isovaleryl-CoA dehydrogenase (IVD) - coding DNA reference sequence

(used for variant description)

(last modified November 27, 2012)


This file was created to facilitate the description of sequence variants on transcript NM_002225.3 in the IVD gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000015.9, covering IVD transcript NM_002225.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5034
                           tttccgcagttaggggctgctatttcaacgcagg       c.-301

 .         .         .         .         .         .                g.5094
 gagataaaaagaaaaaaacacttgctcttctaccccgctaaaaacactcatcctagggag       c.-241

 .         .         .         .         .         .                g.5154
 cacgccagcatttgcagcgttcggggcagggccactcggcctgcggccgttgcactggct       c.-181

 .         .         .         .         .         .                g.5214
 ggaagctggcaggcgatcacggttgattggctcgggtgcggtccaagggcagcaacgcct       c.-121

 .         .         .         .         .         .                g.5274
 tcggcgggccgcctagggtgattggctgctgcagcccaccccctagccggtttggtgggc       c.-61

 .         .         .         .         .         .                g.5334
 ggcgaagcctggattggtggagctaagagctggctcagtttcagcgctggctcttcgtgc       c.-1

          .         .         .         .         .         .       g.5394
 ATGGCAGAGATGGCGACTGCGACTCGGCTGCTGGGGTGGCGTGTGGCGAGCTGGAGGCTG       c.60
 M  A  E  M  A  T  A  T  R  L  L  G  W  R  V  A  S  W  R  L         p.20

          .         .         .         .         .         .       g.5454
 CGGCCGCCGCTTGCCGGCTTCGTTTCCCAGCGGGCCCACTCGCTTTTGCCCGTGGACGAT       c.120
 R  P  P  L  A  G  F  V  S  Q  R  A  H  S  L  L  P  V  D  D         p.40

          .         .         .    | 02    .         .         .    g.7178
 GCAATCAATGGGCTAAGCGAGGAGCAGAGGCAG | CTTCGTCAGACCATGGCTAAGTTCCTT    c.180
 A  I  N  G  L  S  E  E  Q  R  Q   | L  R  Q  T  M  A  K  F  L      p.60

          .         .         .         .         .         .       g.7238
 CAGGAGCACCTGGCCCCCAAGGCCCAGGAGATCGATCGCAGCAATGAGTTCAAGAACCTG       c.240
 Q  E  H  L  A  P  K  A  Q  E  I  D  R  S  N  E  F  K  N  L         p.80

     | 03    .         .         .         .         .      | 04  . g.10146
 CGA | GAATTTTGGAAGCAGCTGGGGAACCTGGGCGTATTGGGCATCACAGCCCCTG | TTCAG c.300
 R   | E  F  W  K  Q  L  G  N  L  G  V  L  G  I  T  A  P  V |   Q   p.100

          .         .         .         .         .         .       g.10206
 TATGGCGGCTCCGGCCTGGGCTACCTGGAGCATGTGCTGGTGATGGAGGAGATATCCCGA       c.360
 Y  G  G  S  G  L  G  Y  L  E  H  V  L  V  M  E  E  I  S  R         p.120

          .         .         .         .         .         .       g.10266
 GCTTCCGGAGCAGTGGGGCTCAGTTACGGTGCCCACTCCAACCTCTGCATCAACCAGCTT       c.420
 A  S  G  A  V  G  L  S  Y  G  A  H  S  N  L  C  I  N  Q  L         p.140

          .         .         .         .      | 05  .         .    g.10788
 GTACGCAATGGGAATGAGGCCCAGAAAGAGAAGTATCTCCCGAAG | CTGATCAGTGGTGAG    c.480
 V  R  N  G  N  E  A  Q  K  E  K  Y  L  P  K   | L  I  S  G  E      p.160

          .         .         .         .         .         .       g.10848
 TACATCGGAGCCCTGGCCATGAGTGAGCCCAATGCAGGCTCTGATGTTGTCTCTATGAAG       c.540
 Y  I  G  A  L  A  M  S  E  P  N  A  G  S  D  V  V  S  M  K         p.180

