K(lysine) acetyltransferase 5 (KAT5) - coding DNA reference sequence

(used for variant description)

(last modified August 22, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_006388.3 in the KAT5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033057.1, covering KAT5 transcript NM_006388.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5026
                                   gcacccggtgggcgtcacgtgacgga       c.-241

 .         .         .         .         .         .                g.5086
 ctcagtagaccgccactggctgtgcacgttatggggtttccacctagggctcggcctgag       c.-181

 .         .         .         .         .         .                g.5146
 gcttgtaacactccgttttcccccgagtcacaggggcagtcttgcccctcgcagctgggt       c.-121

 .         .         .         .         .         .                g.5206
 cgcggtgtctctcaaaggtccccctctacaggggcttcgtgaggcccgggcccacagggc       c.-61

 .         .         .         .         .         .                g.5266
 gctcggtcccggaagtgacgtctcccagaggggccggaagtggcagtggagggagggaag       c.-1

          .   | 02     .         .         .         .         .    g.5425
 ATGGCGGAGGTG | GGGGAGATAATCGAGGGCTGCCGCCTACCCGTGCTGCGGCGGAACCAG    c.60
 M  A  E  V   | G  E  I  I  E  G  C  R  L  P  V  L  R  R  N  Q      p.20

          .          | 03        .         .         .         .    g.5805
 GACAACGAAGATGAGTGGC | CCCTGGCCGAGATCCTGAGCGTGAAGGACATCAGTGGCCGG    c.120
 D  N  E  D  E  W  P |   L  A  E  I  L  S  V  K  D  I  S  G  R      p.40

          .         .         | 04         .         .         .    g.5952
 AAGCTTTTCTACGTCCATTACATTGACT | TCAACAAACGTCTGGATGAATGGGTGACGCAT    c.180
 K  L  F  Y  V  H  Y  I  D  F |   N  K  R  L  D  E  W  V  T  H      p.60

          .         .         .         .         .         .       g.6012
 GAGCGGCTGGACCTAAAGAAGATCCAGTTCCCCAAGAAAGAGGCCAAGACCCCCACTAAG       c.240
 E  R  L  D  L  K  K  I  Q  F  P  K  K  E  A  K  T  P  T  K         p.80

          .         .         .         .      | 05  .         .    g.6361
 AACGGACTTCCTGGGTCCCGTCCTGGCTCTCCAGAGAGAGAGGTG | CCGGCCTCGGCGCAG    c.300
 N  G  L  P  G  S  R  P  G  S  P  E  R  E  V   | P  A  S  A  Q      p.100

          .         .         .         .         .         .       g.6421
 GCCAGCGGGAAGACCTTGCCAATCCCGGTCCAGATCACACTCCGCTTCAACCTGCCCAAG       c.360
 A  S  G  K  T  L  P  I  P  V  Q  I  T  L  R  F  N  L  P  K         p.120

          .         .         .         .         .         .       g.6481
 GAGCGGGAGGCCATTCCCGGTGGCGAGCCTGACCAGCCGCTCTCCTCCAGCTCCTGCCTG       c.420
 E  R  E  A  I  P  G  G  E  P  D  Q  P  L  S  S  S  S  C  L         p.140

          .         .  | 06      .         .         .         .    g.6630
 CAGCCCAACCACCGCTCAACG | AAACGGAAGGTGGAGGTGGTTTCACCAGCAACTCCAGTG    c.480
 Q  P  N  H  R  S  T   | K  R  K  V  E  V  V  S  P  A  T  P  V      p.160

          .         .         .       | 07 .         .         .    g.6796
 CCCAGCGAGACAGCCCCGGCCTCGGTTTTTCCCCAG | AATGGAGCCGCCCGTAGGGCAGTG    c.540
 P  S  E  T  A  P  A  S  V  F  P  Q   | N  G  A  A  R  R  A  V      p.180

          .         .         .         .         .  | 08      .    g.7502
 GCAGCCCAGCCAGGACGGAAGCGAAAATCGAATTGTTTGGGCACTGATGAG | GACTCCCAG    c.600
 A  A  Q  P  G  R  K  R  K  S  N  C  L  G  T  D  E   | D  S  Q      p.200

          .         .         .         .         .         .       g.7562
 GACAGCTCTGATGGAATACCGTCAGCACCACGCATGACTGGCAGCCTGGTGTCTGATCGA       c.660
 D  S  S  D  G  I  P  S  A  P  R  M  T  G  S  L  V  S  D  R         p.220

          .         .         .         .         .         .       g.7622
 AGCCACGACGACATCGTCACCCGGATGAAGAACATTGAGTGCATTGAGCTGGGCCGGCAC       c.720
 S  H  D  D  I  V  T  R  M  K  N  I  E  C  I  E  L  G  R  H         p.240

          .         .         .         .         .         .       g.7682
 CGCCTCAAGCCGTGGTACTTCTCCCCGTACCCACAGGAACTCACCACATTGCCTGTCCTC       c.780
 R  L  K  P  W  Y  F  S  P  Y  P  Q  E  L  T  T  L  P  V  L         p.260

