interferon regulatory factor 4 (IRF4) - coding DNA reference sequence

(used for variant description)

(last modified July 27, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_002460.3 in the IRF4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_027728.1, covering IRF4 transcript NM_002460.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5006
                                                       acctcg       c.-121

 .         .         .         .         .         .                g.5066
 cactctcagtttcaccgctcgatcttgggacccaccgctgccctcagctccgagtccagg       c.-61

 .     | 02   .         .         .         .         .             g.6414
 gcgag | tgcagagcagagcgggcggaggaccccgggcgcgggcgcggacggcacgcggggc    c.-1

          .         .         .         .         .         .       g.6474
 ATGAACCTGGAGGGCGGCGGCCGAGGCGGAGAGTTCGGCATGAGCGCGGTGAGCTGCGGC       c.60
 M  N  L  E  G  G  G  R  G  G  E  F  G  M  S  A  V  S  C  G         p.20

          .         .         .         .         .         .       g.6534
 AACGGGAAGCTCCGCCAGTGGCTGATCGACCAGATCGACAGCGGCAAGTACCCCGGGCTG       c.120
 N  G  K  L  R  Q  W  L  I  D  Q  I  D  S  G  K  Y  P  G  L         p.40

          .         .         .         .         .         .       g.6594
 GTGTGGGAGAACGAGGAGAAGAGCATCTTCCGCATCCCCTGGAAGCACGCGGGCAAGCAG       c.180
 V  W  E  N  E  E  K  S  I  F  R  I  P  W  K  H  A  G  K  Q         p.60

          .         .         .       | 03 .         .         .    g.8106
 GACTACAACCGCGAGGAGGACGCCGCGCTCTTCAAG | GCTTGGGCACTGTTTAAAGGAAAG    c.240
 D  Y  N  R  E  E  D  A  A  L  F  K   | A  W  A  L  F  K  G  K      p.80

          .         .         .         .         .         .       g.8166
 TTCCGAGAAGGCATCGACAAGCCGGACCCTCCCACCTGGAAGACGCGCCTGCGGTGCGCT       c.300
 F  R  E  G  I  D  K  P  D  P  P  T  W  K  T  R  L  R  C  A         p.100

          .         .         .         .         .         .       g.8226
 TTGAACAAGAGCAATGACTTTGAGGAACTGGTTGAGCGGAGCCAGCTGGACATCTCAGAC       c.360
 L  N  K  S  N  D  F  E  E  L  V  E  R  S  Q  L  D  I  S  D         p.120

          .         .         .         .    | 04    .         .    g.9125
 CCGTACAAAGTGTACAGGATTGTTCCTGAGGGAGCCAAAAAAG | GAGCCAAGCAGCTCACC    c.420
 P  Y  K  V  Y  R  I  V  P  E  G  A  K  K  G |   A  K  Q  L  T      p.140

          .         .         .         .         .         .       g.9185
 CTGGAGGACCCGCAGATGTCCATGAGCCACCCCTACACCATGACAACGCCTTACCCTTCG       c.480
 L  E  D  P  Q  M  S  M  S  H  P  Y  T  M  T  T  P  Y  P  S         p.160

          .   | 05     .         .         .         .         .    g.10417
 CTCCCAGCCCAG | CAGGTTCACAACTACATGATGCCACCCCTCGACCGAAGCTGGAGGGAC    c.540
 L  P  A  Q   | Q  V  H  N  Y  M  M  P  P  L  D  R  S  W  R  D      p.180

          .         .         .         .         .         .       g.10477
 TACGTCCCGGATCAGCCACACCCGGAAATCCCGTACCAATGTCCCATGACGTTTGGACCC       c.600
 Y  V  P  D  Q  P  H  P  E  I  P  Y  Q  C  P  M  T  F  G  P         p.200

          .         .         .        | 06.         .         .    g.12112
 CGCGGCCACCACTGGCAAGGCCCAGCTTGTGAAAATG | GTTGCCAGGTGACAGGAACCTTT    c.660
 R  G  H  H  W  Q  G  P  A  C  E  N  G |   C  Q  V  T  G  T  F      p.220

          .         .         .         .         .         .       g.12172
 TATGCTTGTGCCCCACCTGAGTCCCAGGCTCCCGGAGTCCCCACAGAGCCAAGCATAAGG       c.720
 Y  A  C  A  P  P  E  S  Q  A  P  G  V  P  T  E  P  S  I  R         p.240