          .          | 06        .         .         .         .    g.11109
 CTCAAAGCGGAAAAGAAAG | GAAATCACTACATCCTGAATGGCAACAAGTTCTGGATCACT    c.600
 L  K  A  E  K  K  G |   N  H  Y  I  L  N  G  N  K  F  W  I  T      p.200

          .         .         .         .         .         .       g.11169
 AATGGCCCTGATGCTGACGTCCTGATTGTCTATGCCAAGACAGATCTGGCTGCTGTGCCA       c.660
 N  G  P  D  A  D  V  L  I  V  Y  A  K  T  D  L  A  A  V  P         p.220

          .         .         .       | 07 .         .         .    g.12528
 GCTTCTCGGGGCATCACAGCCTTCATTGTGGAGAAG | GGTATGCCTGGCTTTAGCACCTCT    c.720
 A  S  R  G  I  T  A  F  I  V  E  K   | G  M  P  G  F  S  T  S      p.240

          .         .         .         .         .         .       g.12588
 AAGAAGCTGGACAAGCTGGGGATGAGGGGCTCTAACACCTGTGAGCTAATCTTTGAAGAC       c.780
 K  K  L  D  K  L  G  M  R  G  S  N  T  C  E  L  I  F  E  D         p.260

          .    | 08    .         .         .         .         .    g.14449
 TGCAAGATTCCTG | CTGCCAACATCCTGGGCCATGAGAATAAGGGTGTCTACGTGCTGATG    c.840
 C  K  I  P  A |   A  N  I  L  G  H  E  N  K  G  V  Y  V  L  M      p.280

          .         .         .         .        | 09.         .    g.14927
 AGTGGGCTGGACCTGGAGCGGCTGGTGCTGGCCGGGGGGCCTCTTGG | GCTCATGCAAGCG    c.900
 S  G  L  D  L  E  R  L  V  L  A  G  G  P  L  G  |  L  M  Q  A      p.300

          .         .         .         .         .         .       g.14987
 GTCCTGGACCACACCATTCCCTACCTGCACGTGAGGGAAGCCTTTGGCCAGAAGATCGGC       c.960
 V  L  D  H  T  I  P  Y  L  H  V  R  E  A  F  G  Q  K  I  G         p.320

           | 10        .         .         .         .         .    g.15642
 CACTTCCAG | TTGATGCAGGGGAAGATGGCTGACATGTACACCCGCCTCATGGCGTGTCGG    c.1020
 H  F  Q   | L  M  Q  G  K  M  A  D  M  Y  T  R  L  M  A  C  R      p.340

          .         .         .         .         .     | 11   .    g.15809
 CAGTATGTCTACAATGTCGCCAAGGCCTGCGATGAGGGCCATTGCACTGCTAAG | GACTGT    c.1080
 Q  Y  V  Y  N  V  A  K  A  C  D  E  G  H  C  T  A  K   | D  C      p.360

          .         .         .         .         .         .       g.15869
 GCAGGTGTGATTCTTTACTCAGCTGAGTGTGCCACACAGGTAGCCCTGGACGGCATTCAG       c.1140
 A  G  V  I  L  Y  S  A  E  C  A  T  Q  V  A  L  D  G  I  Q         p.380

         | 12.         .         .         .         .         .    g.17696
 TGTTTTG | GTGGCAATGGCTACATCAATGACTTTCCCATGGGCCGCTTTCTTCGAGATGCC    c.1200
 C  F  G |   G  N  G  Y  I  N  D  F  P  M  G  R  F  L  R  D  A      p.400

          .         .         .         .         .         .       g.17756
 AAGCTGTATGAGATAGGGGCTGGGACCAGCGAGGTGAGGCGGCTGGTCATCGGCAGAGCC       c.1260
 K  L  Y  E  I  G  A  G  T  S  E  V  R  R  L  V  I  G  R  A         p.420

          .         .                                               g.17777
 TTCAATGCAGACTTTCACTAG                                              c.1281
 F  N  A  D  F  H  X                                                p.426

          .         .         .         .         .         .       g.17837
 tcctgagacccttcgcccccttttcctgcacctagtggcctttcttgggaagtagagatg       c.*60

