potassium voltage-gated channel, Shaw-related subfamily, member 1 (KCNC1) - coding DNA reference sequence

(used for variant description)

(last modified September 29, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001112741.1 in the KCNC1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_041827.1, covering KCNC1 transcript NM_001112741.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5055
      ggcggccgctcccatgggtgtcgctgggccgcgccatgcctaagggggcgccgcg       c.-1

          .         .         .         .         .         .       g.5115
 ATGGGCCAAGGGGACGAGAGCGAGCGCATCGTGATCAACGTGGGCGGCACGCGCCACCAG       c.60
 M  G  Q  G  D  E  S  E  R  I  V  I  N  V  G  G  T  R  H  Q         p.20

          .         .         .         .         .         .       g.5175
 ACGTACCGCTCGACCCTGCGCACGCTGCCCGGCACGCGGCTCGCCTGGCTGGCGGAGCCC       c.120
 T  Y  R  S  T  L  R  T  L  P  G  T  R  L  A  W  L  A  E  P         p.40

          .         .         .         .         .         .       g.5235
 GACGCCCACAGCCACTTCGACTATGACCCGCGTGCTGACGAGTTCTTCTTCGACCGCCAC       c.180
 D  A  H  S  H  F  D  Y  D  P  R  A  D  E  F  F  F  D  R  H         p.60

          .         .         .         .         .         .       g.5295
 CCCGGCGTCTTCGCGCACATCCTGAACTACTACCGCACGGGCAAGCTGCACTGCCCAGCC       c.240
 P  G  V  F  A  H  I  L  N  Y  Y  R  T  G  K  L  H  C  P  A         p.80

          .         .         .         .         .         .       g.5355
 GACGTGTGCGGGCCGCTCTACGAGGAGGAGCTGGCCTTCTGGGGCATCGACGAGACCGAC       c.300
 D  V  C  G  P  L  Y  E  E  E  L  A  F  W  G  I  D  E  T  D         p.100

          .         .         .         .         .         .       g.5415
 GTGGAGCCCTGCTGCTGGATGACGTACCGCCAGCACCGCGACGCCGAGGAGGCTCTGGAC       c.360
 V  E  P  C  C  W  M  T  Y  R  Q  H  R  D  A  E  E  A  L  D         p.120

          .         .         .         .         .         .       g.5475
 AGCTTCGGCGGCGCTCCTCTGGACAACAGCGCCGACGACGCGGACGCCGACGGCCCTGGC       c.420
 S  F  G  G  A  P  L  D  N  S  A  D  D  A  D  A  D  G  P  G         p.140

          .         .         .         .         .         .       g.5535
 GACTCGGGCGACGGCGAGGACGAGCTGGAGATGACCAAGCGCCTGGCGCTCAGTGACTCC       c.480
 D  S  G  D  G  E  D  E  L  E  M  T  K  R  L  A  L  S  D  S         p.160

          .         .         .         .         .         .       g.5595
 CCGGATGGCCGGCCTGGCGGCTTTTGGCGCCGCTGGCAGCCGCGCATCTGGGCGCTCTTC       c.540
 P  D  G  R  P  G  G  F  W  R  R  W  Q  P  R  I  W  A  L  F         p.180

          .         .         . | 02       .         .         .    g.40747
 GAGGACCCGTACTCGTCCCGCTACGCGCGG | TATGTGGCCTTCGCTTCCCTCTTCTTCATC    c.600
 E  D  P  Y  S  S  R  Y  A  R   | Y  V  A  F  A  S  L  F  F  I      p.200

          .         .         .         .         .         .       g.40807
 CTGGTCTCCATCACCACCTTCTGCCTGGAGACCCACGAGCGCTTCAACCCCATCGTGAAC       c.660
 L  V  S  I  T  T  F  C  L  E  T  H  E  R  F  N  P  I  V  N         p.220

          .         .         .         .         .         .       g.40867
 AAGACGGAGATCGAGAACGTTCGCAATGGCACGCAAGTGCGCTACTACCGGGAGGCCGAG       c.720
 K  T  E  I  E  N  V  R  N  G  T  Q  V  R  Y  Y  R  E  A  E         p.240

          .         .         .         .         .         .       g.40927
 ACGGAGGCCTTCCTTACCTACATCGAGGGCGTCTGTGTGGTCTGGTTCACCTTCGAGTTC       c.780
 T  E  A  F  L  T  Y  I  E  G  V  C  V  V  W  F  T  F  E  F         p.260

