junctophilin 2 (JPH2) - coding DNA reference sequence

(used for variant description)

(last modified June 6, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_020433.4 in the JPH2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000020.10, covering JPH2 transcript NM_020433.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5033
                            ggattttcagtgttccaggactgggtgttctgc       c.-841

 .         .         .         .         .         .                g.5093
 tggtctccctctcccctcccttccccgattccccggtgccctccctgcgcgcagacccag       c.-781

 .         .         .         .         .         .                g.5153
 gggactctgagaatggaagggagctctcattcccgggaggaaaagacaccaggttccctg       c.-721

 .         .         .         .         .         .                g.5213
 ggctgcctgcactcagttctcagcctccttcctcatgcctccagccactgcccgggtctg       c.-661

 .         .         .         .         .         .                g.5273
 cggcacgggcgcgatttgaaatacccctccttcccgctttgaagaaggctgggctggctg       c.-601

 .         .         .         .         .         .                g.5333
 ggggttattttgggagcagcttctgagatccaatggccttgttagggcaacactgacctt       c.-541

 .         .         .         .         .         .                g.5393
 tccgtcccagaaggagggcaggattggagaagggggcggggcagcggcggggagaccgac       c.-481

 .         .         .         .         .         .                g.5453
 agccccgcacacccactggggtggagaagggggccagcgggctgcgggaattcagcctcc       c.-421

 .         .         .         .         .         .                g.5513
 ggcgggggctgccaccgaggggaatttcccctctttgaaaaggctggggacccctccacc       c.-361

 .         .         .         .         .         .                g.5573
 ccaccctttcactgggcttcttaaagagatcacaccgttttcccttggacttcttggaag       c.-301

 .         .         .         .         .         .                g.5633
 gcagacttgggacgctttgtggggactttgaacctttccttcctgctttctttccagcag       c.-241

 .         .         .         .         .         .                g.5693
 gcagccttgctctggctggtggagtcggggctcccgggcatggcactgactagccgaccc       c.-181

 .         .         .         .         .         .                g.5753
 ggtgctgacttggcgccggggctctttcagcctctgctggcatcctgcttcccccctcct       c.-121

 .         .         .         .         .         .                g.5813
 ggggtgcagtggtgagtctgggggcctgcccccgagggcactggaggagtgttgcaggca       c.-61

 .         .         .         .         .         .                g.5873
 tcacccacgccctctgcacccacgctggaggacggggaggttgtcaggggctatgatgag       c.-1

          .         .         .         .         .         .       g.5933
 ATGAGTGGGGGCCGCTTCGACTTTGATGATGGAGGGGCGTACTGCGGGGGCTGGGAGGGG       c.60
 M  S  G  G  R  F  D  F  D  D  G  G  A  Y  C  G  G  W  E  G         p.20

          .         .         .         .         .         .       g.5993
 GGAAAGGCCCATGGGCATGGACTGTGCACAGGCCCCAAGGGCCAGGGCGAATACTCTGGC       c.120
 G  K  A  H  G  H  G  L  C  T  G  P  K  G  Q  G  E  Y  S  G         p.40

          .         .         .         .         .         .       g.6053
 TCCTGGAACTTTGGCTTTGAGGTGGCAGGTGTCTACACCTGGCCCAGCGGAAACACCTTT       c.180
 S  W  N  F  G  F  E  V  A  G  V  Y  T  W  P  S  G  N  T  F         p.60

          .         .         .         .         .         .       g.6113
 GAGGGATACTGGAGCCAGGGCAAACGGCATGGGCTGGGCATAGAGACCAAGGGGCGCTGG       c.240
 E  G  Y  W  S  Q  G  K  R  H  G  L  G  I  E  T  K  G  R  W         p.80

          .         .         .         .         .         .       g.6173
 CTCTACAAGGGCGAGTGGACACATGGCTTCAAGGGACGCTACGGAATCCGGCAGAGCTCA       c.300
 L  Y  K  G  E  W  T  H  G  F  K  G  R  Y  G  I  R  Q  S  S         p.100

          .         .         .         .         .         .       g.6233
 AGCAGCGGTGCCAAGTATGAGGGCACCTGGAACAATGGCCTGCAAGACGGCTATGGCACC       c.360
 S  S  G  A  K  Y  E  G  T  W  N  N  G  L  Q  D  G  Y  G  T         p.120

          .          | 02        .         .         .         .    g.32212
 GAGACCTATGCTGATGGAG | GGACGTACCAAGGCCAGTTCACCAACGGCATGCGCCATGGC    c.420
 E  T  Y  A  D  G  G |   T  Y  Q  G  Q  F  T  N  G  M  R  H  G      p.140