          .         .         .         .         .         .       g.17897
 tggcggctttcccaccctgcccacagcaggccctcctgcccagctgctcttgtcagccct       c.*120

          .         .         .         .         .         .       g.17957
 ctggcctctggatgaggttgagttctccacaacagctcccaagcatcatgggcctcgcag       c.*180

          .         .         .         .         .         .       g.18017
 ccgggcctgtgccacggctagtgttgtgtgatttaaaatggactcagcaggaagcatatt       c.*240

          .         .         .         .         .         .       g.18077
 gtctggggattgttgggacaggttttggtgactctgtgcccttgctctctaacttctgag       c.*300

          .         .         .         .         .         .       g.18137
 cccacctcccagggtaggcacctgggggcatgcaggtgcccacctcccagggtaggcacc       c.*360

          .         .         .         .         .         .       g.18197
 tgggggcatgcaggtacccacctctttctcttgggtgaggctctggcaaggagatctctc       c.*420

          .         .         .         .         .         .       g.18257
 tgctcaagcacagcagaatcatggcccctctccatgaattggaacttggtacaggttaag       c.*480

          .         .         .         .         .         .       g.18317
 tatccctaatcctgaaatctgaaacacttgtggttccaagcattttggataaggcaaatt       c.*540

          .         .         .         .         .         .       g.18377
 caactttcagtctcttttctgggggaaaaaaataataaacctagcctagccaggcgtggt       c.*600

          .         .         .         .         .         .       g.18437
 ggctcatgcttgtaatcccagcacttcaggaggctgagatgggtggatcacctgaggtca       c.*660

          .         .         .         .         .         .       g.18497
 ggagttcaagaccagcctggccaacatgtggaaacctcgcctcaactaaaaatagaaaaa       c.*720

          .         .         .         .         .         .       g.18557
 aattagttgggcatggtggtgggcacctgtaatcccagctacttcaggaggctgaggcag       c.*780

          .         .         .         .         .         .       g.18617
 gagaattacttgaacccaggaggcggacgttgcagtgagccgagcttgtgccattgcact       c.*840

          .         .         .         .         .         .       g.18677
 ccagcctgggcgacaagagcaaaactcttcaaaaaacaaaacaaaacaaaaaaaccctgg       c.*900

          .         .         .         .         .         .       g.18737
 cccttgtttcttccagtttctagaggtatcagctcctagcagcttatgaacacatatgct       c.*960

          .         .         .         .         .         .       g.18797
 tgcttggccaggcaaggtggtgtgtgcctgtaatcccagcactttgggaggccaaggcag       c.*1020

          .         .         .         .         .         .       g.18857
 gtggatcacttgcagtcaggagttcaagaccagcctgtccaacgtggtgaaaccccatct       c.*1080

          .         .         .         .         .         .       g.18917
 ctactaaaaatacaaaaattagccaggggtggtggtgcacgtctgtaatcccagctactc       c.*1140

          .         .         .         .         .         .       g.18977
 aggaggctgaggcaggagaatcacttgaacccgggaggtggaggttgcaatgagccaata       c.*1200

          .         .         .         .         .         .       g.19037
 tgacaccgctgcagtccagcctgggccatagagtgagactctgtctcaaaaaaggaaaga       c.*1260

          .         .         .         .         .         .       g.19097
 aaaataggctgggcacagtgactcatgcctgtaatcccaacactttgggaggccgaggca       c.*1320

          .         .         .         .         .         .       g.19157
 ggtggatcacgaggtcaggagttcaagaccagcctggccaagatggtaaaacctcgtctc       c.*1380

          .         .         .         .         .         .       g.19217
 tactaaaaatacaaaaattagccaggtgtggtggcaggctcctgtaatcccagctactca       c.*1440

          .         .         .         .         .         .       g.19277
 ggaggctgaggcagagaattgcttgaacccgggaggcagagtttgcagtgagccaagatc       c.*1500

          .         .         .         .         .         .       g.19337
 acaccactgcactccagcttggacgacagagcgagactctgtctcaaaaaataataggcc       c.*1560

