integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX) - coding DNA reference sequence

(used for variant description)

(last modified January 21, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_000887.3 in the ITGAX gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering ITGAX transcript NM_000887.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5007
                                                      agtacct       c.-61

 .         .         .         .         .         .                g.5067
 tggtccagctcttcctgcaacggcccaggagctcagagctccacatctgaccttctagtc       c.-1

          .         .         .        | 02.         .         .    g.5728
 ATGACCAGGACCAGGGCAGCACTCCTCCTGTTCACAG | CCTTAGCAACTTCTCTAGGTTTC    c.60
 M  T  R  T  R  A  A  L  L  L  F  T  A |   L  A  T  S  L  G  F      p.20

          .         .         .         .         .         .       g.5788
 AACTTGGACACAGAGGAGCTGACAGCCTTCCGTGTGGACAGCGCTGGGTTTGGAGACAGC       c.120
 N  L  D  T  E  E  L  T  A  F  R  V  D  S  A  G  F  G  D  S         p.40

          .         .    | 03    .         .         .         .    g.6474
 GTGGTCCAGTATGCCAACTCCTG | GGTGGTGGTTGGAGCCCCCCAAAAGATAACAGCTGCC    c.180
 V  V  Q  Y  A  N  S  W  |  V  V  V  G  A  P  Q  K  I  T  A  A      p.60

          .         .         .         .         .         .       g.6534
 AACCAAACGGGTGGCCTCTACCAGTGTGGCTACAGCACTGGTGCCTGTGAGCCCATCGGC       c.240
 N  Q  T  G  G  L  Y  Q  C  G  Y  S  T  G  A  C  E  P  I  G         p.80

         | 04.         .         .         .         .         .    g.6896
 CTGCAGG | TGCCCCCGGAGGCCGTGAACATGTCCCTGGGCCTGTCCCTGGCGTCTACCACC    c.300
 L  Q  V |   P  P  E  A  V  N  M  S  L  G  L  S  L  A  S  T  T      p.100

          .         | 05         .         .         .         .    g.7107
 AGCCCTTCCCAGCTGCTG | GCCTGCGGCCCCACCGTGCACCACGAGTGCGGGAGGAACATG    c.360
 S  P  S  Q  L  L   | A  C  G  P  T  V  H  H  E  C  G  R  N  M      p.120

          .         .         .         .         .         .       g.7167
 TACCTCACCGGACTCTGCTTCCTCCTGGGCCCCACCCAGCTCACCCAGAGGCTCCCGGTG       c.420
 Y  L  T  G  L  C  F  L  L  G  P  T  Q  L  T  Q  R  L  P  V         p.140

          . | 06       .         .         .         .         .    g.9562
 TCCAGGCAGG | AGTGCCCAAGACAGGAGCAGGACATTGTGTTCCTGATCGATGGCTCAGGC    c.480
 S  R  Q  E |   C  P  R  Q  E  Q  D  I  V  F  L  I  D  G  S  G      p.160

          .         .         .         .         .         .       g.9622
 AGCATCTCCTCCCGCAACTTTGCCACGATGATGAACTTCGTGAGAGCTGTGATAAGCCAG       c.540
 S  I  S  S  R  N  F  A  T  M  M  N  F  V  R  A  V  I  S  Q         p.180

          .         .  | 07      .         .         .         .    g.9771
 TTCCAGAGACCCAGCACCCAG | TTTTCCCTGATGCAGTTCTCCAACAAATTCCAAACACAC    c.600
 F  Q  R  P  S  T  Q   | F  S  L  M  Q  F  S  N  K  F  Q  T  H      p.200

          .         .         .         .         .         .       g.9831
 TTCACTTTCGAGGAATTCAGGCGCAGCTCAAACCCCCTCAGCCTGTTGGCTTCTGTTCAC       c.660
 F  T  F  E  E  F  R  R  S  S  N  P  L  S  L  L  A  S  V  H         p.220

          .         .         .         .        | 08.         .    g.10135
 CAGCTGCAAGGGTTTACATACACGGCCACCGCCATCCAAAATGTCGT | GCACCGATTGTTC    c.720
 Q  L  Q  G  F  T  Y  T  A  T  A  I  Q  N  V  V  |  H  R  L  F      p.240

          .         .         .         .         .         .       g.10195
 CATGCCTCATATGGGGCCCGTAGGGATGCCGCCAAAATTCTCATTGTCATCACTGATGGG       c.780
 H  A  S  Y  G  A  R  R  D  A  A  K  I  L  I  V  I  T  D  G         p.260

