potassium voltage-gated channel, Shaw-related subfamily, member 2 (KCNC2) - coding DNA reference sequence

(used for variant description)

(last modified December 4, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_153748.2 in the KCNC2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000012.11, covering KCNC2 transcript NM_153748.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5021
                                        actctttcctgagccctgtgc       c.-541

 .         .         .         .         .         .                g.5081
 ttcggatggcggcgggaggttgatggcgagtggtgctgaagggacagctccagcagtggc       c.-481

 .         .         .         .         .         .                g.5141
 tgatttgggggagaaacaaaatctgcagatggaatccgagcagggcgacttcaccttcaa       c.-421

 .         .         .         .         .         .                g.5201
 gtggtgagctctcctgacctgcggccagtctccactccattcacggccagccgatctgcc       c.-361

 .         .         .         .         .         .                g.5261
 cgctcccggaggggtcgggcagtgccggctggacccgccccgagctccatggtttgccca       c.-301

 .         .         .         .         .         .                g.5321
 accctgcgcgatggtgactctgggcgcggaggttggcgactggcaaatccgcagatcaca       c.-241

 .         .         .         .         .         .                g.5381
 gaatgaaggcggggagcgcggccggcggccggcgggggctttctcccccaccccagcgcc       c.-181

 .         .         .         .         .         .                g.5441
 cagggaagcggctcaaccacctgaatccggaaaacgccaacaagtagtttctcgtcggag       c.-121

 .         .         .         .         .         .                g.5501
 aagggcggctcacctgggcgccaagactcagtcccgctgcccagagaacctcgtccactc       c.-61

 .         .         .         .         . | 02       .             g.6765
 ggaaaccaaagcagaaccacttttctctcggtctcgttaag | tcatgtctgagtcacagag    c.-1

          .         .         .         .         .         .       g.6825
 ATGGGCAAGATCGAGAACAACGAGAGGGTGATCCTCAATGTCGGGGGCACCCGGCACGAA       c.60
 M  G  K  I  E  N  N  E  R  V  I  L  N  V  G  G  T  R  H  E         p.20

          .         .         .         .         .         .       g.6885
 ACCTACCGCAGCACCCTCAAGACCCTGCCTGGAACACGCCTGGCCCTTCTTGCCTCCTCC       c.120
 T  Y  R  S  T  L  K  T  L  P  G  T  R  L  A  L  L  A  S  S         p.40

          .         .         .         .         .         .       g.6945
 GAGCCCCCAGGCGACTGCTTGACCACGGCGGGCGACAAGCTGCAGCCGTCGCCGCCTCCA       c.180
 E  P  P  G  D  C  L  T  T  A  G  D  K  L  Q  P  S  P  P  P         p.60

          .         .         .         .         .         .       g.7005
 CTGTCGCCGCCGCCGAGAGCGCCCCCGCTGTCCCCCGGGCCAGGCGGCTGCTTCGAGGGC       c.240
 L  S  P  P  P  R  A  P  P  L  S  P  G  P  G  G  C  F  E  G         p.80

          .         .         .         .         .         .       g.7065
 GGCGCGGGCAACTGCAGTTCCCGCGGCGGCAGGGCCAGCGACCATCCCGGTGGCGGCCGC       c.300
 G  A  G  N  C  S  S  R  G  G  R  A  S  D  H  P  G  G  G  R         p.100

          .         .         .         .         .         .       g.7125
 GAGTTCTTCTTCGACCGGCACCCGGGCGTCTTCGCCTATGTGCTCAATTACTACCGCACC       c.360
 E  F  F  F  D  R  H  P  G  V  F  A  Y  V  L  N  Y  Y  R  T         p.120

          .         .         .         .         .         .       g.7185
 GGCAAGCTGCACTGCCCCGCAGACGTGTGCGGGCCGCTCTTCGAGGAGGAGCTGGCCTTC       c.420
 G  K  L  H  C  P  A  D  V  C  G  P  L  F  E  E  E  L  A  F         p.140

          .         .         .         .         .         .       g.7245
 TGGGGCATCGACGAGACCGACGTGGAGCCCTGCTGCTGGATGACCTACCGGCAGCACCGC       c.480
 W  G  I  D  E  T  D  V  E  P  C  C  W  M  T  Y  R  Q  H  R         p.160

          .         .         .         .         .         .       g.7305
 GACGCCGAGGAGGCGCTGGACATCTTCGAGACCCCCGACCTCATTGGCGGCGACCCCGGC       c.540
 D  A  E  E  A  L  D  I  F  E  T  P  D  L  I  G  G  D  P  G         p.180