          .         .         .         .         .         .       g.19397
 aggcatggtggctcaacgtctgtaatcccagcactttgggaggccgaggcgggcagatca       c.*1620

          .         .         .         .         .         .       g.19457
 caaggtcaggagttcgagaccagcctgacgaccaacatggtgaaacctcgtctctactaa       c.*1680

          .         .         .         .         .         .       g.19517
 aaatacaaaaattagccaggcctggtggcacgcgcctgtaatcccagttacacagaagac       c.*1740

          .         .         .         .         .         .       g.19577
 tgaggcaggagaatcgcttgaacgcaggaggcagaggttgcaggagctgagatcgcgcca       c.*1800

          .         .         .         .         .         .       g.19637
 ttgcactccagcctgggcaacagagtgagactctgtctcaaaaaataataataaaataaa       c.*1860

          .         .         .         .         .         .       g.19697
 tgaacacacatgctgctgagtccgcagggggggcagagcagaggacagcgtgcttttgtg       c.*1920

          .         .         .         .         .         .       g.19757
 tactgttggaagactggctcctcctgtacagcacctctgagcccttgtgcaccgccctgc       c.*1980

          .         .         .         .         .         .       g.19817
 cacgggcaccatccagtcctggccgtgtgaccacccacagctgactgggcagcaggcaca       c.*2040

          .         .         .         .         .         .       g.19877
 ggccctacccgagcaggccggagttggctcgcatgactccagctgaggctgcctgtgtac       c.*2100

          .         .         .         .         .         .       g.19937
 atttctccagataccctatggctaattttgttataactgcacagtggctgctgccatttt       c.*2160

          .         .         .         .         .         .       g.19997
 gtattaaatatattgtgaaacaaacctatctggggagaagcaatctacttgccgctgctt       c.*2220

          .         .         .         .         .         .       g.20057
 cctgtctggatccagcttgtgtccttggagagtggctggcccaggtcctattcctgtcct       c.*2280

          .         .         .         .         .         .       g.20117
 ccagcccgttctttcatgagggacaggaaggtaaaatcagcccttaggagagaggtctca       c.*2340

          .         .         .         .         .         .       g.20177
 gcctccctttcccagatctcccagtgagttttaaaggaagcagggagcccagagtgctaa       c.*2400

          .         .         .         .         .         .       g.20237
 gttcttacagccagaaggaagcttatagatttctgaaaaccgcccctttgtttttaaaaa       c.*2460

          .         .         .         .         .         .       g.20297
 gatcaacacaatttgactttctcaaggtcaaaacgaactagaatccagatctgctcatgg       c.*2520

          .         .         .         .         .         .       g.20357
 caaaaatgggggtgttctgagaattccagctttgggccgcactgtacagcagtctggata       c.*2580

          .         .         .         .         .         .       g.20417
 gagtgtgatctgagaagggaatgggtctgggttgttccaccccttccgagttccaaaaag       c.*2640

          .         .         .         .         .         .       g.20477
 agggaactggttttcttggttctcagcccagcagcacctatcctggctcttggtcctggc       c.*2700

          .         .         .         .         .         .       g.20537
 ctgcagccaagtgctgttcctagcctgaggcttgagacaggtggggttggctcctcacca       c.*2760

          .         .         .         .         .         .       g.20597
 accccagttccgtcccatcctgagggcaagatcctgggctcataggcagtccctttcact       c.*2820

          .         .         .         .         .         .       g.20657
 tccttgtcttgctccctgctatgttggagatgaatgtgactaaaagggccatcttgctgg       c.*2880

          .         .         .         .         .         .       g.20717
 cttaatgtgtggctggagagaccagcctggagacaatgtggcaaaatggggcgcttcatc       c.*2940

          .         .         .         .         .         .       g.20777
 cagtctgtctaagccctgtcgacttggggaggtgatttctttcctggttctatatgtgaa       c.*3000

          .         .         .         .         .                 g.20827
 gcaaaataaatgttttaaaattaaaagcaaaaaaaacaaaatgaaccatg                 c.*3050

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Isovaleryl-CoA dehydrogenase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build beta-10b
©2004-2012 Leiden University Medical Center