interferon regulatory factor 6 (IRF6) - coding DNA reference sequence

(used for variant description)

(last modified June 29, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_006147.3 in the IRF6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007081.2, covering IRF6 transcript NM_006147.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5004
                                                         ggat       c.-301

 .         .         .         .         .         .                g.5064
 gcgaaggctgcggcgtcctggggcgaggcgctgacgtgagctcggcgcacctgggctggg       c.-241

 .         .         .         .         .         .                g.5124
 caggtaagggctggtgcgggacggggagaggaacctgcagtccctacttgggtagagcca       c.-181

 .         .         .         .         .         .                g.5184
 ggcgccccttggctaagacgtcgaggagcgtggtagcgacgggtgatcttcgctgcggac       c.-121

 .         .         .         .         .     | 02   .             g.9147
 ttggttcggagggacgtccgcttctggtggacagattgagcaaag | aatctttgagcggtc    c.-61

 .         .         .         .         .         .       | 03     g.9762
 aagggaaagacaagccgactcttcagatccctgtggacacactgcctgctcttccat | atc    c.-1

          .         .         .         .         .         .       g.9822
 ATGGCCCTCCACCCCCGCAGAGTCCGGCTAAAGCCCTGGCTGGTGGCCCAGGTGGATAGT       c.60
 M  A  L  H  P  R  R  V  R  L  K  P  W  L  V  A  Q  V  D  S         p.20

          .         .         .         .         .         .       g.9882
 GGCCTCTACCCTGGGCTCATCTGGCTACACAGGGACTCTAAACGCTTCCAGATTCCCTGG       c.120
 G  L  Y  P  G  L  I  W  L  H  R  D  S  K  R  F  Q  I  P  W         p.40

          .         .         .         .         .     | 04   .    g.14629
 AAACATGCCACCCGGCATAGCCCTCAACAAGAAGAGGAAAATACCATTTTTAAG | GCCTGG    c.180
 K  H  A  T  R  H  S  P  Q  Q  E  E  E  N  T  I  F  K   | A  W      p.60

          .         .         .         .         .         .       g.14689
 GCTGTAGAGACAGGGAAGTACCAGGAAGGGGTGGATGACCCTGACCCAGCTAAATGGAAG       c.240
 A  V  E  T  G  K  Y  Q  E  G  V  D  D  P  D  P  A  K  W  K         p.80

          .         .         .         .         .         .       g.14749
 GCCCAGCTGCGCTGTGCTCTCAATAAGAGCAGAGAATTCAACCTGATGTATGATGGCACC       c.300
 A  Q  L  R  C  A  L  N  K  S  R  E  F  N  L  M  Y  D  G  T         p.100

          .         .         .         .         .         .       g.14809
 AAGGAGGTGCCCATGAACCCAGTGAAGATATATCAAGTGTGTGACATCCCTCAGCCCCAG       c.360
 K  E  V  P  M  N  P  V  K  I  Y  Q  V  C  D  I  P  Q  P  Q         p.120

          .          | 05        .         .         .         .    g.15798
 GGCTCGATCATTAACCCAG | GATCCACAGGGTCTGCTCCCTGGGATGAGAAGGATAATGAT    c.420
 G  S  I  I  N  P  G |   S  T  G  S  A  P  W  D  E  K  D  N  D      p.140

          .         .         .         .         .         .       g.15858
 GTGGATGAAGAAGATGAGGAAGATGAGCTGGATCAGTCGCAGCACCATGTTCCCATCCAG       c.480
 V  D  E  E  D  E  E  D  E  L  D  Q  S  Q  H  H  V  P  I  Q         p.160

          .         .         | 06         .         .         .    g.18780
 GACACCTTCCCCTTCCTGAACATCAATG | GTTCTCCCATGGCGCCAGCCAGTGTGGGCAAT    c.540
 D  T  F  P  F  L  N  I  N  G |   S  P  M  A  P  A  S  V  G  N      p.180

