         .         .         .         .       g.10754
 TTCCTGCTCCCAGCCGAGGCCGACTATGCCCAGGACCTGTATGTCATCGGGGTCCAGGAG       c.1020
 F  L  L  P  A  E  A  D  Y  A  Q  D  L  Y  V  I  G  V  Q  E         p.340

          .     | 04   .         .         .         .         .    g.11571
 GGCTGTTCTGACAG | GCGGGAGTGGGAGACTCGTCTGCAGGAGACGCTGGGCCCGCACTAT    c.1080
 G  C  S  D  R  |  R  E  W  E  T  R  L  Q  E  T  L  G  P  H  Y      p.360

          .         .         .         .         .         .       g.11631
 GTGCTGCTGTCCTCGGCGGCCCACGGCGTGCTCTACATGTCGCTCTTCATCCGCAGGGAC       c.1140
 V  L  L  S  S  A  A  H  G  V  L  Y  M  S  L  F  I  R  R  D         p.380

          .          | 05        .         .         .         .    g.11770
 CTCATCTGGTTCTGCTCAG | AGGTGGAGTGCTCCACGGTGACCACACGCATCGTGTCTCAG    c.1200
 L  I  W  F  C  S  E |   V  E  C  S  T  V  T  T  R  I  V  S  Q      p.400

          .         .         .         .         .         .       g.11830
 ATCAAGACCAAGGGGGCCTTGGGCATCAGCTTCACCTTTTTTGGCACTTCCTTCCTCTTC       c.1260
 I  K  T  K  G  A  L  G  I  S  F  T  F  F  G  T  S  F  L  F         p.420

          .          | 06        .         .         .         .    g.12259
 ATCACGTCCCACTTCACCT | CAGGTGACGGGAAGGTGGCGGAGCGGCTGCTGGACTACACC    c.1320
 I  T  S  H  F  T  S |   G  D  G  K  V  A  E  R  L  L  D  Y  T      p.440

          .         .         .         .         .         .       g.12319
 AGGACTGTACAAGCCCTGGTCCTGCCCAGAAATGTGCCCGACACCAACCCCTATCGCTCC       c.1380
 R  T  V  Q  A  L  V  L  P  R  N  V  P  D  T  N  P  Y  R  S         p.460

         | 07.         .         .         .         .         .    g.12872
 AGCGCAG | CGGACGTCACCACCCGCTTCGATGAGGTGTTCTGGTTTGGAGACTTCAACTTC    c.1440
 S  A  A |   D  V  T  T  R  F  D  E  V  F  W  F  G  D  F  N  F      p.480

          .         .         .         .         .         .       g.12932
 CGCCTGAGTGGCGGGCGCACAGTCGTGGACGCCCTCCTGTGCCAGGGCCTGGTGGTGGAC       c.1500
 R  L  S  G  G  R  T  V  V  D  A  L  L  C  Q  G  L  V  V  D         p.500

          .         .         .         .          | 08        .    g.13698
 GTGCCGGCGCTGCTGCAGCACGACCAGCTCATCCGGGAGATGCGGAAAG | GGTCCATCTTC    c.1560
 V  P  A  L  L  Q  H  D  Q  L  I  R  E  M  R  K  G |   S  I  F      p.520

          .         .         .         .         .         .       g.13758
 AAGGGCTTCCAGGAGCCGGACATCCACTTCCTCCCATCATACAAGTTTGACATCGGGAAG       c.1620
 K  G  F  Q  E  P  D  I  H  F  L  P  S  Y  K  F  D  I  G  K         p.540

          .         .         .         .      | 09  .         .    g.14406
 GACACGTACGACAGCACCTCCAAGCAGAGGACGCCCTCATACACG | GACCGCGTCTTGTAC    c.1680
 D  T  Y  D  S  T  S  K  Q  R  T  P  S  Y  T   | D  R  V  L  Y      p.560

          .         .         .         .         .         .       g.14466
 AGAAGCCGCCACAAGGGTGACATCTGTCCTGTGAGCTACTCTTCCTGCCCCGGGATCAAG       c.1740
 R  S  R  H  K  G  D  I  C  P  V  S  Y  S  S  C  P  G  I  K         p.580

