Janus kinase 1 (JAK1) - coding DNA reference sequence

(used for variant description)

(last modified August 5, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_002227.2 in the JAK1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_023402.2, covering JAK1 transcript NM_002227.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5009
                                                    tgcagacag       c.-241

 .         .         .         .         .         .                g.5069
 tgcgggcctgcgcccagtcccggctgtcctcgccgcgacccctcctcagccctgggcgcg       c.-181

 .         .         .         .         .         .                g.5129
 cgcacgctggggccccgcggggctggccgcctagcgagcctgccggtcgaccccagccag       c.-121

 .         .         .         .         .   | 02     .             g.85180
 cgcagcgacggggcgctgcctggcccaggcgcacacggaagtg | cgcttctctgaagtagc    c.-61

 .         .         .         .         .         .                g.85240
 tttggaaagtagagaagaaaatccagtttgcttcttggagaacactggacagctgaataa       c.-1

        | 03 .         .         .         .         .         .    g.88083
 ATGCAG | TATCTAAATATAAAAGAGGACTGCAATGCCATGGCTTTCTGTGCTAAAATGAGG    c.60
 M  Q   | Y  L  N  I  K  E  D  C  N  A  M  A  F  C  A  K  M  R      p.20

          .         .         .         .         .         .       g.88143
 AGCTCCAAGAAGACTGAGGTGAACCTGGAGGCCCCTGAGCCAGGGGTGGAAGTGATCTTC       c.120
 S  S  K  K  T  E  V  N  L  E  A  P  E  P  G  V  E  V  I  F         p.40

          .         .         .         .         .         .       g.88203
 TATCTGTCGGACAGGGAGCCCCTCCGGCTGGGCAGTGGAGAGTACACAGCAGAGGAACTG       c.180
 Y  L  S  D  R  E  P  L  R  L  G  S  G  E  Y  T  A  E  E  L         p.60

          .         .      | 04  .         .         .         .    g.92391
 TGCATCAGGGCTGCACAGGCATGCC | GTATCTCTCCTCTTTGTCACAACCTCTTTGCCCTG    c.240
 C  I  R  A  A  Q  A  C  R |   I  S  P  L  C  H  N  L  F  A  L      p.80

          .         .         .         .         .         .       g.92451
 TATGACGAGAACACCAAGCTCTGGTATGCTCCAAATCGCACCATCACCGTTGATGACAAG       c.300
 Y  D  E  N  T  K  L  W  Y  A  P  N  R  T  I  T  V  D  D  K         p.100

          .         .          | 05        .         .         .    g.98012
 ATGTCCCTCCGGCTCCACTACCGGATGAG | GTTCTATTTCACCAATTGGCATGGAACCAAC    c.360
 M  S  L  R  L  H  Y  R  M  R  |  F  Y  F  T  N  W  H  G  T  N      p.120

          .         .         .         .         .         .       g.98072
 GACAATGAGCAGTCAGTGTGGCGTCATTCTCCAAAGAAGCAGAAAAATGGCTACGAGAAA       c.420
 D  N  E  Q  S  V  W  R  H  S  P  K  K  Q  K  N  G  Y  E  K         p.140

          .         .         .         .         .         .       g.98132
 AAAAAGATTCCAGATGCAACCCCTCTCCTTGATGCCAGCTCACTGGAGTATCTGTTTGCT       c.480
 K  K  I  P  D  A  T  P  L  L  D  A  S  S  L  E  Y  L  F  A         p.160

     | 06    .         .         .         .         .         .    g.102087
 CAG | GGACAGTATGATTTGGTGAAATGCCTGGCTCCTATTCGAGACCCCAAGACCGAGCAG    c.540
 Q   | G  Q  Y  D  L  V  K  C  L  A  P  I  R  D  P  K  T  E  Q      p.180

          .         .         .         .         .         .       g.102147
 GATGGACATGATATTGAGAACGAGTGTCTAGGGATGGCTGTCCTGGCCATCTCACACTAT       c.600
 D  G  H  D  I  E  N  E  C  L  G  M  A  V  L  A  I  S  H  Y         p.200

          .         .         .         .        | 07.         .    g.104309
 GCCATGATGAAGAAGATGCAGTTGCCAGAACTGCCCAAGGACATCAG | CTACAAGCGATAT    c.660
 A  M  M  K  K  M  Q  L  P  E  L  P  K  D  I  S  |  Y  K  R  Y      p.220

          .         .         .         .         .         .       g.104369
 ATTCCAGAAACATTGAATAAGTCCATCAGACAGAGGAACCTTCTCACCAGGATGCGGATA       c.720
 I  P  E  T  L  N  K  S  I  R  Q  R  N  L  L  T  R  M  R  I         p.240