          .         .         .         .         .         .       g.40987
 CTCATGCGTGTCATCTTCTGCCCCAACAAGGTAGAGTTCATCAAGAACTCGCTCAACATC       c.840
 L  M  R  V  I  F  C  P  N  K  V  E  F  I  K  N  S  L  N  I         p.280

          .         .         .         .         .         .       g.41047
 ATTGACTTTGTGGCCATCCTGCCCTTCTACCTGGAGGTGGGGCTGAGCGGCCTGTCCTCC       c.900
 I  D  F  V  A  I  L  P  F  Y  L  E  V  G  L  S  G  L  S  S         p.300

          .         .         .         .         .         .       g.41107
 AAGGCAGCCAAGGACGTGCTGGGCTTCCTGCGCGTCGTCCGCTTCGTGCGCATCTTGCGC       c.960
 K  A  A  K  D  V  L  G  F  L  R  V  V  R  F  V  R  I  L  R         p.320

          .         .         .         .         .         .       g.41167
 ATCTTTAAGCTGACCCGCCACTTTGTGGGCCTGCGGGTCCTGGGCCACACGCTCCGAGCC       c.1020
 I  F  K  L  T  R  H  F  V  G  L  R  V  L  G  H  T  L  R  A         p.340

          .         .         .         .         .         .       g.41227
 AGCACCAACGAGTTCCTGCTGCTCATCATCTTCCTGGCCTTGGGCGTGCTGATCTTCGCC       c.1080
 S  T  N  E  F  L  L  L  I  I  F  L  A  L  G  V  L  I  F  A         p.360

          .         .         .         .         .         .       g.41287
 ACCATGATCTACTACGCCGAGAGGATAGGGGCACAGCCCAATGACCCCAGCGCCAGTGAG       c.1140
 T  M  I  Y  Y  A  E  R  I  G  A  Q  P  N  D  P  S  A  S  E         p.380

          .         .         .         .         .         .       g.41347
 CACACGCACTTTAAGAACATCCCCATCGGCTTCTGGTGGGCCGTGGTCACCATGACGACC       c.1200
 H  T  H  F  K  N  I  P  I  G  F  W  W  A  V  V  T  M  T  T         p.400

          .         .         .         .         .         .       g.41407
 CTGGGCTATGGAGACATGTACCCGCAGACGTGGTCCGGCATGCTGGTGGGGGCTCTGTGT       c.1260
 L  G  Y  G  D  M  Y  P  Q  T  W  S  G  M  L  V  G  A  L  C         p.420

          .         .         .         .         .         .       g.41467
 GCGCTGGCGGGCGTGCTCACCATCGCCATGCCCGTGCCCGTCATCGTGAACAATTTCGGG       c.1320
 A  L  A  G  V  L  T  I  A  M  P  V  P  V  I  V  N  N  F  G         p.440

          .         .         .         .         .         .       g.41527
 ATGTATTACTCCTTAGCCATGGCTAAGCAGAAACTACCAAAGAAAAAAAAGAAGCATATT       c.1380
 M  Y  Y  S  L  A  M  A  K  Q  K  L  P  K  K  K  K  K  H  I         p.460

          .         .         .         .         .         .       g.41587
 CCGCGGCCACCGCAGCTGGGATCTCCCAATTATTGTAAATCTGTCGTAAACTCTCCACAC       c.1440
 P  R  P  P  Q  L  G  S  P  N  Y  C  K  S  V  V  N  S  P  H         p.480

          .         .         .         .         .         .       g.41647
 CACAGTACTCAGAGTGACACATGTCCGCTGGCCCAGGAAGAAATTTTAGAAATTAACAGA       c.1500
 H  S  T  Q  S  D  T  C  P  L  A  Q  E  E  I  L  E  I  N  R         p.500

      | 03   .         .         .         .         .         .    g.48564
 GCAG | ATTCCAAACTGAATGGGGAGGTGGCGAAGGCCGCGCTGGCGAACGAAGACTGCCCC    c.1560
 A  D |   S  K  L  N  G  E  V  A  K  A  A  L  A  N  E  D  C  P      p.520

          .         .         .         .         .         .       g.48624
 CACATAGACCAGGCCCTCACTCCCGATGAGGGCCTGCCCTTTACGCGCTCGGGCACCCGC       c.1620
 H  I  D  Q  A  L  T  P  D  E  G  L  P  F  T  R  S  G  T  R         p.540

