Janus kinase 2 (JAK2) - coding DNA reference sequence

(used for variant description)

(last modified July 24, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_004972.3 in the JAK2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009904.1, covering JAK2 transcript NM_004972.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               ctgcaggaaggaga       c.-481

 .         .         .         .         .         .                g.5074
 gaggaagaggagcagaagggggcagcagcggacgccgctaacggcctccctcggcgctga       c.-421

 .         .         .         .         .         .                g.5134
 caggctgggccggcgcccggctcgcttgggtgttcgcgtcgccacttcggcttctcggcc       c.-361

 .         .         .         .         .         .                g.5194
 ggtcgggcccctcggcccgggcttgcggcgcgcgtcggggctgagggctgctgcggcgca       c.-301

 .         .         .         .         .         .                g.5254
 gggagaggcctggtcctcgctgccgagggatgtgagtgggagctgagcccacactggagg       c.-241

 .         .         .         .         .         .                g.5314
 gcccccgagggcccagcctggaggtcgttcagagccgtgcccgtcccggggcttcgcaga       c.-181

 .         .         .         .         .         .                g.5374
 ccttgacccgccgggtaggagccgcccctgcgggctcgagggcgcgctctggtcgcccga       c.-121

 .         .  | 02      .         .         .         .             g.5743
 tctgtgtagccg | gtttcagaagcaggcaacaggaacaagatgtgaactgtttctcttctg    c.-61

 .         .         .         .     | 03   .         .             g.41743
 cagaaaaagaggctcttcctcctcctcccgcgacg | gcaaatgttctgaaaaagactctgc    c.-1

          .         .         .         .         .         .       g.41803
 ATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCACCTCTTCTATATAT       c.60
 M  G  M  A  C  L  T  M  T  E  M  E  G  T  S  T  S  S  I  Y         p.20

          .         .         .         .         .         .       g.41863
 CAGAATGGTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAGATCCAGTTCTTCAG       c.120
 Q  N  G  D  I  S  G  N  A  N  S  M  K  Q  I  D  P  V  L  Q         p.40

          .         .         .         .         .         .       g.41923
 GTGTATCTTTACCATTCCCTTGGGAAATCTGAGGCAGATTATCTGACCTTTCCATCTGGG       c.180
 V  Y  L  Y  H  S  L  G  K  S  E  A  D  Y  L  T  F  P  S  G         p.60

          .         .         .         .       | 04 .         .    g.49552
 GAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTG | GTATCACACCTGTG    c.240
 E  Y  V  A  E  E  I  C  I  A  A  S  K  A  C  G |   I  T  P  V      p.80

          .         .         .         .         .         .       g.49612
 TATCATAATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCACCCAACCAT       c.300
 Y  H  N  M  F  A  L  M  S  E  T  E  R  I  W  Y  P  P  N  H         p.100

          .         .         .         .         . | 05       .    g.64168
 GTCTTCCATATAGATGAGTCAACCAGGCATAATGTACTCTACAGAATAAG | ATTTTACTTT    c.360
 V  F  H  I  D  E  S  T  R  H  N  V  L  Y  R  I  R  |  F  Y  F      p.120

          .         .         .         .         .         .       g.64228
 CCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAATATCTCGAGGTGCT       c.420
 P  R  W  Y  C  S  G  S  N  R  A  Y  R  H  G  I  S  R  G  A         p.140

          .         .         .         .         | 06         .    g.70453
 GAAGCTCCTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTCAG | TGGCGGCATGAT    c.480
 E  A  P  L  L  D  D  F  V  M  S  Y  L  F  A  Q   | W  R  H  D      p.160

          .         .         .         .         .         .       g.70513
 TTTGTGCACGGATGGATAAAAGTACCTGTGACTCATGAAACACAGGAAGAATGTCTTGGG       c.540
 F  V  H  G  W  I  K  V  P  V  T  H  E  T  Q  E  E  C  L  G         p.180

          .         .         .         .         .         .       g.70573
 ATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAACCCCACTGGCCATC       c.600
 M  A  V  L  D  M  M  R  I  A  K  E  N  D  Q  T  P  L  A  I         p.200

          .     | 07   .         .         .         .         .    g.74364
 TATAACTCTATCAG | CTACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGAC    c.660
 Y  N  S  I  S  |  Y  K  T  F  L  P  K  C  I  R  A  K  I  Q  D      p.220

