junctophilin 1 (JPH1) - coding DNA reference sequence

(used for variant description)

(last modified September 26, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_020647.2 in the JPH1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000008.10, covering JPH1 transcript NM_020647.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5040
                     tccgtgcccctgcggggagcgcgccggggctgccccccga       c.-1

          .         .         .         .         .         .       g.5100
 ATGACGGGCGGAAGGTTCGACTTCGACGATGGCGGCACCTACTGCGGCGGCTGGGAGGAG       c.60
 M  T  G  G  R  F  D  F  D  D  G  G  T  Y  C  G  G  W  E  E         p.20

          .         .         .         .         .         .       g.5160
 GGCAAGGCGCACGGGCATGGCATCTGCACGGGGCCCAAGGGCCAGGGCGAGTACTCGGGC       c.120
 G  K  A  H  G  H  G  I  C  T  G  P  K  G  Q  G  E  Y  S  G         p.40

          .         .         .         .         .         .       g.5220
 TCCTGGTCGCACGGCTTCGAGGTGGTCGGAGGCTACACCTGGCCCAGCGGCAACACCTAC       c.180
 S  W  S  H  G  F  E  V  V  G  G  Y  T  W  P  S  G  N  T  Y         p.60

          .         .         .         .         .         .       g.5280
 CAGGGCTACTGGGCGCAGGGCAAGCGGCACGGGCTGGGGGTGGAGACGAAGGGCAAGTGG       c.240
 Q  G  Y  W  A  Q  G  K  R  H  G  L  G  V  E  T  K  G  K  W         p.80

          .         .         .         .         .         .       g.5340
 ATGTACCGGGGGGAGTGGTCACATGGTTTCAAGGGGCGCTACGGGGTCCGGCAGAGCCTG       c.300
 M  Y  R  G  E  W  S  H  G  F  K  G  R  Y  G  V  R  Q  S  L         p.100

          .         .         .         .         .         .       g.5400
 TGCACCCCCGCTCGCTACGAGGGTACCTGGAGTAACGGGCTGCAAGACGGGTACGGCGTG       c.360
 C  T  P  A  R  Y  E  G  T  W  S  N  G  L  Q  D  G  Y  G  V         p.120

          .          | 02        .         .         .         .    g.10748
 GAGACCTACGGGGACGGAG | GTACCTACCAGGGCCAGTGGGCCGGAGGCATGCGGCATGGC    c.420
 E  T  Y  G  D  G  G |   T  Y  Q  G  Q  W  A  G  G  M  R  H  G      p.140

          .         .         .         .         .         .       g.10808
 TACGGCGTGCGCCAGAGCGTGCCCTACGGCATGGCCACGGTGATCCGCTCACCGCTGCGT       c.480
 Y  G  V  R  Q  S  V  P  Y  G  M  A  T  V  I  R  S  P  L  R         p.160

          .         .         .         .         .         .       g.10868
 ACCTCGCTGGCCTCGCTGCGCAGCGAGCAGAGCAATGGCAGCGTGCTCCACGACGCCGCA       c.540
 T  S  L  A  S  L  R  S  E  Q  S  N  G  S  V  L  H  D  A  A         p.180

          .         .         .         .         .         .       g.10928
 GCCGCCGCCGACAGCCCGGCCGGCACCCGCGGCGGTTTCGTGCTCAACTTCCACGCAGAC       c.600
 A  A  A  D  S  P  A  G  T  R  G  G  F  V  L  N  F  H  A  D         p.200

          .         .         .         .         .         .       g.10988
 GCTGAGCTAGCGGGCAAGAAGAAGGGCGGCCTCTTCCGGAGGGGCTCCCTTCTTGGAAGC       c.660
 A  E  L  A  G  K  K  K  G  G  L  F  R  R  G  S  L  L  G  S         p.220

          .         .         .         .         .         .       g.11048
 ATGAAACTTCGCAAGTCCGAATCCAAGTCTTCCATCTCGAGCAAGCGCAGCTCTGTCCGC       c.720
 M  K  L  R  K  S  E  S  K  S  S  I  S  S  K  R  S  S  V  R         p.240

          .         .         .         .         .         .       g.11108
 AGCGACGCGGCCATGAGCAGAATTAGTTCCAGCGATGCCAACTCCACGATCAGCTTTGGC       c.780
 S  D  A  A  M  S  R  I  S  S  S  D  A  N  S  T  I  S  F  G         p.260