          .         .         .         .         .         .       g.104429
 AATAATGTTTTCAAGGATTTCCTAAAGGAATTTAACAACAAGACCATTTGTGACAGCAGC       c.780
 N  N  V  F  K  D  F  L  K  E  F  N  N  K  T  I  C  D  S  S         p.260

          .         .         .         .         .         .       g.104489
 GTGTCCACGCATGACCTGAAGGTGAAATACTTGGCTACCTTGGAAACTTTGACAAAACAT       c.840
 V  S  T  H  D  L  K  V  K  Y  L  A  T  L  E  T  L  T  K  H         p.280

          .         .         .         .         .         .       g.104549
 TACGGTGCTGAAATATTTGAGACTTCCATGTTACTGATTTCATCAGAAAATGAGATGAAT       c.900
 Y  G  A  E  I  F  E  T  S  M  L  L  I  S  S  E  N  E  M  N         p.300

          .         .         .         .         .         .       g.104609
 TGGTTTCATTCGAATGACGGTGGAAACGTTCTCTACTACGAAGTGATGGTGACTGGGAAT       c.960
 W  F  H  S  N  D  G  G  N  V  L  Y  Y  E  V  M  V  T  G  N         p.320

          .         .         . | 08       .         .         .    g.106562
 CTTGGAATCCAGTGGAGGCATAAACCAAAT | GTTGTTTCTGTTGAAAAGGAAAAAAATAAA    c.1020
 L  G  I  Q  W  R  H  K  P  N   | V  V  S  V  E  K  E  K  N  K      p.340

          .         .         .         .         .         .       g.106622
 CTGAAGCGGAAAAAACTGGAAAATAAACACAAGAAGGATGAGGAGAAAAACAAGATCCGG       c.1080
 L  K  R  K  K  L  E  N  K  H  K  K  D  E  E  K  N  K  I  R         p.360

          .         .         .         .         .         .       g.106682
 GAAGAGTGGAACAATTTTTCTTACTTCCCTGAAATCACTCACATTGTAATAAAGGAGTCT       c.1140
 E  E  W  N  N  F  S  Y  F  P  E  I  T  H  I  V  I  K  E  S         p.380

          .         .         .       | 09 .         .         .    g.111266
 GTGGTCAGCATTAACAAGCAGGACAACAAGAAAATG | GAACTGAAGCTCTCTTCCCACGAG    c.1200
 V  V  S  I  N  K  Q  D  N  K  K  M   | E  L  K  L  S  S  H  E      p.400

          .         .         .         .         .         .       g.111326
 GAGGCCTTGTCCTTTGTGTCCCTGGTAGATGGCTACTTCCGGCTCACAGCAGATGCCCAT       c.1260
 E  A  L  S  F  V  S  L  V  D  G  Y  F  R  L  T  A  D  A  H         p.420

          .         .         .         .         .         .       g.111386
 CATTACCTCTGCACCGACGTGGCCCCCCCGTTGATCGTCCACAACATACAGAATGGCTGT       c.1320
 H  Y  L  C  T  D  V  A  P  P  L  I  V  H  N  I  Q  N  G  C         p.440

          .     | 10   .         .         .         .         .    g.113771
 CATGGTCCAATCTG | TACAGAATACGCCATCAATAAATTGCGGCAAGAAGGAAGCGAGGAG    c.1380
 H  G  P  I  C  |  T  E  Y  A  I  N  K  L  R  Q  E  G  S  E  E      p.460

          .         .         .         .         .         .       g.113831
 GGGATGTACGTGCTGAGGTGGAGCTGCACCGACTTTGACAACATCCTCATGACCGTCACC       c.1440
 G  M  Y  V  L  R  W  S  C  T  D  F  D  N  I  L  M  T  V  T         p.480

          .         | 11         .         .         .         .    g.115848
 TGCTTTGAGAAGTCTGAG | CAGGTGCAGGGTGCCCAGAAGCAGTTCAAGAACTTTCAGATC    c.1500
 C  F  E  K  S  E   | Q  V  Q  G  A  Q  K  Q  F  K  N  F  Q  I      p.500

          .         .         .         .         .         .       g.115908
 GAGGTGCAGAAGGGCCGCTACAGTCTGCACGGTTCGGACCGCAGCTTCCCCAGCTTGGGA       c.1560
 E  V  Q  K  G  R  Y  S  L  H  G  S  D  R  S  F  P  S  L  G         p.520

