integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) (ITGA2B) - coding DNA reference sequence

(used for variant description)

(last modified December 10, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_000419.3 in the ITGA2B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering ITGA2B transcript NM_000419.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5032
                             attcctgcctgggaggttgtggaagaaggaag       c.-1

          .         .         .         .         .         .       g.5092
 ATGGCCAGAGCTTTGTGTCCACTGCAAGCCCTCTGGCTTCTGGAGTGGGTGCTGCTGCTC       c.60
 M  A  R  A  L  C  P  L  Q  A  L  W  L  L  E  W  V  L  L  L         p.20

          .         .         .         .         .         .       g.5152
 TTGGGACCTTGTGCTGCCCCTCCAGCCTGGGCCTTGAACCTGGACCCAGTGCAGCTCACC       c.120
 L  G  P  C  A  A  P  P  A  W  A  L  N  L  D  P  V  Q  L  T         p.40

          .         .         .         .         .         .       g.5212
 TTCTATGCAGGCCCCAATGGCAGCCAGTTTGGATTTTCACTGGACTTCCACAAGGACAGC       c.180
 F  Y  A  G  P  N  G  S  Q  F  G  F  S  L  D  F  H  K  D  S         p.60

          | 02         .         .         .         .         .    g.8426
 CATGGGAG | AGTGGCCATCGTGGTGGGCGCCCCGCGGACCCTGGGCCCCAGCCAGGAGGAG    c.240
 H  G  R  |  V  A  I  V  V  G  A  P  R  T  L  G  P  S  Q  E  E      p.80

          .         .         .         .         .         .       g.8486
 ACGGGCGGCGTGTTCCTGTGCCCCTGGAGGGCCGAGGGCGGCCAGTGCCCCTCGCTGCTC       c.300
 T  G  G  V  F  L  C  P  W  R  A  E  G  G  Q  C  P  S  L  L         p.100

          . | 03       .         .         .         .         .    g.8634
 TTTGACCTCC | GTGATGAGACCCGAAATGTAGGCTCCCAAACTTTACAAACCTTCAAGGCC    c.360
 F  D  L  R |   D  E  T  R  N  V  G  S  Q  T  L  Q  T  F  K  A      p.120

          .         .         .         .         | 04         .    g.8801
 CGCCAAGGACTGGGGGCGTCGGTCGTCAGCTGGAGCGACGTCATTGTG | GCCTGCGCCCCC    c.420
 R  Q  G  L  G  A  S  V  V  S  W  S  D  V  I  V   | A  C  A  P      p.140

          .         .         .         .         .         .       g.8861
 TGGCAGCACTGGAACGTCCTAGAAAAGACTGAGGAGGCTGAGAAGACGCCCGTAGGTAGC       c.480
 W  Q  H  W  N  V  L  E  K  T  E  E  A  E  K  T  P  V  G  S         p.160

          .         .         .         .         .         .       g.8921
 TGCTTTTTGGCTCAGCCAGAGAGCGGCCGCCGCGCCGAGTACTCCCCCTGTCGCGGGAAC       c.540
 C  F  L  A  Q  P  E  S  G  R  R  A  E  Y  S  P  C  R  G  N         p.180

          .         .         .     | 05   .         .         .    g.9196
 ACCCTGAGCCGCATTTACGTGGAAAATGATTTTA | GCTGGGACAAGCGTTACTGTGAAGCG    c.600
 T  L  S  R  I  Y  V  E  N  D  F  S |   W  D  K  R  Y  C  E  A      p.200

          .         .     | 06   .         .         .         .    g.9332
 GGCTTCAGCTCCGTGGTCACTCAG | GCCGGAGAGCTGGTGCTTGGGGCTCCTGGCGGCTAT    c.660
 G  F  S  S  V  V  T  Q   | A  G  E  L  V  L  G  A  P  G  G  Y      p.220

          . | 07       .         .         .         .         .    g.9479
 TATTTCTTAG | GTCTCCTGGCCCAGGCTCCAGTTGCGGATATTTTCTCGAGTTACCGCCCA    c.720
 Y  F  L  G |   L  L  A  Q  A  P  V  A  D  I  F  S  S  Y  R  P      p.240

          .         .         .         .         .         .       g.9539
 GGCATCCTTTTGTGGCACGTGTCCTCCCAGAGCCTCTCCTTTGACTCCAGCAACCCAGAG       c.780
 G  I  L  L  W  H  V  S  S  Q  S  L  S  F  D  S  S  N  P  E         p.260

