lysyl-tRNA synthetase (KARS) - coding DNA reference sequence

(used for variant description)

(last modified August 31, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_001130089.1 in the KARS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_028025.1, covering KARS transcript NM_001130089.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5024
                                     aaattaacgtactatcctccttac       c.-121

 .         .         .         .         .         .                g.5084
 ttttgggtcgggccctccgggaagatggcggccgtgcaggcggccgaggtgaaagtggat       c.-61

 .         .         .      | 02  .         .         .             g.8259
 ggcagcgagccgaaactgagcaagaa | gtggtggtaatcattagttccagggtgctctgcc    c.-1

          .         .         .         .         .         .       g.8319
 ATGTTGACGCAAGCTGCTGTAAGGCTTGTTAGGGGGTCCCTGCGCAAAACCTCCTGGGCA       c.60
 M  L  T  Q  A  A  V  R  L  V  R  G  S  L  R  K  T  S  W  A         p.20

          .         .         .         .         .         .       g.8379
 GAGTGGGGTCACAGGGAACTGCGACTGGGTCAACTTGCTCCTTTCACAGCGCCTCACAAG       c.120
 E  W  G  H  R  E  L  R  L  G  Q  L  A  P  F  T  A  P  H  K         p.40

          .         .       | 03 .         .         .         .    g.10998
 GACAAGTCATTTTCTGATCAAAGAAG | TGAGCTGAAGAGACGCCTGAAAGCTGAGAAGAAA    c.180
 D  K  S  F  S  D  Q  R  S  |  E  L  K  R  R  L  K  A  E  K  K      p.60

          .         .         .         .         .         .       g.11058
 GTAGCAGAGAAGGAGGCCAAACAGAAAGAGCTCAGTGAGAAACAGCTAAGCCAAGCCACT       c.240
 V  A  E  K  E  A  K  Q  K  E  L  S  E  K  Q  L  S  Q  A  T         p.80

          .         .         .         .         .         .       g.11118
 GCTGCTGCCACCAACCACACCACTGATAATGGTGTGGGTCCTGAGGAAGAGAGCGTGGAC       c.300
 A  A  A  T  N  H  T  T  D  N  G  V  G  P  E  E  E  S  V  D         p.100

        | 04 .         .         .         .         .         .    g.12392
 CCAAAT | CAATACTACAAAATCCGCAGTCAAGCAATTCATCAGCTGAAGGTCAATGGGGAA    c.360
 P  N   | Q  Y  Y  K  I  R  S  Q  A  I  H  Q  L  K  V  N  G  E      p.120

          .         .         .         .         .         .       g.12452
 GACCCATACCCACACAAGTTCCATGTAGACATCTCACTCACTGACTTCATCCAAAAATAT       c.420
 D  P  Y  P  H  K  F  H  V  D  I  S  L  T  D  F  I  Q  K  Y         p.140

          .         .         .         .         .   | 05     .    g.16148
 AGTCACCTGCAGCCTGGGGATCACCTGACTGACATCACCTTAAAGGTGGCAG | GTAGGATC    c.480
 S  H  L  Q  P  G  D  H  L  T  D  I  T  L  K  V  A  G |   R  I      p.160

          .         .         .         .         .         .       g.16208
 CATGCCAAAAGAGCTTCTGGGGGAAAGCTCATCTTCTATGATCTTCGAGGAGAGGGGGTG       c.540
 H  A  K  R  A  S  G  G  K  L  I  F  Y  D  L  R  G  E  G  V         p.180

          .         .       | 06 .         .         .         .    g.16623
 AAGTTGCAAGTCATGGCCAATTCCAG | AAATTATAAATCAGAAGAAGAATTTATTCATATT    c.600
 K  L  Q  V  M  A  N  S  R  |  N  Y  K  S  E  E  E  F  I  H  I      p.200

          .         .         .         .         .         .       g.16683
 AATAACAAACTGCGTCGGGGAGACATAATTGGAGTTCAGGGGAATCCTGGTAAAACCAAG       c.660
 N  N  K  L  R  R  G  D  I  I  G  V  Q  G  N  P  G  K  T  K         p.220

          .         .         .         .         .         .       g.16743
 AAGGGTGAGCTGAGCATCATTCCGTATGAGATCACACTGCTGTCTCCCTGTTTGCATATG       c.720
 K  G  E  L  S  I  I  P  Y  E  I  T  L  L  S  P  C  L  H  M         p.240

          .         .         .    | 07    .         .         .    g.16909
 TTACCTCATCTTCACTTTGGCCTCAAAGACAAG | GAAACAAGGTATCGCCAGAGATACTTG    c.780
 L  P  H  L  H  F  G  L  K  D  K   | E  T  R  Y  R  Q  R  Y  L      p.260

          .         .         .         .         .         .       g.16969
 GACTTGATCCTGAATGACTTTGTGAGGCAGAAATTTATCATCCGCTCTAAGATCATCACA       c.840
 D  L  I  L  N  D  F  V  R  Q  K  F  I  I  R  S  K  I  I  T         p.280

          .         .         .          | 08        .         .    g.18416
 TATATAAGAAGTTTCTTAGATGAGCTGGGATTCCTAGAG | ATTGAAACTCCCATGATGAAC    c.900
 Y  I  R  S  F  L  D  E  L  G  F  L  E   | I  E  T  P  M  M  N      p.300

          .         .         .         .         .         .       g.18476
 ATCATCCCAGGGGGAGCCGTGGCCAAGCCTTTCATCACTTATCACAACGAGCTGGACATG       c.960
 I  I  P  G  G  A  V  A  K  P  F  I  T  Y  H  N  E  L  D  M         p.320