          .         .         .         .         .         .       g.18840
 TGCAGTGTGGGCAACTGCAGCCCGGAGGCAGTGTGGCCCAAAACTGAACCCCTGGAGATG       c.600
 C  S  V  G  N  C  S  P  E  A  V  W  P  K  T  E  P  L  E  M         p.200

          .         .         .         .         .         .       g.18900
 GAAGTACCCCAGGCACCTATACAGCCCTTCTATAGCTCTCCAGAACTGTGGATCAGCTCT       c.660
 E  V  P  Q  A  P  I  Q  P  F  Y  S  S  P  E  L  W  I  S  S         p.220

         | 07.         .         .         .         .         .    g.20341
 CTCCCAA | TGACTGACCTGGACATCAAGTTTCAGTACCGTGGGAAGGAGTACGGGCAGACC    c.720
 L  P  M |   T  D  L  D  I  K  F  Q  Y  R  G  K  E  Y  G  Q  T      p.240

          .         .         .         .         .         .       g.20401
 ATGACCGTGAGCAACCCTCAGGGCTGCCGACTCTTCTATGGGGACCTGGGTCCCATGCCT       c.780
 M  T  V  S  N  P  Q  G  C  R  L  F  Y  G  D  L  G  P  M  P         p.260

          .         .         .         .         .         .       g.20461
 GACCAGGAGGAGCTCTTTGGTCCCGTCAGCCTGGAGCAGGTCAAATTCCCAGGTCCTGAG       c.840
 D  Q  E  E  L  F  G  P  V  S  L  E  Q  V  K  F  P  G  P  E         p.280

          .         .         .         .         .         .       g.20521
 CATATTACCAATGAGAAGCAGAAGCTGTTCACTAGCAAGCTGCTGGACGTCATGGACAGA       c.900
 H  I  T  N  E  K  Q  K  L  F  T  S  K  L  L  D  V  M  D  R         p.300

          .         .         .         .         .         .       g.20581
 GGACTGATCCTGGAGGTCAGCGGTCATGCCATTTATGCCATCAGGCTGTGCCAGTGCAAG       c.960
 G  L  I  L  E  V  S  G  H  A  I  Y  A  I  R  L  C  Q  C  K         p.320

          .         .         .         .         .         .       g.20641
 GTGTACTGGTCTGGGCCATGTGCCCCATCACTTGTTGCTCCCAACCTGATTGAGAGACAA       c.1020
 V  Y  W  S  G  P  C  A  P  S  L  V  A  P  N  L  I  E  R  Q         p.340

          .         .         .         . | 08       .         .    g.21410
 AAGAAGGTCAAGCTATTTTGTCTGGAAACATTCCTTAGCG | ATCTCATTGCCCACCAGAAA    c.1080
 K  K  V  K  L  F  C  L  E  T  F  L  S  D |   L  I  A  H  Q  K      p.360

          .         .         .         .         .         .       g.21470
 GGACAGATAGAGAAGCAGCCACCGTTTGAGATCTACTTATGCTTTGGGGAAGAATGGCCA       c.1140
 G  Q  I  E  K  Q  P  P  F  E  I  Y  L  C  F  G  E  E  W  P         p.380

          .         .         .          | 09        .         .    g.22552
 GATGGGAAACCATTGGAAAGGAAACTCATCTTGGTTCAG | GTCATTCCAGTAGTGGCTCGG    c.1200
 D  G  K  P  L  E  R  K  L  I  L  V  Q   | V  I  P  V  V  A  R      p.400

          .         .         .         .         .         .       g.22612
 ATGATCTACGAGATGTTTTCTGGTGATTTCACACGATCCTTTGATAGTGGCAGTGTCCGC       c.1260
 M  I  Y  E  M  F  S  G  D  F  T  R  S  F  D  S  G  S  V  R         p.420

          .         .         .         .         .         .       g.22672
 CTGCAGATCTCAACCCCAGACATCAAGGATAACATCGTTGCTCAGCTGAAGCAGCTGTAC       c.1320
 L  Q  I  S  T  P  D  I  K  D  N  I  V  A  Q  L  K  Q  L  Y         p.440