          .          | 08        .         .         .         .    g.9961
 TACTTCGACGGCTACTGGG | GGTACTCGGTGGCCGTGGGCGAGTTCGACGGGGATCTCAAC    c.840
 Y  F  D  G  Y  W  G |   Y  S  V  A  V  G  E  F  D  G  D  L  N      p.280

         | 09.         .         .         .         .  | 10      . g.10376
 ACTACAG | AATATGTCGTCGGTGCCCCCACTTGGAGCTGGACCCTGGGAGCG | GTGGAAATT c.900
 T  T  E |   Y  V  V  G  A  P  T  W  S  W  T  L  G  A   | V  E  I   p.300

          .         .         .         .      | 11  .         .    g.10574
 TTGGATTCCTACTACCAGAGGCTGCATCGGCTGCGCGGAGAGCAG | ATGGCGTCGTATTTT    c.960
 L  D  S  Y  Y  Q  R  L  H  R  L  R  G  E  Q   | M  A  S  Y  F      p.320

          .         .         .         | 12         .         .    g.10823
 GGGCATTCAGTGGCTGTCACTGACGTCAACGGGGATGG | GAGGCATGATCTGCTGGTGGGC    c.1020
 G  H  S  V  A  V  T  D  V  N  G  D  G  |  R  H  D  L  L  V  G      p.340

          .         .         .         .         .         .       g.10883
 GCTCCACTGTATATGGAGAGCCGGGCAGACCGAAAACTGGCCGAAGTGGGGCGTGTGTAT       c.1080
 A  P  L  Y  M  E  S  R  A  D  R  K  L  A  E  V  G  R  V  Y         p.360

          .         .         .         .         .         .       g.10943
 TTGTTCCTGCAGCCGCGAGGCCCCCACGCGCTGGGTGCCCCCAGCCTCCTGCTGACTGGC       c.1140
 L  F  L  Q  P  R  G  P  H  A  L  G  A  P  S  L  L  L  T  G         p.380

          .         .         .         .         .         .       g.11003
 ACACAGCTCTATGGGCGATTCGGCTCTGCCATCGCACCCCTGGGCGACCTCGACCGGGAT       c.1200
 T  Q  L  Y  G  R  F  G  S  A  I  A  P  L  G  D  L  D  R  D         p.400

          . | 13       .         .         .         .         .    g.13494
 GGCTACAATG | ACATTGCAGTGGCTGCCCCCTACGGGGGTCCCAGTGGCCGGGGCCAAGTG    c.1260
 G  Y  N  D |   I  A  V  A  A  P  Y  G  G  P  S  G  R  G  Q  V      p.420

          .         .         .         .         .         .       g.13554
 CTGGTGTTCCTGGGTCAGAGTGAGGGGCTGAGGTCACGTCCCTCCCAGGTCCTGGACAGC       c.1320
 L  V  F  L  G  Q  S  E  G  L  R  S  R  P  S  Q  V  L  D  S         p.440

          .         .         .         .         .         .       g.13614
 CCCTTCCCCACAGGCTCTGCCTTTGGCTTCTCCCTTCGAGGTGCCGTAGACATCGATGAC       c.1380
 P  F  P  T  G  S  A  F  G  F  S  L  R  G  A  V  D  I  D  D         p.460

          .    | 14    .         .         .         .          | 15 g.14016
 AACGGATACCCAG | ACCTGATCGTGGGAGCTTACGGGGCCAACCAGGTGGCTGTGTACAG | A c.1440
 N  G  Y  P  D |   L  I  V  G  A  Y  G  A  N  Q  V  A  V  Y  R  |   p.480

          .         .         .         .         .         .       g.14076
 GCTCAGCCAGTGGTGAAGGCCTCTGTCCAGCTACTGGTGCAAGATTCACTGAATCCTGCT       c.1500
 A  Q  P  V  V  K  A  S  V  Q  L  L  V  Q  D  S  L  N  P  A         p.500

          .         .         .         .     | 16   .         .    g.14220
 GTGAAGAGCTGTGTCCTACCTCAGACCAAGACACCCGTGAGCTG | CTTCAACATCCAGATG    c.1560
 V  K  S  C  V  L  P  Q  T  K  T  P  V  S  C  |  F  N  I  Q  M      p.520