          .         .         .         .         .         .       g.74424
 TATCATATTTTGACAAGGAAGCGAATAAGGTACAGATTTCGCAGATTTATTCAGCAATTC       c.720
 Y  H  I  L  T  R  K  R  I  R  Y  R  F  R  R  F  I  Q  Q  F         p.240

          .         .         .         .         .         .       g.74484
 AGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTATAAATCTGGAAACT       c.780
 S  Q  C  K  A  T  A  R  N  L  K  L  K  Y  L  I  N  L  E  T         p.260

          .         .         .         .         .         .       g.74544
 CTGCAGTCTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCA       c.840
 L  Q  S  A  F  Y  T  E  K  F  E  V  K  E  P  G  S  G  P  S         p.280

          .         .         .         .         .         .       g.74604
 GGTGAGGAGATTTTTGCAACCATTATAATAACTGGAAACGGTGGAATTCAGTGGTCAAGA       c.900
 G  E  E  I  F  A  T  I  I  I  T  G  N  G  G  I  Q  W  S  R         p.300

          .         .         .       | 08 .         .         .    g.75448
 GGGAAACATAAAGAAAGTGAGACACTGACAGAACAG | GATTTACAGTTATATTGCGATTTT    c.960
 G  K  H  K  E  S  E  T  L  T  E  Q   | D  L  Q  L  Y  C  D  F      p.320

          .         .         .         .         .         .       g.75508
 CCTAATATTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGA       c.1020
 P  N  I  I  D  V  S  I  K  Q  A  N  Q  E  G  S  N  E  S  R         p.340

          .         .         .       | 09 .         .         .    g.84662
 GTTGTAACTATCCATAAGCAAGATGGTAAAAATCTG | GAAATTGAACTTAGCTCATTAAGG    c.1080
 V  V  T  I  H  K  Q  D  G  K  N  L   | E  I  E  L  S  S  L  R      p.360

          .         .         .         .         .         .       g.84722
 GAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAACTGCAGATGCACAT       c.1140
 E  A  L  S  F  V  S  L  I  D  G  Y  Y  R  L  T  A  D  A  H         p.380

          .         .         .         .         .         .       g.84782
 CATTACCTCTGTAAAGAAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGT       c.1200
 H  Y  L  C  K  E  V  A  P  P  A  V  L  E  N  I  Q  S  N  C         p.400

          .     | 10   .         .         .         .         .    g.86479
 CATGGCCCAATTTC | GATGGATTTTGCCATTAGTAAACTGAAGAAAGCAGGTAATCAGACT    c.1260
 H  G  P  I  S  |  M  D  F  A  I  S  K  L  K  K  A  G  N  Q  T      p.420

          .         .         .         .         .         .       g.86539
 GGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATTTTTTGACTTTTGCT       c.1320
 G  L  Y  V  L  R  C  S  P  K  D  F  N  K  Y  F  L  T  F  A         p.440

        | 11 .         .         .         .         .         .    g.88831
 GTCGAG | CGAGAAAATGTCATTGAATATAAACACTGTTTGATTACAAAAAATGAGAATGAA    c.1380
 V  E   | R  E  N  V  I  E  Y  K  H  C  L  I  T  K  N  E  N  E      p.460

          .         .         .         .         .         .       g.88891
 GAGTACAACCTCAGTGGGACAAAGAAGAACTTCAGCAGTCTTAAAGATCTTTTGAATTGT       c.1440
 E  Y  N  L  S  G  T  K  K  N  F  S  S  L  K  D  L  L  N  C         p.480

          .         .         .         .         .         .       g.88951
 TACCAGATGGAAACTGTTCGCTCAGACAATATAATTTTCCAGTTTACTAAATGCTGTCCC       c.1500
 Y  Q  M  E  T  V  R  S  D  N  I  I  F  Q  F  T  K  C  C  P         p.500

          .    | 12    .         .         .         .         .    g.89727
 CCAAAGCCAAAAG | ATAAATCAAACCTTCTAGTCTTCAGAACGAATGGTGTTTCTGATGTA    c.1560
 P  K  P  K  D |   K  S  N  L  L  V  F  R  T  N  G  V  S  D  V      p.520

          .         .         .         .         .         .       g.89787
 CCAACCTCACCAACATTACAGAGGCCTACTCATATGAACCAAATGGTGTTTCACAAAATC       c.1620
 P  T  S  P  T  L  Q  R  P  T  H  M  N  Q  M  V  F  H  K  I         p.540