          .         .         .         .         .         .       g.11168
 GATGTAGATTGTGATTTTTGCCCGGTGGAAGACCACGTGGACGCCACCACCACGGAAACC       c.840
 D  V  D  C  D  F  C  P  V  E  D  H  V  D  A  T  T  T  E  T         p.280

          .         .         .         .         .         .       g.11228
 TACATGGGCGAGTGGAAGAACGACAAGCGCAACGGCTTCGGCGTTAGCGAGCGCTCCAAT       c.900
 Y  M  G  E  W  K  N  D  K  R  N  G  F  G  V  S  E  R  S  N         p.300

          .         .         .         .         .         .       g.11288
 GGCATGAAGTATGAAGGGGAGTGGGCAAATAACAAGAGGCATGGATATGGCTGTACCGTG       c.960
 G  M  K  Y  E  G  E  W  A  N  N  K  R  H  G  Y  G  C  T  V         p.320

          .         .         .         .         .         .       g.11348
 TTTCCTGACGGCTCCAAAGAAGAGGGAAAATACAAAAATAATATTCTGGTCCGTGGGATA       c.1020
 F  P  D  G  S  K  E  E  G  K  Y  K  N  N  I  L  V  R  G  I         p.340

          .         .         .         .         .         .       g.11408
 AGGAAGCAGCTTATACCAATAAGACATACAAAAACTAGGGAGAAGGTGGACAGAGCAATT       c.1080
 R  K  Q  L  I  P  I  R  H  T  K  T  R  E  K  V  D  R  A  I         p.360

          .         .         .         .         .          | 03    g.66825
 GAAGGCGCCCAAAGGGCAGCTGCCATGGCCAGAACCAAAGTGGAAATAGCAAATTCAAG | G    c.1140
 E  G  A  Q  R  A  A  A  M  A  R  T  K  V  E  I  A  N  S  R  |      p.380

          .         .         .         .         .         .       g.66885
 ACTGCACATGCCAGAGCGAAGGCCGATGCCGCCGACCAGGCCGCGCTGGCCGCTCGCCAG       c.1200
 T  A  H  A  R  A  K  A  D  A  A  D  Q  A  A  L  A  A  R  Q         p.400

          .         .         .         .         .         | 04    g.81154
 GAGTGCGACATCGCGAGAGCTGTGGCCAGGGAGCTGTCACCTGATTTCTACCAACCAG | GC    c.1260
 E  C  D  I  A  R  A  V  A  R  E  L  S  P  D  F  Y  Q  P  G |       p.420

          .         .         .         .         .         .       g.81214
 CCTGATTACGTCAAACAGAGATTTCAGGAAGGTGTAGATGCTAAAGAAAATCCAGAAGAA       c.1320
 P  D  Y  V  K  Q  R  F  Q  E  G  V  D  A  K  E  N  P  E  E         p.440

          .         .         .         .         .         .       g.81274
 AAGGTACCAGAAAAGCCACCTACACCAAAGGAGTCTCCTCATTTTTATCGCAAAGGCACG       c.1380
 K  V  P  E  K  P  P  T  P  K  E  S  P  H  F  Y  R  K  G  T         p.460

          .         .         .         .         .         .       g.81334
 ACACCCCCAAGATCTCCTGAGGCAAGTCCCAAACACAGCCACTCTCCTGCTTCCTCCCCA       c.1440
 T  P  P  R  S  P  E  A  S  P  K  H  S  H  S  P  A  S  S  P         p.480

          .         .         .         .         .         .       g.81394
 AAGCCCCTGAAGAAGCAAAACCCCAGCTCAGGGGCGAGACTCAACCAAGACAAAAGGAGT       c.1500
 K  P  L  K  K  Q  N  P  S  S  G  A  R  L  N  Q  D  K  R  S         p.500

          .         .         .         .         .         .       g.81454
 GTGGCTGATGAGCAGGTGACGGCCATTGTCAATAAGCCCTTGATGTCAAAGGCTCCCACG       c.1560
 V  A  D  E  Q  V  T  A  I  V  N  K  P  L  M  S  K  A  P  T         p.520

