potassium channel, subfamily V, member 2 (KCNV2) - coding DNA reference sequence

(used for variant description)

(last modified September 4, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_133497.3 in the KCNV2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012181.1, covering KCNV2 transcript NM_133497.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5034
                           gactgcgttcagaccctgcaggctgggctggcct       c.-181

 .         .         .         .         .         .                g.5094
 gcccaggacctgagaaggggcagctccggtggcaatgtctgagcccctagctgtgctggt       c.-121

 .         .         .         .         .         .                g.5154
 ccgggctggcctctctaagacagtgcaggccacgtgatccatcctcctagaggcagtgag       c.-61

 .         .         .         .         .         .                g.5214
 caggtgagggacccctaccacagccaggaggaaaaagctaggcgtccactttccgcagcc       c.-1

          .         .         .         .         .         .       g.5274
 ATGCTCAAACAGAGTGAGAGGAGACGGTCCTGGAGCTACAGGCCCTGGAACACGACGGAG       c.60
 M  L  K  Q  S  E  R  R  R  S  W  S  Y  R  P  W  N  T  T  E         p.20

          .         .         .         .         .         .       g.5334
 AATGAGGGCAGCCAACACCGCAGGAGCATTTGCTCCCTGGGTGCCCGTTCCGGCTCCCAG       c.120
 N  E  G  S  Q  H  R  R  S  I  C  S  L  G  A  R  S  G  S  Q         p.40

          .         .         .         .         .         .       g.5394
 GCCAGCATCCACGGCTGGACAGAGGGCAACTATAACTACTACATCGAGGAAGACGAAGAC       c.180
 A  S  I  H  G  W  T  E  G  N  Y  N  Y  Y  I  E  E  D  E  D         p.60

          .         .         .         .         .         .       g.5454
 GGCGAGGAGGAGGACCAGTGGAAGGACGACCTGGCAGAAGAGGACCAGCAGGCAGGGGAG       c.240
 G  E  E  E  D  Q  W  K  D  D  L  A  E  E  D  Q  Q  A  G  E         p.80

          .         .         .         .         .         .       g.5514
 GTCACCACCGCCAAGCCCGAGGGCCCCAGCGACCCTCCGGCCCTGCTGTCCACGCTGAAT       c.300
 V  T  T  A  K  P  E  G  P  S  D  P  P  A  L  L  S  T  L  N         p.100

          .         .         .         .         .         .       g.5574
 GTGAACGTGGGTGGCCACAGCTACCAGCTGGACTACTGCGAGCTGGCCGGCTTCCCCAAG       c.360
 V  N  V  G  G  H  S  Y  Q  L  D  Y  C  E  L  A  G  F  P  K         p.120

          .         .         .         .         .         .       g.5634
 ACGCGCCTAGGTCGCCTGGCCACCTCCACCAGCCGCAGCCGCCAGCTAAGCCTGTGCGAC       c.420
 T  R  L  G  R  L  A  T  S  T  S  R  S  R  Q  L  S  L  C  D         p.140

          .         .         .         .         .         .       g.5694
 GACTACGAGGAGCAGACAGACGAATACTTCTTCGACCGCGACCCGGCCGTCTTCCAGCTG       c.480
 D  Y  E  E  Q  T  D  E  Y  F  F  D  R  D  P  A  V  F  Q  L         p.160

          .         .         .         .         .         .       g.5754
 GTCTACAATTTCTACCTGTCCGGGGTGCTGCTGGTGCTCGACGGGCTGTGTCCGCGCCGC       c.540
 V  Y  N  F  Y  L  S  G  V  L  L  V  L  D  G  L  C  P  R  R         p.180

          .         .         .         .         .         .       g.5814
 TTCCTGGAGGAGCTGGGCTACTGGGGCGTGCGGCTCAAGTACACGCCACGCTGCTGCCGC       c.600
 F  L  E  E  L  G  Y  W  G  V  R  L  K  Y  T  P  R  C  C  R         p.200

          .         .         .         .         .         .       g.5874
 ATCTGCTTCGAGGAGCGGCGCGACGAGCTGAGCGAACGGCTCAAGATCCAGCACGAGCTG       c.660
 I  C  F  E  E  R  R  D  E  L  S  E  R  L  K  I  Q  H  E  L         p.220

          .         .         .         .         .         .       g.5934
 CGCGCGCAGGCGCAGGTCGAGGAGGCGGAGGAACTCTTCCGCGACATGCGCTTCTACGGC       c.720
 R  A  Q  A  Q  V  E  E  A  E  E  L  F  R  D  M  R  F  Y  G         p.240

          .         .         .         .         .         .       g.5994
 CCGCAGCGGCGCCGCCTCTGGAACCTCATGGAGAAGCCATTCTCCTCGGTGGCCGCCAAG       c.780
 P  Q  R  R  R  L  W  N  L  M  E  K  P  F  S  S  V  A  A  K         p.260

          .         .         .         .         .         .       g.6054
 GCCATCGGGGTGGCCTCCAGCACCTTCGTGCTCGTCTCCGTGGTGGCGCTGGCGCTCAAC       c.840
 A  I  G  V  A  S  S  T  F  V  L  V  S  V  V  A  L  A  L  N         p.280