          .         .         .         .         .         .       g.10255
 AAGAAAGAAGGCGACAGCCTGGATTATAAGGATGTCATCCCCATGGCTGATGCAGCAGGC       c.840
 K  K  E  G  D  S  L  D  Y  K  D  V  I  P  M  A  D  A  A  G         p.280

          .         .  | 09      .         .         .         .    g.10914
 ATCATCCGCTATGCAATTGGG | GTTGGATTAGCTTTTCAAAACAGAAATTCTTGGAAAGAA    c.900
 I  I  R  Y  A  I  G   | V  G  L  A  F  Q  N  R  N  S  W  K  E      p.300

          .         .         .         .         .         .       g.10974
 TTAAATGACATTGCATCGAAGCCCTCCCAGGAACACATATTTAAAGTGGAGGACTTTGAT       c.960
 L  N  D  I  A  S  K  P  S  Q  E  H  I  F  K  V  E  D  F  D         p.320

          .         .         .         .         .   | 10     .    g.11656
 GCTCTGAAAGATATTCAAAACCAACTGAAGGAGAAGATCTTTGCCATTGAGG | GTACGGAG    c.1020
 A  L  K  D  I  Q  N  Q  L  K  E  K  I  F  A  I  E  G |   T  E      p.340

          .         .         .         .         .         .       g.11716
 ACCACAAGCAGTAGCTCCTTCGAATTGGAGATGGCACAGGAGGGCTTCAGCGCTGTGTTC       c.1080
 T  T  S  S  S  S  F  E  L  E  M  A  Q  E  G  F  S  A  V  F         p.360

        | 11 .         .         .         .         .         .    g.11941
 ACACCT | GATGGCCCCGTTCTGGGGGCTGTGGGGAGCTTCACCTGGTCTGGAGGTGCCTTC    c.1140
 T  P   | D  G  P  V  L  G  A  V  G  S  F  T  W  S  G  G  A  F      p.380

          .         .         .         .         .         .       g.12001
 CTGTACCCCCCAAATATGAGCCCTACCTTCATCAACATGTCTCAGGAGAATGTGGACATG       c.1200
 L  Y  P  P  N  M  S  P  T  F  I  N  M  S  Q  E  N  V  D  M         p.400

          .       | 12 .         .         .         .         .    g.12467
 AGGGACTCTTACCTGG | GTTACTCCACCGAGCTGGCCCTCTGGAAAGGGGTGCAGAGCCTG    c.1260
 R  D  S  Y  L  G |   Y  S  T  E  L  A  L  W  K  G  V  Q  S  L      p.420

          .         .         .         .         .         .       g.12527
 GTCCTGGGGGCCCCCCGCTACCAGCACACCGGGAAGGCTGTCATCTTCACCCAGGTGTCC       c.1320
 V  L  G  A  P  R  Y  Q  H  T  G  K  A  V  I  F  T  Q  V  S         p.440

          .         .         .          | 13        .         .    g.12768
 AGGCAATGGAGGATGAAGGCCGAAGTCACGGGGACTCAG | ATCGGCTCCTACTTCGGGGCC    c.1380
 R  Q  W  R  M  K  A  E  V  T  G  T  Q   | I  G  S  Y  F  G  A      p.460

          .         .         .         .         .         .       g.12828
 TCCCTCTGCTCCGTGGACGTAGACAGCGACGGCAGCACCGACCTGGTCCTCATCGGGGCC       c.1440
 S  L  C  S  V  D  V  D  S  D  G  S  T  D  L  V  L  I  G  A         p.480

          .         .         .         .         .         .       g.12888
 CCCCATTACTACGAGCAGACCCGAGGGGGCCAGGTGTCTGTGTGTCCCTTGCCCAGGGGG       c.1500
 P  H  Y  Y  E  Q  T  R  G  G  Q  V  S  V  C  P  L  P  R  G         p.500

  | 14       .         .         .         .         .         .    g.13037
  | TGGAGAAGGTGGTGGTGTGATGCTGTTCTCTACGGGGAGCAGGGCCACCCCTGGGGTCGC    c.1560
  | W  R  R  W  W  C  D  A  V  L  Y  G  E  Q  G  H  P  W  G  R      p.520

          .         .         .         .         .         .       g.13097
 TTTGGGGCGGCTCTGACAGTGCTGGGGGATGTGAATGGGGACAAGCTGACAGACGTGGTC       c.1620
 F  G  A  A  L  T  V  L  G  D  V  N  G  D  K  L  T  D  V  V         p.540