          .         .         .         .         .         .       g.115968
 GACCTCATGAGCCACCTCAAGAAGCAGATCCTGCGCACGGATAACATCAGCTTCATGCTA       c.1620
 D  L  M  S  H  L  K  K  Q  I  L  R  T  D  N  I  S  F  M  L         p.540

          .         .         | 12         .         .         .    g.120626
 AAACGCTGCTGCCAGCCCAAGCCCCGAG | AAATCTCCAACCTGCTGGTGGCTACTAAGAAA    c.1680
 K  R  C  C  Q  P  K  P  R  E |   I  S  N  L  L  V  A  T  K  K      p.560

          .         .         .         .         .         .       g.120686
 GCCCAGGAGTGGCAGCCCGTCTACCCCATGAGCCAGCTGAGTTTCGATCGGATCCTCAAG       c.1740
 A  Q  E  W  Q  P  V  Y  P  M  S  Q  L  S  F  D  R  I  L  K         p.580

          .      | 13  .         .         .         .         .    g.123874
 AAGGATCTGGTGCAG | GGCGAGCACCTTGGGAGAGGCACGAGAACACACATCTATTCTGGG    c.1800
 K  D  L  V  Q   | G  E  H  L  G  R  G  T  R  T  H  I  Y  S  G      p.600

          .         .         .         .         .         .       g.123934
 ACCCTGATGGATTACAAGGATGACGAAGGAACTTCTGAAGAGAAGAAGATAAAAGTGATC       c.1860
 T  L  M  D  Y  K  D  D  E  G  T  S  E  E  K  K  I  K  V  I         p.620

          .         .         .          | 14        .         .    g.124789
 CTCAAAGTCTTAGACCCCAGCCACAGGGATATTTCCCTG | GCCTTCTTCGAGGCAGCCAGC    c.1920
 L  K  V  L  D  P  S  H  R  D  I  S  L   | A  F  F  E  A  A  S      p.640

          .         .         .         .         .         .       g.124849
 ATGATGAGACAGGTCTCCCACAAACACATCGTGTACCTCTATGGCGTCTGTGTCCGCGAC       c.1980
 M  M  R  Q  V  S  H  K  H  I  V  Y  L  Y  G  V  C  V  R  D         p.660

         | 15.         .         .         .         .         .    g.125917
 GTGGAGA | ATATCATGGTGGAAGAGTTTGTGGAAGGGGGTCCTCTGGATCTCTTCATGCAC    c.2040
 V  E  N |   I  M  V  E  E  F  V  E  G  G  P  L  D  L  F  M  H      p.680

          .         .         .         .         .         .       g.125977
 CGGAAAAGCGATGTCCTTACCACACCATGGAAATTCAAAGTTGCCAAACAGCTGGCCAGT       c.2100
 R  K  S  D  V  L  T  T  P  W  K  F  K  V  A  K  Q  L  A  S         p.700

          .      | 16  .         .         .         .         .    g.126660
 GCCCTGAGCTACTTG | GAGGATAAAGACCTGGTCCATGGAAATGTGTGTACTAAAAACCTC    c.2160
 A  L  S  Y  L   | E  D  K  D  L  V  H  G  N  V  C  T  K  N  L      p.720

          .         .         .         .         .         .       g.126720
 CTCCTGGCCCGTGAGGGCATCGACAGTGAGTGTGGCCCATTCATCAAGCTCAGTGACCCC       c.2220
 L  L  A  R  E  G  I  D  S  E  C  G  P  F  I  K  L  S  D  P         p.740

          .         .         .  | 17      .         .         .    g.127318
 GGCATCCCCATTACGGTGCTGTCTAGGCAAG | AATGCATTGAACGAATCCCATGGATTGCT    c.2280
 G  I  P  I  T  V  L  S  R  Q  E |   C  I  E  R  I  P  W  I  A      p.760

          .         .         .         .         .         .       g.127378
 CCTGAGTGTGTTGAGGACTCCAAGAACCTGAGTGTGGCTGCTGACAAGTGGAGCTTTGGA       c.2340
 P  E  C  V  E  D  S  K  N  L  S  V  A  A  D  K  W  S  F  G         p.780

          .         .         .         .         .         .       g.127438
 ACCACGCTCTGGGAAATCTGCTACAATGGCGAGATCCCCTTGAAAGACAAGACGCTGATT       c.2400
 T  T  L  W  E  I  C  Y  N  G  E  I  P  L  K  D  K  T  L  I         p.800

     | 18    .         .         .         .         .         .    g.129960
 GAG | AAAGAGAGATTCTATGAAAGCCGGTGCAGGCCAGTGACACCATCATGTAAGGAGCTG    c.2460
 E   | K  E  R  F  Y  E  S  R  C  R  P  V  T  P  S  C  K  E  L      p.820