          .         .         .         .         .         .       g.6114
 ACCGTGGAGGAGATGCAGCAGCACTCGGGGCAGGGCGAGGGCGGCCCAGACCTGCGGCCC       c.900
 T  V  E  E  M  Q  Q  H  S  G  Q  G  E  G  G  P  D  L  R  P         p.300

          .         .         .         .         .         .       g.6174
 ATCCTGGAGCACGTGGAGATGCTGTGCATGGGCTTCTTCACGCTCGAGTACCTGCTGCGC       c.960
 I  L  E  H  V  E  M  L  C  M  G  F  F  T  L  E  Y  L  L  R         p.320

          .         .         .         .         .         .       g.6234
 CTAGCCTCCACGCCCGACCTGAGGCGCTTCGCGCGCAGCGCCCTCAACCTGGTGGACCTG       c.1020
 L  A  S  T  P  D  L  R  R  F  A  R  S  A  L  N  L  V  D  L         p.340

          .         .         .         .         .         .       g.6294
 GTGGCCATCCTGCCGCTCTACCTTCAGCTGCTGCTCGAGTGCTTCACGGGCGAGGGCCAC       c.1080
 V  A  I  L  P  L  Y  L  Q  L  L  L  E  C  F  T  G  E  G  H         p.360

          .         .         .         .         .         .       g.6354
 CAACGCGGCCAGACGGTGGGCAGCGTGGGTAAGGTGGGTCAGGTGTTGCGCGTCATGCGC       c.1140
 Q  R  G  Q  T  V  G  S  V  G  K  V  G  Q  V  L  R  V  M  R         p.380

          .         .         .         .         .         .       g.6414
 CTCATGCGCATCTTCCGCATCCTCAAGCTGGCGCGCCACTCCACCGGACTGCGTGCCTTC       c.1200
 L  M  R  I  F  R  I  L  K  L  A  R  H  S  T  G  L  R  A  F         p.400

          .         .         .         .         .         .       g.6474
 GGCTTCACGCTGCGCCAGTGCTACCAGCAGGTGGGCTGCCTGCTGCTCTTCATCGCCATG       c.1260
 G  F  T  L  R  Q  C  Y  Q  Q  V  G  C  L  L  L  F  I  A  M         p.420

          .         .         .         .         .         .       g.6534
 GGCATCTTCACTTTCTCTGCGGCTGTCTACTCTGTGGAGCACGATGTGCCCAGCACCAAC       c.1320
 G  I  F  T  F  S  A  A  V  Y  S  V  E  H  D  V  P  S  T  N         p.440

          .         .         .       | 02 .         .         .    g.16944
 TTCACTACCATCCCCCACTCCTGGTGGTGGGCCGCG | GTGAGCATCTCCACCGTGGGCTAC    c.1380
 F  T  T  I  P  H  S  W  W  W  A  A   | V  S  I  S  T  V  G  Y      p.460

          .         .         .         .         .         .       g.17004
 GGAGACATGTACCCAGAGACCCACCTGGGCAGGTTTTTTGCCTTCCTCTGCATTGCTTTT       c.1440
 G  D  M  Y  P  E  T  H  L  G  R  F  F  A  F  L  C  I  A  F         p.480

          .         .         .         .         .         .       g.17064
 GGGATCATTCTCAACGGGATGCCCATTTCCATCCTCTACAACAAGTTTTCTGATTACTAC       c.1500
 G  I  I  L  N  G  M  P  I  S  I  L  Y  N  K  F  S  D  Y  Y         p.500

          .         .         .         .         .         .       g.17124
 AGCAAGCTGAAGGCTTATGAGTATACCACCATACGCAGGGAGAGGGGAGAGGTGAACTTC       c.1560
 S  K  L  K  A  Y  E  Y  T  T  I  R  R  E  R  G  E  V  N  F         p.520

          .         .         .         .         .         .       g.17184
 ATGCAGAGAGCCAGAAAGAAGATAGCTGAGTGTTTGCTTGGAAGCAACCCACAGCTCACC       c.1620
 M  Q  R  A  R  K  K  I  A  E  C  L  L  G  S  N  P  Q  L  T         p.540

          .                                                         g.17202
 CCAAGACAAGAGAATTAG                                                 c.1638
 P  R  Q  E  N  X                                                   p.545

          .         .         .         .         .         .       g.17262
 tattttataggacatgtggctggtagattccatgaacttcaaggcttcattgctcttttt       c.*60

          .         .         .         .         .         .       g.17322
 ttaatcattatgattggcagcaaaaggaaatgtgaagcagacatacacaaaggccatttc       c.*120

          .         .         .         .         .         .       g.17382
 gttcacaaagtactgcctctagaaatactcattttggcccaaactcagaatgtctcatag       c.*180

          .         .         .         .         .         .       g.17442
 ttgctctgtgttgtgtgaaacatctgaccttctcaatgacgttgatattgaaaacctgag       c.*240

          .         .         .         .         .         .       g.17502
 gggagcaacagcttagatttttcttgtagcttctcgtggcatctagctcaataaatattt       c.*300

          .                                                         g.17512
 ttggacttga                                                         c.*310

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Potassium channel, subfamily V, member 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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