          .         .      | 07  .         .         .         .    g.14720
 TCTGCCGAAGCCTTGGCGTTCTCAG | ACTGCCGGCTGCACATCTGCCTGTACTACCGGGAA    c.780
 S  A  E  A  L  A  F  S  D |   C  R  L  H  I  C  L  Y  Y  R  E      p.260

          .         .         .         .         .         .       g.14780
 ATCCTCGTGAAGGAGCTGACCACGTCCAGCCCCGAGGGCTGCCGGATCTCCCATGGACAT       c.840
 I  L  V  K  E  L  T  T  S  S  P  E  G  C  R  I  S  H  G  H         p.280

          .         .         .         .         .         .       g.14840
 ACGTATGACGCCAGCAACCTGGACCAGGTCCTGTTCCCCTACCCAGAGGACAATGGCCAG       c.900
 T  Y  D  A  S  N  L  D  Q  V  L  F  P  Y  P  E  D  N  G  Q         p.300

          .         .         .         .         .         .       g.14900
 AGGAAAAACATTGAGAAGCTGCTGAGCCACCTGGAGAGGGGCGTGGTCCTCTGGATGGCC       c.960
 R  K  N  I  E  K  L  L  S  H  L  E  R  G  V  V  L  W  M  A         p.320

          .         .         .         .         .         .       g.14960
 CCCGACGGGCTCTATGCGAAAAGACTGTGCCAGAGCAGGATCTACTGGGACGGGCCCCTG       c.1020
 P  D  G  L  Y  A  K  R  L  C  Q  S  R  I  Y  W  D  G  P  L         p.340

          .         .         .         .         .         .       g.15020
 GCGCTGTGCAACGACCGGCCCAACAAACTGGAGAGAGACCAGACCTGCAAGCTCTTTGAC       c.1080
 A  L  C  N  D  R  P  N  K  L  E  R  D  Q  T  C  K  L  F  D         p.360

          .          | 08        .         .         .         .    g.18320
 ACACAGCAGTTCTTGTCAG | AGCTGCAAGCGTTTGCTCACCACGGCCGCTCCCTGCCAAGA    c.1140
 T  Q  Q  F  L  S  E |   L  Q  A  F  A  H  H  G  R  S  L  P  R      p.380

          .         .         .         .         .         .       g.18380
 TTCCAGGTGACTCTATGCTTTGGAGAGGAGTTTCCAGACCCTCAGAGGCAAAGAAAGCTC       c.1200
 F  Q  V  T  L  C  F  G  E  E  F  P  D  P  Q  R  Q  R  K  L         p.400

          .   | 09     .         .         .         .         .    g.20764
 ATCACAGCTCAC | GTAGAACCTCTGCTAGCCAGACAACTATATTATTTTGCTCAACAAAAC    c.1260
 I  T  A  H   | V  E  P  L  L  A  R  Q  L  Y  Y  F  A  Q  Q  N      p.420

          .         .         .         .         .         .       g.20824
 AGTGGACATTTCCTGAGGGGCTACGATTTACCAGAACACATCAGCAATCCAGAAGATTAC       c.1320
 S  G  H  F  L  R  G  Y  D  L  P  E  H  I  S  N  P  E  D  Y         p.440

          .         .         .                                     g.20860
 CACAGATCTATCCGCCATTCCTCTATTCAAGAATGA                               c.1356
 H  R  S  I  R  H  S  S  I  Q  E  X                                 p.451

          .         .         .         .         .         .       g.20920
 aaaatgtcaagatgagtggttttctttttcctttttttttttttttttttgatacgggga       c.*60

          .         .         .         .         .         .       g.20980
 tacggggtcttgctctgtctcccaggctggagtgcagtgacacaatctcagctcactgtg       c.*120

          .         .         .         .         .         .       g.21040
 acctccgcctcctgggttcaagagactctcctgcctcagcctccctggtagctgggatta       c.*180

          .         .         .         .         .         .       g.21100
 caggtgtgagccactgcacccacccaagacaagtgattttcattgtaaatatttgacttt       c.*240

          .         .         .         .         .         .       g.21160
 agtgaaagcgtccaattgactgccctcttactgttttgaggaattcagaagtggagattt       c.*300

          .         .         .         .         .         .       g.21220
 cagttcagcggttgaggagaattgcggcgagacaagcatggaaaatcagtgacatctgat       c.*360

          .         .         .         .         .         .       g.21280
 tggcagatgagcttatttcaaaaggaagggtggctttgcatttcttgtgttctgtagact       c.*420

          .         .         .         .         .         .       g.21340
 gccatcattgatgatcactgtgaaaattgaccaagtgatgtgtttacatttactgaaatg       c.*480

