potassium voltage-gated channel, Shab-related subfamily, member 1 (KCNB1) - coding DNA reference sequence

(used for variant description)

(last modified November 29, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_004975.2 in the KCNB1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_041781.2, covering KCNB1 transcript NM_004975.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5044
                 gtcgggatggaggtgagaagacggccgtgacgcgcgcccgcggg       c.-121

 .         .         .         .         .         .                g.5104
 gccccctgcacccccagcagcccacagcgctccctgcccccctcccccgcagcagcgggc       c.-61

 .         .         .         .         .         .                g.5164
 cttgccgtcgagtgacagcggcctgggggggcagggggggcgggggcggccggatcagcg       c.-1

          .         .         .         .         .         .       g.5224
 ATGCCGGCGGGCATGACGAAGCATGGCTCCCGCTCCACCAGCTCGCTGCCGCCCGAGCCC       c.60
 M  P  A  G  M  T  K  H  G  S  R  S  T  S  S  L  P  P  E  P         p.20

          .         .         .         .         .         .       g.5284
 ATGGAGATCGTGCGCAGCAAGGCGTGCTCTCGGCGGGTCCGCCTCAACGTCGGGGGGCTG       c.120
 M  E  I  V  R  S  K  A  C  S  R  R  V  R  L  N  V  G  G  L         p.40

          .         .         .         .         .         .       g.5344
 GCGCACGAGGTACTCTGGCGTACCCTGGACCGCCTGCCCCGCACGCGGCTGGGCAAGCTC       c.180
 A  H  E  V  L  W  R  T  L  D  R  L  P  R  T  R  L  G  K  L         p.60

          .         .         .         .         .         .       g.5404
 CGCGACTGCAACACGCACGACTCGCTGCTCGAGGTGTGCGATGACTACAGCCTCGACGAC       c.240
 R  D  C  N  T  H  D  S  L  L  E  V  C  D  D  Y  S  L  D  D         p.80

          .         .         .         .         .         .       g.5464
 AACGAGTACTTCTTTGACCGCCACCCGGGCGCCTTCACCTCCATCCTCAACTTCTACCGC       c.300
 N  E  Y  F  F  D  R  H  P  G  A  F  T  S  I  L  N  F  Y  R         p.100

          .         .         .         .         .         .       g.5524
 ACTGGGCGACTGCACATGATGGAGGAGATGTGCGCGCTCAGCTTCAGCCAAGAGCTCGAC       c.360
 T  G  R  L  H  M  M  E  E  M  C  A  L  S  F  S  Q  E  L  D         p.120

          .         .         .         .         .         .       g.5584
 TACTGGGGCATCGACGAGATCTACCTGGAGTCCTGCTGCCAGGCCCGCTACCACCAGAAG       c.420
 Y  W  G  I  D  E  I  Y  L  E  S  C  C  Q  A  R  Y  H  Q  K         p.140

          .         .         .         .         .         .       g.5644
 AAAGAGCAGATGAACGAGGAGCTCAAGCGTGAGGCCGAGACCCTACGGGAGCGGGAAGGC       c.480
 K  E  Q  M  N  E  E  L  K  R  E  A  E  T  L  R  E  R  E  G         p.160

          .         .         .         .         .         .       g.5704
 GAGGAGTTCGATAACACGTGCTGCGCAGAGAAGAGGAAAAAACTCTGGGACCTACTGGAG       c.540
 E  E  F  D  N  T  C  C  A  E  K  R  K  K  L  W  D  L  L  E         p.180

          .         .        | 02.         .         .         .    g.112685
 AAGCCCAATTCCTCTGTGGCTGCCAAG | ATCCTTGCCATAATTTCCATCATGTTCATCGTC    c.600
 K  P  N  S  S  V  A  A  K   | I  L  A  I  I  S  I  M  F  I  V      p.200

          .         .         .         .         .         .       g.112745
 CTCTCCACCATTGCCCTGTCCCTCAACACGCTGCCTGAGCTACAGAGCCTCGATGAGTTC       c.660
 L  S  T  I  A  L  S  L  N  T  L  P  E  L  Q  S  L  D  E  F         p.220

