iodotyrosine deiodinase (IYD) - coding DNA reference sequence

(used for variant description)

(last modified October 15, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_001164694.1 in the IYD gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering IYD transcript NM_001164694.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5020
                                         gaagagttctgcactttgtt       c.-121

 .         .         .         .         .         .                g.5080
 ccttccctggcacacctgtgtctgcattccttctatctcccggcattctccactcctgtc       c.-61

 .         .         .         .         .         .                g.5140
 tctgtgtgtttaaaaaccggtgtgggaagtgtgcacgcctgtgacgtcagactccagacc       c.-1

          .         .         .         .         .         .       g.5200
 ATGTATTTCCTGACTCCCATCTTGGTAGCCATTCTCTGCATTTTGGTTGTGTGGATCTTT       c.60
 M  Y  F  L  T  P  I  L  V  A  I  L  C  I  L  V  V  W  I  F         p.20

          .         .         .         .         .         .       g.5260
 AAAAATGCCGACAGAAGCATGGAGAAAAAGAAGGGGGAGCCTAGAACCAGGGCCGAAGCT       c.120
 K  N  A  D  R  S  M  E  K  K  K  G  E  P  R  T  R  A  E  A         p.40

          .         .         .         .         .         | 02    g.25462
 CGCCCCTGGGTGGATGAAGACTTAAAAGACAGCAGTGACCTGCACCAAGCAGAAGAAG | AT    c.180
 R  P  W  V  D  E  D  L  K  D  S  S  D  L  H  Q  A  E  E  D |       p.60

          .         .         .         .         .         .       g.25522
 GCTGATGAATGGCAAGAATCAGAAGAAAATGTTGAACACATCCCCTTCTCTCATAACCAC       c.240
 A  D  E  W  Q  E  S  E  E  N  V  E  H  I  P  F  S  H  N  H         p.80

          .         .         .         .         .         .       g.25582
 TATCCTGAGAAGGAAATGGTTAAGAGGTCTCAGGAATTTTATGAACTTCTCAATAAGAGA       c.300
 Y  P  E  K  E  M  V  K  R  S  Q  E  F  Y  E  L  L  N  K  R         p.100

          .         .         .         .         .         .       g.25642
 CGGTCAGTCAGGTTCATAAGTAATGAGCAAGTCCCAATGGAAGTCATTGATAATGTCATC       c.360
 R  S  V  R  F  I  S  N  E  Q  V  P  M  E  V  I  D  N  V  I         p.120

          . | 03       .         .         .         .         .    g.28503
 AGAACGGCAG | GAACAGCCCCGAGTGGGGCTCACACAGAGCCCTGGACCTTCGTGGTTGTG    c.420
 R  T  A  G |   T  A  P  S  G  A  H  T  E  P  W  T  F  V  V  V      p.140

          .         .         .         .         .         .       g.28563
 AAGGACCCAGACGTGAAGCACAAGATTCGAAAGATCATTGAGGAGGAAGAGGAGATCAAC       c.480
 K  D  P  D  V  K  H  K  I  R  K  I  I  E  E  E  E  E  I  N         p.160

          .         .         .         .         . | 04       .    g.30217
 TACATGAAAAGGATGGGACATCGCTGGGTCACAGACCTCAAGAAACTGAG | AACCAACTGG    c.540
 Y  M  K  R  M  G  H  R  W  V  T  D  L  K  K  L  R  |  T  N  W      p.180

          .         .         .         .         .         .       g.30277
 ATTAAAGAGTACTTGGATACTGCCCCTATTTTGATTCTCATTTTCAAACAAGTACATGGT       c.600
 I  K  E  Y  L  D  T  A  P  I  L  I  L  I  F  K  Q  V  H  G         p.200

          .         .         .         .         .         .       g.30337
 TTCGCCGCAAATGGCAAGAAAAAAGTCCACTACTACAATGAGATCAGTGTTTCCATCGCT       c.660
 F  A  A  N  G  K  K  K  V  H  Y  Y  N  E  I  S  V  S  I  A         p.220

          .         .        | 05.         .         .         .    g.31596
 TGTGGCATCCTGCTAGCTGCCCTGCAG | GTAAATAATGGAATCACCATGCGGCATCAGACT    c.720
 C  G  I  L  L  A  A  L  Q   | V  N  N  G  I  T  M  R  H  Q  T      p.240

          .         .         .         .         .         .       g.31656
 GCGAGGCACCGCCACCTGATTGAGGGTCCTGGAAGAAGCAGCGAAGCCTGCAGCAAGCTC       c.780
 A  R  H  R  H  L  I  E  G  P  G  R  S  S  E  A  C  S  K  L         p.260