          .         .         .         .         .         .       g.14526
 ACGTCCGACCACCGCCCTGTGTATGGCCTCTTCCGGGTGAAAGTGAGGCCGGGGCGAGAC       c.1800
 T  S  D  H  R  P  V  Y  G  L  F  R  V  K  V  R  P  G  R  D         p.600

    | 10     .         .         .         .         .         .    g.15055
 AA | CATTCCGTTGGCAGCTGGCAAATTTGATAGAGAACTGTACTTACTAGGAATTAAAAGA    c.1860
 N  |  I  P  L  A  A  G  K  F  D  R  E  L  Y  L  L  G  I  K  R      p.620

          .         .         .         .         .         .       g.15115
 CGGATTTCGAAGGAGATTCAGAGGCAGCAAGCACTACAGAGTCAGAACTCCAGCACCATC       c.1920
 R  I  S  K  E  I  Q  R  Q  Q  A  L  Q  S  Q  N  S  S  T  I         p.640

          .                                                         g.15130
 TGCTCCGTTTCTTGA                                                    c.1935
 C  S  V  S  X                                                      p.644

          .         .         .         .         .         .       g.15190
 agtttgctgaacgaggactcacagctgcaacgtggggtgattgtattgatcaaaacccac       c.*60

          .         .         .         .         .         .       g.15250
 tgggaaggacaaagagtttgccgcctttcggggatccgagggactgtggcgaccgtgcct       c.*120

          .         .         .         .         .         .       g.15310
 ctgtgccagcgtcccaggaaggaagccaaccctgagcgagcctgtcctctgtggcaggtc       c.*180

          .         .         .         .         .         .       g.15370
 cacacggtgtgggtgggcagggcttggacccccgtctccatggcaggtccatacagcatg       c.*240

          .         .         .         .         .         .       g.15430
 ggtggcagggtttggacccgcccagcagcaccacggaccccagccactctcgggggcaga       c.*300

          .         .         .         .         .         .       g.15490
 cgtcagaatccgttcctgagcagctcctgtgccctgggggcagtcacagagccccccaac       c.*360

          .         .         .         .         .         .       g.15550
 acccccgtgctctgcaccagcctctccctccacacccgaagcaggcgtccatctgtgtcc       c.*420

          .         .         .         .         .         .       g.15610
 tcctggcagcccctcaaacacacaccaccccatgtcacacgggtatccagagcaaggctg       c.*480

          .         .         .         .         .         .       g.15670
 gatctgggctaggtgacccctggggcctcagacctctgagtgggccccagagcccagctg       c.*540

          .         .         .         .         .         .       g.15730
 aggaagccacacagcctccaggacgtggcacggttcccctccacttggctgcaagtcgcc       c.*600

          .         .         .         .         .         .       g.15790
 tgccatggggcgaggaggcctgcaccccagtataagggcctccccagctgagtaagaagc       c.*660

          .         .         .         .         .         .       g.15850
 tgcttcccctcctctcataggccaagcctattgtgtgaaaccatctcatggtcttggtga       c.*720

          .         .         .         .         .         .       g.15910
 cgtagaccatttttgaaaccgtctcatggtcttggtgacgtagaccgtttgcttctttaa       c.*780

          .         .         .         .         .         .       g.15970
 ctccagccgcggaatgacattagtggaaccgggctagggaactgctggaagttcaggatg       c.*840

          .         .         .         .         .         .       g.16030
 ccaccaccttgaacacctaggccagggatccccaccatgtcccgggtttctttcttcgag       c.*900

          .         .         .         .         .         .       g.16090
 agtatagaaccgttcattcttgctttgtgtcccattccatctcttgaaaaaatgtagtct       c.*960

          .         .         .         .         .         .       g.16150
 ttgaatgtgtgaaaatctagggacattcaatctagtcttttaaattatttttccatattt       c.*1020

          .         .         .         .                           g.16190
 atatttttaaataaatgcatatattgagtcttaaaatctc                           c.*1060

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Inositol polyphosphate-5-phosphatase, 72 kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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