          .         .  | 13      .         .         .         .    g.92286
 AGAAATGAAGATTTGATATTT | AATGAAAGCCTTGGCCAAGGCACTTTTACAAAGATTTTT    c.1680
 R  N  E  D  L  I  F   | N  E  S  L  G  Q  G  T  F  T  K  I  F      p.560

          .         .         .         .         .         .       g.92346
 AAAGGCGTACGAAGAGAAGTAGGAGACTACGGTCAACTGCATGAAACAGAAGTTCTTTTA       c.1740
 K  G  V  R  R  E  V  G  D  Y  G  Q  L  H  E  T  E  V  L  L         p.580

          .         .         .       | 14 .         .         .    g.93477
 AAAGTTCTGGATAAAGCACACAGAAACTATTCAGAG | TCTTTCTTTGAAGCAGCAAGTATG    c.1800
 K  V  L  D  K  A  H  R  N  Y  S  E   | S  F  F  E  A  A  S  M      p.600

          .         .         .         .         .         .       g.93537
 ATGAGCAAGCTTTCTCACAAGCATTTGGTTTTAAATTATGGAGTATGTGTCTGTGGAGAC       c.1860
 M  S  K  L  S  H  K  H  L  V  L  N  Y  G  V  C  V  C  G  D         p.620

      | 15   .         .         .         .         .         .    g.97264
 GAGA | ATATTCTGGTTCAGGAGTTTGTAAAATTTGGATCACTAGATACATATCTGAAAAAG    c.1920
 E  N |   I  L  V  Q  E  F  V  K  F  G  S  L  D  T  Y  L  K  K      p.640

          .         .         .         .         .         .       g.97324
 AATAAAAATTGTATAAATATATTATGGAAACTTGAAGTTGCTAAACAGTTGGCATGGGCC       c.1980
 N  K  N  C  I  N  I  L  W  K  L  E  V  A  K  Q  L  A  W  A         p.660

          .   | 16     .         .         .         .         .    g.98109
 ATGCATTTTCTA | GAAGAAAACACCCTTATTCATGGGAATGTATGTGCCAAAAATATTCTG    c.2040
 M  H  F  L   | E  E  N  T  L  I  H  G  N  V  C  A  K  N  I  L      p.680

          .         .         .         .         .         .       g.98169
 CTTATCAGAGAAGAAGACAGGAAGACAGGAAATCCTCCTTTCATCAAACTTAGTGATCCT       c.2100
 L  I  R  E  E  D  R  K  T  G  N  P  P  F  I  K  L  S  D  P         p.700

          .         .         .  | 17      .         .         .    g.100013
 GGCATTAGTATTACAGTTTTGCCAAAGGACA | TTCTTCAGGAGAGAATACCATGGGTACCA    c.2160
 G  I  S  I  T  V  L  P  K  D  I |   L  Q  E  R  I  P  W  V  P      p.720

          .         .         .         .         .         .       g.100073
 CCTGAATGCATTGAAAATCCTAAAAATTTAAATTTGGCAACAGACAAATGGAGTTTTGGT       c.2220
 P  E  C  I  E  N  P  K  N  L  N  L  A  T  D  K  W  S  F  G         p.740

          .         .         .         .         .         .       g.100133
 ACCACTTTGTGGGAAATCTGCAGTGGAGGAGATAAACCTCTAAGTGCTCTGGATTCTCAA       c.2280
 T  T  L  W  E  I  C  S  G  G  D  K  P  L  S  A  L  D  S  Q         p.760

     | 18    .         .         .         .         .         .    g.100345
 AGA | AAGCTACAATTTTATGAAGATAGGCATCAGCTTCCTGCACCAAAGTGGGCAGAATTA    c.2340
 R   | K  L  Q  F  Y  E  D  R  H  Q  L  P  A  P  K  W  A  E  L      p.780

          .         .         .         .         .         .       g.100405
 GCAAACCTTATAAATAATTGTATGGATTATGAACCAGATTTCAGGCCTTCTTTCAGAGCC       c.2400
 A  N  L  I  N  N  C  M  D  Y  E  P  D  F  R  P  S  F  R  A         p.800

          .         .         .     | 19   .         .         .    g.101506
 ATCATACGAGATCTTAACAGTTTGTTTACTCCAG | ATTATGAACTATTAACAGAAAATGAC    c.2460
 I  I  R  D  L  N  S  L  F  T  P  D |   Y  E  L  L  T  E  N  D      p.820