          .         .         .         . | 17       .         .    g.14372
 TGTGTTGGAGCCACTGGGCACAACATTCCTCAGAAGCTAT | CCCTAAATGCCGAGCTGCAG    c.1620
 C  V  G  A  T  G  H  N  I  P  Q  K  L  S |   L  N  A  E  L  Q      p.540

          .         .         .         .         .         .       g.14432
 CTGGACCGGCAGAAGCCCCGCCAGGGCCGGCGGGTGCTGCTGCTGGGCTCTCAACAGGCA       c.1680
 L  D  R  Q  K  P  R  Q  G  R  R  V  L  L  L  G  S  Q  Q  A         p.560

          .         .         .         .         .         .       g.14492
 GGCACCACCCTGAACCTGGATCTGGGCGGAAAGCACAGCCCCATCTGCCACACCACCATG       c.1740
 G  T  T  L  N  L  D  L  G  G  K  H  S  P  I  C  H  T  T  M         p.580

          .   | 18     .         .         .         .         .    g.14739
 GCCTTCCTTCGA | GATGAGGCAGACTTCCGGGACAAGCTGAGCCCCATTGTGCTCAGCCTC    c.1800
 A  F  L  R   | D  E  A  D  F  R  D  K  L  S  P  I  V  L  S  L      p.600

          .         .         .         .         .         .       g.14799
 AATGTGTCCCTACCGCCCACGGAGGCTGGAATGGCCCCTGCTGTCGTGCTGCATGGAGAC       c.1860
 N  V  S  L  P  P  T  E  A  G  M  A  P  A  V  V  L  H  G  D         p.620

          .         | 19         .         .         .         .    g.15837
 ACCCATGTGCAGGAGCAG | ACACGAATCGTCCTGGACTGTGGGGAAGATGACGTATGTGTG    c.1920
 T  H  V  Q  E  Q   | T  R  I  V  L  D  C  G  E  D  D  V  C  V      p.640

          .         .       | 20 .         .         .         .    g.16030
 CCCCAGCTTCAGCTCACTGCCAGCGT | GACGGGCTCCCCGCTCCTAGTTGGGGCAGATAAT    c.1980
 P  Q  L  Q  L  T  A  S  V  |  T  G  S  P  L  L  V  G  A  D  N      p.660

          .         .         .         .         .         .       g.16090
 GTCCTGGAGCTGCAGATGGACGCAGCCAACGAGGGCGAGGGGGCCTATGAAGCAGAGCTG       c.2040
 V  L  E  L  Q  M  D  A  A  N  E  G  E  G  A  Y  E  A  E  L         p.680

          .         .         .         .         .     | 21   .    g.16721
 GCCGTGCACCTGCCCCAGGGCGCCCACTACATGCGGGCCCTAAGCAATGTCGAG | GGCTTT    c.2100
 A  V  H  L  P  Q  G  A  H  Y  M  R  A  L  S  N  V  E   | G  F      p.700

          .         .         .         .         .         .       g.16781
 GAGAGACTCATCTGTAATCAGAAGAAGGAGAATGAGACCAGGGTGGTGCTGTGTGAGCTG       c.2160
 E  R  L  I  C  N  Q  K  K  E  N  E  T  R  V  V  L  C  E  L         p.720

          .         .        | 22.         .         .         .    g.17450
 GGCAACCCCATGAAGAAGAACGCCCAG | ATAGGAATCGCGATGTTGGTGAGCGTGGGGAAT    c.2220
 G  N  P  M  K  K  N  A  Q   | I  G  I  A  M  L  V  S  V  G  N      p.740

          .         .         .         .        | 23.         .    g.18130
 CTGGAAGAGGCTGGGGAGTCTGTGTCCTTCCAGCTGCAGATACGGAG | CAAGAACAGCCAG    c.2280
 L  E  E  A  G  E  S  V  S  F  Q  L  Q  I  R  S  |  K  N  S  Q      p.760

          .         .         .         .         .         .       g.18190
 AATCCAAACAGCAAGATTGTGCTGCTGGACGTGCCGGTCCGGGCAGAGGCCCAAGTGGAG       c.2340
 N  P  N  S  K  I  V  L  L  D  V  P  V  R  A  E  A  Q  V  E         p.780

          | 24         .         .         .         .         .    g.18373
 CTGCGAGG | GAACTCCTTTCCAGCCTCCCTGGTGGTGGCAGCAGAAGAAGGTGAGAGGGAG    c.2400
 L  R  G  |  N  S  F  P  A  S  L  V  V  A  A  E  E  G  E  R  E      p.800