          .         .         .         .         .         .       g.48684
 GAGAGATACGGACCCTGCTTCCTCTTATCAACCGGGGAGTACGCGTGCCCACCTGGTGGA       c.1680
 E  R  Y  G  P  C  F  L  L  S  T  G  E  Y  A  C  P  P  G  G         p.560

          .    | 04    .         .         .         .         .    g.50769
 GGAATGAGAAAGG | ATCTTTGCAAAGAAAGCCCTGTCATTGCTAAGTATATGCCGACAGAG    c.1740
 G  M  R  K  D |   L  C  K  E  S  P  V  I  A  K  Y  M  P  T  E      p.580

          .                                                         g.50787
 GCTGTGAGAGTGACTTGA                                                 c.1758
 A  V  R  V  T  X                                                   p.585

          .         .         .         .         .         .       g.50847
 ccaggcggcttggccgaggacactggtggctattaagcatctgggtggacctgcagcccc       c.*60

          .         .         .         .         .         .       g.50907
 tcctcaccctcggacagagtaaattcacgccatgcaggtttgccggacgagtccgagtgg       c.*120

          .         .         .         .         .         .       g.50967
 cccaggcattgtactaggacggacgtagctttttctacggccaaatggtaactgaccgta       c.*180

          .         .         .         .         .         .       g.51027
 gaggatttcttttccttcttttcattttttaaaattttattttatttggggagggggggt       c.*240

          .         .         .         .         .         .       g.51087
 ggaggggctccttagcatgacttgcatgaagttaaacagaaaacccagcaaaccaaaccc       c.*300

          .         .         .         .         .         .       g.51147
 accaaccccctgcaactgtatgattaccctgaacaacaataatgaaaagaaaaacatcaa       c.*360

          .         .         .         .         .         .       g.51207
 agccctctattttctttcaaagctcttgactttcacacacgttgttggagccaaactgta       c.*420

          .         .         .         .         .         .       g.51267
 acggcgttcagtagaaacctgtacatttctgggggtgaggggcgaggggaggagggacag       c.*480

          .         .         .         .         .         .       g.51327
 agatggggaatggattgcttcctttttgtacacaagatcaagaggaaagcttccaaaaag       c.*540

          .         .         .         .         .         .       g.51387
 ggcagtcggtcagtcatcggtcatattgacctcaccttcatagttcatctctcacgtgga       c.*600

          .         .         .         .         .         .       g.51447
 aactgagaactttgctccaaatagaattgtggaaactcgcacggctgccttcttccccgt       c.*660

          .         .         .         .         .         .       g.51507
 ttggcatgcttgtgacccagcggatgtctccccaagacccctgacagcagctagtctagg       c.*720

          .         .         .         .         .         .       g.51567
 ttgattctctcatcttatcggtgtgtagatccagtgtgaccaactttcataacaaattgt       c.*780

          .         .         .         .         .         .       g.51627
 tcatagtaaataatcaccaccgtatggattttccaagtgttccattaaaaccaggatgta       c.*840

          .         .         .         .         .         .       g.51687
 gagcaccaaaagatcaggaccacgggaggagcagcctcctccacctttactaaggcacaa       c.*900

          .         .         .         .         .         .       g.51747
 cctggcattgtatgcaatttagtacttcagagtaaaaacctgcatgcccaatgttatgca       c.*960

          .         .         .         .         .         .       g.51807
 aagcgattctagcatgaaataaattttgtatcatggtttctgtatagtctaaagcagatt       c.*1020

          .         .         .         .         .         .       g.51867
 tgttttcctgaagcagtcggaggtttgcagagacacacttctgcatctcgaataaatata       c.*1080

          .         .         .         .         .         .       g.51927
 gtattttcccaacagaaacagaggacagtagcttggctttggtctgattctaaaattagt       c.*1140

          .         .         .         .         .         .       g.51987
 ggggtgggggggaaggatgatatttttgaaaaacacatgcttgagttgaaaaaaatgcaa       c.*1200

          .         .         .         .         .         .       g.52047
 catctcaagctttcactgcagctcacaacatttcctggaaagagagcaatgatgctttag       c.*1260

          .         .         .         .         .         .       g.52107
 ctcaacaacctcccctccctgggccctggcccccaataataaaaaactgacttttgagat       c.*1320

                                                                    g.52108
 g                                                                  c.*1321

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Potassium voltage-gated channel, Shaw-related subfamily, member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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