          .         .         .         .         .         .       g.32272
 TACGGAGTACGCCAGAGCGTGCCCTACGGGATGGCCGTGGTGGTGCGCTCGCCGCTGCGC       c.480
 Y  G  V  R  Q  S  V  P  Y  G  M  A  V  V  V  R  S  P  L  R         p.160

          .         .         .         .         .         .       g.32332
 ACGTCGCTGTCGTCCCTGCGCAGCGAGCACAGCAACGGCACGGTGGCCCCGGACTCTCCC       c.540
 T  S  L  S  S  L  R  S  E  H  S  N  G  T  V  A  P  D  S  P         p.180

          .         .         .         .         .         .       g.32392
 GCCTCGCCGGCCTCCGACGGCCCCGCGCTGCCCTCGCCCGCCATCCCGCGTGGCGGCTTC       c.600
 A  S  P  A  S  D  G  P  A  L  P  S  P  A  I  P  R  G  G  F         p.200

          .         .         .         .         .         .       g.32452
 GCGCTCAGCCTCCTGGCCAATGCCGAGGCGGCCGCGCGGGCGCCCAAGGGCGGCGGCCTC       c.660
 A  L  S  L  L  A  N  A  E  A  A  A  R  A  P  K  G  G  G  L         p.220

          .         .         .         .         .         .       g.32512
 TTCCAGCGGGGCGCGCTGCTGGGCAAGCTGCGGCGCGCAGAGTCGCGCACGTCCGTGGGT       c.720
 F  Q  R  G  A  L  L  G  K  L  R  R  A  E  S  R  T  S  V  G         p.240

          .         .         .         .         .         .       g.32572
 AGCCAGCGCAGCCGTGTCAGCTTCCTTAAGAGCGACCTCAGCTCGGGCGCCAGCGACGCC       c.780
 S  Q  R  S  R  V  S  F  L  K  S  D  L  S  S  G  A  S  D  A         p.260

          .         .         .         .         .         .       g.32632
 GCGTCCACCGCCAGCCTGGGAGAGGCCGCCGAGGGCGCCGACGAGGCCGCACCCTTCGAG       c.840
 A  S  T  A  S  L  G  E  A  A  E  G  A  D  E  A  A  P  F  E         p.280

          .         .         .         .         .         .       g.32692
 GCCGATATCGACGCCACCACCACCGAGACCTACATGGGCGAGTGGAAGAACGACAAACGC       c.900
 A  D  I  D  A  T  T  T  E  T  Y  M  G  E  W  K  N  D  K  R         p.300

          .         .         .         .         .         .       g.32752
 TCGGGCTTCGGCGTGAGCGAACGCTCCAGTGGCCTCCGCTACGAGGGCGAGTGGCTGGAC       c.960
 S  G  F  G  V  S  E  R  S  S  G  L  R  Y  E  G  E  W  L  D         p.320

          .         .         .         .         .         .       g.32812
 AACCTGCGCCACGGCTATGGCTGCACCACGCTGCCCGACGGCCACCGCGAGGAGGGCAAG       c.1020
 N  L  R  H  G  Y  G  C  T  T  L  P  D  G  H  R  E  E  G  K         p.340

          .         .         .         .         .         .       g.32872
 TACCGCCACAACGTGCTGGTCAAGGACACCAAGCGCCGCATGCTGCAGCTCAAGAGCAAC       c.1080
 Y  R  H  N  V  L  V  K  D  T  K  R  R  M  L  Q  L  K  S  N         p.360

          .         .         .         .         .         .       g.32932
 AAGGTCCGCCAGAAAGTGGAGCACAGTGTGGAGGGTGCCCAGCGCGCCGCTGCTATCGCG       c.1140
 K  V  R  Q  K  V  E  H  S  V  E  G  A  Q  R  A  A  A  I  A         p.380

          .         .          | 03        .         .         .    g.73986
 CGCCAGAAGGCCGAGATTGCCGCCTCCAG | GACAAGCCACGCCAAGGCCAAAGCTGAGGCA    c.1200
 R  Q  K  A  E  I  A  A  S  R  |  T  S  H  A  K  A  K  A  E  A      p.400

          .         .         .         .         .         .       g.74046
 GCGGAACAGGCCGCCCTGGCTGCCAACCAGGAGTCCAACATTGCTCGCACTTTGGCCAGG       c.1260
 A  E  Q  A  A  L  A  A  N  Q  E  S  N  I  A  R  T  L  A  R         p.420

