IQ motif containing B1 (IQCB1) - coding DNA reference sequence

(used for variant description)

(last modified November 25, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_001023570.2 in the IQCB1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_015887.1, covering IQCB1 transcript NM_001023570.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5035
                          cgcctccaggccccttcccgcgtcgcgacgcacgc       c.-181

 .         .         .         .         .         .                g.5095
 tgccccggaaggccgcggcgctgtagtgcggcgtgggagccccaggttctttagtggaag       c.-121

 .         .         | 02         .         .         .             g.5641
 aacgcgaagcgaggatgag | tgatccgtggaggcagtaacaggcgcggcgagggagaagtg    c.-61

 .         .         .         .         .        | 03.             g.11119
 attcccgaagaatcaaggctgggccggacccggtggcctggcaacagg | gtaataagagaa    c.-1

          .         .         .         .         .         .       g.11179
 ATGAAGCCAACAGGTACAGACCCAAGGATCTTATCTATAGCTGCTGAAGTTGCAAAAAGC       c.60
 M  K  P  T  G  T  D  P  R  I  L  S  I  A  A  E  V  A  K  S         p.20

          .         .         .         . | 04       .         .    g.11467
 CCTGAGCAGAATGTCCCTGTTATACTGTTGAAGTTAAAAG | AAATAATAAACATCACACCT    c.120
 P  E  Q  N  V  P  V  I  L  L  K  L  K  E |   I  I  N  I  T  P      p.40

          .         .         .         .         .         .       g.11527
 TTAGGAAGCTCAGAGTTGAAGAAAATCAAACAAGATATATATTGTTATGATCTCATTCAA       c.180
 L  G  S  S  E  L  K  K  I  K  Q  D  I  Y  C  Y  D  L  I  Q         p.60

          .         .         .         .         .         .       g.11587
 TATTGCCTCTTGGTCCTCAGTCAAGATTATTCTCGAATCCAGGGTGGTTGGACTACAATT       c.240
 Y  C  L  L  V  L  S  Q  D  Y  S  R  I  Q  G  G  W  T  T  I         p.80

          .         .    | 05    .         .         .         .    g.13936
 TCCCAGCTTACACAGATATTAAG | CCATTGCTGTGTGGGCTTGGAGCCAGGAGAAGATGCA    c.300
 S  Q  L  T  Q  I  L  S  |  H  C  C  V  G  L  E  P  G  E  D  A      p.100

          .         .         .         .         .         .       g.13996
 GAGGAATTTTACAATGAATTACTTCCATCAGCTGCAGAAAATTTTCTAGTTTTGGGGAGA       c.360
 E  E  F  Y  N  E  L  L  P  S  A  A  E  N  F  L  V  L  G  R         p.120

          .         .         .    | 06    .         .         .    g.31097
 CAATTACAAACATGTTTTATCAATGCAGCTAAG | GCTGAAGAAAAAGATGAATTACTACAC    c.420
 Q  L  Q  T  C  F  I  N  A  A  K   | A  E  E  K  D  E  L  L  H      p.140

          .         .         .         .         .         .       g.31157
 TTTTTCCAAATTGTGACTGATTCTCTCTTCTGGCTTTTGGGAGGCCATGTTGAACTTATT       c.480
 F  F  Q  I  V  T  D  S  L  F  W  L  L  G  G  H  V  E  L  I         p.160

         | 07.         .         .         .         .         .    g.32689
 CAGAATG | TACTACAAAGTGATCATTTCTTACATTTACTGCAAGCTGACAATGTCCAAATA    c.540
 Q  N  V |   L  Q  S  D  H  F  L  H  L  L  Q  A  D  N  V  Q  I      p.180

          .         .         .         .        | 08.         .    g.40718
 GGATCTGCAGTCATGATGATGCTACAGAATATACTACAGATCAACAG | TGGTGATTTACTC    c.600
 G  S  A  V  M  M  M  L  Q  N  I  L  Q  I  N  S  |  G  D  L  L      p.200