          .          | 06        .         .         .         .    g.34204
 AGCTCACAAGGCTGCCCAG | AATGCAGGTCTGGTGACTGTCACTACCACTCCTCTCAACTG    c.840
 S  S  Q  G  C  P  E |   C  R  S  G  D  C  H  Y  H  S  S  Q  L      p.280

          .         .         .         .                           g.34246
 TGGCCCTCGACTGAGGGTGCTCCTGGGCCGCCCCGCACATGA                         c.882
 W  P  S  T  E  G  A  P  G  P  P  R  T  X                           p.293

          .         .         .         .         .         .       g.34306
 aaagctgctgatgctgctccccgtggggtaccccagcaaggaggccacggtgcctgacct       c.*60

          .         .         .         .         .         .       g.34366
 caagcgcaaacctctggaccagatcatggtgacagtgtaggcagggccccccaagggagt       c.*120

          .         .         .         .         .         .       g.34426
 ggcagggagatggcgcccctgcttttccctgagcctctcgcctgctcctcttgggtctct       c.*180

          .         .         .         .         .         .       g.34486
 tggctgctctttctccaggtgtcaggtcccctcattgctcttctcaggtggccacactat       c.*240

          .         .         .         .         .         .       g.34546
 gtcaagaagcctctccacactctgtggcacttccagtcccataaatcctgtttcttatcc       c.*300

          .         .         .         .         .         .       g.34606
 actttggaaatgcatgaacactttacaaagaacatgcccgggtttttacattttaaaagt       c.*360

          .         .         .         .         .         .       g.34666
 tattctagacaatcactattggcttttttcttttatttttaaaaaactcacatagaggag       c.*420

          .         .         .         .         .         .       g.34726
 acaatcagaaatttaccatagtcccaagaattcagctacatgatgactcgaatttaaatt       c.*480

          .         .         .         .         .         .       g.34786
 tagattaatcaaatggtctcctgttctctgatttctggtggcttttagacactaattttt       c.*540

          .         .         .         .         .         .       g.34846
 gagaactacttttttttttttaccaaacttcagggacactctgctagttttgaataagta       c.*600

          .         .         .         .         .         .       g.34906
 accatcaaagttactaaaacatggccaggcgcagtggctcatgcctgtaatcccagcact       c.*660

          .         .         .         .         .         .       g.34966
 ttgggaggccgaggtgggcagattgcctgagctcaagagttcgagaccagcctggccaac       c.*720

          .         .         .         .         .         .       g.35026
 atggtgaaaccccatctctactaaaaatacaaaaaattagctgggcatgcacttgtaatt       c.*780

          .         .         .         .         .         .       g.35086
 ccagctactcaggaggctgaggcaagagaactgcttgaatccgggaggtagagattgcag       c.*840

          .         .         .         .         .         .       g.35146
 tgagtcaagatgctgagatgccaccactgcactccagcctgggcaacagagcgagaacct       c.*900

          .         .         .         .         .         .       g.35206
 gtctcaaaaaaaacaaaaacaaagttactaaaatgtcaccttcacagaacaggacagggt       c.*960

          .         .         .         .         .         .       g.35266
 acccttgggtcgcacgggcctggctggcatgtaaacggtcagttgcactgcctagtggtt       c.*1020

          .         .         .         .         .         .       g.35326
 tggtagatctgacttgtaagcagttcatagaagctgctcaatactcaagaatcttgcaag       c.*1080

          .         .         .         .         .         .       g.35386
 acagttattaaacattcatagcttgaaattgcccatggtgggagagtttacatcacaacc       c.*1140

          .         .         .         .         .         .       g.35446
 actacaaatcagcacttgctttcttcttcttaaagagagctgcttaccatacatagcacc       c.*1200

          .         .         .         .         .         .       g.35506
 cacagtgtctcccttctcttctaccccaacccctgaaacacactgacccctattctccag       c.*1260

          .         .         .         .         .         .       g.35566
 atgacagcacagctgtttgggactgatagggtcacagttgccaggttgggaatgctagat       c.*1320

          .         .         .         .         .         .       g.35626
 gtagtcttcacccatcaccttctgtcgtcctcccaggggtgtcatatttacagaggcaaa       c.*1380

          .         .         .         .         .         .       g.35686
 ctcttacagcttggatgatttctcatcaagcaactctactcacctctttttcccctttcc       c.*1440

