interleukin-1 receptor-associated kinase 4 (IRAK4) - coding DNA reference sequence

(used for variant description)

(last modified February 10, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_001114182.2 in the IRAK4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009892.1, covering IRAK4 transcript NM_001114182.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5010
                                                   cccgcccctt       c.-121

 .         .         .         .         .         .                g.5070
 cgcggcgcttcctagttcggctggttcttctgtcgccggcttcagcagcccgcgcccggg       c.-61

 .   | 02     .         .         .         .         . | 03        g.14168
 cag | gggcctggagcagtatctagcacaaagtagacactcagtaaatatttg | gaatagaag c.-1

          .         .         .         .         .         .       g.14228
 ATGAACAAACCCATAACACCATCAACATATGTGCGCTGCCTCAATGTTGGACTAATTAGG       c.60
 M  N  K  P  I  T  P  S  T  Y  V  R  C  L  N  V  G  L  I  R         p.20

          .         .         .         .         .         .       g.14288
 AAGCTGTCAGATTTTATTGATCCTCAAGAAGGATGGAAGAAGTTAGCTGTAGCTATTAAA       c.120
 K  L  S  D  F  I  D  P  Q  E  G  W  K  K  L  A  V  A  I  K         p.40

          .         .         .         .  | 04      .         .    g.17295
 AAACCATCTGGTGATGATAGATACAATCAGTTTCACATAAG | GAGATTTGAAGCATTACTT    c.180
 K  P  S  G  D  D  R  Y  N  Q  F  H  I  R  |  R  F  E  A  L  L      p.60

          .         .         .         .         .         .       g.17355
 CAAACTGGAAAAAGTCCCACTTCTGAATTACTGTTTGACTGGGGCACCACAAATTGCACA       c.240
 Q  T  G  K  S  P  T  S  E  L  L  F  D  W  G  T  T  N  C  T         p.80

          .         .         .         .         .         .       g.17415
 GTTGGTGATCTTGTGGATCTTTTGATCCAAAATGAATTTTTTGCTCCTGCGAGTCTTTTG       c.300
 V  G  D  L  V  D  L  L  I  Q  N  E  F  F  A  P  A  S  L  L         p.100

         | 05.         .         .         .         .         .    g.18289
 CTCCCAG | ATGCTGTTCCCAAAACTGCTAATACACTACCTTCTAAAGAAGCTATAACAGTT    c.360
 L  P  D |   A  V  P  K  T  A  N  T  L  P  S  K  E  A  I  T  V      p.120

          .         .         .         .         .         .       g.18349
 CAGCAAAAACAGATGCCTTTCTGTGACAAAGACAGGACATTGATGACACCTGTGCAGAAT       c.420
 Q  Q  K  Q  M  P  F  C  D  K  D  R  T  L  M  T  P  V  Q  N         p.140

          .         .         .         .         .         .       g.18409
 CTTGAACAAAGCTATATGCCACCTGACTCCTCAAGTCCAGAAAATAAAAGTTTAGAAGTT       c.480
 L  E  Q  S  Y  M  P  P  D  S  S  S  P  E  N  K  S  L  E  V         p.160

          . | 06       .         .         .         .         .    g.19018
 AGTGATACAC | GTTTTCACAGTTTTTCATTTTATGAATTGAAGAATGTCACAAATAACTTT    c.540
 S  D  T  R |   F  H  S  F  S  F  Y  E  L  K  N  V  T  N  N  F      p.180

          .         .         .         .         .         .       g.19078
 GATGAACGACCCATTTCTGTTGGTGGTAATAAAATGGGAGAGGGAGGATTTGGAGTTGTA       c.600
 D  E  R  P  I  S  V  G  G  N  K  M  G  E  G  G  F  G  V  V         p.200