          .         .         .         .         .         .       g.40778
 AGAATAGGAAGAAAAGCCCTGTATTCAATTTTAGATGAAGTTATTTTCAAGCTTTTTTCA       c.660
 R  I  G  R  K  A  L  Y  S  I  L  D  E  V  I  F  K  L  F  S         p.220

          .         .         .         .         .         .       g.40838
 ACTCCTAGTCCAGTTATAAGAAGTACTGCTACAAAACTCCTACTGTTGATGGCTGAATCC       c.720
 T  P  S  P  V  I  R  S  T  A  T  K  L  L  L  L  M  A  E  S         p.240

          .         .         .         .       | 09 .         .    g.42866
 CATCAGGAAATTTTGATTTTACTGAGACAAAGTACCTGCTACAAAG | GACTCAGACGTCTA    c.780
 H  Q  E  I  L  I  L  L  R  Q  S  T  C  Y  K  G |   L  R  R  L      p.260

          .         .         .         .         .         .       g.42926
 CTAAGTAAACAGGAAACTGGGACTGAATTCAGTCAAGAACTTAGACAGCTTGTTGGCCTT       c.840
 L  S  K  Q  E  T  G  T  E  F  S  Q  E  L  R  Q  L  V  G  L         p.280

          .         .         .       | 10 .         .         .    g.44537
 TTAAGCCCAATGGTCTATCAGGAAGTAGAAGAGCAG | AAACTACATCAAGCAGCATGCTTG    c.900
 L  S  P  M  V  Y  Q  E  V  E  E  Q   | K  L  H  Q  A  A  C  L      p.300

          .         .         .         .         .         .       g.44597
 ATTCAAGCCTATTGGAAGGGTTTTCAGACAAGAAAGAGATTAAAGAAGCTTCCATCTGCT       c.960
 I  Q  A  Y  W  K  G  F  Q  T  R  K  R  L  K  K  L  P  S  A         p.320

          .         .       | 11 .         .         .         .    g.49898
 GTGATTGCTTTGCAGAGGAGTTTCAG | ATCCAAACGATCAAAGATGTTGCTGGAGATAAAT    c.1020
 V  I  A  L  Q  R  S  F  R  |  S  K  R  S  K  M  L  L  E  I  N      p.340

          .         .         .         .         .         .       g.49958
 AGGCAGAAGGAAGAAGAGGACCTCAAATTACAATTGCAACTTCAAAGACAGAGAGCCATG       c.1080
 R  Q  K  E  E  E  D  L  K  L  Q  L  Q  L  Q  R  Q  R  A  M         p.360

          .         .         .         .          | 12        .    g.51658
 AGACTTTCCCGAGAATTGCAGCTGAGTATGCTCGAAATAGTTCATCCAG | GTCAGGTGGAG    c.1140
 R  L  S  R  E  L  Q  L  S  M  L  E  I  V  H  P  G |   Q  V  E      p.380

          .         .         .         .         .         .       g.51718
 AAACACTATCGGGAAATGGAAGAGAAATCAGCACTGATTATCCAGAAACATTGGAGAGGG       c.1200
 K  H  Y  R  E  M  E  E  K  S  A  L  I  I  Q  K  H  W  R  G         p.400

          .         .         .         .         .         .       g.51778
 TACAGGGAAAGGAAAAATTTTCACCAACAGAGGCAGTCTCTCATAGAGTATAAAGCAGCT       c.1260
 Y  R  E  R  K  N  F  H  Q  Q  R  Q  S  L  I  E  Y  K  A  A         p.420

          .         | 13         .         .         .         .    g.58247
 GTCACACTTCAAAGAGCA | GCGCTTAAATTCCTAGCGAAGTGCCGTAAGAAAAAGAAACTA    c.1320
 V  T  L  Q  R  A   | A  L  K  F  L  A  K  C  R  K  K  K  K  L      p.440

