potassium voltage-gated channel, subfamily H (eag-related), member 5 (KCNH5) - coding DNA reference sequence

(used for variant description)

(last modified November 29, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_139318.4 in the KCNH5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_034062.1, covering KCNH5 transcript NM_139318.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5052
         gcatccccccctcccccgccgcggatcctggccgctgctctccagacccagg       c.-1

          .         .         .         .         .         .       g.5112
 ATGCCGGGGGGCAAGAGAGGGCTGGTGGCACCGCAGAACACATTTTTGGAGAACATCGTC       c.60
 M  P  G  G  K  R  G  L  V  A  P  Q  N  T  F  L  E  N  I  V         p.20

          .    | 02    .         .         .         .         .    g.33331
 AGGCGCTCCAGTG | AATCAAGTTTCTTACTGGGAAATGCCCAGATTGTGGATTGGCCTGTA    c.120
 R  R  S  S  E |   S  S  F  L  L  G  N  A  Q  I  V  D  W  P  V      p.40

          .         .         .         .         .         .       g.33391
 GTTTATAGTAATGACGGTTTTTGTAAACTCTCTGGATATCATCGAGCTGACGTCATGCAG       c.180
 V  Y  S  N  D  G  F  C  K  L  S  G  Y  H  R  A  D  V  M  Q         p.60

          .        | 03.         .         .         .         .    g.43809
 AAAAGCAGCACTTGCAG | TTTTATGTATGGGGAATTGACTGACAAGAAGACCATTGAGAAA    c.240
 K  S  S  T  C  S  |  F  M  Y  G  E  L  T  D  K  K  T  I  E  K      p.80

          .         .         .         .         .         .       g.43869
 GTCAGGCAAACTTTTGACAACTACGAATCAAACTGCTTTGAAGTTCTTCTGTACAAGAAA       c.300
 V  R  Q  T  F  D  N  Y  E  S  N  C  F  E  V  L  L  Y  K  K         p.100

      | 04   .         .         .         .         .         .    g.48835
 AACA | GAACCCCTGTTTGGTTTTATATGCAAATTGCACCAATAAGAAATGAACATGAAAAG    c.360
 N  R |   T  P  V  W  F  Y  M  Q  I  A  P  I  R  N  E  H  E  K      p.120

          .         .         .         .         .         .       g.48895
 GTGGTCTTGTTCCTGTGTACTTTCAAGGATATTACGTTGTTCAAACAGCCAATAGAGGAT       c.420
 V  V  L  F  L  C  T  F  K  D  I  T  L  F  K  Q  P  I  E  D         p.140

          .    | 05    .         .         .         .         .    g.63098
 GATTCAACAAAAG | GTTGGACGAAATTTGCCCGATTGACACGGGCTTTGACAAATAGCCGA    c.480
 D  S  T  K  G |   W  T  K  F  A  R  L  T  R  A  L  T  N  S  R      p.160

          .         .         .         .         .         .       g.63158
 AGTGTTTTGCAGCAGCTCACGCCAATGAATAAAACAGAGGTGGTCCATAAACATTCAAGA       c.540
 S  V  L  Q  Q  L  T  P  M  N  K  T  E  V  V  H  K  H  S  R         p.180

           | 06        .         .         .         .         .    g.69025
 CTAGCTGAA | GTTCTTCAGCTGGGATCAGATATCCTTCCTCAGTATAAACAAGAAGCGCCA    c.600
 L  A  E   | V  L  Q  L  G  S  D  I  L  P  Q  Y  K  Q  E  A  P      p.200

          .         .         .         .         .         .       g.69085
 AAGACGCCACCACACATTATTTTACATTATTGTGCTTTTAAAACTACTTGGGATTGGGTG       c.660
 K  T  P  P  H  I  I  L  H  Y  C  A  F  K  T  T  W  D  W  V         p.220

          .         .         .         .         .         .       g.69145
 ATTTTAATTCTTACCTTCTACACCGCCATTATGGTTCCTTATAATGTTTCCTTCAAAACA       c.720
 I  L  I  L  T  F  Y  T  A  I  M  V  P  Y  N  V  S  F  K  T         p.240

          .         .         .         .         .         .       g.69205
 AAGCAGAACAACATAGCCTGGCTGGTACTGGATAGTGTGGTGGACGTTATTTTTCTGGTT       c.780
 K  Q  N  N  I  A  W  L  V  L  D  S  V  V  D  V  I  F  L  V         p.260

          .         .         .         .         .         .       g.69265
 GACATCGTTTTAAATTTTCACACGACTTTCGTGGGGCCCGGTGGAGAGGTCATTTCTGAC       c.840
 D  I  V  L  N  F  H  T  T  F  V  G  P  G  G  E  V  I  S  D         p.280