          .         .         .         .         .         .       g.112805
 GGCCAGTCCACAGACAACCCCCAGCTGGCCCACGTGGAGGCCGTGTGCATCGCATGGTTC       c.720
 G  Q  S  T  D  N  P  Q  L  A  H  V  E  A  V  C  I  A  W  F         p.240

          .         .         .         .         .         .       g.112865
 ACCATGGAGTACCTGCTGAGGTTCCTCTCCTCGCCCAAGAAGTGGAAGTTCTTCAAGGGC       c.780
 T  M  E  Y  L  L  R  F  L  S  S  P  K  K  W  K  F  F  K  G         p.260

          .         .         .         .         .         .       g.112925
 CCACTCAATGCCATTGACTTGTTGGCCATTCTGCCATACTATGTCACCATTTTCCTCACC       c.840
 P  L  N  A  I  D  L  L  A  I  L  P  Y  Y  V  T  I  F  L  T         p.280

          .         .         .         .         .         .       g.112985
 GAATCCAACAAGAGCGTGCTGCAATTCCAGAATGTCCGCCGCGTGGTCCAGATCTTCCGC       c.900
 E  S  N  K  S  V  L  Q  F  Q  N  V  R  R  V  V  Q  I  F  R         p.300

          .         .         .         .         .         .       g.113045
 ATCATGCGAATTCTCCGCATCCTTAAGCTTGCACGCCACTCCACTGGCCTCCAGTCTCTG       c.960
 I  M  R  I  L  R  I  L  K  L  A  R  H  S  T  G  L  Q  S  L         p.320

          .         .         .         .         .         .       g.113105
 GGCTTCACTTTGCGGAGGAGCTACAATGAGTTGGGCTTGCTCATCCTCTTCCTTGCCATG       c.1020
 G  F  T  L  R  R  S  Y  N  E  L  G  L  L  I  L  F  L  A  M         p.340

          .         .         .         .         .         .       g.113165
 GGCATTATGATCTTCTCCAGCCTTGTCTTCTTTGCTGAGAAGGATGAGGACGACACCAAG       c.1080
 G  I  M  I  F  S  S  L  V  F  F  A  E  K  D  E  D  D  T  K         p.360

          .         .         .         .         .         .       g.113225
 TTCAAAAGCATCCCAGCCTCTTTCTGGTGGGCCACCATCACCATGACTACTGTTGGGTAT       c.1140
 F  K  S  I  P  A  S  F  W  W  A  T  I  T  M  T  T  V  G  Y         p.380

          .         .         .         .         .         .       g.113285
 GGAGACATCTACCCCAAGACTCTCCTGGGGAAAATTGTTGGGGGACTCTGCTGCATTGCA       c.1200
 G  D  I  Y  P  K  T  L  L  G  K  I  V  G  G  L  C  C  I  A         p.400

          .         .         .         .         .         .       g.113345
 GGAGTCCTGGTGATTGCTCTTCCCATCCCCATCATCGTCAATAACTTCTCTGAGTTCTAT       c.1260
 G  V  L  V  I  A  L  P  I  P  I  I  V  N  N  F  S  E  F  Y         p.420

          .         .         .         .         .         .       g.113405
 AAGGAGCAGAAGAGACAGGAGAAAGCAATCAAACGGCGAGAGGCTCTGGAGAGAGCCAAG       c.1320
 K  E  Q  K  R  Q  E  K  A  I  K  R  R  E  A  L  E  R  A  K         p.440

          .         .         .         .         .         .       g.113465
 AGGAATGGCAGCATCGTATCCATGAACATGAAGGATGCTTTTGCCCGGAGCATTGAGATG       c.1380
 R  N  G  S  I  V  S  M  N  M  K  D  A  F  A  R  S  I  E  M         p.460

          .         .         .         .         .         .       g.113525
 ATGGACATTGTGGTTGAGAAAAATGGGGAGAATATGGGTAAGAAAGACAAAGTACAAGAT       c.1440
 M  D  I  V  V  E  K  N  G  E  N  M  G  K  K  D  K  V  Q  D         p.480

          .         .         .         .         .         .       g.113585
 AACCACTTGTCTCCTAACAAATGGAAATGGACAAAGAGGACACTGTCTGAAACCAGCTCA       c.1500
 N  H  L  S  P  N  K  W  K  W  T  K  R  T  L  S  E  T  S  S         p.500