          .         .         .         .         .         .       g.58307
 TTTGCTCCTTGGCGAGGACTCCAAGAACTCACTGATGCACGCCGAGTTGAACTGAAGAAA       c.1380
 F  A  P  W  R  G  L  Q  E  L  T  D  A  R  R  V  E  L  K  K         p.460

          .         .         . | 14       .         .         .    g.67396
 CGAGTGGATGACTATGTCAGAAGACATTTG | GGCTCTCCAATGTCAGATGTGGTCAGTAGG    c.1440
 R  V  D  D  Y  V  R  R  H  L   | G  S  P  M  S  D  V  V  S  R      p.480

          .         .         .         .         .         .       g.67456
 GAGCTCCATGCCCAAGCTCAAGAACGACTGCAACACTACTTTATGGGCAGGGCCCTAGAA       c.1500
 E  L  H  A  Q  A  Q  E  R  L  Q  H  Y  F  M  G  R  A  L  E         p.500

          .         .         .         .         .         .       g.67516
 GAGCGAGCCCAGCAGCACAGAGAAGCTCTGATAGCACAGATCAGCACCAACGTTGAACAG       c.1560
 E  R  A  Q  Q  H  R  E  A  L  I  A  Q  I  S  T  N  V  E  Q         p.520

         | 15.         .         .         .         .         .    g.69558
 CTAATGA | AGGCACCAAGTCTGAAGGAGGCAGAAGGGAAAGAACCTGAGCTCTTCCTAAGT    c.1620
 L  M  K |   A  P  S  L  K  E  A  E  G  K  E  P  E  L  F  L  S      p.540

          .         .         .         .         .         .       g.69618
 AGATCCAGGCCTGTGGCAGCCAAGGCCAAGCAGGCCCATCTCACAACCCTGAAGCACATA       c.1680
 R  S  R  P  V  A  A  K  A  K  Q  A  H  L  T  T  L  K  H  I         p.560

          .         .         .         .         .         .       g.69678
 CAAGCACCCTGGTGGAAGAAGCTTGGAGAAGAATCTGGAGATGAGATTGATGTTCCAAAG       c.1740
 Q  A  P  W  W  K  K  L  G  E  E  S  G  D  E  I  D  V  P  K         p.580

          .         .         .         .         .                 g.69735
 GATGAGCTTAGTATAGAATTAGAAAATTTATTCATTGGTGGAACCAAACCACCTTAG          c.1797
 D  E  L  S  I  E  L  E  N  L  F  I  G  G  T  K  P  P  X            p.598

          .         .         .         .         .         .       g.69795
 tgagtaaccctaagaattgacacaaatctcatattttaggagattatattggttctgcct       c.*60

          .         .         .         .         .         .       g.69855
 ctggcatgctggtagactagggccatcctaacttattattttccagaggttctcctccag       c.*120

          .         .         .         .         .         .       g.69915
 acaagacctgcagtaagcaaagagttatattctacctctctctcaattttctttttcttt       c.*180

          .         .         .         .         .         .       g.69975
 tctctgtatcctcatcgttagccacacacagatttgtgtggcttttattgtagaactaaa       c.*240

          .         .         .         .         .         .       g.70035
 cttagcatagtgttctgttgtttacatgaagtgtgtttttctttggtttcttctgttttc       c.*300

          .         .         .         .         .         .       g.70095
 caactaaatatttttttctaaataaatattttcaacaattgatttgaaaaatttgtcagg       c.*360

          .         .         .         .         .         .       g.70155
 attatttcaacttttcacatttgttatctgaaattcctatttcctgttaacataggaggt       c.*420

          .         .         .         .         .         .       g.70215
 gtgtgcagactttattaatgtgaggaaaagaaatgctcaattgaaggacatttccctgtt       c.*480

          .         .         .         .         .         .       g.70275
 ttctataaagcaatggttgaactcattttctattttgttatttctaaaaggaactgcata       c.*540

          .         .         .         .                           g.70317
 ccaaaaaaatgcattctttctattaaactgtgagaactacat                         c.*582

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The IQ motif containing B1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 25b
©2004-2020 Leiden University Medical Center