          .         .         .         .         .         .       g.69325
 CCTAAGCTCATAAGGATGAACTATCTGAAAACTTGGTTTGTGATCGATCTGCTGTCTTGT       c.900
 P  K  L  I  R  M  N  Y  L  K  T  W  F  V  I  D  L  L  S  C         p.300

          .         .         .         .   | 07     .         .    g.99697
 TTACCTTATGACATCATCAATGCCTTTGAAAATGTGGATGAG | GGAATCAGCAGTCTCTTC    c.960
 L  P  Y  D  I  I  N  A  F  E  N  V  D  E   | G  I  S  S  L  F      p.320

          .         .         .         .         .         .       g.99757
 AGTTCTTTAAAAGTGGTGCGTCTCTTACGACTGGGCCGTGTGGCTAGGAAACTGGACCAT       c.1020
 S  S  L  K  V  V  R  L  L  R  L  G  R  V  A  R  K  L  D  H         p.340

          .         .         .         .         .         .       g.99817
 TACCTAGAATATGGAGCAGCAGTCCTCGTGCTCCTGGTGTGTGTGTTTGGACTGGTGGCC       c.1080
 Y  L  E  Y  G  A  A  V  L  V  L  L  V  C  V  F  G  L  V  A         p.360

          .         .         .         .         .         .       g.99877
 CACTGGCTGGCCTGCATATGGTATAGCATCGGAGACTACGAGGTCATTGATGAAGTCACT       c.1140
 H  W  L  A  C  I  W  Y  S  I  G  D  Y  E  V  I  D  E  V  T         p.380

          .         .         .         .         .         .       g.99937
 AACACCATCCAAATAGACAGTTGGCTCTACCAGCTGGCTTTGAGCATTGGGACTCCATAT       c.1200
 N  T  I  Q  I  D  S  W  L  Y  Q  L  A  L  S  I  G  T  P  Y         p.400

          .         .         .         .         .         .       g.99997
 CGCTACAATACCAGTGCTGGGATATGGGAAGGAGGACCCAGCAAGGATTCATTGTACGTG       c.1260
 R  Y  N  T  S  A  G  I  W  E  G  G  P  S  K  D  S  L  Y  V         p.420

          .         .         .         .         .         .       g.100057
 TCCTCTCTCTACTTTACCATGACAAGCCTTACAACCATAGGATTTGGAAACATAGCTCCT       c.1320
 S  S  L  Y  F  T  M  T  S  L  T  T  I  G  F  G  N  I  A  P         p.440

          .         .         .         .          | 08        .    g.200397
 ACCACAGATGTGGAGAAGATGTTTTCGGTGGCTATGATGATGGTTGGCT | CTCTTCTTTAT    c.1380
 T  T  D  V  E  K  M  F  S  V  A  M  M  M  V  G  S |   L  L  Y      p.460

          .         .         .         .         .         .       g.200457
 GCAACTATTTTTGGAAATGTTACAACAATTTTCCAGCAAATGTATGCCAACACCAACCGA       c.1440
 A  T  I  F  G  N  V  T  T  I  F  Q  Q  M  Y  A  N  T  N  R         p.480

          .         .         .         .         .         .       g.200517
 TACCATGAGATGCTGAATAATGTACGGGACTTCCTAAAACTCTATCAGGTCCCAAAAGGC       c.1500
 Y  H  E  M  L  N  N  V  R  D  F  L  K  L  Y  Q  V  P  K  G         p.500

          .         .         .         .         .         .       g.200577
 CTTAGTGAGCGAGTCATGGATTATATTGTCTCAACATGGTCCATGTCAAAAGGCATTGAT       c.1560
 L  S  E  R  V  M  D  Y  I  V  S  T  W  S  M  S  K  G  I  D         p.520

           | 09        .         .         .         .         .    g.247708
 ACAGAAAAG | GTCCTCTCCATCTGTCCCAAGGACATGAGAGCTGATATCTGTGTTCATCTA    c.1620
 T  E  K   | V  L  S  I  C  P  K  D  M  R  A  D  I  C  V  H  L      p.540

          .         .         .         .         .         .       g.247768
 AACCGGAAGGTTTTTAATGAACATCCTGCTTTTCGATTGGCCAGCGATGGGTGTCTGCGC       c.1680
 N  R  K  V  F  N  E  H  P  A  F  R  L  A  S  D  G  C  L  R         p.560