          .         .         .         .         .         .       g.21400
 cgctctttaatttgttgtagattaggtcttgctggaagacagagaaaacttgcctttcag       c.*540

          .         .         .         .         .         .       g.21460
 tattgacactgactagagtgatgactgcttgtaggtatgtctgtgccatttctcagggaa       c.*600

          .         .         .         .         .         .       g.21520
 gtaagatgtaaattgaagaagcctcacacgtaaaagaaatgtattaatgtatgtaggagc       c.*660

          .         .         .         .         .         .       g.21580
 tgcagttcttgtggaagacacttgctgagtgaaggaaatgaatctttgactgaagccgtg       c.*720

          .         .         .         .         .         .       g.21640
 cctgtagccttggggaggcccatcccccacctgccagcggtttcctggtgtgggtccctc       c.*780

          .         .         .         .         .         .       g.21700
 tgccccgccctccttcccattggctttctctccttggcctttcctggaagccagttagta       c.*840

          .         .         .         .         .         .       g.21760
 aacttcctattttcttgagtcaaaaaacatgagcgctactcttggatgggacatttttgt       c.*900

          .         .         .         .         .         .       g.21820
 ctgtcctacaatctagtaatgtctaagtaatggttaagttttcttgtttctgcatctttt       c.*960

          .         .         .         .         .         .       g.21880
 tgaccctcattctttagagatgctaaaattcttcgcataaagaagaagaaattaaggaac       c.*1020

          .         .         .         .         .         .       g.21940
 ataaatcttaatacttgaactgttgcccttctgtccaagtacttaactatctgttccctt       c.*1080

          .         .         .         .         .         .       g.22000
 cctctgtgccacgctcctctgtttgtttggctgtccagcgatcagccatggcgacactaa       c.*1140

          .         .         .         .         .         .       g.22060
 aggaggaggagccggggactcccaggctggagagcactgccaggacccaccactggaagc       c.*1200

          .         .         .         .         .         .       g.22120
 aggatggagctgactacggaactgcacactcagtgggctgtttctgcttatttcatctgt       c.*1260

          .         .         .         .         .         .       g.22180
 tctatgcttcctcgtgccaattatagtttgacagggccttaaaattacttggctttttcc       c.*1320

          .         .         .         .         .         .       g.22240
 aaatgcttctatttatagaatcccaaagacctccacttgcttaagtatacctatcactta       c.*1380

          .         .         .         .         .         .       g.22300
 catttttgtggttttgagaaagtacagcagtagactggggcgtcacctccaggccgtttc       c.*1440

          .         .         .         .         .         .       g.22360
 tcatactacaggatatttactattactcccaggatcagcagaagattgcgtagctctcaa       c.*1500

          .         .         .         .         .         .       g.22420
 atgtgtgttcctgcttttctaatggatattttaaattcattcaacaagcacctagtaagt       c.*1560

          .         .         .         .         .         .       g.22480
 gcctgctgtatccctacattacacagttcagcctttatcaagcttagtgagcagtgagca       c.*1620

          .         .         .         .         .         .       g.22540
 ctgaaacattattttttaatgtttaaaaagtttctaatattaaagtcagaatattaatac       c.*1680

          .         .         .         .         .         .       g.22600
 aattaatattaatattaactacagaaaagacaaacagtagagaacagcaaaaaaataaaa       c.*1740

          .         .         .         .         .         .       g.22660
 aggatctccttttttcccagcccaaattctcctctctaaaagtgtccacaagaaggggtg       c.*1800

          .         .         .         .         .         .       g.22720
 tttattcttccaacacatttcacttttctgtaaatatacataaacttaaaaagaaaacct       c.*1860

          .         .         .         .         .         .       g.22780
 catggagtcatcttgcacacactttcatgcagtgctctttgtagctaacagtgaagattt       c.*1920

          .         .         .         .         .         .       g.22840
 acctcgttctgctcagaggccttgctgtggagctccactgccatgtacccagtagggttt       c.*1980

          .         .         .         .         .         .       g.22900
 gacatttcattagccatgcaacatggatatgtattgggcagcagactgtgtttcgtgaac       c.*2040

          .         .         .         .         .         .       g.22960
 tgcagtgatgtatacatcttatagatgcaaagtattttggggtatattatcctaagggaa       c.*2100

          .         .         .         .         .         .       g.23020
 gataaagatgatattaagaactgctgtttcacggggcccttacctgtgaccctctttgct       c.*2160

