potassium voltage-gated channel, Shal-related subfamily, member 3 (KCND3) - coding DNA reference sequence

(used for variant description)

(last modified July 4, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_004980.4 in the KCND3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032011.2, covering KCND3 transcript NM_004980.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5060
 ggagagaaatggctgaaagtggaaacccggagcggtttggggcgcttcgcaaagttctcc       c.-421

 .         .         .         .         .         .                g.5120
 agctcggcgagccggcggtgtgtctaccagaggctgggggccagtccatctggtcctgcc       c.-361

 .         .         .         .         .         .                g.5180
 cgacgccacttccaccccgcgagctctgggaaaggtctctacgtgacgccaagggccgtc       c.-301

 .         .         .         .         .         .                g.5240
 gcggccccggggagagggatcgaaagactcactctgcgaggtgtttacactggaggtggg       c.-241

 .         .         .         .         .         .                g.5300
 ggacgggaagggactgggcaaagttacctggactcaactaaattcctgcgcttgcttagt       c.-181

 .         .         .         .         .         .                g.5360
 gttgacatttgaataggatccgagatgttctgcttttatcccgggcagccctgatatgtc       c.-121

 .         .         .         .         .        | 02.             g.11369
 agcaacaggctgaggttccagacctgaaatcgcactgcaagaaaaagg | ggtttgctgaac    c.-61

 .         .         .         .         .         .                g.11429
 taactccaagctggtgtgcctagcgtccgcgcggctgccggcccaagagctggagtcacc       c.-1

          .         .         .         .         .         .       g.11489
 ATGGCGGCCGGAGTTGCGGCCTGGCTGCCTTTTGCCCGGGCTGCGGCCATCGGGTGGATG       c.60
 M  A  A  G  V  A  A  W  L  P  F  A  R  A  A  A  I  G  W  M         p.20

          .         .         .         .         .         .       g.11549
 CCGGTGGCCAACTGCCCCATGCCCCTGGCCCCGGCCGACAAGAACAAGCGGCAGGATGAG       c.120
 P  V  A  N  C  P  M  P  L  A  P  A  D  K  N  K  R  Q  D  E         p.40

          .         .         .         .         .         .       g.11609
 CTGATTGTCCTCAACGTGAGTGGGCGGAGGTTCCAGACCTGGAGGACCACGCTGGAGCGC       c.180
 L  I  V  L  N  V  S  G  R  R  F  Q  T  W  R  T  T  L  E  R         p.60

          .         .         .         .         .         .       g.11669
 TACCCGGACACCCTGCTGGGCAGCACGGAGAAGGAGTTCTTCTTCAACGAGGACACCAAG       c.240
 Y  P  D  T  L  L  G  S  T  E  K  E  F  F  F  N  E  D  T  K         p.80

          .         .         .         .         .         .       g.11729
 GAGTACTTCTTCGACCGGGACCCCGAGGTGTTCCGCTGCGTGCTCAACTTCTACCGCACG       c.300
 E  Y  F  F  D  R  D  P  E  V  F  R  C  V  L  N  F  Y  R  T         p.100

          .         .         .         .         .         .       g.11789
 GGGAAGCTGCACTACCCGCGCTACGAGTGCATCTCTGCCTACGACGACGAGCTGGCCTTC       c.360
 G  K  L  H  Y  P  R  Y  E  C  I  S  A  Y  D  D  E  L  A  F         p.120

          .         .         .         .         .         .       g.11849
 TACGGCATCCTCCCGGAGATCATCGGGGACTGCTGCTACGAGGAGTACAAGGACCGCAAG       c.420
 Y  G  I  L  P  E  I  I  G  D  C  C  Y  E  E  Y  K  D  R  K         p.140

          .         .         .         .         .         .       g.11909
 AGGGAGAACGCCGAGCGGCTCATGGACGACAACGACTCGGAGAACAACCAGGAGTCCATG       c.480
 R  E  N  A  E  R  L  M  D  D  N  D  S  E  N  N  Q  E  S  M         p.160

          .         .         .         .         .         .       g.11969
 CCCTCGCTCAGCTTCCGCCAGACCATGTGGCGGGCCTTCGAGAACCCCCACACCAGCACG       c.540
 P  S  L  S  F  R  Q  T  M  W  R  A  F  E  N  P  H  T  S  T         p.180