          .         .         .         .         | 25         .    g.18532
 CAGAACAGCTTGGACAGCTGGGGACCCAAAGTGGAGCACACCTATGAG | CTCCACAACAAT    c.2460
 Q  N  S  L  D  S  W  G  P  K  V  E  H  T  Y  E   | L  H  N  N      p.820

          .         .         .         .         .         .       g.18592
 GGCCCTGGGACTGTGAATGGTCTTCACCTCAGCATCCACCTTCCGGGACAGTCCCAGCCC       c.2520
 G  P  G  T  V  N  G  L  H  L  S  I  H  L  P  G  Q  S  Q  P         p.840

          .         .         .         .         .         .       g.18652
 TCCGACCTGCTCTACATCCTGGATATACAGCCCCAGGGGGGCCTTCAGTGCTTCCCACAG       c.2580
 S  D  L  L  Y  I  L  D  I  Q  P  Q  G  G  L  Q  C  F  P  Q         p.860

          .         .  | 26      .         .         .         .    g.18828
 CCTCCTGTCAACCCTCTCAAG | GTGGACTGGGGGCTGCCCATCCCCAGCCCCTCCCCCATT    c.2640
 P  P  V  N  P  L  K   | V  D  W  G  L  P  I  P  S  P  S  P  I      p.880

          .         .         .         .         .         .       g.18888
 CACCCGGCCCATCACAAGCGGGATCGCAGACAGATCTTCCTGCCAGAGCCCGAGCAGCCC       c.2700
 H  P  A  H  H  K  R  D  R  R  Q  I  F  L  P  E  P  E  Q  P         p.900

          .         .        | 27.         .         .         .    g.19427
 TCGAGGCTTCAGGATCCAGTTCTCGTA | AGCTGCGACTCGGCGCCCTGTACTGTGGTGCAG    c.2760
 S  R  L  Q  D  P  V  L  V   | S  C  D  S  A  P  C  T  V  V  Q      p.920

          .         .         .         .         .         .       g.19487
 TGTGACCTGCAGGAGATGGCGCGCGGGCAGCGGGCCATGGTCACGGTGCTGGCCTTCCTG       c.2820
 C  D  L  Q  E  M  A  R  G  Q  R  A  M  V  T  V  L  A  F  L         p.940

          .         .  | 28      .         .         .         .    g.19784
 TGGCTGCCCAGCCTCTACCAG | AGGCCTCTGGATCAGTTTGTGCTGCAGTCGCACGCATGG    c.2880
 W  L  P  S  L  Y  Q   | R  P  L  D  Q  F  V  L  Q  S  H  A  W      p.960

          .         .         .         .         .         .       g.19844
 TTCAACGTGTCCTCCCTCCCCTATGCGGTGCCCCCGCTCAGCCTGCCCCGAGGGGAAGCT       c.2940
 F  N  V  S  S  L  P  Y  A  V  P  P  L  S  L  P  R  G  E  A         p.980

     | 29    .         .         .         .         .         .    g.20092
 CAG | GTGTGGACACAGCTGCTCCGGGCCTTGGAGGAGAGGGCCATTCCAATCTGGTGGGTG    c.3000
 Q   | V  W  T  Q  L  L  R  A  L  E  E  R  A  I  P  I  W  W  V      p.1000

          .         .         .         .         .         .       g.20152
 CTGGTGGGTGTGCTGGGTGGCCTGCTGCTGCTCACCATCCTGGTCCTGGCCATGTGGAAG       c.3060
 L  V  G  V  L  G  G  L  L  L  L  T  I  L  V  L  A  M  W  K         p.1020

  | 30       .         .         .         .         .         .    g.22142
  | GTCGGCTTCTTCAAGCGGAACCGGCCACCCCTGGAAGAAGATGATGAAGAGGGGGAGTGA    c.3120
  | V  G  F  F  K  R  N  R  P  P  L  E  E  D  D  E  E  G  E  X      p.1039

          .         .         .         .         .         .       g.22202
 tggtgcagcctacactattctagcaggagggttgggcgtgctacctgcaccgccccttct       c.*60

          .         .         .         .         .         .       g.22262
 ccaacaagttgcctccaagctttgggttggagctgttccattgggtcctcttggtgtcgt       c.*120

          .         .         .         .         .         .       g.22322
 ttccctcccaacagagctgggctaccccccctcctgctgcctaataaagagactgagccc       c.*180

                                                                    g.22324
 tg                                                                 c.*182

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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