          .         .         .         .         .         .       g.35746
 ctgtgcgtttcttcttcttgtcctcattttccttgagaaaactctctctataaaaaattt       c.*1500

          .         .         .         .         .         .       g.35806
 ccatagagtatgtggctgataaacaacagaaatttgtttctcacagttctggaggctgga       c.*1560

          .         .         .         .         .         .       g.35866
 agtccaaggtcggggtgccctcatggtcaggtgctggtgaggaccctgatctgggttgca       c.*1620

          .         .         .         .         .         .       g.35926
 gactgctgacttcttattgtgtcctcgtggtagaaagagggttagagcctctggcatgcc       c.*1680

          .         .         .         .         .         .       g.35986
 ttttataagggtactaatcccatcatgaggccccgtccttatgacctcatcacctcccaa       c.*1740

          .         .         .         .         .         .       g.36046
 aggaccccctcctaataccatcacattgggggttagggtttcaacatatgaattgcgggg       c.*1800

          .         .         .         .         .         .       g.36106
 gacacaaacattccgtccatggcacctacttcatagggtttggcatgctgctcggtacat       c.*1860

          .         .         .         .         .         .       g.36166
 ggttaacattcataaatggtgggggcccttactgtggtagaaaccattgtcactgcaagg       c.*1920

          .         .         .         .         .         .       g.36226
 cagccctgcttgggattcaggtgaacaaatgtaacgtgggtgggtgagggactccctcct       c.*1980

          .         .         .         .         .         .       g.36286
 cttcagagaagccctcctgtggctcaggggcagctgcagggccagatggagttggcctgc       c.*2040

          .         .         .         .         .         .       g.36346
 agggagtcagccttaccccatcagagaccaacttgaaagatttttttctctgtgtagttc       c.*2100

          .         .         .         .         .         .       g.36406
 gtgttatcaatctgatctgcagccaggttatttacttctgaagcattggagttatcgatt       c.*2160

          .         .         .         .         .         .       g.36466
 gccattgccccatggttctcactctttgcaggcactcttcaaatttttattttaaaaatt       c.*2220

          .         .         .         .         .         .       g.36526
 ataatgcaaacatctggccatcaccttaaccaagtgacaaagtcctagcacaccattaat       c.*2280

          .         .         .         .         .         .       g.36586
 ggtaggataactgacattaagtgttcctgctgggatgaattatgaagtattccttccaaa       c.*2340

          .         .         .         .         .         .       g.36646
 gatgtcaatggaaactaatcgagtcttacacctaattttcagtttacagtaaatacagag       c.*2400

          .         .         .         .         .         .       g.36706
 gataaagaagttaatggcatggtggaataaccaaaatgtgtatcattctacaaaaaaata       c.*2460

          .         .         .         .         .         .       g.36766
 ggcctggactatttaaggagtgagtgtcactgtgggaagaataagagggggactgtcttg       c.*2520

          .         .         .         .         .         .       g.36826
 tccttgctactcaaagagtggtcctgggcctgtatcatcattgggaccacctgggcgctt       c.*2580

          .         .         .         .         .         .       g.36886
 gttagaatcaaagactctcaggcctcacctagacatccagaatcaaaatctgcattttaa       c.*2640

          .         .         .         .         .         .       g.36946
 caagatgcccaggtgatctgcatgcctgttaaagtctgagctctgttgcagataaccaga       c.*2700

          .         .         .         .         .         .       g.37006
 gacccaacaaccaaaggcaaagcgtaagccttgattggattttggtttaggaaaaatctc       c.*2760

          .         .         .         .         .         .       g.37066
 ataggtataaaagacaactgggaatgttgaatgtggatctggtggtaggtgatattgtta       c.*2820

          .         .         .         .         .         .       g.37126
 gtgatgtgagtgatgcctgctgaagtactgagagatgaagcatcatattgacaacttact       c.*2880

          .         .         .         .         .         .       g.37186
 ccaggaaaaaaggtgtgtgtataggtgtgtgtttggagagtgtgagcgagaactaacatg       c.*2940

          .         .         .         .         .         .       g.37246
 gtaaaatgttaggtggagcatatacagttctcattatactcttattttaaatttatattt       c.*3000

          .         .         .         .         .         .       g.37306
 gaacacagtcaaatctgaatggaaatacatttaaataagcatttctttcagtcatataag       c.*3060

          .         .         .         .         .         .       g.37366
 taatttgcctaaaaatgccctctaagtccatcattaggttaagcgatttactgaaggtgc       c.*3120