          .         .         .         .         .         .       g.7742
 TACCTGTGCGAGTTCTGCCTCAAGTACGGCCGTAGTCTCAAGTGTCTTCAGCGTCATTTG       c.840
 Y  L  C  E  F  C  L  K  Y  G  R  S  L  K  C  L  Q  R  H  L         p.280

  | 09       .         .         .         .         .         .    g.7879
  | ACCAAGTGTGACCTACGACATCCTCCAGGCAATGAGATTTACCGCAAGGGCACCATCTCC    c.900
  | T  K  C  D  L  R  H  P  P  G  N  E  I  Y  R  K  G  T  I  S      p.300

          .         .         . | 10       .         .         .    g.9695
 TTCTTTGAGATTGATGGACGTAAGAACAAG | AGTTATTCCCAGAACCTGTGTCTTTTGGCC    c.960
 F  F  E  I  D  G  R  K  N  K   | S  Y  S  Q  N  L  C  L  L  A      p.320

          .         .         .         .         .         .       g.9755
 AAGTGTTTCCTTGACCATAAGACACTGTACTATGACACAGACCCTTTCCTCTTCTACGTC       c.1020
 K  C  F  L  D  H  K  T  L  Y  Y  D  T  D  P  F  L  F  Y  V         p.340

          .         .         .         .         .  | 11      .    g.9896
 ATGACAGAGTATGACTGTAAGGGCTTCCACATCGTGGGCTACTTCTCCAAG | GAGAAAGAA    c.1080
 M  T  E  Y  D  C  K  G  F  H  I  V  G  Y  F  S  K   | E  K  E      p.360

          .         .         .         .         .         .       g.9956
 TCAACGGAAGACTACAATGTGGCCTGCATCCTAACCCTGCCTCCCTACCAGCGCCGGGGC       c.1140
 S  T  E  D  Y  N  V  A  C  I  L  T  L  P  P  Y  Q  R  R  G         p.380

          .         .      | 12  .         .         .         .    g.11623
 TACGGCAAGCTGCTGATCGAGTTCA | GCTATGAACTCTCCAAAGTGGAAGGGAAAACAGGG    c.1200
 Y  G  K  L  L  I  E  F  S |   Y  E  L  S  K  V  E  G  K  T  G      p.400

          .         .         .         .         .         .       g.11683
 ACCCCTGAGAAGCCCCTCTCAGACCTTGGCCTCCTATCCTATCGAAGCTACTGGTCCCAG       c.1260
 T  P  E  K  P  L  S  D  L  G  L  L  S  Y  R  S  Y  W  S  Q         p.420

          .         .         .         .         .         .       g.11743
 ACCATCCTGGAGATCCTGATGGGGCTGAAGTCGGAGAGCGGGGAGAGGCCACAGATCACC       c.1320
 T  I  L  E  I  L  M  G  L  K  S  E  S  G  E  R  P  Q  I  T         p.440

       | 13  .         .         .         .         .         .    g.11926
 ATCAA | TGAGATTAGTGAAATCACCAGCATCAAGAAGGAGGATGTCATCTCCACTCTGCAG    c.1380
 I  N  |  E  I  S  E  I  T  S  I  K  K  E  D  V  I  S  T  L  Q      p.460

          .         .        | 14.         .         .         .    g.12078
 TACCTCAATCTCATCAACTACTACAAG | GGCCAGTACATCCTCACACTGTCAGAGGACATC    c.1440
 Y  L  N  L  I  N  Y  Y  K   | G  Q  Y  I  L  T  L  S  E  D  I      p.480

          .         .         .         .         .         .       g.12138
 GTGGATGGCCATGAGCGGGCCATGCTCAAGCGGCTCCTGCGGATCGACTCCAAGTGTCTG       c.1500
 V  D  G  H  E  R  A  M  L  K  R  L  L  R  I  D  S  K  C  L         p.500

          .         .         .         .                           g.12180
 CACTTCACTCCCAAGGACTGGAGCAAGAGGGGGAAGTGGTGA                         c.1542
 H  F  T  P  K  D  W  S  K  R  G  K  W  X                           p.513

          .         .         .         .         .         .       g.12240
 ccagacactgcccactgcagtgccaagacggcagcaggactggggctgatagcccacccc       c.*60

          .         .         .         .         .         .       g.12300
 gcccccactgcagctcccacaaagcactctaagggagatggggctgaggacagctcaaaa       c.*120

          .         .         .         .         .         .       g.12360
 aggagaggacaggcctggcaggggcccactggtgcccagcaccaaggcgagctccgggct       c.*180

          .         .         .         .         .         .       g.12420
 cagaccaactccaaggtcagctggccacaggcccaggcctcctctgaagcagggaccaga       c.*240

          .         .         .         .         .         .       g.12480
 gggagccaggcagctgtgtacagtgagaagggatccggatgggggagctctgtacagagg       c.*300

          .         .         .         .         .         .       g.12540
 gctggtgattgtaaaaatttcttttgtaaagtagaagttgggggtggggtgggtgctggc       c.*360

          .         .         .         .         .         .       g.12600
 tgcaaaaatttctggcttctcttacccctattgcccccggcaataaattgtttctatatg       c.*420

                                                                    g.12605
 ccaga                                                              c.*425

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The K(lysine) acetyltransferase 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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