          .         .         .         .         .         .       g.81514
 AAGGAGGCAGGAGCGGTTGTGCCCCAGTCCAAGTACTCTGGCCGCCACCACATCCCCAAC       c.1620
 K  E  A  G  A  V  V  P  Q  S  K  Y  S  G  R  H  H  I  P  N         p.540

          .         .         .         .         .         .       g.81574
 CCCAGTAACGGGGAGCTGCATTCTCAGTATCACGGCTACTACGTGAAGCTGAACGCCCCC       c.1680
 P  S  N  G  E  L  H  S  Q  Y  H  G  Y  Y  V  K  L  N  A  P         p.560

          .         .         .         .         .         .       g.81634
 CAGCACCCTCCAGTAGACGTGGAGGACGGCGATGGATCCAGCCAGTCTTCCTCAGCACTG       c.1740
 Q  H  P  P  V  D  V  E  D  G  D  G  S  S  Q  S  S  S  A  L         p.580

          .         .         .         .         .         .       g.81694
 GTGCACAAGCCATCCGCTAACAAGTGGAGTCCCTCCAAATCTGTGACAAAACCAGTTGCC       c.1800
 V  H  K  P  S  A  N  K  W  S  P  S  K  S  V  T  K  P  V  A         p.600

          .         .         .         .         .         .       g.81754
 AAAGAAAGCAAAGCTGAGCCAAAAGCTAAGAAGTCTGAACTTGCTATACCAAAGAATCCA       c.1860
 K  E  S  K  A  E  P  K  A  K  K  S  E  L  A  I  P  K  N  P         p.620

          .         .         .         .      | 05  .         .    g.89039
 GCAAGCAACGATTCATGCCCTGCTTTGGAAAAAGAAGCCAATTCA | GGCCCTAATTCAATC    c.1920
 A  S  N  D  S  C  P  A  L  E  K  E  A  N  S   | G  P  N  S  I      p.640

          .         .         .         .         .         .       g.89099
 ATGATTGTCCTTGTCATGCTGTTGAATATCGGGTTGGCCATTCTTTTTGTTCACTTTCTA       c.1980
 M  I  V  L  V  M  L  L  N  I  G  L  A  I  L  F  V  H  F  L         p.660

                                                                g.89105
 ACTTGA |                                                          c.1987
 T  X                                                            p.661

          .      | 06  .         .         .         .         .    g.89337
 ttggaattaggaaag | tgaagtcctgacaactagtggtgtgttagcccacagttctctgca    c.*60

          .         .         .         .         .         .       g.89397
 gtggtgccgtcagccctttaaatggcccaccccaggcagactcagacacagggaaggagg       c.*120

          .         .         .         .         .         .       g.89457
 cttggaattaggatgggatcgcgagagagatgaaacttggaaaattcagccagaggacct       c.*180

          .         .         .         .         .         .       g.89517
 gttcggttcccctgggagtgctttgtggctttggggtcctctgggagctgaagcacacgg       c.*240

          .         .         .         .         .         .       g.89577
 ccatgttggagagcaaaacttaataataattcttttttaaaatctgctgaagcagcccca       c.*300

          .         .         .         .         .         .       g.89637
 tccggcgaagttcttggcattggctactccatctgtcctagcagagtgtgactaaactgg       c.*360

          .         .         .         .         .         .       g.89697
 aaatgtatggagctgcattttttttttttttttgatggaagtcaacagctgccttactat       c.*420

          .         .         .         .         .         .       g.89757
 tttaccatctgacgtttttagtagggagctggggaaacgactgcccgaggaatgcggtcg       c.*480

          .         .         .         .         .         .       g.89817
 gaggattgtgttgctgtggacgtggttccaacattcactcctatctcattagaagaaata       c.*540

          .         .         .         .         .         .       g.89877
 ggtagcagcatcactcaccagtcttatgccatgacctgctgctttaacatctcctggaat       c.*600

          .         .         .         .         .         .       g.89937
 gttctgggagagaacgtttcgtttgcttgtgcacgactctgttcatttttgctgtttatt       c.*660

          .         .         .         .         .         .       g.89997
 taaatctgacgtatagtcatctaccacctgcggtcctggccggacgaaacacacgtgttg       c.*720

          .         .         .         .         .         .       g.90057
 catctcaaggaaaagaaacaacaaaatgctagtgaaaatgtgcttattttgatagcaata       c.*780