          .         .         .         .         .         .       g.130020
 GCTGACCTCATGACCCGCTGCATGAACTATGACCCCAATCAGAGGCCTTTCTTCCGAGCC       c.2520
 A  D  L  M  T  R  C  M  N  Y  D  P  N  Q  R  P  F  F  R  A         p.840

          .         .         .     | 19   .         .         .    g.130191
 ATCATGAGAGACATTAATAAGCTTGAAGAGCAGA | ATCCAGATATTGTTTCAGAAAAAAAA    c.2580
 I  M  R  D  I  N  K  L  E  E  Q  N |   P  D  I  V  S  E  K  K      p.860

          .         .         .         .         .         .       g.130251
 CCAGCAACTGAAGTGGACCCCACACATTTTGAAAAGCGCTTCCTAAAGAGGATCCGTGAC       c.2640
 P  A  T  E  V  D  P  T  H  F  E  K  R  F  L  K  R  I  R  D         p.880

           | 20        .         .         .         .         .    g.131760
 TTGGGAGAG | GGCCACTTTGGGAAGGTTGAGCTCTGCAGGTATGACCCCGAAGGGGACAAT    c.2700
 L  G  E   | G  H  F  G  K  V  E  L  C  R  Y  D  P  E  G  D  N      p.900

          .         .         .         .         .         .       g.131820
 ACAGGGGAGCAGGTGGCTGTTAAATCTCTGAAGCCTGAGAGTGGAGGTAACCACATAGCT       c.2760
 T  G  E  Q  V  A  V  K  S  L  K  P  E  S  G  G  N  H  I  A         p.920

          .         .         .         .         .         .       g.131880
 GATCTGAAAAAGGAAATCGAGATCTTAAGGAACCTCTATCATGAGAACATTGTGAAGTAC       c.2820
 D  L  K  K  E  I  E  I  L  R  N  L  Y  H  E  N  I  V  K  Y         p.940

          .         .   | 21     .         .         .         .    g.132953
 AAAGGAATCTGCACAGAAGACG | GAGGAAATGGTATTAAGCTCATCATGGAATTTCTGCCT    c.2880
 K  G  I  C  T  E  D  G |   G  N  G  I  K  L  I  M  E  F  L  P      p.960

          .         .         .         .         .         .       g.133013
 TCGGGAAGCCTTAAGGAATATCTTCCAAAGAATAAGAACAAAATAAACCTCAAACAGCAG       c.2940
 S  G  S  L  K  E  Y  L  P  K  N  K  N  K  I  N  L  K  Q  Q         p.980

          .         .        | 22.         .         .         .    g.133433
 CTAAAATATGCCGTTCAGATTTGTAAG | GGGATGGACTATTTGGGTTCTCGGCAATACGTT    c.3000
 L  K  Y  A  V  Q  I  C  K   | G  M  D  Y  L  G  S  R  Q  Y  V      p.1000

          .         .         .         .         .         .       g.133493
 CACCGGGACTTGGCAGCAAGAAATGTCCTTGTTGAGAGTGAACACCAAGTGAAAATTGGA       c.3060
 H  R  D  L  A  A  R  N  V  L  V  E  S  E  H  Q  V  K  I  G         p.1020

          .         .         .         .         .         .       g.133553
 GACTTCGGTTTAACCAAAGCAATTGAAACCGATAAGGAGTATTACACCGTCAAGGATGAC       c.3120
 D  F  G  L  T  K  A  I  E  T  D  K  E  Y  Y  T  V  K  D  D         p.1040

          .         . | 23       .         .         .         .    g.135329
 CGGGACAGCCCTGTGTTTTG | GTATGCTCCAGAATGTTTAATGCAATCTAAATTTTATATT    c.3180
 R  D  S  P  V  F  W  |  Y  A  P  E  C  L  M  Q  S  K  F  Y  I      p.1060

          .         .         .         .         .         .       g.135389
 GCCTCTGACGTCTGGTCTTTTGGAGTCACTCTGCATGAGCTGCTGACTTACTGTGATTCA       c.3240
 A  S  D  V  W  S  F  G  V  T  L  H  E  L  L  T  Y  C  D  S         p.1080

          .         | 24         .         .         .         .    g.136040
 GATTCTAGTCCCATGGCT | TTGTTCCTGAAAATGATAGGCCCAACCCATGGCCAGATGACA    c.3300
 D  S  S  P  M  A   | L  F  L  K  M  I  G  P  T  H  G  Q  M  T      p.1100