          .         .         .         .         .         .       g.7365
 GACGACGAGGACCTGGCGGCCAAGAGGCTGGGCATCGAGGACGCGGCGGGGCTCGGGGGC       c.600
 D  D  E  D  L  A  A  K  R  L  G  I  E  D  A  A  G  L  G  G         p.200

          .         .         .         .         .         .       g.7425
 CCCGACGGCAAATCTGGCCGCTGGAGGAGGCTGCAGCCCCGCATGTGGGCCCTCTTCGAA       c.660
 P  D  G  K  S  G  R  W  R  R  L  Q  P  R  M  W  A  L  F  E         p.220

          .         .        | 03.         .         .         .    g.163464
 GACCCCTACTCGTCCAGAGCCGCCAGG | TTTATTGCTTTTGCTTCTTTATTCTTCATCCTG    c.720
 D  P  Y  S  S  R  A  A  R   | F  I  A  F  A  S  L  F  F  I  L      p.240

          .         .         .         .         .         .       g.163524
 GTTTCAATTACAACTTTTTGCCTGGAAACACATGAAGCTTTCAATATTGTTAAAAACAAG       c.780
 V  S  I  T  T  F  C  L  E  T  H  E  A  F  N  I  V  K  N  K         p.260

          .         .         .         .         .         .       g.163584
 ACAGAACCAGTCATCAATGGCACAAGTGTTGTTCTACAGTATGAAATTGAAACGGATCCT       c.840
 T  E  P  V  I  N  G  T  S  V  V  L  Q  Y  E  I  E  T  D  P         p.280

          .         .         .         .         .         .       g.163644
 GCCTTGACGTATGTAGAAGGAGTGTGTGTGGTGTGGTTTACTTTTGAATTTTTAGTCCGT       c.900
 A  L  T  Y  V  E  G  V  C  V  V  W  F  T  F  E  F  L  V  R         p.300

          .         .         .         .         .         .       g.163704
 ATTGTTTTTTCACCCAATAAACTTGAATTCATCAAAAATCTCTTGAATATCATTGACTTT       c.960
 I  V  F  S  P  N  K  L  E  F  I  K  N  L  L  N  I  I  D  F         p.320

          .         .         .         .         .         .       g.163764
 GTGGCCATCCTACCTTTCTACTTAGAGGTGGGACTCAGTGGGCTGTCATCCAAAGCTGCT       c.1020
 V  A  I  L  P  F  Y  L  E  V  G  L  S  G  L  S  S  K  A  A         p.340

          .         .         .         .         .         .       g.163824
 AAAGATGTGCTTGGCTTCCTCAGGGTGGTAAGGTTTGTGAGGATCCTGAGAATTTTCAAG       c.1080
 K  D  V  L  G  F  L  R  V  V  R  F  V  R  I  L  R  I  F  K         p.360

          .         .         .         .         .         .       g.163884
 CTCACCCGCCATTTTGTAGGTCTGAGGGTGCTTGGACATACTCTTCGAGCTAGTACTAAT       c.1140
 L  T  R  H  F  V  G  L  R  V  L  G  H  T  L  R  A  S  T  N         p.380

          .         .         .         .         .         .       g.163944
 GAATTTTTGCTGCTGATAATTTTCCTGGCTCTAGGAGTTTTGATATTTGCTACCATGATC       c.1200
 E  F  L  L  L  I  I  F  L  A  L  G  V  L  I  F  A  T  M  I         p.400

          .         .         .         .         .         .       g.164004
 TACTATGCCGAGAGAGTGGGAGCTCAACCTAACGACCCTTCAGCTAGTGAGCACACACAG       c.1260
 Y  Y  A  E  R  V  G  A  Q  P  N  D  P  S  A  S  E  H  T  Q         p.420

          .         .         .         .         .         .       g.164064
 TTCAAAAACATTCCCATTGGGTTCTGGTGGGCTGTAGTGACCATGACTACCCTGGGTTAT       c.1320
 F  K  N  I  P  I  G  F  W  W  A  V  V  T  M  T  T  L  G  Y         p.440

          .         .         .         .         .         .       g.164124
 GGGGATATGTACCCCCAAACATGGTCAGGCATGCTGGTGGGAGCCCTGTGTGCTCTGGCT       c.1380
 G  D  M  Y  P  Q  T  W  S  G  M  L  V  G  A  L  C  A  L  A         p.460

          .         .         .         .         .         .       g.164184
 GGAGTGCTGACAATAGCCATGCCAGTGCCTGTCATTGTCAATAATTTTGGAATGTACTAC       c.1440
 G  V  L  T  I  A  M  P  V  P  V  I  V  N  N  F  G  M  Y  Y         p.480