          .         .         .         .         .         .       g.22732
 CGCATCCTTCAAACCCAGGAGAGCTGGCAGCCCATGCAGCCCACCCCCAGCATGCAACTG       c.1380
 R  I  L  Q  T  Q  E  S  W  Q  P  M  Q  P  T  P  S  M  Q  L         p.460

          .         .                                               g.22756
 CCCCCTGCCCTGCCTCCCCAGTAA                                           c.1404
 P  P  A  L  P  P  Q  X                                             p.467

          .         .         .         .         .         .       g.22816
 ttgtgaatgccatcttcttccttctcttttttataatattgtacatatggatttttttat       c.*60

          .         .         .         .         .         .       g.22876
 tgtttagatttaaccagcttttaaatctctcttttctctaacagtgttagaagtttgtga       c.*120

          .         .         .         .         .         .       g.22936
 ttctccaaatatgcctagatttaaagctgatttaatttatggaaaaatcacccttcagac       c.*180

          .         .         .         .         .         .       g.22996
 tttgcttttctttttcaaatctcctaatggtagtatgatatagcatagtagaaggagatt       c.*240

          .         .         .         .         .         .       g.23056
 tggcctgggagtttggacaccaaagttctagctgcagctttgcttccaatgtgaccttga       c.*300

          .         .         .         .         .         .       g.23116
 acaagtcctttaacctctgggcttcagatttattgcttataaagtgaagagattggagta       c.*360

          .         .         .         .         .         .       g.23176
 gtgcctgaaattgcatccagctttagaacggactcaatgaccttcttctacttgtacaag       c.*420

          .         .         .         .         .         .       g.23236
 gctaaactgcctggaacagaatccttctgcattgttcttgtaccacatttttccttggtt       c.*480

          .         .         .         .         .         .       g.23296
 ttgttaaagtttcctcaagcactgatttgtccaggatcgagctctgtttgacctgttctg       c.*540

          .         .         .         .         .         .       g.23356
 ctagtatagtaagctggctccctgatgggggaagtgagagggagaggagctggctggctg       c.*600

          .         .         .         .         .         .       g.23416
 gttgcttagaaactatgcttgatatctaaatagaaatgggtgccaaagtctgaaagtcac       c.*660

          .         .         .         .         .         .       g.23476
 ccagcctgtggagtgaaagctcacaaatttggcttctaaagggaagctgttgacacagaa       c.*720

          .         .         .         .         .         .       g.23536
 agcctagggattctgtggaagaataggttgtcaggcatttaccttattaccactcaaata       c.*780

          .         .         .         .         .         .       g.23596
 ccagtgtgtgtgtgttgggggggcggcagggagagggggtaggtgacagtatgtgactca       c.*840

          .         .         .         .         .         .       g.23656
 ggtgttagctttaagaggaaagagctctatttttcttgttttcttctctgagctagactg       c.*900

          .         .         .         .         .         .       g.23716
 agctggggatctaagatgtacttctctgactacaaaagggacagtatcatttagattttt       c.*960

          .         .         .         .         .         .       g.23776
 tgcagttggaagaaatgggttgttgagtgtgttaaggctgggatgaagaagggctgggca       c.*1020

          .         .         .         .         .         .       g.23836
 gtactcttctggaaaggctcacctagcacgaacctgcttgtctcccttactagtggaggt       c.*1080

          .         .         .         .         .         .       g.23896
 atctgagtgtgaacagtgaaggtaaagagtggtatagaacaatgcagctgtatctgtcac       c.*1140

          .         .         .         .         .         .       g.23956
 aaactggtcttatctagaaacatctgctgagtctctaaccctttcagctttctcttcttt       c.*1200

          .         .         .         .         .         .       g.24016
 tttgagacagagtcttgctttgttgcccaggctggagtgcagtggcaagtcaccacttac       c.*1260

          .         .         .         .         .         .       g.24076
 tgcagctttaagctcctgggctcaagcaatcgtcctgccccagcctcctgagtagttggg       c.*1320