          .         .         .         .         .         .       g.13157
 ATCGGGGCCCCAGGAGAGGAGGAGAACCGGGGTGCTGTCTACCTGTTTCACGGAGTCTTG       c.1680
 I  G  A  P  G  E  E  E  N  R  G  A  V  Y  L  F  H  G  V  L         p.560

          .         .         . | 15       .         .         .    g.20926
 GGACCCAGCATCAGCCCCTCCCACAGCCAG | CGGATCGCGGGCTCCCAGCTCTCCTCCAGG    c.1740
 G  P  S  I  S  P  S  H  S  Q   | R  I  A  G  S  Q  L  S  S  R      p.580

          .         .         .         .         .         .       g.20986
 CTGCAGTATTTTGGGCAGGCACTGAGCGGGGGTCAAGACCTCACCCAGGATGGACTGGTG       c.1800
 L  Q  Y  F  G  Q  A  L  S  G  G  Q  D  L  T  Q  D  G  L  V         p.600

          .         .         .         .  | 16      .         .    g.21165
 GACCTGGCTGTGGGGGCCCGGGGCCAGGTGCTCCTGCTCAG | GACCAGACCTGTGCTCTGG    c.1860
 D  L  A  V  G  A  R  G  Q  V  L  L  L  R  |  T  R  P  V  L  W      p.620

          .         .         .         .         .         .       g.21225
 GTGGGGGTGAGCATGCAGTTCATACCTGCCGAGATCCCCAGGTCTGCGTTTGAGTGTCGG       c.1920
 V  G  V  S  M  Q  F  I  P  A  E  I  P  R  S  A  F  E  C  R         p.640

          .         .         .         .         .         .       g.21285
 GAGCAGGTGGTCTCTGAGCAGACCCTGGTACAGTCCAACATCTGCCTTTACATTGACAAA       c.1980
 E  Q  V  V  S  E  Q  T  L  V  Q  S  N  I  C  L  Y  I  D  K         p.660

          .         .      | 17  .         .         .         .    g.21477
 CGTTCTAAGAACCTGCTTGGGAGCC | GTGACCTCCAAAGCTCTGTGACCTTGGACCTGGCC    c.2040
 R  S  K  N  L  L  G  S  R |   D  L  Q  S  S  V  T  L  D  L  A      p.680

          .         .         .         .         .         .       g.21537
 CTCGACCCTGGCCGCCTGAGTCCCCGTGCCACCTTCCAGGAAACAAAGAACCGGAGTCTG       c.2100
 L  D  P  G  R  L  S  P  R  A  T  F  Q  E  T  K  N  R  S  L         p.700

          .         .         .         .         .         .       g.21597
 AGCCGAGTCCGAGTCCTCGGGCTGAAGGCACACTGTGAAAACTTCAACCTGCTGCTCCCG       c.2160
 S  R  V  R  V  L  G  L  K  A  H  C  E  N  F  N  L  L  L  P         p.720

  | 18       .         .         .         .         .         .    g.22250
  | AGCTGCGTGGAGGACTCTGTGACCCCCATTACCTTGCGTCTGAACTTCACGCTGGTGGGC    c.2220
  | S  C  V  E  D  S  V  T  P  I  T  L  R  L  N  F  T  L  V  G      p.740

          .         .         .         .         .         .       g.22310
 AAGCCCCTCCTTGCCTTCAGAAACCTGCGGCCTATGCTGGCCGCCGATGCTCAGAGATAC       c.2280
 K  P  L  L  A  F  R  N  L  R  P  M  L  A  A  D  A  Q  R  Y         p.760

          .   | 19     .         .         .         .         .    g.22457
 TTCACGGCCTCC | CTACCCTTTGAGAAGAACTGTGGAGCCGACCATATCTGCCAGGACAAT    c.2340
 F  T  A  S   | L  P  F  E  K  N  C  G  A  D  H  I  C  Q  D  N      p.780

          .         .       | 20 .         .         .         .    g.23095
 CTCGGCATCTCCTTCAGCTTCCCAGG | CTTGAAGTCCCTGCTGGTGGGGAGTAACCTGGAG    c.2400
 L  G  I  S  F  S  F  P  G  |  L  K  S  L  L  V  G  S  N  L  E      p.800

