potassium channel tetramerisation domain containing 7 (KCTD7) - coding DNA reference sequence

(used for variant description)

(last modified April 3, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_153033.4 in the KCTD7 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_028110.1, covering KCTD7 transcript NM_153033.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5004
                                                         agct       c.-181

 .         .         .         .         .         .                g.5064
 gggcgcgagcgggtcggcgttgagggagccaccgccctcccgcctgcgcactgcctctcg       c.-121

 .         .         .         .         .         .                g.5124
 cccccctccggccagcccgcagccggccgcgtcatgccaggcgctgctcggcggtaggga       c.-61

 .         .         .         .         .         .                g.5184
 gtgcccggggccgccgcctccgcccgcccgaagccgcgcccactgcccagagccagaggg       c.-1

          .         .         .         .         .         .       g.5244
 ATGGTGGTAGTCACGGGGCGGGAGCCAGACAGCCGTCGTCAGGACGGTGCCATGTCCAGC       c.60
 M  V  V  V  T  G  R  E  P  D  S  R  R  Q  D  G  A  M  S  S         p.20

          .         .         .         .         .         .       g.5304
 TCTGACGCCGAAGACGACTTTCTGGAGCCGGCCACGCCGACGGCCACGCAGGCGGGGCAC       c.120
 S  D  A  E  D  D  F  L  E  P  A  T  P  T  A  T  Q  A  G  H         p.40

          .         .     | 02   .         .         .         .    g.9430
 GCGCTGCCCCTGCTGCCACAGGAG | TTTCCTGAGGTTGTTCCCCTTAACATCGGAGGGGCT    c.180
 A  L  P  L  L  P  Q  E   | F  P  E  V  V  P  L  N  I  G  G  A      p.60

          .         .         .         .         .         .       g.9490
 CACTTCACTACACGCCTGTCCACACTGCGGTGCTACGAAGACACCATGTTGGCAGCCATG       c.240
 H  F  T  T  R  L  S  T  L  R  C  Y  E  D  T  M  L  A  A  M         p.80

          .         .         .         .         .         .       g.9550
 TTCAGTGGGCGGCACTACATCCCCACGGACTCCGAGGGCCGGTACTTCATCGACCGAGAT       c.300
 F  S  G  R  H  Y  I  P  T  D  S  E  G  R  Y  F  I  D  R  D         p.100

          .     | 03   .         .         .         .         .    g.14418
 GGCACACACTTTGG | AGATGTGCTGAATTTCCTGCGCTCAGGGGACCTCCCACCCAGGGAG    c.360
 G  T  H  F  G  |  D  V  L  N  F  L  R  S  G  D  L  P  P  R  E      p.120

          .         .         .         .         .         .       g.14478
 CGTGTTCGAGCTGTGTACAAAGAGGCCCAGTACTATGCCATCGGGCCCCTCCTGGAGCAG       c.420
 R  V  R  A  V  Y  K  E  A  Q  Y  Y  A  I  G  P  L  L  E  Q         p.140

          .         .         .         .         .         .       g.14538
 CTGGAGAACATGCAGCCACTGAAGGGCGAGAAGGTGCGCCAAGCGTTTCTGGGACTCATG       c.480
 L  E  N  M  Q  P  L  K  G  E  K  V  R  Q  A  F  L  G  L  M         p.160

          .    | 04    .         .         .         .         .    g.15022
 CCCTATTACAAAG | ACCACTTGGAGCGGATTGTGGAGATCGCCCGGCTGCGTGCGGTCCAG    c.540
 P  Y  Y  K  D |   H  L  E  R  I  V  E  I  A  R  L  R  A  V  Q      p.180

          .         .         .         .         .         .       g.15082
 CGGAAGGCCCGCTTTGCCAAGCTCAAGGTCTGTGTCTTCAAGGAGGAGATGCCCATCACC       c.600
 R  K  A  R  F  A  K  L  K  V  C  V  F  K  E  E  M  P  I  T         p.200