          .         .         .         .         .  | 07      .    g.20030
 TATAAAGGCTACGTAAATAACACAACTGTGGCAGTGAAGAAGCTTGCAGCA | ATGGTTGAC    c.660
 Y  K  G  Y  V  N  N  T  T  V  A  V  K  K  L  A  A   | M  V  D      p.220

          .         .         .         .         .       | 08 .    g.23690
 ATTACTACTGAAGAACTGAAACAGCAGTTTGATCAAGAAATAAAAGTAATGGCAAA | GTGT    c.720
 I  T  T  E  E  L  K  Q  Q  F  D  Q  E  I  K  V  M  A  K  |  C      p.240

          .         .         .         .         .         .       g.23750
 CAACATGAAAACTTAGTAGAACTACTTGGTTTCTCAAGTGATGGAGATGACCTCTGCTTA       c.780
 Q  H  E  N  L  V  E  L  L  G  F  S  S  D  G  D  D  L  C  L         p.260

          .         .         .         .         .  | 09      .    g.24258
 GTATATGTTTACATGCCTAATGGTTCATTGCTAGACAGACTCTCTTGCTTG | GATGGTACT    c.840
 V  Y  V  Y  M  P  N  G  S  L  L  D  R  L  S  C  L   | D  G  T      p.280

          .         .         .         .         .         .       g.24318
 CCACCACTTTCTTGGCACATGAGATGCAAGATTGCTCAGGGTGCAGCTAATGGCATCAAT       c.900
 P  P  L  S  W  H  M  R  C  K  I  A  Q  G  A  A  N  G  I  N         p.300

          .         .         .         .  | 10      .         .    g.28382
 TTTCTACATGAAAATCATCATATTCATAGAGATATTAAAAG | TGCAAATATCTTACTGGAT    c.960
 F  L  H  E  N  H  H  I  H  R  D  I  K  S  |  A  N  I  L  L  D      p.320

          .         .         .         .         .         .       g.28442
 GAAGCTTTTACTGCTAAAATATCTGACTTTGGCCTTGCACGGGCTTCTGAGAAGTTTGCC       c.1020
 E  A  F  T  A  K  I  S  D  F  G  L  A  R  A  S  E  K  F  A         p.340

          .         .         .         .         .         .       g.28502
 CAGACAGTCATGACTAGCAGAATTGTGGGAACAACAGCTTATATGGCACCAGAAGCTTTG       c.1080
 Q  T  V  M  T  S  R  I  V  G  T  T  A  Y  M  A  P  E  A  L         p.360

          .         .         .         .      | 11  .         .    g.29733
 CGTGGAGAAATAACACCCAAATCTGATATTTACAGCTTTGGTGTG | GTTTTACTAGAAATA    c.1140
 R  G  E  I  T  P  K  S  D  I  Y  S  F  G  V   | V  L  L  E  I      p.380

          .         .         .         .         | 12         .    g.32467
 ATAACTGGACTTCCAGCTGTGGATGAACACCGTGAACCTCAGTTATTG | CTAGATATTAAA    c.1200
 I  T  G  L  P  A  V  D  E  H  R  E  P  Q  L  L   | L  D  I  K      p.400

          .         .         .         .         .         .       g.32527
 GAAGAAATTGAAGATGAAGAAAAGACAATTGAAGATTATATTGATAAAAAGATGAATGAT       c.1260
 E  E  I  E  D  E  E  K  T  I  E  D  Y  I  D  K  K  M  N  D         p.420

          .         .         .         .         .         .       g.32587
 GCTGATTCCACTTCAGTTGAAGCTATGTACTCTGTTGCTAGTCAATGTCTGCATGAAAAG       c.1320
 A  D  S  T  S  V  E  A  M  Y  S  V  A  S  Q  C  L  H  E  K         p.440

          .         .        | 13.         .         .         .    g.32769
 AAAAATAAGAGACCAGACATTAAGAAG | GTTCAACAGCTGCTGCAAGAGATGACAGCTTCT    c.1380
 K  N  K  R  P  D  I  K  K   | V  Q  Q  L  L  Q  E  M  T  A  S      p.460