          .         .         .         .         .         .       g.23155
 CTGAACGCAGAAGTGATGGTGTGGAATGACGGGGAAGACTCCTACGGAACCACCATCACC       c.2460
 L  N  A  E  V  M  V  W  N  D  G  E  D  S  Y  G  T  T  I  T         p.820

          .         .         .         .         | 21         .    g.26623
 TTCTCCCACCCCGCAGGACTGTCCTACCGCTACGTGGCAGAGGGCCAG | AAACAAGGGCAG    c.2520
 F  S  H  P  A  G  L  S  Y  R  Y  V  A  E  G  Q   | K  Q  G  Q      p.840

          .         .         .         .         .         .       g.26683
 CTGCGTTCCCTGCACCTGACATGTGACAGCGCCCCAGTTGGGAGCCAGGGCACCTGGAGC       c.2580
 L  R  S  L  H  L  T  C  D  S  A  P  V  G  S  Q  G  T  W  S         p.860

          .         .         .         .      | 22  .         .    g.26827
 ACCAGCTGCAGAATCAACCACCTCATCTTCCGTGGCGGCGCCCAG | ATCACCTTCTTGGCT    c.2640
 T  S  C  R  I  N  H  L  I  F  R  G  G  A  Q   | I  T  F  L  A      p.880

          .         .         .         .         .         .       g.26887
 ACCTTTGACGTCTCCCCCAAGGCTGTCCTGGGAGACCGGCTGCTTCTGACAGCCAATGTG       c.2700
 T  F  D  V  S  P  K  A  V  L  G  D  R  L  L  L  T  A  N  V         p.900

       | 23  .         .         .         .         .         .    g.27049
 AGCAG | TGAGAACAACACTCCCAGGACCAGCAAGACCACCTTCCAGCTGGAGCTCCCGGTG    c.2760
 S  S  |  E  N  N  T  P  R  T  S  K  T  T  F  Q  L  E  L  P  V      p.920

          .         .          | 24        .         .         .    g.29411
 AAGTATGCTGTCTACACTGTGGTTAGCAG | CCACGAACAATTCACCAAATACCTCAACTTC    c.2820
 K  Y  A  V  Y  T  V  V  S  S  |  H  E  Q  F  T  K  Y  L  N  F      p.940

          .         .         .         .         | 25         .    g.29581
 TCAGAGTCTGAGGAGAAGGAAAGCCATGTGGCCATGCACAGATACCAG | GTCAATAACCTG    c.2880
 S  E  S  E  E  K  E  S  H  V  A  M  H  R  Y  Q   | V  N  N  L      p.960

          .         .         .         .         .         .       g.29641
 GGACAGAGGGACCTGCCTGTCAGCATCAACTTCTGGGTGCCTGTGGAGCTGAACCAGGAG       c.2940
 G  Q  R  D  L  P  V  S  I  N  F  W  V  P  V  E  L  N  Q  E         p.980

          .         .         .       | 26 .         .         .    g.29818
 GCTGTGTGGATGGATGTGGAGGTCTCCCACCCCCAG | AACCCATCCCTTCGGTGCTCCTCA    c.3000
 A  V  W  M  D  V  E  V  S  H  P  Q   | N  P  S  L  R  C  S  S      p.1000

          .         .         .         .         .         .       g.29878
 GAGAAAATCGCACCCCCAGCATCTGACTTCCTGGCGCACATTCAGAAGAATCCCGTGCTG       c.3060
 E  K  I  A  P  P  A  S  D  F  L  A  H  I  Q  K  N  P  V  L         p.1020

  | 27       .         .         .         .         .         .    g.30138
  | GACTGCTCCATTGCTGGCTGCCTGCGGTTCCGCTGTGACGTCCCCTCCTTCAGCGTCCAG    c.3120
  | D  C  S  I  A  G  C  L  R  F  R  C  D  V  P  S  F  S  V  Q      p.1040

          .         .         .         .         .     | 28   .    g.30341
 GAGGAGCTGGATTTCACCCTGAAGGGCAACCTCAGCTTTGGCTGGGTCCGCCAG | ATATTG    c.3180
 E  E  L  D  F  T  L  K  G  N  L  S  F  G  W  V  R  Q   | I  L      p.1060

          .         .         .         .         .         .       g.30401
 CAGAAGAAGGTGTCGGTCGTGAGTGTGGCTGAAATTACGTTCGACACATCCGTGTACTCC       c.3240
 Q  K  K  V  S  V  V  S  V  A  E  I  T  F  D  T  S  V  Y  S         p.1080

