potassium voltage-gated channel, shaker-related subfamily, member 2 (KCNA2) - coding DNA reference sequence

(used for variant description)

(last modified October 21, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_004974.3 in the KCNA2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering KCNA2 transcript NM_004974.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.30142
                                        gtgctccctgccgaggagatg       c.-601

 .         .         .         .         .         .                g.30202
 tgagggattttctcttgggggagaaatcagtggtcgagcgcctgcccagctcaaatgcca       c.-541

 .         .         .         .         .     | 02   .             g.30767
 cccggctcagagggaggcctgcggcccagggatcccggagggaga | gcaacgtcacacctc    c.-481

 .         .         .         .         .         .                g.30827
 ctgaggacagccaggactccagcttttgctgagctttgcatcttgcctccttccttcaaa       c.-421

 .         .         .         .         .         .                g.30887
 aggctccaggcccatgctcggctgtcttcaagtcccgcatgcccctggccaggcacctca       c.-361

 .         .         .         .         .         .                g.30947
 ccgcccctccagcccagcccaatcctagagctcacctccaggacccagagtctgcccttc       c.-301

 .         .         .         .         .         .                g.31007
 tgcccagaatgactcaccattatttctagctcgagtgagaagacgtgatgaggagttggg       c.-241

 .         .         .         .         .         .                g.31067
 ctgcctgttggtgcatctcagattcctgcagcatctgatcagctctgcaaggaagagagc       c.-181

 .         .       | 03 .         .         .         .             g.31572
 ttcacgtctctggtcag | ccaagcgaggctgtctctccagctctcagagagctctcggggc    c.-121

 .         .         .         .         .         .                g.31632
 tctcctgcaggagaccaggccaatgctcctgtgcttcctggggccagtagcagcaccctg       c.-61

 .         .         .         .         .         .                g.31692
 agctccctgccaccaggcagctgaaaggcatagcgtgaggtgcttctctcagtcccaatt       c.-1

          .         .         .         .         .         .       g.31752
 ATGACAGTGGCCACCGGAGACCCAGCAGACGAGGCTGCTGCCCTCCCTGGGCACCCACAG       c.60
 M  T  V  A  T  G  D  P  A  D  E  A  A  A  L  P  G  H  P  Q         p.20

          .         .         .         .         .         .       g.31812
 GACACCTATGACCCAGAGGCAGACCACGAGTGCTGTGAGAGGGTGGTGATCAACATCTCA       c.120
 D  T  Y  D  P  E  A  D  H  E  C  C  E  R  V  V  I  N  I  S         p.40

          .         .         .         .         .         .       g.31872
 GGGCTGCGGTTTGAGACCCAGCTAAAGACCTTAGCCCAGTTTCCAGAGACCCTCTTAGGG       c.180
 G  L  R  F  E  T  Q  L  K  T  L  A  Q  F  P  E  T  L  L  G         p.60

          .         .         .         .         .         .       g.31932
 GACCCAAAGAAACGAATGAGGTACTTTGACCCCCTCCGAAATGAGTACTTTTTCGATCGG       c.240
 D  P  K  K  R  M  R  Y  F  D  P  L  R  N  E  Y  F  F  D  R         p.80

          .         .         .         .         .         .       g.31992
 AACCGCCCTAGCTTTGATGCCATTTTGTACTACTACCAGTCAGGGGGCCGATTGAGGCGA       c.300
 N  R  P  S  F  D  A  I  L  Y  Y  Y  Q  S  G  G  R  L  R  R         p.100

          .         .         .         .         .         .       g.32052
 CCTGTGAATGTGCCCTTAGATATATTCTCTGAAGAAATTCGGTTTTATGAGCTGGGAGAA       c.360
 P  V  N  V  P  L  D  I  F  S  E  E  I  R  F  Y  E  L  G  E         p.120

          .         .         .         .         .         .       g.32112
 GAAGCGATGGAGATGTTTCGGGAAGATGAAGGCTACATCAAGGAGGAAGAGCGTCCTCTG       c.420
 E  A  M  E  M  F  R  E  D  E  G  Y  I  K  E  E  E  R  P  L         p.140

          .         .         .         .         .         .       g.32172
 CCTGAAAATGAGTTTCAGAGACAAGTGTGGCTTCTCTTTGAATACCCAGAGAGCTCAGGG       c.480
 P  E  N  E  F  Q  R  Q  V  W  L  L  F  E  Y  P  E  S  S  G         p.160

          .         .         .         .         .         .       g.32232
 CCTGCCAGGATTATAGCTATTGTGTCTGTCATGGTGATTCTGATCTCAATTGTCAGCTTC       c.540
 P  A  R  I  I  A  I  V  S  V  M  V  I  L  I  S  I  V  S  F         p.180

          .         .         .         .         .         .       g.32292
 TGTCTGGAAACATTGCCCATCTTCCGGGATGAGAATGAAGACATGCATGGTAGTGGGGTG       c.600
 C  L  E  T  L  P  I  F  R  D  E  N  E  D  M  H  G  S  G  V         p.200