                                                                    g.32772
 TAA                                                                c.1383
 X                                                                  p.460

          .         .         .         .         .         .       g.32832
 aactttattggaaaagactcttgactttttatatacacctatctcaaccatttttttaac       c.*60

          .         .         .         .         .         .       g.32892
 tgatttttttcctaaatattcttctttacctttaacaaggcataggctgttgcaggacag       c.*120

          .         .         .         .         .         .       g.32952
 tggttattaaagcatgggttgaacttccaaaatataaaaatagagccaccatatcaacac       c.*180

          .         .         .         .         .         .       g.33012
 ttagccctacccattagtatcacccccagttcttacagtaatccctgagaaatctccttc       c.*240

          .         .         .         .         .         .       g.33072
 aagcatcaccaaacacagtttgaaaattacagggttagcaaaaagagcctgggctgtatg       c.*300

          .         .         .         .         .         .       g.33132
 tagggtggaaacactctgatctgaagcccagctgactccactactaatttgctgtaaagc       c.*360

          .         .         .         .         .         .       g.33192
 tttggacatacacttagctgctgtgagccactaataacattgggctaatatctgctgtgc       c.*420

          .         .         .         .         .         .       g.33252
 ttctctgacaggtagtcatgaaaatcaaatgatgcaaaatatatacaagcactttgtaaa       c.*480

          .         .         .         .         .         .       g.33312
 ttgtaaaatgatacaaaatttaaagtttatagagccagttacaaaatcctattagtcata       c.*540

          .         .         .         .         .         .       g.33372
 tatttatagattgtgttcacagcaatcatttaaccacaaataaaatatcccttgatgata       c.*600

          .         .         .         .         .         .       g.33432
 ctgccataatgatatgtccattattagattatgttacatgacaaagttgaaggaatttgg       c.*660

          .         .         .         .         .         .       g.33492
 cagatgcagttaaggttcctaaacaactcactttgagactgttgaaagggcctgacctaa       c.*720

          .         .         .         .         .         .       g.33552
 tcaagtgaacccttgcaagaagaattctccttgtaagccttgaagaagtatgtgagaggg       c.*780

          .         .         .         .         .         .       g.33612
 ccacattggctaaaacctaaaggtggcctctaggagatgagacctaccttccagttgtca       c.*840

          .         .         .         .         .         .       g.33672
 gcaagcaggaaaaaaaaattgggacctcagttgcaaccacaaggaactgaattctgccaa       c.*900

          .         .         .         .         .         .       g.33732
 aaatctgagtcagcttagaagagtactccaagcttcagatgataaccacagcctgggctg       c.*960

          .         .         .         .         .         .       g.33792
 acacctggatttcagctttgcatgatcctcagtatgagaatctatctgttctgtgctgga       c.*1020

          .         .         .         .         .         .       g.33852
 cttctaatatatagaactgtgagataatgggtcacattggctggatgtggtggctcatac       c.*1080

          .         .         .         .         .         .       g.33912
 ctgtaaatcccagcactttgggaggccgaggcaggcagatcacctgaggtcaagagttca       c.*1140

          .         .         .         .         .         .       g.33972
 agaccggcctggccaacatggtgaaaccccgtctctactaaaaatacaaaaattagacga       c.*1200

          .         .         .         .         .         .       g.34032
 gcgtggtggtggacacctgtagtcccagctacttgggaggctgaggcaggagactagctg       c.*1260

          .         .         .         .         .         .       g.34092
 gaaccagggaggtagaggttgcagtgagctgagatcgtgccactgcactccagcctgggt       c.*1320

          .         .         .         .         .         .       g.34152
 gacagagtgagactccatcataaataaataaataaataaatgggtcacattaagccttta       c.*1380