          .         .         .         .         .         .       g.37426
 agatatcatgcttatttcattgggttgttttggaatgtcccccacttggagagtttgagg       c.*3180

          .         .         .         .         .         .       g.37486
 aatggaaatgagaatcggaggagaaataaggccagaggctcacattgcttgcagggaacc       c.*3240

          .         .         .         .         .         .       g.37546
 gactgagtaatgaagaagaggaaggaagcccttggaaggaacgtaaaatccatttcagcc       c.*3300

          .         .         .         .         .         .       g.37606
 tgccgccccttggaatggagggtcttctagggaccagaaacaccagacacttcttctgcc       c.*3360

          .         .         .         .         .         .       g.37666
 ccaagcacaccccacactaatttctgctgcagcatcacgatcagggcaaatcagcacagc       c.*3420

          .         .         .         .         .         .       g.37726
 cccccagccatcagtggtgtctagaaaagtaaggataattttcttccttctcactgcagc       c.*3480

          .         .         .         .         .         .       g.37786
 cccaagctcttattaaccttcttttatgtgttcattaaatgcagtcatgtgacaactgtg       c.*3540

          .         .         .         .         .         .       g.37846
 ttcaaagttagaaatagtggtcggggaggcttatagatcctcttgctgttctgaggcctt       c.*3600

          .         .         .         .         .         .       g.37906
 aaaaccaaaaaaataatggaatgattgcatcactgcgaggaagtatacttaattaagaaa       c.*3660

          .         .         .         .         .         .       g.37966
 gttgaaaatggtttgtgtcttactaataggactcacctgaagactctactttgccaagag       c.*3720

          .         .         .         .         .         .       g.38026
 ggaatttttaactcaaagttgtgtcagccagcacggggtagagccatggtcctcatactt       c.*3780

          .         .         .         .         .         .       g.38086
 gctggcatccctcatctggtggtctgttaaagcacagattgctgggccgcaccctcaggg       c.*3840

          .         .         .         .         .         .       g.38146
 tgtgtgattgtgtgattcagtattgctgggtggtgcccaaatgctccagttctaatgtat       c.*3900

          .         .         .         .         .         .       g.38206
 tcccaggtgttgctgatgctggtgattgggtaccacattttgagaaccatggggcattgg       c.*3960

          .         .         .         .         .         .       g.38266
 caatcaacaaatgcaatgcttgtgacttgacgtgataaaagttcatttattgggcaggca       c.*4020

          .         .         .         .         .         .       g.38326
 aagtcctctgcaggcctggaaaccctccgagacaattacttgcatggggtaacccagtaa       c.*4080

          .         .         .         .         .         .       g.38386
 tactgtgggatgcaacttctagggcatggctgcctccttcctagaggcagcagggggaga       c.*4140

          .         .         .         .         .         .       g.38446
 aaacactggaagaggtcaccccaacaattccatcgtaccttggcctaggagtgacctcct       c.*4200

          .         .         .         .         .         .       g.38506
 cagtctcacaaccctttggctagaactagtcatgtgacctcacaggaggtggagcagtgt       c.*4260

          .         .         .         .         .         .       g.38566
 cgtcaatgttatcatccccctgcacctgcaaggaaggaggcccagatgtgtgtaggtgct       c.*4320

          .         .         .         .         .         .       g.38626
 ggatgtctcttccccaaaacatataactctggatttggaaaacaaaactggatataacag       c.*4380

          .         .         .         .         .         .       g.38686
 aaaagaaaaggaggggagaaggaaagttgaagaaattggtgaaatcagaataggacagtg       c.*4440

          .         .         .         .         .         .       g.38746
 aaaggcataaagattttcttctgaaacgctaagatcggttgatatttgtctaatacagct       c.*4500

          .         .         .         .         .         .       g.38806
 ttaaatagagtatcactttgggccaaagaaaattgatataaacatacataaagtggaact       c.*4560

          .         .         .         .         .         .       g.38866
 aagattgacttcttcctagacatctctgcctctgtccacaaaatggaaacttccatcaag       c.*4620

          .         .         .         .         .         .       g.38926
 gagtactggaggacagttcagtatttcttcttatttgctcctccctatgaaaggaagagt       c.*4680

          .         .         .         .         .         .       g.38986
 gacttctctgctgcatgatattgggggtaaatagttattgcacatttgctcaaaccccag       c.*4740

          .         .         .         .         .         .       g.39046
 caaagtgcaccccattttaagccaaatttacaaacttacaaagatgatccaccaatagtt       c.*4800