          .         .         .         .         .         .       g.12029
 CTGGCCCTGGTCTTCTACTACGTGACTGGCTTCTTCATCGCTGTCTCGGTCATCACCAAC       c.600
 L  A  L  V  F  Y  Y  V  T  G  F  F  I  A  V  S  V  I  T  N         p.200

          .         .         .         .         .         .       g.12089
 GTGGTGGAGACGGTGCCGTGCGGCACGGTCCCGGGCAGCAAGGAGCTGCCGTGCGGGGAG       c.660
 V  V  E  T  V  P  C  G  T  V  P  G  S  K  E  L  P  C  G  E         p.220

          .         .         .         .         .         .       g.12149
 CGCTACTCGGTGGCCTTCTTCTGCCTGGACACGGCGTGCGTCATGATCTTCACCGTGGAG       c.720
 R  Y  S  V  A  F  F  C  L  D  T  A  C  V  M  I  F  T  V  E         p.240

          .         .         .         .         .         .       g.12209
 TACCTCCTGCGGCTCTTCGCGGCTCCCAGCCGCTACCGCTTCATCCGCAGCGTCATGAGC       c.780
 Y  L  L  R  L  F  A  A  P  S  R  Y  R  F  I  R  S  V  M  S         p.260

          .         .         .         .         .         .       g.12269
 ATCATCGACGTGGTGGCCATCATGCCCTACTACATCGGTCTGGTCATGACCAACAACGAG       c.840
 I  I  D  V  V  A  I  M  P  Y  Y  I  G  L  V  M  T  N  N  E         p.280

          .         .         .         .         .         .       g.12329
 GACGTGTCCGGCGCCTTCGTCACGCTCCGGGTCTTCCGCGTCTTCAGGATCTTCAAGTTT       c.900
 D  V  S  G  A  F  V  T  L  R  V  F  R  V  F  R  I  F  K  F         p.300

          .         .         .         .         .         .       g.12389
 TCCCGCCACTCCCAGGGCCTGCGGATCCTGGGCTACACACTGAAGAGCTGTGCCTCCGAA       c.960
 S  R  H  S  Q  G  L  R  I  L  G  Y  T  L  K  S  C  A  S  E         p.320

          .         .         .         .         .         .       g.12449
 CTGGGCTTTCTTCTCTTCTCCCTCACCATGGCCATCATCATCTTTGCCACTGTGATGTTT       c.1020
 L  G  F  L  L  F  S  L  T  M  A  I  I  I  F  A  T  V  M  F         p.340

          .         .         .         .         .         .       g.12509
 TATGCCGAGAAGGGCTCCTCGGCCAGCAAGTTCACAAGCATCCCTGCCTCGTTTTGGTAC       c.1080
 Y  A  E  K  G  S  S  A  S  K  F  T  S  I  P  A  S  F  W  Y         p.360

          .         .       | 03 .         .         .         .    g.207083
 ACCATTGTCACCATGACCACACTGGG | ATACGGAGACATGGTGCCTAAGACGATTGCAGGG    c.1140
 T  I  V  T  M  T  T  L  G  |  Y  G  D  M  V  P  K  T  I  A  G      p.380

          .         .         .         .         .         .       g.207143
 AAGATCTTCGGCTCCATCTGCTCCTTGAGTGGCGTCCTGGTCATTGCCCTGCCAGTCCCT       c.1200
 K  I  F  G  S  I  C  S  L  S  G  V  L  V  I  A  L  P  V  P         p.400

          .         .         .         .         .         .       g.207203
 GTGATTGTTTCCAACTTTAGCCGGATTTACCACCAGAATCAGAGAGCTGATAAACGCAGG       c.1260
 V  I  V  S  N  F  S  R  I  Y  H  Q  N  Q  R  A  D  K  R  R         p.420

           | 04        .         .         .         .         .    g.213415
 GCACAAAAG | AAGGCCCGCCTTGCCAGGATCCGTGTGGCCAAAACAGGCAGTTCGAATGCA    c.1320
 A  Q  K   | K  A  R  L  A  R  I  R  V  A  K  T  G  S  S  N  A      p.440

