junctional adhesion molecule 2 (JAM2) - coding DNA reference sequence

(used for variant description)

(last modified February 11, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_001270408.1 in the JAM2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000021.8, covering JAM2 transcript NM_001270408.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5060
 gggaagaaaggagttggggcaaaacaggaggcgtttccctacccgcatacatccccgtcc       c.-481

 .         .         .         .         .         .                g.5120
 ccgagacacccaatccccccacccccagcctgcccgcgcctcccgcccccagctcctcgc       c.-421

 .         .         .         .         .         .                g.5180
 cctggggacagctggcagccccgcgcggaccagacacaaagccgatcaatcccggaggcg       c.-361

 .         .         .         .         .         .                g.5240
 tgggggcggagggacgacccgccggggctttcccgggcgctgctctcctcctgctgcccc       c.-301

 .         .         .         .         .         .                g.5300
 ctcgctaggacccggcggacgcctcgtctggttttcacgccctctagcccctacccccac       c.-241

 .         .         .         .         .         .                g.5360
 acccccaaaacagaacagacccccatccctgggctggaggacccgcctcttggcagccag       c.-181

 .         .         .         .         .         .                g.5420
 ctgagaaggcgccccggggagggggaaactgacatcccatctagagccgtccctcctctt       c.-121

 .         .         .         .         .         .                g.5480
 cctcccctcccgactctctgctcctttcccgccccagaagttcaagggcccccggcctcc       c.-61

 .         .         .         .         .         .                g.5540
 tgcgctcctgccgccgggaccctcgacctcctcagagcagccggctgccgccccgggaag       c.-1

          .         .         .         .         .         .       g.5600
 ATGGCGAGGAGGAGCCGCCACCGCCTCCTCCTGCTGCTGCTGCGCTACCTGGTGGTCGCC       c.60
 M  A  R  R  S  R  H  R  L  L  L  L  L  L  R  Y  L  V  V  A         p.20

         | 02.         .         .         .         .         .    g.49654
 CTGGGCT | ATCATAAGGCCTATGGGTTTTCTGCCCCAAAAGACCAACAAGTAGTCACAGCA    c.120
 L  G  Y |   H  K  A  Y  G  F  S  A  P  K  D  Q  Q  V  V  T  A      p.40

          .    | 03    .         .         .         .         .    g.55631
 GTAGAGTACCAAG | AGGCTATTTTAGCCTGCAAAACCCCAAAGAAGACTGTTTCCTCCAGA    c.180
 V  E  Y  Q  E |   A  I  L  A  C  K  T  P  K  K  T  V  S  S  R      p.60

          .         .         .         .         .         .       g.55691
 TTAGAGTGGAAGAAACTGGGTCGGAGTGTCTCCTTTGTCTACTATCAACAGACTCTTCAA       c.240
 L  E  W  K  K  L  G  R  S  V  S  F  V  Y  Y  Q  Q  T  L  Q         p.80

   | 04      .         .         .         .         .         .    g.59533
 G | GTGATTTTAAAAATCGAGCTGAGATGATAGATTTCAATATCCGGATCAAAAATGTGACA    c.300
 G |   D  F  K  N  R  A  E  M  I  D  F  N  I  R  I  K  N  V  T      p.100

          .         .         .         .         .         .       g.59593
 AGAAGTGATGCGGGGAAATATCGTTGTGAAGTTAGTGCCCCATCTGAGCAAGGCCAAAAC       c.360
 R  S  D  A  G  K  Y  R  C  E  V  S  A  P  S  E  Q  G  Q  N         p.120

          .         .         .     | 05   .         .         .    g.64421
 CTGGAAGAGGATACAGTCACTCTGGAAGTATTAG | TGGCTCCAGCAGTTCCATCATGTGAA    c.420
 L  E  E  D  T  V  T  L  E  V  L  V |   A  P  A  V  P  S  C  E      p.140

          .         .         .         .         .         .       g.64481
 GTACCCTCTTCTGCTCTGAGTGGAACTGTGGTAGAGCTACGATGTCAAGACAAAGAAGGG       c.480
 V  P  S  S  A  L  S  G  T  V  V  E  L  R  C  Q  D  K  E  G         p.160

          .         .         .         .         .         .       g.64541
 AATCCAGCTCCTGAATACACATGGTTTAAGGATGGCATCCGTTTGCTAGAAAATCCCAGA       c.540
 N  P  A  P  E  Y  T  W  F  K  D  G  I  R  L  L  E  N  P  R         p.180

          .         .         .         .         .        | 06.    g.67891
 CTTGGCTCCCAAAGCACCAACAGCTCATACACAATGAATACAAAAACTGGAACTCTG | CAA    c.600
 L  G  S  Q  S  T  N  S  S  Y  T  M  N  T  K  T  G  T  L   | Q      p.200

          .         .         .         .         .         .       g.67951
 TTTAATACTGTTTCCAAACTGGACACTGGAGAATATTCCTGTGAAGCCCGCAATTCTGTT       c.660
 F  N  T  V  S  K  L  D  T  G  E  Y  S  C  E  A  R  N  S  V         p.220

          .         .         .        | 07.         .         .    g.71720
 GGATATCGCAGGTGTCCTGGGAAACGAATGCAAGTAG | ATGATCTCAACATAAGTGGCATC    c.720
 G  Y  R  R  C  P  G  K  R  M  Q  V  D |   D  L  N  I  S  G  I      p.240

          .         .         .         .         .         .       g.71780
 ATAGCAGCCGTAGTAGTTGTGGCCTTAGTGATTTCCGTTTGTGGCCTTGGTGTATGCTAT       c.780
 I  A  A  V  V  V  V  A  L  V  I  S  V  C  G  L  G  V  C  Y         p.260

          .         .      | 08  .         .  | 09      .         . g.78077
 GCTCAGAGGAAAGGCTACTTTTCAA | AAGAAACCTCCTTCCA | GAAGAGTAATTCTTCATCT c.840
 A  Q  R  K  G  Y  F  S  K |   E  T  S  F  Q  |  K  S  N  S  S  S   p.280

          .         .     | 10   .         .         .         .    g.79985
 AAAGCCACGACAATGAGTGAAAAT | GTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGG    c.900
 K  A  T  T  M  S  E  N   | V  Q  W  L  T  P  V  I  P  A  L  W      p.300

          .         .         .                                     g.80024
 AAGGCCGCGGCGGGCGGATCACGAGGTCAGGAGTTCTAG                            c.939
 K  A  A  A  G  G  S  R  G  Q  E  F  X                              p.312

          .         .         .         .         .         .       g.80084
 accagtctggccaatatggtgaaaccccatctctactaaaatacaaaaattagctgggca       c.*60

          .         .         .         .         .         .       g.80144
 tggtggcatgtgcctgcagttccagctgcttgggagacaggagaatcacttgaacccggg       c.*120

          .         .         .         .         .         .       g.80204
 aggcggaggttgcagtgagctgagatcacgccactgcagtccagcctgggtaacagagca       c.*180

          .         .         .         .         .         .       g.80264
 agattccatctcaaaaaataaaataaataaataaataaatactggtttttacctgtagaa       c.*240

          .         .                                               g.80292
 ttcttacaataaatatagcttgatattc                                       c.*268

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Junctional adhesion molecule 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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