          .         .         .         .         .         .       g.39106
 ttctctatttactttattcttgctctgtcacccaggctagaatgcagtggtgtgattata       c.*4860

          .         .         .         .         .         .       g.39166
 gctcactgcagcctccaacttctggactcaagtgatcctcccaccttagcttcccaggta       c.*4920

          .         .         .         .         .         .       g.39226
 gctgggatacaggtgcacgccaccacacccaggctagtttttctaaatattggagttccc       c.*4980

          .         .         .         .         .         .       g.39286
 aaagagtattcaaactgatgtgatattttaaaagacattttgtaagcatcttttaggaat       c.*5040

          .         .         .         .         .         .       g.39346
 atcagtaagtggaagaaaaacacatagttatcagtggatattatgccagagaggcatgag       c.*5100

          .         .         .         .         .         .       g.39406
 aaatataattttattttgctaggtatcagcagagtgccctcttataatttgtgtgaaatg       c.*5160

          .         .         .         .         .         .       g.39466
 gaaacaaaggtaacatcgtgttttcaattcacacatatatacaagtaatgagaggtccag       c.*5220

          .         .         .         .         .         .       g.39526
 aagaaatgtggcttcagctctgctgctactgtgcctcccttctcctgccccactcagccc       c.*5280

          .         .         .         .         .         .       g.39586
 acaaaataggctggacactcaaaaaacgttgcgtttatctaccttttagagagggtgaat       c.*5340

          .         .         .         .         .         .       g.39646
 agcagagaactggaggtgggaatggtaaggaactcccagcagggtagtggagggaatggg       c.*5400

          .         .         .         .         .         .       g.39706
 ctgacgcatctaaggctgatgccaggtctgctccctatctgggtggcctcagcaaatgac       c.*5460

          .         .         .         .         .         .       g.39766
 gtccagcacatccaggggcaggctcaagggagaacagcccccaaagctaagatcctgcca       c.*5520

          .         .         .         .         .         .       g.39826
 agctaaatacagtagttctaatgaaatgtgagaggctataatcccatttgggaaattcct       c.*5580

          .         .         .         .         .         .       g.39886
 aaaaagtcatgaggcaggggattggtttatgttattatcatgacctgagagtcatggctc       c.*5640

          .         .         .         .         .         .       g.39946
 agagccaaatgttcaggattgaattcaacagcatttaaatgtctttagagcaggatggaa       c.*5700

          .         .         .         .         .         .       g.40006
 atatgttagcaatgcctgcagagtgccaagtaaacgcaaaagccaatgagatcataaagg       c.*5760

          .         .         .         .         .         .       g.40066
 aagttgttagctaacctaggtggagtcgccaacttccttctactctaataattaaaaata       c.*5820

          .         .         .         .         .         .       g.40126
 aaaataatacttgggaggtaactggaataaaggttctaaaatcaaaaccctctgaagggt       c.*5880

          .         .         .         .         .         .       g.40186
 gaaaactgggagcctcctgttcccatagtaaccacagcactcagggcactgtctcccagc       c.*5940

          .         .         .         .         .         .       g.40246
 gctggagtactgtcttatgaccagagatcctaagcaacctctgctcatctgagttgtcca       c.*6000

          .         .         .         .         .         .       g.40306
 ccatattgtgggcatgagtccttgacaatagtaaatagcacctctgttcccttattgggt       c.*6060

          .         .         .         .         .         .       g.40366
 aaatgattttccaactctgggaatgtgtagaattcattatggaaataatgcaataattca       c.*6120

          .         .         .         .         .         .       g.40426
 aatccataatattgatactttcatgttaagtttaggactaatcttgtgtatgctccttaa       c.*6180

          .         .         .         .         .         .       g.40486
 gtgatttgaatctttaaaaagcttatgattccaatttgaaatgtgaaattgattttacgt       c.*6240

          .         .         .         .         .         .       g.40546
 ttgtgatttgaagttgaaaggtataagaatatttaacttagctcatgaaaagtattagac       c.*6300

          .         .         .         .         .         .       g.40606
 tagatttactataagtttaatgtattagatttacaagagatgcttaaatatatgagaatg       c.*6360

          .         .         .         .         .         .       g.40666
 ttttgtcttaattggttataatcttgtcatatcaatgatttgaagtgctaaaatagaaaa       c.*6420

          .         .         .         .         .         .       g.40726
 ttaaatatgataaattacacaagaagtttagaatgtttaaaagattttaataaacaaagc       c.*6480

          .                                                         g.40738
 ctataactaaga                                                       c.*6492

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Iodotyrosine deiodinase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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