          .         .         .         .         .         .       g.136100
 GTCACAAGACTTGTGAATACGTTAAAAGAAGGAAAACGCCTGCCGTGCCCACCTAACTGT       c.3360
 V  T  R  L  V  N  T  L  K  E  G  K  R  L  P  C  P  P  N  C         p.1120

           | 25        .         .         .         .         .    g.136898
 CCAGATGAG | GTTTATCAACTTATGAGGAAATGCTGGGAATTCCAACCATCCAATCGGACA    c.3420
 P  D  E   | V  Y  Q  L  M  R  K  C  W  E  F  Q  P  S  N  R  T      p.1140

          .         .         .         .                           g.136943
 AGCTTTCAGAACCTTATTGAAGGATTTGAAGCACTTTTAAAATAA                      c.3465
 S  F  Q  N  L  I  E  G  F  E  A  L  L  K  X                        p.1154

          .         .         .         .         .         .       g.137003
 gaagcatgaataacatttaaattccacagattatcaagtccttctcctgcaacaaatgcc       c.*60

          .         .         .         .         .         .       g.137063
 caagtcattttttaaaaatttctaatgaaagaagtttgtgttctgtccaaaaagtcactg       c.*120

          .         .         .         .         .         .       g.137123
 aactcatacttcagtacatatacatgtataaggcacactgtagtgcttaatatgtgtaag       c.*180

          .         .         .         .         .         .       g.137183
 gacttcctctttaaatttggtaccagtaacttagtgacacataatgacaaccaaaatatt       c.*240

          .         .         .         .         .         .       g.137243
 tgaaagcacttaagcactcctccttgtggaaagaatataccaccatttcatctggctagt       c.*300

          .         .         .         .         .         .       g.137303
 tcaccatcacaactgcattaccaaaaggggatttttgaaaacgaggagttgaccaaaata       c.*360

          .         .         .         .         .         .       g.137363
 atatctgaagatgattgcttttccctgctgccagctgatctgaaatgttttgctggcaca       c.*420

          .         .         .         .         .         .       g.137423
 ttaatcatagataaagaaagattgatggacttagccctcaaatttcagtatctatacagt       c.*480

          .         .         .         .         .         .       g.137483
 actagaccatgcattcttaaaatattagataccaggtagtatatattgtttctgtacaaa       c.*540

          .         .         .         .         .         .       g.137543
 aatgactgtattctctcaccagtaggacttaaactttgtttctccagtggcttagctcct       c.*600

          .         .         .         .         .         .       g.137603
 gttcctttgggtgatcactagcacccatttttgagaaagctggttctacatggggggata       c.*660

          .         .         .         .         .         .       g.137663
 gctgtggaatagataatttgctgcatgttaattctcaagaactaagcctgtgccagtgct       c.*720

          .         .         .         .         .         .       g.137723
 ttcctaagcagtatacctttaatcagaactcattcccagaacctggatgctattacacat       c.*780

          .         .         .         .         .         .       g.137783
 gcttttaagaaacgtcaatgtatatccttttataactctaccactttggggcaagctatt       c.*840

          .         .         .         .         .         .       g.137843
 ccagcactggttttgaatgctgtatgcaaccagtctgaataccacatacgctgcactgtt       c.*900

          .         .         .         .         .         .       g.137903
 cttagagggtttccatacttaccaccgatctacaagggttgatccctgtttttaccatca       c.*960

          .         .         .         .         .         .       g.137963
 atcatcaccctgtggtgcaacacttgaaagacccggctagaggcactatggacttcagga       c.*1020

          .         .         .         .         .         .       g.138023
 tccactagacagttttcagtttgcttggaggtagctgggtaatcaaaaatgtttagtcat       c.*1080

          .         .         .         .         .         .       g.138083
 tgattcaatgtgaacgattacggtctttatgaccaagagtctgaaaatctttttgttatg       c.*1140

          .         .         .         .         .         .       g.138143
 ctgtttagtattcgtttgatattgttacttttcacctgttgagcccaaattcaggattgg       c.*1200

          .         .         .         .         .         .       g.138203
 ttcagtggcagcaatgaagttgccatttaaatttgttcatagcctacatcaccaaggtct       c.*1260

          .         .         .         .         .         .       g.138263
 ctgtgtcaaacctgtggccactctatatgcactttgtttactctttatacaaataaatat       c.*1320

          .                                                         g.138282
 actaaagactttacatgca                                                c.*1339

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Janus kinase 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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