          .         .         | 04         .         .         .    g.76224
 GAGCTGGCTCCGGACTTCTACCAGCCAG | GTCCGGAATATCAGAAGCGCCGGCTGCTGCAG    c.1320
 E  L  A  P  D  F  Y  Q  P  G |   P  E  Y  Q  K  R  R  L  L  Q      p.440

          .         .         .         .         .         .       g.76284
 GAGATCCTGGAGAACTCGGAGAGCCTGCTGGAGCCCCCCGACCGGGGCGCCGGCGCAGCG       c.1380
 E  I  L  E  N  S  E  S  L  L  E  P  P  D  R  G  A  G  A  A         p.460

          .         .         .         .         .         .       g.76344
 GGCCTCCCACAGCCGCCCCGCGAGAGCCCGCAGCTGCACGAGCGTGAGACCCCTCGGCCC       c.1440
 G  L  P  Q  P  P  R  E  S  P  Q  L  H  E  R  E  T  P  R  P         p.480

          .         .         .         .         .         .       g.76404
 GAGGGTGGCTCCCCGTCACCGGCCGGGACGCCCCCGCAGCCCAAGCGGCCCAGGCCCGGG       c.1500
 E  G  G  S  P  S  P  A  G  T  P  P  Q  P  K  R  P  R  P  G         p.500

          .         .         .         .         .         .       g.76464
 GTGTCCAAGGACGGCCTGCTGAGCCCAGGCGCCTGGAACGGCGAGCCCAGCGGTGAGGGC       c.1560
 V  S  K  D  G  L  L  S  P  G  A  W  N  G  E  P  S  G  E  G         p.520

          .         .         .         .         .         .       g.76524
 AGCCGGTCAGTCACTCCGTCCGAGGGCGCGGGCCGCCGCAGCCCCGCGCGTCCAGCCACC       c.1620
 S  R  S  V  T  P  S  E  G  A  G  R  R  S  P  A  R  P  A  T         p.540

          .         .         .         .         .         .       g.76584
 GAGCGCATGGCCATCGAGGCTCTGCAGGCACCGCCTGCGCCGTCGCGGGAGCCGGAGGTG       c.1680
 E  R  M  A  I  E  A  L  Q  A  P  P  A  P  S  R  E  P  E  V         p.560

          .         .         .         .         .         .       g.76644
 GCGCTTTACCAGGGCTACCACAGCTATGCTGTGCGCACCACGCCGCCCGAGCCCCCACCC       c.1740
 A  L  Y  Q  G  Y  H  S  Y  A  V  R  T  T  P  P  E  P  P  P         p.580

          .         .         .         .         .         .       g.76704
 TTTGAGGACCAGCCCGAGCCCGAGGTCTCCGGGTCCGAGTCCGCGCCCTCGTCCCCGGCC       c.1800
 F  E  D  Q  P  E  P  E  V  S  G  S  E  S  A  P  S  S  P  A         p.600

          .         .         .         .         .         .       g.76764
 ACCGCCCCGCTGCAGGCCCCCACGCTCCGAGGCCCCGAGCCTGCACGCGAGACCCCCGCC       c.1860
 T  A  P  L  Q  A  P  T  L  R  G  P  E  P  A  R  E  T  P  A         p.620

          .         .         .         .         .         .       g.76824
 AAGCTGGAGCCCAAGCCCATCATCCCCAAAGCCGAGCCCAGGGCCAAGGCCCGCAAGACT       c.1920
 K  L  E  P  K  P  I  I  P  K  A  E  P  R  A  K  A  R  K  T         p.640

          .         .         .         .         .         .       g.76884
 GAGGCTCGAGGGCTGACCAAGGCGGGGGCCAAGAAGAAGGCGCGGAAGGAGGCCGCACTG       c.1980
 E  A  R  G  L  T  K  A  G  A  K  K  K  A  R  K  E  A  A  L         p.660

          .         .         . | 05       .         .         .    g.77732
 GCGGCAGAGGCGGAGGTGGAGGTGGAAGAG | GTCCCCAACACCATCCTCATCTGCATGGTG    c.2040
 A  A  E  A  E  V  E  V  E  E   | V  P  N  T  I  L  I  C  M  V      p.680

          .         .         .         .         .                 g.77783
 ATCCTGCTGAACATCGGCCTGGCCATCCTCTTTGTTCACCTCCTGACCTGA                c.2091
 I  L  L  N  I  G  L  A  I  L  F  V  H  L  L  T  X                  p.696

          .     | 06   .         .         .         .         .    g.79121
 ccgtcgcttaccag | agccagaagttcctgctgaggacatgaggacccgtctttttgcagt    c.*60

          .         .         .         .         .         .       g.79181
 gccaggcagggtggccaaagaggactggactctggacctggagccccgtggtccagttca       c.*120