          .         .         .       | 29 .         .         .    g.30733
 CAGCTTCCAGGACAGGAGGCATTTATGAGAGCTCAG | ACGACAACGGTGCTGGAGAAGTAC    c.3300
 Q  L  P  G  Q  E  A  F  M  R  A  Q   | T  T  T  V  L  E  K  Y      p.1100

          .         .         .         .         .         .       g.30793
 AAGGTCCACAACCCCACCCCCCTCATCGTAGGCAGCTCCATTGGGGGTCTGTTGCTGCTG       c.3360
 K  V  H  N  P  T  P  L  I  V  G  S  S  I  G  G  L  L  L  L         p.1120

          .         .        | 30.         .         .         .    g.31648
 GCACTCATCACAGCGGTACTGTACAAA | GTTGGCTTCTTCAAGCGTCAGTACAAGGAAATG    c.3420
 A  L  I  T  A  V  L  Y  K   | V  G  F  F  K  R  Q  Y  K  E  M      p.1140

          .         .         .         .         .         .       g.31708
 ATGGAGGAGGCAAATGGACAAATTGCCCCAGAAAACGGGACACAGACCCCCAGCCCGCCC       c.3480
 M  E  E  A  N  G  Q  I  A  P  E  N  G  T  Q  T  P  S  P  P         p.1160

          .                                                         g.31720
 AGTGAGAAATGA                                                       c.3492
 S  E  K  X                                                         p.1163

          .         .         .         .         .         .       g.31780
 tcccctctttgccttggacttcttctcccccgcgagttttccccacttacttaccctcac       c.*60

          .         .         .         .         .         .       g.31840
 ctgtcaggcctgacggggaggaaccactgcaccaccgagagaggctgggatgggcctgct       c.*120

          .         .         .         .         .         .       g.31900
 tcctgtctttgggagaaaacgtcttgcttgggaaggggcctttgtcttgtcaaggttcca       c.*180

          .         .         .         .         .         .       g.31960
 actggaaacccttaggacagggtccctgctgtgttccccaaaggacttgacttgcaattt       c.*240

          .         .         .         .         .         .       g.32020
 ctacctagaaatacatggacaatacccccaggcctcagtctcccttctcccatgaggcac       c.*300

          .         .         .         .         .         .       g.32080
 gaatgatctttctttcctttctttttttttttttttcttttcttttttttttttttgaga       c.*360

          .         .         .         .         .         .       g.32140
 cggagtctcgctctgtcacccaggctggagtgcaatggcgtgatctcggctcactgcaac       c.*420

          .         .         .         .         .         .       g.32200
 ctccgcctcccgggttcaagtaattctgctgtctcagcctcctgagtagctgggactaca       c.*480

          .         .         .         .         .         .       g.32260
 ggcacacgccacctcgcccggcccgatctttctaaaatacagttctgaatatgctgctca       c.*540

          .         .         .         .         .         .       g.32320
 tccccacctgtcttcaacagctccccattaccctcaggacaatgtctgaactctccagct       c.*600

          .         .         .         .         .         .       g.32380
 tcgcgtgagaagtccccttccatcccagagggtgggcttcagggcgcacagcatgagagg       c.*660

          .         .         .         .         .         .       g.32440
 ctctgtgcccccatcaccctcgtttccagtgaattagtgtcatgtcagcatcagctcagg       c.*720

          .         .         .         .         .         .       g.32500
 gcttcatcgtggggctctcagttccgatttcccaggctgaattgggagtgagatgcctgc       c.*780

          .         .         .         .         .         .       g.32560
 atgctgggttctgcacagctggcctcccgcgttgggcaacattgctggctggaagggagg       c.*840

          .         .         .         .         .         .       g.32620
 agcgccctctagggagggacatggccccggtgcggctgcagctcacccagccccaggggc       c.*900

          .         .         .         .         .         .       g.32680
 agaagagacccaaccacttctattttttgaggctatgaatatagtacctgaaaaaatgcc       c.*960

          .         .         .         .         .         .       g.32740
 aagacatgattatttttttaaaaagcgtactttaaatgtttgtgttaataaattaaaaca       c.*1020

          .         .         .         .         .         .       g.32800
 tgcacaaaaagatgcatctaccgctcttgggaaatatgtcaaaggtctaaaaataaaaaa       c.*1080

          .                                                         g.32810
 gccttctgtg                                                         c.*1090

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Integrin, alpha X (complement component 3 receptor 4 subunit) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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