          .         .         .         .         .         .       g.113645
 AGTAAGTCCTTTGAAACCAAGGAACAGGGATCCCCTGAAAAAGCCAGATCGTCTTCTAGT       c.1560
 S  K  S  F  E  T  K  E  Q  G  S  P  E  K  A  R  S  S  S  S         p.520

          .         .         .         .         .         .       g.113705
 CCTCAGCACCTGAACGTTCAGCAGTTGGAAGACATGTACAATAAGATGGCCAAGACCCAA       c.1620
 P  Q  H  L  N  V  Q  Q  L  E  D  M  Y  N  K  M  A  K  T  Q         p.540

          .         .         .         .         .         .       g.113765
 TCCCAACCCATCCTCAATACCAAGGAGTCAGCAGCACAGAGCAAACCAAAGGAAGAACTT       c.1680
 S  Q  P  I  L  N  T  K  E  S  A  A  Q  S  K  P  K  E  E  L         p.560

          .         .         .         .         .         .       g.113825
 GAAATGGAGAGTATCCCCAGCCCCGTAGCCCCTCTGCCCACTCGCACAGAAGGGGTCATT       c.1740
 E  M  E  S  I  P  S  P  V  A  P  L  P  T  R  T  E  G  V  I         p.580

          .         .         .         .         .         .       g.113885
 GACATGCGAAGTATGTCAAGCATTGATAGTTTCATTAGCTGTGCCACAGACTTCCCTGAG       c.1800
 D  M  R  S  M  S  S  I  D  S  F  I  S  C  A  T  D  F  P  E         p.600

          .         .         .         .         .         .       g.113945
 GCCACCAGATTCTCCCACAGCCCTTTGACATCACTCCCCAGCAAGACTGGGGGCAGCACA       c.1860
 A  T  R  F  S  H  S  P  L  T  S  L  P  S  K  T  G  G  S  T         p.620

          .         .         .         .         .         .       g.114005
 GCCCCAGAAGTGGGCTGGCGGGGAGCTCTGGGTGCCAGTGGTGGTAGGTTTGTGGAGGCC       c.1920
 A  P  E  V  G  W  R  G  A  L  G  A  S  G  G  R  F  V  E  A         p.640

          .         .         .         .         .         .       g.114065
 AACCCCAGCCCTGATGCCAGCCAGCACTCTAGTTTCTTCATCGAGAGCCCCAAGAGTTCC       c.1980
 N  P  S  P  D  A  S  Q  H  S  S  F  F  I  E  S  P  K  S  S         p.660

          .         .         .         .         .         .       g.114125
 ATGAAAACTAACAACCCTTTGAAGCTCCGAGCACTTAAAGTCAACTTCATGGAGGGTGAC       c.2040
 M  K  T  N  N  P  L  K  L  R  A  L  K  V  N  F  M  E  G  D         p.680

          .         .         .         .         .         .       g.114185
 CCCAGTCCACTCCTCCCCGTTCTAGGGATGTACCATGACCCTCTCAGGAACCGGGGGAGT       c.2100
 P  S  P  L  L  P  V  L  G  M  Y  H  D  P  L  R  N  R  G  S         p.700

          .         .         .         .         .         .       g.114245
 GCTGCGGCTGCTGTCGCTGGACTGGAGTGTGCCACGCTTTTGGACAAGGCTGTGCTGAGC       c.2160
 A  A  A  A  V  A  G  L  E  C  A  T  L  L  D  K  A  V  L  S         p.720

          .         .         .         .         .         .       g.114305
 CCAGAGTCCTCCATCTACACCACAGCAAGTGCTAAGACACCCCCCCGGTCTCCTGAGAAA       c.2220
 P  E  S  S  I  Y  T  T  A  S  A  K  T  P  P  R  S  P  E  K         p.740

          .         .         .         .         .         .       g.114365
 CACACAGCAATAGCGTTCAACTTTGAGGCGGGTGTCCACCAGTACATTGACGCAGACACA       c.2280
 H  T  A  I  A  F  N  F  E  A  G  V  H  Q  Y  I  D  A  D  T         p.760