          .         .         .         .         .         .       g.101566
 ATGTTACCAAATATGAGGATAGGTGCCCTGGGGTTTTCTGGTGCCTTTGAAGACCGGGAT       c.2520
 M  L  P  N  M  R  I  G  A  L  G  F  S  G  A  F  E  D  R  D         p.840

          .         .         .         .         .  | 20      .    g.109438
 CCTACACAGTTTGAAGAGAGACATTTGAAATTTCTACAGCAACTTGGCAAG | GGTAATTTT    c.2580
 P  T  Q  F  E  E  R  H  L  K  F  L  Q  Q  L  G  K   | G  N  F      p.860

          .         .         .         .         .         .       g.109498
 GGGAGTGTGGAGATGTGCCGGTATGACCCTCTACAGGACAACACTGGGGAGGTGGTCGCT       c.2640
 G  S  V  E  M  C  R  Y  D  P  L  Q  D  N  T  G  E  V  V  A         p.880

          .         .         .         .         .         .       g.109558
 GTAAAAAAGCTTCAGCATAGTACTGAAGAGCACCTAAGAGACTTTGAAAGGGAAATTGAA       c.2700
 V  K  K  L  Q  H  S  T  E  E  H  L  R  D  F  E  R  E  I  E         p.900

          .         .         .         .         .         .       g.109618
 ATCCTGAAATCCCTACAGCATGACAACATTGTAAAGTACAAGGGAGTGTGCTACAGTGCT       c.2760
 I  L  K  S  L  Q  H  D  N  I  V  K  Y  K  G  V  C  Y  S  A         p.920

   | 21      .         .         .         .         .         .    g.110260
 G | GTCGGCGTAATCTAAAATTAATTATGGAATATTTACCATATGGAAGTTTACGAGACTAT    c.2820
 G |   R  R  N  L  K  L  I  M  E  Y  L  P  Y  G  S  L  R  D  Y      p.940

          .         .         .         .         .         .       g.110320
 CTTCAAAAACATAAAGAACGGATAGATCACATAAAACTTCTGCAGTACACATCTCAGATA       c.2880
 L  Q  K  H  K  E  R  I  D  H  I  K  L  L  Q  Y  T  S  Q  I         p.960

        | 22 .         .         .         .         .         .    g.110548
 TGCAAG | GGTATGGAGTATCTTGGTACAAAAAGGTATATCCACAGGGATCTGGCAACGAGA    c.2940
 C  K   | G  M  E  Y  L  G  T  K  R  Y  I  H  R  D  L  A  T  R      p.980

          .         .         .         .         .         .       g.110608
 AATATATTGGTGGAGAACGAGAACAGAGTTAAAATTGGAGATTTTGGGTTAACCAAAGTC       c.3000
 N  I  L  V  E  N  E  N  R  V  K  I  G  D  F  G  L  T  K  V         p.1000

          .         .         .         .         .          | 23    g.142760
 TTGCCACAAGACAAAGAATACTATAAAGTAAAAGAACCTGGTGAAAGTCCCATATTCTG | G    c.3060
 L  P  Q  D  K  E  Y  Y  K  V  K  E  P  G  E  S  P  I  F  W  |      p.1020

          .         .         .         .         .         .       g.142820
 TATGCTCCAGAATCACTGACAGAGAGCAAGTTTTCTGTGGCCTCAGATGTTTGGAGCTTT       c.3120
 Y  A  P  E  S  L  T  E  S  K  F  S  V  A  S  D  V  W  S  F         p.1040

          .         .         .         .         .        | 24.    g.146091
 GGAGTGGTTCTGTATGAACTTTTCACATACATTGAGAAGAGTAAAAGTCCACCAGCG | GAA    c.3180
 G  V  V  L  Y  E  L  F  T  Y  I  E  K  S  K  S  P  P  A   | E      p.1060

          .         .         .         .         .         .       g.146151
 TTTATGCGTATGATTGGCAATGACAAACAAGGACAGATGATCGTGTTCCATTTGATAGAA       c.3240
 F  M  R  M  I  G  N  D  K  Q  G  Q  M  I  V  F  H  L  I  E         p.1080

          .         .         .         .         .  | 25      .    g.146448
 CTTTTGAAGAATAATGGAAGATTACCAAGACCAGATGGATGCCCAGATGAG | ATCTATATG    c.3300
 L  L  K  N  N  G  R  L  P  R  P  D  G  C  P  D  E   | I  Y  M      p.1100