          .         .         .         .         .         .       g.32352
 ACCTTCCACACCTATTCCAACAGCACCATCGGGTACCAGCAGTCCACTTCCTTCACAGAC       c.660
 T  F  H  T  Y  S  N  S  T  I  G  Y  Q  Q  S  T  S  F  T  D         p.220

          .         .         .         .         .         .       g.32412
 CCTTTCTTCATTGTAGAGACACTCTGCATCATCTGGTTCTCCTTTGAATTCTTGGTGAGG       c.720
 P  F  F  I  V  E  T  L  C  I  I  W  F  S  F  E  F  L  V  R         p.240

          .         .         .         .         .         .       g.32472
 TTCTTTGCCTGTCCCAGCAAAGCCGGCTTCTTCACCAACATCATGAACATCATTGACATT       c.780
 F  F  A  C  P  S  K  A  G  F  F  T  N  I  M  N  I  I  D  I         p.260

          .         .         .         .         .         .       g.32532
 GTGGCCATCATCCCCTACTTCATCACCCTGGGGACAGAGTTGGCTGAGAAGCCAGAGGAC       c.840
 V  A  I  I  P  Y  F  I  T  L  G  T  E  L  A  E  K  P  E  D         p.280

          .         .         .         .         .         .       g.32592
 GCTCAGCAAGGCCAGCAGGCCATGTCACTGGCCATCCTCCGTGTCATCCGGTTGGTAAGA       c.900
 A  Q  Q  G  Q  Q  A  M  S  L  A  I  L  R  V  I  R  L  V  R         p.300

          .         .         .         .         .         .       g.32652
 GTCTTTAGGATTTTCAAGTTGTCCAGACACTCCAAAGGTCTCCAGATTCTAGGTCAGACC       c.960
 V  F  R  I  F  K  L  S  R  H  S  K  G  L  Q  I  L  G  Q  T         p.320

          .         .         .         .         .         .       g.32712
 CTCAAAGCCAGCATGAGAGAATTGGGCCTCCTGATATTCTTTCTCTTCATAGGGGTCATC       c.1020
 L  K  A  S  M  R  E  L  G  L  L  I  F  F  L  F  I  G  V  I         p.340

          .         .         .         .         .         .       g.32772
 CTTTTCTCTAGTGCTGTGTATTTTGCAGAGGCCGATGAGCGAGAGTCCCAGTTCCCCAGC       c.1080
 L  F  S  S  A  V  Y  F  A  E  A  D  E  R  E  S  Q  F  P  S         p.360

          .         .         .         .         .         .       g.32832
 ATCCCAGATGCCTTCTGGTGGGCAGTCGTCTCCATGACAACTGTAGGCTATGGAGACATG       c.1140
 I  P  D  A  F  W  W  A  V  V  S  M  T  T  V  G  Y  G  D  M         p.380

          .         .         .         .         .         .       g.32892
 GTTCCGACTACCATTGGGGGAAAGATAGTGGGTTCCCTATGTGCGATTGCAGGTGTGTTA       c.1200
 V  P  T  T  I  G  G  K  I  V  G  S  L  C  A  I  A  G  V  L         p.400

          .         .         .         .         .         .       g.32952
 ACTATTGCCTTACCGGTCCCTGTCATTGTGTCCAATTTCAACTACTTCTACCACCGGGAG       c.1260
 T  I  A  L  P  V  P  V  I  V  S  N  F  N  Y  F  Y  H  R  E         p.420

          .         .         .         .         .         .       g.33012
 ACAGAGGGAGAGGAACAGGCCCAATACTTGCAAGTGACAAGCTGTCCAAAGATCCCATCC       c.1320
 T  E  G  E  E  Q  A  Q  Y  L  Q  V  T  S  C  P  K  I  P  S         p.440

          .         .         .         .         .         .       g.33072
 TCCCCTGACCTAAAGAAAAGTAGAAGTGCCTCTACCATTAGTAAGTCTGATTACATGGAG       c.1380
 S  P  D  L  K  K  S  R  S  A  S  T  I  S  K  S  D  Y  M  E         p.460

          .         .         .         .         .         .       g.33132
 ATCCAGGAGGGTGTAAATAACAGTAATGAGGACTTTAGAGAGGAAAACTTGAAAACAGCC       c.1440
 I  Q  E  G  V  N  N  S  N  E  D  F  R  E  E  N  L  K  T  A         p.480

          .         .         .         .         .         .       g.33192
 AACTGTACCTTGGCTAACACAAACTATGTGAATATTACCAAAATGTTAACTGATGTCTGA       c.1500
 N  C  T  L  A  N  T  N  Y  V  N  I  T  K  M  L  T  D  V  X         p.499

          .         .         .         .         .         .       g.33252
 ttgaaacctattaccgtactcacagctcaatggaactaatgcagatgttgcataatagcc       c.*60

          .         .         .         .         .         .       g.33312
 tgcattgtagtcagtgtgttctacagtgtgtatctggttctgcatggaaagcaatagttg       c.*120

                                                                    g.33321
 tgcaagtga                                                          c.*129

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Potassium voltage-gated channel, shaker-related subfamily, member 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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