          .         .         .         .         .         .       g.34212
 agtttgtggtaatttattattcagtaatagaaaacaaatacagatactctcccatgatgt       c.*1440

          .         .         .         .         .         .       g.34272
 ttttcccatgatgatttcccatgatatttacaggttttgcccacatttgaggggtatgtg       c.*1500

          .         .         .         .         .         .       g.34332
 gaaattatacagagcatgtacagcgggaggcttatagtgtacgtactgaaatgtggggtt       c.*1560

          .         .         .         .         .         .       g.34392
 ggagccccaacacagagaccccagcaggacactgcctagtagagctatgggaagggtgct       c.*1620

          .         .         .         .         .         .       g.34452
 gccaccctccagacttgagaattgtagagccaccagcagcttgcactctgagcttggaaa       c.*1680

          .         .         .         .         .         .       g.34512
 agccacaggcactcaacttcaaccatgagggaagccacgcaccctgcaaagccacaggag       c.*1740

          .         .         .         .         .         .       g.34572
 tggagctgcccacggcctcgagggcccaccccttgcaccagtgtgccaggatgtgggaca       c.*1800

          .         .         .         .         .         .       g.34632
 tggaatcaaggaatatgttagggcttttttttttttttttttgagacggagtcttgctct       c.*1860

          .         .         .         .         .         .       g.34692
 gttgcccaggctggagtgcagtggcacgatctcggctcactgcaagctctgcctcccagg       c.*1920

          .         .         .         .         .         .       g.34752
 ttcacgccattcccctgcctcagcctccccagtagctgggactacaggtgcccgccacca       c.*1980

          .         .         .         .         .         .       g.34812
 tgcccagctaattttttttgtatttttagtagagatggggtttcactgtgttagccagga       c.*2040

          .         .         .         .         .         .       g.34872
 tggtcttgatctcctgacctcgtgatcacccgcctcggcctcccaaagtgccagtattta       c.*2100

          .         .         .         .         .         .       g.34932
 aagtttaatgtcttcccagctgggtttcagacttgccaggatcctgttgcccctttcttt       c.*2160

          .         .         .         .         .         .       g.34992
 agccaatttctcccttttgggacaagaatgttttacttattgcctgtaccaccaactgta       c.*2220

          .         .         .         .         .         .       g.35052
 tcttggaaataaataacttatattttatttcagaggctcataggcggcaggaacttacct       c.*2280

          .         .         .         .         .         .       g.35112
 tgagtctcaaatgagacttaggacttttgagtgatgctagaatgagttaagactttggga       c.*2340

          .         .         .         .         .         .       g.35172
 agggatgattatattttgcaatgtgagaaagacattagatttggggggctgggggtagaa       c.*2400

          .         .         .         .         .         .       g.35232
 tgacattgtttagatgtttgtctccttcaaatttcatgtttaaatgtaatccccagtgtt       c.*2460

          .         .         .         .         .         .       g.35292
 gggggtggaggtggggcctgatgggaagtgtttgggtcatggtggatgatccctcatgaa       c.*2520

          .         .         .         .         .         .       g.35352
 tggcttagagccactggtgatgagtgagttctcactcagttcgtgtgagatctggtggct       c.*2580

          .         .         .         .         .         .       g.35412
 taaaagagtctgctccccctttgccttccattgtgattgtaaccttcctggggccttcat       c.*2640

          .         .         .         .         .         .       g.35472
 caaaggccaggcaaatattggtgccgtgctagtatggcctgcagaaccgtaagccaaaac       c.*2700

          .         .         .         .         .         .       g.35532
 aaaccttttttctttataaattacccagcctcagttattcctttatagtgatgcaaaacg       c.*2760

          .         .         .         .         .         .       g.35592
 ggctaactatataaatttgtaatttttaagttatagattgtttttattaaacacttatga       c.*2820

                                                                    g.35600
 atactgtt                                                           c.*2828

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Interleukin-1 receptor-associated kinase 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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