          .         .         .         .         .         .       g.247828
 GCCTTGGCGGTAGAGTTCCAAACCATTCACTGTGCTCCCGGGGACCTCATTTACCATGCT       c.1740
 A  L  A  V  E  F  Q  T  I  H  C  A  P  G  D  L  I  Y  H  A         p.580

          .         .         .         .         .         .       g.247888
 GGAGAAAGTGTGGATGCCCTCTGCTTTGTGGTGTCAGGATCCTTGGAAGTCATCCAGGAT       c.1800
 G  E  S  V  D  A  L  C  F  V  V  S  G  S  L  E  V  I  Q  D         p.600

          .         .   | 10     .         .         .         .    g.270352
 GATGAGGTGGTGGCTATTTTAG | GGAAGGGTGATGTATTTGGAGACATCTTCTGGAAGGAA    c.1860
 D  E  V  V  A  I  L  G |   K  G  D  V  F  G  D  I  F  W  K  E      p.620

          .         .         .         .         .         .       g.270412
 ACCACCCTTGCCCATGCATGTGCGAACGTCCGGGCACTGACGTACTGTGACCTACACATC       c.1920
 T  T  L  A  H  A  C  A  N  V  R  A  L  T  Y  C  D  L  H  I         p.640

          .         .         .         .         .         .       g.270472
 ATCAAGCGGGAAGCCTTGCTCAAAGTCCTGGACTTTTATACAGCTTTTGCAAACTCCTTC       c.1980
 I  K  R  E  A  L  L  K  V  L  D  F  Y  T  A  F  A  N  S  F         p.660

          .         .         .          | 11        .         .    g.341804
 TCAAGGAATCTCACTCTTACTTGCAATCTGAGGAAACGG | ATCATCTTTCGTAAGATCAGT    c.2040
 S  R  N  L  T  L  T  C  N  L  R  K  R   | I  I  F  R  K  I  S      p.680

          .         .         .         .         .         .       g.341864
 GATGTGAAGAAAGAGGAGGAGGAGCGCCTCCGGCAGAAGAATGAGGTGACCCTCAGCATT       c.2100
 D  V  K  K  E  E  E  E  R  L  R  Q  K  N  E  V  T  L  S  I         p.700

          .         .         .         .         .         .       g.341924
 CCCGTGGACCACCCAGTCAGAAAGCTCTTCCAGAAGTTCAAGCAGCAGAAGGAGCTGCGG       c.2160
 P  V  D  H  P  V  R  K  L  F  Q  K  F  K  Q  Q  K  E  L  R         p.720

          .         .         .         .         .         .       g.341984
 AATCAGGGCTCAACACAGGGTGACCCTGAGAGGAACCAACTCCAGGTAGAGAGCCGCTCC       c.2220
 N  Q  G  S  T  Q  G  D  P  E  R  N  Q  L  Q  V  E  S  R  S         p.740

          .         .         .         .         .         .       g.342044
 TTACAGAATGGAGCCTCCATCACCGGAACCAGCGTGGTGACTGTGTCACAGATTACTCCC       c.2280
 L  Q  N  G  A  S  I  T  G  T  S  V  V  T  V  S  Q  I  T  P         p.760

          .         .         .         .         .         .       g.342104
 ATTCAGACGTCTCTGGCCTATGTGAAAACCAGTGAATCCCTTAAGCAGAACAACCGTGAT       c.2340
 I  Q  T  S  L  A  Y  V  K  T  S  E  S  L  K  Q  N  N  R  D         p.780

          .         .         .         .         .         .       g.342164
 GCCATGGAACTCAAGCCCAACGGCGGTGCTGACCAAAAATGTCTCAAAGTCAACAGCCCA       c.2400
 A  M  E  L  K  P  N  G  G  A  D  Q  K  C  L  K  V  N  S  P         p.800

          .         .         .         .         .         .       g.342224
 ATAAGAATGAAGAATGGAAATGGAAAAGGGTGGCTGCGACTCAAGAATAATATGGGAGCC       c.2460
 I  R  M  K  N  G  N  G  K  G  W  L  R  L  K  N  N  M  G  A         p.820

          .         .         .         .         .         .       g.342284
 CATGAGGAGAAAAAGGAAGACTGGAATAATGTCACTAAAGCTGAGTCAATGGGGCTATTG       c.2520
 H  E  E  K  K  E  D  W  N  N  V  T  K  A  E  S  M  G  L  L         p.840

          .         .         .         .         .         .       g.342344
 TCTGAGGACCCCAAGAGCAGTGATTCAGAGAACAGTGTGACCAAAAACCCACTAAGAAAA       c.2580
 S  E  D  P  K  S  S  D  S  E  N  S  V  T  K  N  P  L  R  K         p.860

