interferon regulatory factor 3 (IRF3) - coding DNA reference sequence

(used for variant description)

(last modified January 18, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_001571.5 in the IRF3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering IRF3 transcript NM_001571.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5013
                                                ggaaacccaaaaa       c.-241

 .         .         .         .         .         .                g.5073
 agggcataggggcgggaacagcccagcgggccgtcccatcggcttttgggtctgttaccc       c.-181

 .         .         .         .         .         .                g.5133
 aaagaatgataaagttggttttatttcaagaagtcgatcaaaaagaaagccccagcgctc       c.-121

 .         .         .         .         .         .                g.5193
 tagagctcagctgacgggaaagggggtgcgcagcctcgagtttgagagctacccggagct       c.-61

 .         .         .         .         .         .  | 02          g.6037
 ccaagacaggggtgggttccagctgcccgcacgccccgaccttccatcgtag | gccggacc    c.-1

          .         .         .         .         .         .       g.6097
 ATGGGAACCCCAAAGCCACGGATCCTGCCCTGGCTGGTGTCGCAGCTGGACCTGGGGCAA       c.60
 M  G  T  P  K  P  R  I  L  P  W  L  V  S  Q  L  D  L  G  Q         p.20

          .         .         .         .         .         .       g.6157
 CTGGAGGGCGTGGCCTGGGTGAACAAGAGCCGCACGCGCTTCCGCATCCCTTGGAAGCAC       c.120
 L  E  G  V  A  W  V  N  K  S  R  T  R  F  R  I  P  W  K  H         p.40

          .         .         .         .      | 03  .         .    g.7376
 GGCCTACGGCAGGATGCACAGCAGGAGGATTTCGGAATCTTCCAG | GCCTGGGCCGAGGCC    c.180
 G  L  R  Q  D  A  Q  Q  E  D  F  G  I  F  Q   | A  W  A  E  A      p.60

          .         .         .         .         .         .       g.7436
 ACTGGTGCATATGTTCCCGGGAGGGATAAGCCAGACCTGCCAACCTGGAAGAGGAATTTC       c.240
 T  G  A  Y  V  P  G  R  D  K  P  D  L  P  T  W  K  R  N  F         p.80

          .         .         .         .         .         .       g.7496
 CGCTCTGCCCTCAACCGCAAAGAAGGGTTGCGTTTAGCAGAGGACCGGAGCAAGGACCCT       c.300
 R  S  A  L  N  R  K  E  G  L  R  L  A  E  D  R  S  K  D  P         p.100

          .         .         .        | 04.         .         .    g.7640
 CACGACCCACATAAAATCTACGAGTTTGTGAACTCAG | GAGTTGGGGACTTTTCCCAGCCA    c.360
 H  D  P  H  K  I  Y  E  F  V  N  S  G |   V  G  D  F  S  Q  P      p.120

          .         .         .         .         | 05         .    g.8270
 GACACCTCTCCGGACACCAATGGTGGAGGCAGTACTTCTGATACCCAG | GAAGACATTCTG    c.420
 D  T  S  P  D  T  N  G  G  G  S  T  S  D  T  Q   | E  D  I  L      p.140

          .         .         .         .         .         .       g.8330
 GATGAGTTACTGGGTAACATGGTGTTGGCCCCACTCCCAGATCCGGGACCCCCAAGCCTG       c.480
 D  E  L  L  G  N  M  V  L  A  P  L  P  D  P  G  P  P  S  L         p.160

          .         .         .         .         .         .       g.8390
 GCTGTAGCCCCTGAGCCCTGCCCTCAGCCCCTGCGGAGCCCCAGCTTGGACAATCCCACT       c.540
 A  V  A  P  E  P  C  P  Q  P  L  R  S  P  S  L  D  N  P  T         p.180