          .         .         .         .         .         .       g.164244
 TCCTTGGCAATGGCAAAGCAGAAACTTCCAAGGAAAAGAAAGAAGCACATCCCTCCTGCT       c.1500
 S  L  A  M  A  K  Q  K  L  P  R  K  R  K  K  H  I  P  P  A         p.500

          .         .         .         .         .         .       g.164304
 CCTCAGGCAAGCTCACCTACTTTTTGCAAGACAGAATTAAATATGGCCTGCAATAGTACA       c.1560
 P  Q  A  S  S  P  T  F  C  K  T  E  L  N  M  A  C  N  S  T         p.520

          .         .         .         .         .      | 04  .    g.172379
 CAGAGTGACACATGTCTGGGCAAAGACAATCGACTTCTGGAACATAACAGATCAG | ATAAC    c.1620
 Q  S  D  T  C  L  G  K  D  N  R  L  L  E  H  N  R  S  D |   N      p.540

          .         .         .         .         .                 g.172436
 TGCAAAGAGGTTGTCATTACTGGTTACACGCAAGCCGAGGCCAGATCTCTTACTTAA          c.1677
 C  K  E  V  V  I  T  G  Y  T  Q  A  E  A  R  S  L  T  X            p.558

          .         .         .    | 05    .         .         .    g.173569
 tgacttggggaaggcacaaaacatgagagaaag | tgttgtacagaatttatcatggattat    c.*60

          .         .         .         .         .         .       g.173629
 tgactgctgagaaagggacagtggaatttagccataccaaggactatactggaaacagac       c.*120

          .         .         .         .         .         .       g.173689
 ttctgctgctgaatgtgccctgatgtgaccaggttgcacttggaagagatcctcgcgtct       c.*180

          .         .         .         .         .         .       g.173749
 tcatgaggcacttaaagcttataaaagaactgcggctggaactcatctggtgctccccat       c.*240

          .         .         .         .         .         .       g.173809
 gagagtgctctgcttgtagactggccagtgtccatgaaacaactgtaaataccaacatgt       c.*300

          .         .         .         .         .         .       g.173869
 gtgcatgggtcaacagtcttggccatttctcatcaaaagaagccaaattcatgatcaaca       c.*360

          .         .         .         .         .         .       g.173929
 tctctgaagtttcaagtaaggcccacacttctttgaattactcttcatgggcccacatta       c.*420

          .         .         .         .         .         .       g.173989
 ggttgtgctgtgaattacttaaggcagtgatactgatgtagtatagttttgtcttaattt       c.*480

          .         .         .         .         .         .       g.174049
 cccttatttctacttctttggttgaatctatgaacttgattgtataattttcttataaat       c.*540

          .         .         .         .         .         .       g.174109
 tactgatgtaatcagcttgtcaattatgttgtgaaattgttagtattcatttatcaaaaa       c.*600

          .         .         .         .         .         .       g.174169
 tgacctatgtttagtcacatatttgtttagttctgggaaattgttatagcttaaatggaa       c.*660

          .         .         .         .         .         .       g.174229
 ctcaccaacattattcatagtttaagtcttttatcattattacctcaattataaatatta       c.*720

          .         .         .         .         .         .       g.174289
 caaaaacataattctggcaatgagagtatttttttattcaatgatcaaggagcaatgtca       c.*780

          .         .         .         .         .         .       g.174349
 gtatatagtagaatatcaattaaattatatcctaaaatgtatattttgcataaaagagat       c.*840

          .         .         .         .         .         .       g.174409
 attctttaatcaattacttttttgtgagttttgtggcaaatgaagcttgtacgtgtcttt       c.*900

          .         .         .         .         .         .       g.174469
 aaaactgttgtagatgaaactgtataagatttttacatcttgcttaatcaatattttcag       c.*960

          .         .         .         .         .         .       g.174529
 agtctattagttcccctgggattctgaatataacatatagcctattataaatccctgtat       c.*1020

          .         .         .         .         .         .       g.174589
 cgtggaccttttgtgaacatttcaaggcgcatgcacaaccttgatgataaccagtggaaa       c.*1080

          .         .         .         .         .         .       g.174649
 tgtaactaactgaaatgaagaataaaaggcaaatgagctggggataaacttgaatgttat       c.*1140

          .         .                                               g.174671
 ctgattaaattactcaaattat                                             c.*1162

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Potassium voltage-gated channel, Shaw-related subfamily, member 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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