          .         .         .         .         .         .       g.90117
 taccatcttttatgtcatttattcttcctatacttgtaaaaggttatttatctttaaaat       c.*840

          .         .         .         .         .         .       g.90177
 ttagcaatttgaagacactatgccttcctaagaactaatttaattctaaatatttttaac       c.*900

          .         .         .         .         .         .       g.90237
 attactgaggtgaattatttatgcacttaggaagtgctaaattttaaaagctgaaacaca       c.*960

          .         .         .         .         .         .       g.90297
 acagaattctaagaaatatagtccaaacgttgcatggattgcagtaatcagtgtttaaag       c.*1020

          .         .         .         .         .         .       g.90357
 gattcagtttctttgctgacgtactttacaaccaaataaaatcttgtcggtggctgtgtt       c.*1080

          .         .         .         .         .         .       g.90417
 aattcccatgaaagttaagcaagatgctattaataaactgctctgctctttcttgttttc       c.*1140

          .         .         .         .         .         .       g.90477
 tttttccaacttaaatttctgttgaatacattcaggtagaacataaagccttgttcaatc       c.*1200

          .         .         .         .         .         .       g.90537
 actgcctctcagttttctgcctttcctgtttttcaaagtccttttgtaatttcatttcac       c.*1260

          .         .         .         .         .         .       g.90597
 attttaaaggcttagacatttttattttaaatatgtgtcttttacagtcttttgtcattc       c.*1320

          .         .         .         .         .         .       g.90657
 tgacatttctggatttttgctgttttataatttaccctttgttattcagaagcatgctta       c.*1380

          .         .         .         .         .         .       g.90717
 cttatagaaactaaatggtctttataaaagtaattacttaaaaagaaatcaggggaagaa       c.*1440

          .         .         .         .         .         .       g.90777
 agatatctatctaatctattaaatctttataaaacattacattgcagagggggagctact       c.*1500

          .         .         .         .         .         .       g.90837
 cctaaatattttcatgatttgcatggtttaatcagatttttttttttttttacaccatat       c.*1560

          .         .         .         .         .         .       g.90897
 tagctaccttttcaatggagaagagacagttcacacaattccctggttagcacagatgtg       c.*1620

          .         .         .         .         .         .       g.90957
 gactgagtgctttgtcacctgcagggtagtaacccagtgatgtttcttacagaagcacaa       c.*1680

          .         .         .         .         .         .       g.91017
 tatgttgaaaatcctgggtgtgaccaatatggaataaagaagaaggcagaaagagagcaa       c.*1740

          .         .         .         .         .         .       g.91077
 atgaaaaatttcaacttgtatattcattttttacattttgctttgacttttaaatttagg       c.*1800

          .         .         .         .         .         .       g.91137
 aagtccgtttttacctgagaacaaatgtttaaagttcctgcgtcactctcagtactctca       c.*1860

          .         .         .         .         .         .       g.91197
 ctgcccctcccaaaccctatagctccttacgctgggaaagctggttttttaaaaaaataa       c.*1920

          .         .         .         .         .         .       g.91257
 taataaaatatttaatcttattaagtgttcatttaaaatgcgtaatgctttggaaataat       c.*1980

          .         .         .         .         .         .       g.91317
 gggtaacagatagcgagaggatatgtttataaagtgagcatgttggtcccatttataaat       c.*2040

          .         .         .         .         .         .       g.91377
 atatgtatgatttataagcttttttaaaacaaagctcaaattgttggtatttttctaaaa       c.*2100

          .         .         .         .         .         .       g.91437
 tgtgcacagctgtattttacatgaaggctctttctaatgggttgttatactgtactcaac       c.*2160

          .         .         .         .         .         .       g.91497
 attttggacagcacatgaagtctgccaatgtacttaataaaacatgactttgtttattta       c.*2220

          .         .         .         .         .         .       g.91557
 aagtttcttgctgtgaaaaagaactccctacctgtgagttcctttatttataattcttga       c.*2280

          .         .         .         .         .         .       g.91617
 aaccaaaatgtataatgtacagttttcacaactgtatctgctctaataaaaaaaagttgg       c.*2340

                                                                    g.91624
 ttattaa                                                            c.*2347

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Junctophilin 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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