          .         .         .         .         .         .       g.342404
 ACAGATTCTTGTGACAGTGGAATTACAAAAAGTGACCTTCGTTTGGATAAGGCTGGGGAG       c.2640
 T  D  S  C  D  S  G  I  T  K  S  D  L  R  L  D  K  A  G  E         p.880

          .         .         .         .         .         .       g.342464
 GCCCGAAGTCCGCTAGAGCACAGTCCCATCCAGGCTGATGCCAAGCACCCCTTTTATCCC       c.2700
 A  R  S  P  L  E  H  S  P  I  Q  A  D  A  K  H  P  F  Y  P         p.900

          .         .         .         .         .         .       g.342524
 ATCCCCGAGCAGGCCTTACAGACCACACTGCAGGAAGTCAAACACGAACTCAAAGAGGAC       c.2760
 I  P  E  Q  A  L  Q  T  T  L  Q  E  V  K  H  E  L  K  E  D         p.920

          .         .         .         .         .         .       g.342584
 ATCCAGCTGCTCAGCTGCAGAATGACTGCCCTAGAAAAGCAGGTGGCAGAAATTTTAAAA       c.2820
 I  Q  L  L  S  C  R  M  T  A  L  E  K  Q  V  A  E  I  L  K         p.940

          .         .         .         .         .         .       g.342644
 ATACTGTCGGAAAAAAGCGTACCCCAGGCCTCATCTCCCAAATCCCAAATGCCACTCCAA       c.2880
 I  L  S  E  K  S  V  P  Q  A  S  S  P  K  S  Q  M  P  L  Q         p.960

          .         .         .         .         .         .       g.342704
 GTACCCCCCCAGATACCATGTCAGGATATTTTTAGTGTCTCAAGGCCTGAATCACCTGAA       c.2940
 V  P  P  Q  I  P  C  Q  D  I  F  S  V  S  R  P  E  S  P  E         p.980

          .         .                                               g.342731
 TCTGACAAAGATGAAATCCACTTTTAA                                        c.2967
 S  D  K  D  E  I  H  F  X                                          p.988

          .         .         .         .         .         .       g.342791
 tatatatacatatatatttgttaatatattaaaacagtatatacatatgtgtgtatatac       c.*60

          .         .         .         .         .         .       g.342851
 agtatatacatatatatattttcacttgctttcaagatgatgaccacacatggattttga       c.*120

          .         .         .         .         .         .       g.342911
 tatgtaaatattgcatgtccagctggattctggcctgccaaagaagatgatgattaaaaa       c.*180

          .         .         .         .         .         .       g.342971
 catagatattgcttgtatattatgcagttgactgcatgcacactttacatttatttataa       c.*240

          .         .         .         .         .         .       g.343031
 tctctattctataataaaagagtatgatttttgttacccaaggcaatgtaatatttgaag       c.*300

          .         .         .         .         .         .       g.343091
 aatcagggtccaacctgccaatgttgccatgacaaatttgatctcaggctgagtatgtat       c.*360

          .         .         .         .         .         .       g.343151
 atcgagctatcattttctcactgttctgttaagttaaaagtatagattaatgccaaggaa       c.*420

          .         .         .         .         .         .       g.343211
 gagttcagtcttttaaactattagtaccatgttatgatctctttccataggatatttttc       c.*480

          .         .         .         .         .         .       g.343271
 tgtaacttagtgttaggttcttttcccctacaggcagtgtttgctccatttaaatgactg       c.*540

          .         .         .         .         .         .       g.343331
 tttagttgcctaagtcagataagagtgtgggatattgaaaacttattgctatgggttttg       c.*600

          .         .         .         .         .         .       g.343391
 tgcatgaattacatttttgatcaactatacctctcgttttttaacattatacttagatag       c.*660

          .         .         .         .         .         .       g.343451
 taatcattagctcttatgtaaggaaatccctactccctccttcttggagaacagctgcca       c.*720

          .         .         .         .         .         .       g.343511
 tcttgtaagctgacattatcaacatcataaatactaaactattaatatagagtatgttat       c.*780

          .         .         .         .         .         .       g.343571
 tatagaaacactgcaccacagggtataagggccttttgacaattcatgtaagagatgctg       c.*840

          .         .         .         .         .         .       g.343631
 aatttccaaagctgataaatgctctaaatttgtatttccaaaacatgttcaagagtgaca       c.*900

          .         .         .                                     g.343666
 ttgaaaggcttgttagcaaagaaacatacaaaaaa                                c.*935

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Potassium voltage-gated channel, subfamily H (eag-related), member 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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