          .         .         .         .         .         .       g.23080
 gaagaatatttaaccccacacagcacttcaaagaagctgtcttggaagtctgtctcagga       c.*2220

          .         .         .         .         .         .       g.23140
 gcaccctgtcttcttaattctccaagcggatgctccatttcaattgctttgtgacttctt       c.*2280

          .         .         .         .         .         .       g.23200
 cttctttgtttttttaaatattatgctgctttaacagtggagctgaattttctggaaaat       c.*2340

          .         .         .         .         .         .       g.23260
 gcttcttggctggggccactacctcctttcctatctttacatctatgtgtatgttgactt       c.*2400

          .         .         .         .         .         .       g.23320
 tttaaaattctgagtgatccagggtatgacctagggaatgaactagctatgaaatactca       c.*2460

          .         .         .         .         .         .       g.23380
 gggttaggaatcctagcacttgtctcaggactctgaaaaggaacggcttcctcattcctt       c.*2520

          .         .         .         .         .         .       g.23440
 gtcttgataaagtggaattggcaaactagaatttagtttgtactcagtggacagtgctgt       c.*2580

          .         .         .         .         .         .       g.23500
 tgaagatttgaggacttgttaaagagcactgggtcatatggaaaaaatgtatgtgtctcc       c.*2640

          .         .         .         .         .         .       g.23560
 caggtgcatttcttggtttatgtcttgttcttgagattttgtatatttaggaaaacctca       c.*2700

          .         .         .         .         .         .       g.23620
 agcagtaattaatatctcctggaacactatagagaaccaagtgaccgactcatttacaac       c.*2760

          .         .         .         .         .         .       g.23680
 tgaaacctaggaagcccctgagtcctgagcgaaaacaggagagttagtcgccctacagaa       c.*2820

          .         .         .         .         .         .       g.23740
 aacccagctagactattgggtatgaactaaaaagagactgtgccatggtgagaaaaatgt       c.*2880

          .         .         .         .         .         .       g.23800
 aaaatcctacagtgaaatgagcagcccttacagtattgttaccaccaagggcaggtaggt       c.*2940

          .         .         .         .         .         .       g.23860
 attagtgtttgaaaaagctggtctttgagcgagggcataaatacagctagccccaggggt       c.*3000

          .         .         .         .         .         .       g.23920
 ggaacaactctgggagtcttgggtactcgcacctcttggctttgttgatgctccgccagg       c.*3060

          .         .         .         .         .         .       g.23980
 aaggccacttgtgtgtgcgtgtcagttacttttttagtaacaattcagatccagtgtaaa       c.*3120

          .         .         .         .         .         .       g.24040
 cttccgttcattgctctccagtcacatgcccccacttccccacaggtgaaagtttttctg       c.*3180

          .         .         .         .         .         .       g.24100
 aaagtgttgggattggttaaggtctttatttgtattacgtatctcccgaagtcctctgtg       c.*3240

          .         .         .         .         .         .       g.24160
 gccagctgcatctgtctgaatggtgcgtgaaggctctcagaccttacacaccattttgta       c.*3300

          .         .         .         .         .         .       g.24220
 agttatgttttacatgccccgtttttgagactgatctcgatgcaggtggatctccttgag       c.*3360

          .         .         .         .         .         .       g.24280
 atcctgatagcctgttacaggaatgaagtaaaggtcagtttttttttgtattgattttca       c.*3420

          .         .         .         .         .         .       g.24340
 cagctttgaggaacatgcataagaaatgtagctgaagtagaggggacgtgagagaagggc       c.*3480

          .         .         .         .         .         .       g.24400
 caggccggcaggccaaccctcctccaatggaaattcccgtgttgcttcaaactgagacag       c.*3540

          .         .         .         .         .         .       g.24460
 atgggacttaacaggcaatggggtccacttccccctcttcagcatcccccgtaccccact       c.*3600

          .         .         .         .         .         .       g.24520
 ttctgctgaaagaactgccagcaggtaggaccccagaggcccccaaatgaaagcttgaat       c.*3660

          .         .         .         .         .         .       g.24580
 ttcccctactggctctgcgttttgctgagatctgtaggaaaggatgcttcacaaactgag       c.*3720

          .         .         .         .         .         .       g.24640
 gtagataatgctatgctgtcgttggtatacatcatgaatttttatgtaaattgctctgca       c.*3780

          .         .         .         .         .         .       g.24700
 aagcaaattgatatgtttgataaatttatgtttttaggtaaataaaaacttttaaaaatt       c.*3840

                                                                    g.24705
 tgtta                                                              c.*3845

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Interferon regulatory factor 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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