          .         .         .         .         .         .       g.24136
 acaacagtcgtgcactatgatgcttggctaattttttttttatttttgtagagatgaggt       c.*1380

          .         .         .         .         .         .       g.24196
 cttgctatgttgcccaggctggtcttgaactcctgggctcaagcaatctgggacctaaat       c.*1440

          .         .         .         .         .         .       g.24256
 ggcaaataagatgctaatctgtggttgcaagccccagtcctcttgaatagtgatgcctat       c.*1500

          .         .         .         .         .         .       g.24316
 ctgtctgtgtcgggacatagtaaggaagcccatgtctagtctggtacctttaaaccaggc       c.*1560

          .         .         .         .         .         .       g.24376
 catctccaacttttcaaaatgactcaaaagttgagctagccttattttaaaaactaaaag       c.*1620

          .         .         .         .         .         .       g.24436
 ttcaaaatcagtggtgacatgaggacttatttatttaaagtgcttaagccttggttttag       c.*1680

          .         .         .         .         .         .       g.24496
 agtttctaagagacctagtggaatttgctattatgaaaagcatgaaaagattaagaaacc       c.*1740

          .         .         .         .         .         .       g.24556
 tggctaaaggtcaggtgcccagcttcgaggaaaagttgggcttttagggaccgggaagca       c.*1800

          .         .         .         .         .         .       g.24616
 ttaaaggcacagaaactttacattttgggggtcattttgttgagtaggtgaagtgaggga       c.*1860

          .         .         .         .         .         .       g.24676
 tttgggcttgatatttggctgccccatctctacgtgggaactcaaagttaaaaacccact       c.*1920

          .         .         .         .         .         .       g.24736
 gtaggtaaattagaagggcagctcttgaatctgggccagtctatatcccttctgtgaagt       c.*1980

          .         .         .         .         .         .       g.24796
 gctaacagccaggctatctgtagcctgggtgggagcccagataatgtgagctggtaaagg       c.*2040

          .         .         .         .         .         .       g.24856
 gtattggaaaagtgccaagaaatgccaagcttttggttcgtaaccactataaaaagttta       c.*2100

          .         .         .         .         .         .       g.24916
 tgaacatgtcagaggaatggatgagtgatttgtgaggtcttaactagataccccggtttc       c.*2160

          .         .         .         .         .         .       g.24976
 ttccttgttttggcttcttttcagaatgccgggagagtacatgcagggattccatctaat       c.*2220

          .         .         .         .         .         .       g.25036
 caccctcagcactctttctctggtcctgctggatagatttagatttcctttcttttttta       c.*2280

          .         .         .         .         .         .       g.25096
 gggcctcagtctgctatctcctttggtggctaccaccactcactcccttgatatcttcta       c.*2340

          .         .         .         .         .         .       g.25156
 ctcccttgccttcaccttgcttaagactgagaagggagttagattttgtcactagctctt       c.*2400

          .         .         .         .         .         .       g.25216
 ctttttcctcactgtgtaccccaccaaacaagattagttcaagttaaaaagaacctactg       c.*2460

          .         .         .         .         .         .       g.25276
 gaggtaaactgggagagcaagtgttggatctgggctggtccctttcccataaaattaggt       c.*2520

          .         .         .         .         .         .       g.25336
 ccctggttgtatgttcccatagcaccccatacttcctctctcagaataatcatttccctt       c.*2580

          .         .         .         .         .         .       g.25396
 gtaatgctcagcatccgcatcctgcttgactgcaaacttgctgaaggtagggactgtttg       c.*2640

          .         .         .         .         .         .       g.25456
 tcttggacttcgctgccagtccttagaacagtgtctgggacacagtgtgttctcaaatat       c.*2700

          .         .         .         .         .         .       g.25516
 ttgttgctggaataaatgaatgaactaaatcagtcttttagggatttactgttaaccacc       c.*2760

          .         .         .                                     g.25553
 atgggaaaattaaataaatgcggggaaggaaaacgtt                              c.*2797

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Interferon regulatory factor 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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