          .         .         .         .         .  | 05      .    g.213850
 TACCTGCACAGCAAGCGCAACGGGCTCCTCAACGAGGCGCTGGAGCTGACG | GGCACCCCA    c.1380
 Y  L  H  S  K  R  N  G  L  L  N  E  A  L  E  L  T   | G  T  P      p.460

          .         .         .         .         .         .       g.213910
 GAAGAGGAGCACATGGGCAAGACCACCTCACTCATCGAGAGCCAGCATCATCACCTGCTG       c.1440
 E  E  E  H  M  G  K  T  T  S  L  I  E  S  Q  H  H  H  L  L         p.480

          .         .  | 06      .         .         .         .    g.215702
 CACTGCCTGGAAAAAACCACT | GGGTTGTCCTATCTTGTGGATGATCCCCTGTTATCTGTA    c.1500
 H  C  L  E  K  T  T   | G  L  S  Y  L  V  D  D  P  L  L  S  V      p.500

          .         | 07         .         .         .         .    g.216924
 CGAACCTCCACCATCAAG | AACCACGAGTTTATTGATGAGCAGATGTTTGAGCAGAACTGC    c.1560
 R  T  S  T  I  K   | N  H  E  F  I  D  E  Q  M  F  E  Q  N  C      p.520

          .         .         .         .         .         .       g.216984
 ATGGAGAGTTCAATGCAGAACTACCCATCCACAAGAAGTCCCTCACTGTCCAGCCACCCA       c.1620
 M  E  S  S  M  Q  N  Y  P  S  T  R  S  P  S  L  S  S  H  P         p.540

          .         .         .         .         .         .       g.217044
 GGCCTCACTACCACCTGCTGCTCCCGTCGTAGTAAGAAGACCACACACCTGCCCAATTCT       c.1680
 G  L  T  T  T  C  C  S  R  R  S  K  K  T  T  H  L  P  N  S         p.560

          .         .         .         .         .         .       g.217104
 AACCTGCCAGCTACTCGCCTGCGCAGCATGCAAGAGCTCAGCACGATCCACATCCAGGGC       c.1740
 N  L  P  A  T  R  L  R  S  M  Q  E  L  S  T  I  H  I  Q  G         p.580

          .         .       | 08 .         .         .         .    g.217911
 AGTGAGCAGCCCTCCCTCACAACCAG | TCGCTCCAGCCTTAATTTGAAAGCAGACGACGGA    c.1800
 S  E  Q  P  S  L  T  T  S  |  R  S  S  L  N  L  K  A  D  D  G      p.600

          .         .         .         .         .         .       g.217971
 CTGAGACCAAACTGCAAAACATCCCAGATCACCACAGCCATCATCAGCATCCCCACTCCC       c.1860
 L  R  P  N  C  K  T  S  Q  I  T  T  A  I  I  S  I  P  T  P         p.620

          .         .         .         .         .         .       g.218031
 CCAGCGCTAACCCCAGAGGGGGAAAGTCGGCCACCCCCTGCCAGCCCAGGCCCCAACACG       c.1920
 P  A  L  T  P  E  G  E  S  R  P  P  P  A  S  P  G  P  N  T         p.640

          .         .         .         .                           g.218079
 AACATTCCTTCCATAGCCAGCAATGTTGTCAAGGTCTCCGCCTTGTAA                   c.1968
 N  I  P  S  I  A  S  N  V  V  K  V  S  A  L  X                     p.655

          .         .         .         .         .         .       g.218139
 aaccactggacagagggccagagtgggtagtggggaatgaaggggactggcatgttggtg       c.*60

          .         .         .         .         .         .       g.218199
 ggtggtcactgagaccactccctcccccctttccccactatttctgcctgccccattgta       c.*120

          .         .         .         .         .         .       g.218259
 cccctagcactgagacttgtgcctggaaggaaaaagaggtagcaaaggggcacctgaggt       c.*180

          .         .         .         .         .         .       g.218319
 tcacgctgctagcgtggacatagccctgtgatactgcatctcactggggccagaggaagg       c.*240

                                                                    g.218324
 gaggg                                                              c.*245

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Potassium voltage-gated channel, Shal-related subfamily, member 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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