          .         .         .          | 09        .         .    g.20853
 AACTTATATATGAGAATTGCTCCAGAACTCTATCATAAG | ATGCTTGTGGTTGGTGGCATC    c.1020
 N  L  Y  M  R  I  A  P  E  L  Y  H  K   | M  L  V  V  G  G  I      p.340

          .         .         .         .         .         .       g.20913
 GACCGGGTTTATGAAATTGGACGCCAGTTCCGGAATGAGGGGATTGATTTGACGCACAAT       c.1080
 D  R  V  Y  E  I  G  R  Q  F  R  N  E  G  I  D  L  T  H  N         p.360

          .         .         .         .         .         .       g.20973
 CCTGAGTTCACCACCTGTGAGTTCTACATGGCCTATGCAGACTATCACGATCTCATGGAA       c.1140
 P  E  F  T  T  C  E  F  Y  M  A  Y  A  D  Y  H  D  L  M  E         p.380

          .         .   | 10     .         .         .         .    g.21136
 ATCACGGAGAAGATGGTTTCAG | GGATGGTGAAGCATATTACAGGCAGTTACAAGGTCACC    c.1200
 I  T  E  K  M  V  S  G |   M  V  K  H  I  T  G  S  Y  K  V  T      p.400

          .         .         .         .         .         .       g.21196
 TACCACCCAGATGGCCCAGAGGGCCAAGCCTACGATGTTGACTTCACCCCACCCTTCCGG       c.1260
 Y  H  P  D  G  P  E  G  Q  A  Y  D  V  D  F  T  P  P  F  R         p.420

          .         .         .         .         .         .       g.21256
 CGAATCAACATGGTAGAAGAGCTTGAGAAAGCCCTGGGGATGAAGCTGCCAGAAACGAAC       c.1320
 R  I  N  M  V  E  E  L  E  K  A  L  G  M  K  L  P  E  T  N         p.440

          .       | 11 .         .         .         .         .    g.21478
 CTCTTTGAAACTGAAG | AAACTCGCAAAATTCTTGATGATATCTGTGTGGCAAAAGCTGTT    c.1380
 L  F  E  T  E  E |   T  R  K  I  L  D  D  I  C  V  A  K  A  V      p.460

          .         .         .         .   | 12     .         .    g.22197
 GAATGCCCTCCACCTCGGACCACAGCCAGGCTCCTTGACAAG | CTTGTTGGGGAGTTCCTG    c.1440
 E  C  P  P  P  R  T  T  A  R  L  L  D  K   | L  V  G  E  F  L      p.480

          .         .         .         .         .         .       g.22257
 GAAGTGACTTGCATCAATCCTACATTCATCTGTGATCACCCACAGATAATGAGCCCTTTG       c.1500
 E  V  T  C  I  N  P  T  F  I  C  D  H  P  Q  I  M  S  P  L         p.500

          | 13         .         .         .         .         .    g.23198
 GCTAAATG | GCACCGCTCTAAAGAGGGTCTGACTGAGCGCTTTGAGCTGTTTGTCATGAAG    c.1560
 A  K  W  |  H  R  S  K  E  G  L  T  E  R  F  E  L  F  V  M  K      p.520

          .         .         .         .         .         .       g.23258
 AAAGAGATATGCAATGCGTATACTGAGCTGAATGATCCCATGCGGCAGCGGCAGCTTTTT       c.1620
 K  E  I  C  N  A  Y  T  E  L  N  D  P  M  R  Q  R  Q  L  F         p.540

          .      | 14  .         .         .         .         .    g.24020
 GAAGAACAGGCCAAG | GCCAAGGCTGCAGGTGATGATGAGGCCATGTTCATAGATGAAAAC    c.1680
 E  E  Q  A  K   | A  K  A  A  G  D  D  E  A  M  F  I  D  E  N      p.560

          .         .         .         .         .         .       g.24080
 TTCTGTACTGCCCTGGAATATGGGCTGCCCCCCACAGCTGGCTGGGGCATGGGCATTGAT       c.1740
 F  C  T  A  L  E  Y  G  L  P  P  T  A  G  W  G  M  G  I  D         p.580

          .         .         .          | 15        .         .    g.24715
 CGAGTCGCCATGTTTCTCACGGACTCCAACAACATCAAG | GAAGTACTTCTGTTTCCTGCC    c.1800
 R  V  A  M  F  L  T  D  S  N  N  I  K   | E  V  L  L  F  P  A      p.600

          .         .         .         .         .         .       g.24775
 ATGAAACCCGAAGACAAGAAGGAGAATGTAGCAACCACTGATACACTGGAAAGCACAACA       c.1860
 M  K  P  E  D  K  K  E  N  V  A  T  T  D  T  L  E  S  T  T         p.620

          .                                                         g.24793
 GTTGGCACTTCTGTCTAG                                                 c.1878
 V  G  T  S  V  X                                                   p.625

          .         .         .         .         .         .       g.24853
 aaaataataattgcaagttgtataactcaggcgtctttgcatttctgcgaaagatcaagg       c.*60

          .         .         .         .         .         .       g.24913
 tctgcaagggaattcttgtgtgctgctttccatttgacaccgcagttctgttcagccatc       c.*120

          .         .         .         .         .                 g.24964
 agaagagagacaaggaattaaaaatttctttttaatcctgttaccaaataa                c.*171

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Lysyl-tRNA synthetase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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