          .         .         .         .         .         .       g.8450
 CCCTTCCCAAACCTGGGGCCCTCTGAGAACCCACTGAAGCGGCTGTTGGTGCCGGGGGAA       c.600
 P  F  P  N  L  G  P  S  E  N  P  L  K  R  L  L  V  P  G  E         p.200

   | 06      .         .         .         .         .         .    g.8606
 G | AGTGGGAGTTCGAGGTGACAGCCTTCTACCGGGGCCGCCAAGTCTTCCAGCAGACCATC    c.660
 E |   W  E  F  E  V  T  A  F  Y  R  G  R  Q  V  F  Q  Q  T  I      p.220

          .         .         .         .         .         .       g.8666
 TCCTGCCCGGAGGGCCTGCGGCTGGTGGGGTCCGAAGTGGGAGACAGGACGCTGCCTGGA       c.720
 S  C  P  E  G  L  R  L  V  G  S  E  V  G  D  R  T  L  P  G         p.240

          .         .         .         .         .         .       g.8726
 TGGCCAGTCACACTGCCAGACCCTGGCATGTCCCTGACAGACAGGGGAGTGATGAGCTAC       c.780
 W  P  V  T  L  P  D  P  G  M  S  L  T  D  R  G  V  M  S  Y         p.260

          .         .         .         .         .         .       g.8786
 GTGAGGCATGTGCTGAGCTGCCTGGGTGGGGGACTGGCTCTCTGGCGGGCCGGGCAGTGG       c.840
 V  R  H  V  L  S  C  L  G  G  G  L  A  L  W  R  A  G  Q  W         p.280

          .         .         .         .         .         .       g.8846
 CTCTGGGCCCAGCGGCTGGGGCACTGCCACACATACTGGGCAGTGAGCGAGGAGCTGCTC       c.900
 L  W  A  Q  R  L  G  H  C  H  T  Y  W  A  V  S  E  E  L  L         p.300

          .         .         .         .         .         .       g.8906
 CCCAACAGCGGGCATGGGCCTGATGGCGAGGTCCCCAAGGACAAGGAAGGAGGCGTGTTT       c.960
 P  N  S  G  H  G  P  D  G  E  V  P  K  D  K  E  G  G  V  F         p.320

          .         .   | 07     .         .         .         .    g.10085
 GACCTGGGGCCCTTCATTGTAG | ATCTGATTACCTTCACGGAAGGAAGCGGACGCTCACCA    c.1020
 D  L  G  P  F  I  V  D |   L  I  T  F  T  E  G  S  G  R  S  P      p.340

          .         .         .         .         .         .       g.10145
 CGCTATGCCCTCTGGTTCTGTGTGGGGGAGTCATGGCCCCAGGACCAGCCGTGGACCAAG       c.1080
 R  Y  A  L  W  F  C  V  G  E  S  W  P  Q  D  Q  P  W  T  K         p.360

          .         | 08         .         .         .         .    g.11084
 AGGCTCGTGATGGTCAAG | GTTGTGCCCACGTGCCTCAGGGCCTTGGTAGAAATGGCCCGG    c.1140
 R  L  V  M  V  K   | V  V  P  T  C  L  R  A  L  V  E  M  A  R      p.380

          .         .         .         .         .         .       g.11144
 GTAGGGGGTGCCTCCTCCCTGGAGAATACTGTGGACCTGCACATTTCCAACAGCCACCCA       c.1200
 V  G  G  A  S  S  L  E  N  T  V  D  L  H  I  S  N  S  H  P         p.400

          .         .         .         .         .         .       g.11204
 CTCTCCCTCACCTCCGACCAGTACAAGGCCTACCTGCAGGACTTGGTGGAGGGCATGGAT       c.1260
 L  S  L  T  S  D  Q  Y  K  A  Y  L  Q  D  L  V  E  G  M  D         p.420

          .         .                                               g.11228
 TTCCAGGGCCCTGGGGAGAGCTGA                                           c.1284
 F  Q  G  P  G  E  S  X                                             p.427

          .         .         .         .         .         .       g.11288
 gccctcgctcctcatggtgtgcctccaacccccctgttccccaccacctcaaccaataaa       c.*60

          .                                                         g.11307
 ctggttcctgctatgatca                                                c.*79

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Interferon regulatory factor 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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