          .         .         .         .         .         .       g.146508
 ATCATGACAGAATGCTGGAACAATAATGTAAATCAACGCCCCTCCTTTAGGGATCTAGCT       c.3360
 I  M  T  E  C  W  N  N  N  V  N  Q  R  P  S  F  R  D  L  A         p.1120

          .         .         .                                     g.146547
 CTTCGAGTGGATCAAATAAGGGATAACATGGCTGGATGA                            c.3399
 L  R  V  D  Q  I  R  D  N  M  A  G  X                              p.1132

          .         .         .         .         .         .       g.146607
 aagaaatgaccttcattctgagaccaaagtagatttacagaacaaagttttatatttcac       c.*60

          .         .         .         .         .         .       g.146667
 attgctgtggactattattacatatatcattattatataaatcatgatgctagccagcaa       c.*120

          .         .         .         .         .         .       g.146727
 agatgtgaaaatatctgctcaaaactttcaaagtttagtaagtttttcttcatgaggcca       c.*180

          .         .         .         .         .         .       g.146787
 ccagtaaaagacattaatgagaattccttagcaaggattttgtaagaagtttcttaaaca       c.*240

          .         .         .         .         .         .       g.146847
 ttgtcagttaacatcactcttgtctggcaaaagaaaaaaaatagactttttcaactcagc       c.*300

          .         .         .         .         .         .       g.146907
 tttttgagacctgaaaaaattattatgtaaattttgcaatgttaaagatgcacagaatat       c.*360

          .         .         .         .         .         .       g.146967
 gtatgtatagtttttaccacagtggatgtataataccttggcatcttgtgtgatgtttta       c.*420

          .         .         .         .         .         .       g.147027
 cacacatgagggctggtgttcattaatactgttttctaatttttccatagttaatctata       c.*480

          .         .         .         .         .         .       g.147087
 attaattacttcactatacaaacaaattaagatgttcagataattgaataagtacctttg       c.*540

          .         .         .         .         .         .       g.147147
 tgtccttgttcatttatatcgctggccagcattataagcaggtgtatacttttagcttgt       c.*600

          .         .         .         .         .         .       g.147207
 agttccatgtactgtaaatatttttcacataaagggaacaaatgtctagttttatttgta       c.*660

          .         .         .         .         .         .       g.147267
 taggaaatttccctgaccctaaataatacattttgaaatgaaacaagcttacaaagatat       c.*720

          .         .         .         .         .         .       g.147327
 aatctattttattatggtttcccttgtatctatttgtggtgaatgtgttttttaaatgga       c.*780

          .         .         .         .         .         .       g.147387
 actatctccaaatttttctaagactactatgaacagttttcttttaaaattttgagatta       c.*840

          .         .         .         .         .         .       g.147447
 agaatgccaggaatattgtcatcctttgagctgctgactgccaataacattcttcgatct       c.*900

          .         .         .         .         .         .       g.147507
 ctgggatttatgctcatgaactaaatttaagcttaagccataaaatagattagattgttt       c.*960

          .         .         .         .         .         .       g.147567
 tttaaaaatggatagctcattaagaagtgcagcaggttaagaattttttcctaaagactg       c.*1020

          .         .         .         .         .         .       g.147627
 tatatttgaggggtttcagaattttgcattgcagtcatagaagagatttatttccttttt       c.*1080

          .         .         .         .         .         .       g.147687
 agaggggaaatgaggtaaataagtaaaaaagtatgcttgttaattttattcaagaatgcc       c.*1140

          .         .         .         .         .         .       g.147747
 agtagaaaattcataacgtgtatctttaagaaaaatgagcatacatcttaaatcttttca       c.*1200

          .         .         .         .         .         .       g.147807
 attaagtataaggggttgttcgttgttgtcatttgttatagtgctactccactttagaca       c.*1260

          .         .         .         .         .         .       g.147867
 ccatagctaaaataaaatatggtgggttttgtgtgtgtgtgtgtgtgtgtgtgtgtgtgt       c.*1320

          .         .         .         .         .         .       g.147927
 gtgtgtgtgttatttatacaaaacttaaaatacttgctgttttgattaaaaagaaaatag       c.*1380

          .                                                         g.147939
 tttcttacttta                                                       c.*1392

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Janus kinase 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 21
©2004-2018 Leiden University Medical Center