          .         .         .         .         .         .       g.79241
 cattcaccccacaagagtttcaggaggcctcccacggtgcctgtgctgggtggcggtggt       c.*180

          .         .         .         .         .         .       g.79301
 ggtgccaagaggaatggaatgtcctgggctccttcaggagctctctacccaggggcaagg       c.*240

          .         .         .         .         .         .       g.79361
 agagcccagagagaagcgccctggtctcttgagcttcctgatctgctcctgtcccccgct       c.*300

          .         .         .         .         .         .       g.79421
 ctcctccactcccttgcctttccctaggttgtcccctccctgggcttttgtgtgttttgg       c.*360

          .         .         .         .         .         .       g.79481
 gagatgtcacctaaccaggacattgatattcaatcccatcccccttcctcccaccctgcc       c.*420

          .         .         .         .         .         .       g.79541
 ccactttgatttaatcctttggctgtgggctgaggcctcccagggaagctgggtggggtg       c.*480

          .         .         .         .         .         .       g.79601
 ggtgttgagaccccctcagaccagcacagagacctgtccttgtgcagtctgcaccctgca       c.*540

          .         .         .         .         .         .       g.79661
 ctccctcccttgcctgtagatgttctggatgacagtagaggaaatggacaaggtcagttt       c.*600

          .         .         .         .         .         .       g.79721
 gaatatcccagaacacagtgctctgtctcctcccaccagtccagttagcttcccttctgg       c.*660

          .         .         .         .         .         .       g.79781
 accaatagacgaggggagaccccatggatcctctggctgggaagccactgaccaggtggc       c.*720

          .         .         .         .         .         .       g.79841
 cagggggcagggtgggaagaggggttaaggtgcagtgatgatggcctgttttggagtgtg       c.*780

          .         .         .         .         .         .       g.79901
 tctgagactgggattgcatttggggtttcccgtgtgcttgggatgctagagggtcacctg       c.*840

          .         .         .         .         .         .       g.79961
 caggaggcctggggccggcgagaaatctcctgtgatgccctgtgaaatggcttgtctcct       c.*900

          .         .         .         .         .         .       g.80021
 cccccatcagggcccaccgaaagctcaggggagcacagaagcccatggaagcccagggag       c.*960

          .         .         .         .         .         .       g.80081
 atgtccctggggcagacactaaggcaggtgttgaagacaagctgcttgtcaagaagcatt       c.*1020

          .         .         .         .         .         .       g.80141
 tcccggcaagagaggggcaagtctggggctccaactgggtacagcctgggtgcagttata       c.*1080

          .         .         .         .         .         .       g.80201
 agcccctttggcttacttggtagaagatggctacttggatgtacctcacttaaagatgtt       c.*1140

          .         .         .         .         .         .       g.80261
 ttgtaccacactaggtctctgggcccttgtgcttcctgtgggtggggtgagggccaaagg       c.*1200

          .         .         .         .         .         .       g.80321
 ctatggtttcctgcctccaggagaatggagagaaagggcttccaggcccctccaagcctg       c.*1260

          .         .         .         .         .         .       g.80381
 gggaaggacgtggcatccaagctgagccagagggaactgctgctgtcctcccttcatttc       c.*1320

          .         .         .         .         .         .       g.80441
 tgtggaccttggaggctttggctttgtggcagggcctccccaggcagctctgggacctag       c.*1380

          .         .         .         .         .         .       g.80501
 gagtttgcttctgatagggtcagctttcccatttcccttcaatgcttgggaaccttctcc       c.*1440

          .         .         .         .         .         .       g.80561
 cttagcttcacacttgccgtttcaagccctgctgggaccttgtggcttggctggaatcca       c.*1500

          .         .         .         .         .         .       g.80621
 ggactgtattttcatggagaagaacctgcagattcttccatcctcagctggccatggccc       c.*1560

          .         .         .         .         .         .       g.80681
 acagctctgcatctgcatctgagcttctcaagactcctggagcatgaggggaatggggcg       c.*1620

          .         .         .         .         .         .       g.80741
 gggccactgctctgtgctgacgggctccgtctcggagattcttgtcctgttttttttctg       c.*1680

          .         .         .         .         .         .       g.80801
 ttgtttttttttggctggtgctggggacaagcctgtgcctgccaaagctcccaggccaag       c.*1740

          .         .         .         .         .         .       g.80861
 tttgggggctggtgtttggggttgggtttggggttcaggatgctgcagtctgtgcaataa       c.*1800

          .         .                                               g.80882
 taaacccgcatctgctcacgg                                              c.*1821

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Junctophilin 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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