          .         .         .         .         .         .       g.114425
 GATGATGAGGGACAGCTGCTCTACAGTGTGGACTCCAGCCCCCCCAAAAGCCTCCCTGGG       c.2340
 D  D  E  G  Q  L  L  Y  S  V  D  S  S  P  P  K  S  L  P  G         p.780

          .         .         .         .         .         .       g.114485
 AGCACCAGTCCGAAGTTCAGCACGGGGACAAGATCGGAGAAAAACCACTTTGAAAGCTCC       c.2400
 S  T  S  P  K  F  S  T  G  T  R  S  E  K  N  H  F  E  S  S         p.800

          .         .         .         .         .         .       g.114545
 CCTTTACCCACCTCCCCTAAGTTCTTAAGGCAGAACTGTATTTACTCCACAGAAGCATTG       c.2460
 P  L  P  T  S  P  K  F  L  R  Q  N  C  I  Y  S  T  E  A  L         p.820

          .         .         .         .         .         .       g.114605
 ACTGGAAAAGGCCCCAGTGGTCAGGAAAAGTGCAAACTTGAGAACCACATCTCCCCTGAC       c.2520
 T  G  K  G  P  S  G  Q  E  K  C  K  L  E  N  H  I  S  P  D         p.840

          .         .         .         .         .                 g.114662
 GTCCGTGTGTTGCCAGGGGGAGGAGCCCATGGAAGCACACGAGATCAGAGCATCTGA          c.2577
 V  R  V  L  P  G  G  G  A  H  G  S  T  R  D  Q  S  I  X            p.858

          .         .         .         .         .         .       g.114722
 actgccctgccttggaggagagacttttgggtgaggtccaaagaggagagctgttcagct       c.*60

          .         .         .         .         .         .       g.114782
 tacctgccacagagcttttctgcatgaactctggaacagaaaggccctgtaaagccctca       c.*120

          .         .         .         .         .         .       g.114842
 gagagaagagagactccagagaaggctccctaagaccttgagagccatgacaggtccatc       c.*180

          .         .         .         .         .         .       g.114902
 agcatgaagttggccaagccatagggcacagcacctccttgtaacaactctatagccctc       c.*240

          .         .         .         .         .         .       g.114962
 tttgggagatgacatgagtggaactcacagccaccactaccaccactttagacaggaccg       c.*300

          .         .         .         .         .         .       g.115022
 aggccacatactccccattctctcgtggctttccatctcagcctcggagggcaacattga       c.*360

          .         .         .         .         .         .       g.115082
 cagtcctcctggcttcagctagagaaggatgctggaacaagcggctggtgttgaaagagt       c.*420

          .         .         .         .         .         .       g.115142
 gggttgaccaatttggtattgaatgttgcccagccacccctaggaacacctgtccatcac       c.*480

          .         .         .         .         .         .       g.115202
 ctcctggatggattccactgttagacagctacagggaatgattggtcatggggaagtctc       c.*540

          .         .         .         .         .         .       g.115262
 tgcgccataagccacgatcccagcgcaaaacccttactcaaatgtcttcattgacttcgg       c.*600

          .         .         .         .         .         .       g.115322
 tatttcatagtacctgagattttattttgagataccatcagggtgagttgcaccacttgt       c.*660

          .         .         .         .         .         .       g.115382
 actcaattctaattgccccctggcaatctgggaagggttcagaaggtgggcacccagcca       c.*720

          .         .         .         .         .         .       g.115442
 acagcatgaactcagagcattgttttagggttggaggaggaacacgctttctttacatca       c.*780

          .         .         .         .         .         .       g.115502
 ctagtgtagactcaaaagatatgcaagtgtcaaatatgcaaaagaaatagtttattcaaa       c.*840

          .         .         .         .         .         .       g.115562
 gagactgtgtgttactgaagaacagcataaaaatatgatttttttacttgcaaaaatgaa       c.*900

          .         .         .         .         .         .       g.115622
 aggaaaaaaataccacgcattgaaatgcccagttcagactgaataattcctgctgcagca       c.*960

          .         .         .         .         .                 g.115677
 aggaaagtacctactataatagaaattctgttttgttttctgtggttttcaagtt            c.*1015

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Potassium voltage-gated channel, Shab-related subfamily, member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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