          .         .         .         .         .         .       g.15142
 CCCTATGAGTGTCCGCTCCTCAACTCCCTGCGATTTGAGCGGAGTGAGAGTGACGGGCAG       c.660
 P  Y  E  C  P  L  L  N  S  L  R  F  E  R  S  E  S  D  G  Q         p.220

          .         .         .         .         .         .       g.15202
 CTTTTTGAGCACCACTGTGAAGTGGATGTGTCTTTTGGGCCCTGGGAGGCTGTGGCTGAT       c.720
 L  F  E  H  H  C  E  V  D  V  S  F  G  P  W  E  A  V  A  D         p.240

          .         .         .         .         .         .       g.15262
 GTTTATGACCTGCTGCACTGCCTGGTCACGGACCTCTCGGCCCAGGGTCTCACCGTGGAC       c.780
 V  Y  D  L  L  H  C  L  V  T  D  L  S  A  Q  G  L  T  V  D         p.260

          .         .         .         .         .         .       g.15322
 CACCAGTGCATCGGGGTGTGTGACAAGCACCTCGTGAACCACTACTACTGCAAGCGCCCC       c.840
 H  Q  C  I  G  V  C  D  K  H  L  V  N  H  Y  Y  C  K  R  P         p.280

          .         .         .                                     g.15352
 ATCTATGAGTTCAAGATCACATGGTGGTGA                                     c.870
 I  Y  E  F  K  I  T  W  W  X                                       p.289

          .         .         .         .         .         .       g.15412
 gtagccccggtaggcgagagtcccatcagggaggatgtccaccttgcttggtggctctgg       c.*60

          .         .         .         .         .         .       g.15472
 gagtaagatccctgaaggggctgctgactgccccagaatctgccgaggtgagaacagcat       c.*120

          .         .         .         .         .         .       g.15532
 cctgaggcacagctcccaggggacagaggtgtagctccaatctccctgactgcacctcag       c.*180

          .         .         .         .         .         .       g.15592
 ggttgggctcagggcttgcggcctgcaggcactccagccagcgctcacctggcctttcct       c.*240

          .         .         .         .         .         .       g.15652
 caaggcatggtagtctttccttgaggctgatagctagggcttgaccaggaagtcccgaga       c.*300

          .         .         .         .         .         .       g.15712
 agttttgtcaccttcttgaccttgcaagagagtttctgcccattttagagccacgttacc       c.*360

          .         .         .         .         .         .       g.15772
 aaatcgatgtaggcctaatcacttcctcaaccctgttcaagcgtccctcccttgtgctca       c.*420

          .         .         .         .         .         .       g.15832
 gtatattggtgtgaacacggaacatgatgggggatttacctgaccagccaccccatagcc       c.*480

          .         .         .         .         .         .       g.15892
 cctggctgaagaagaaagagcatcttctctcccactgcaccccttctcctccaagaatag       c.*540

          .         .         .         .         .         .       g.15952
 ttgcccacattcccaaaatgtggaaagacttttcttttccttccggaacatgttcttcac       c.*600

          .         .         .         .         .         .       g.16012
 caccttttggagatttaaccatagctgccaaagctatgcacccagttggccttagaaaac       c.*660

          .         .         .         .         .         .       g.16072
 cacaatgtttacagccctgtcttagggccgcggcttctcttatcttccaccaccttcctt       c.*720

          .         .         .         .         .         .       g.16132
 gcttgcagggttatcttctcacagggctggaatgcaaatttcagaggcttcttttgaaga       c.*780

          .         .         .         .         .         .       g.16192
 ttccccaagtcaagcaggcaagatgcctagatcttctgttatctttgacatgtaacatcc       c.*840

          .         .         .         .         .         .       g.16252
 tttttagaggctcagaacacctccttggctgctatctcatgtgttagaatccagtttgtg       c.*900

          .         .         .         .         .         .       g.16312
 gtgaacctctttggaaggggaccccctctctttaaaccctgttcctctgtcctggtaaca       c.*960

          .         .         .         .         .         .       g.16372
 ttctccttctaggagagcctctcttctgagaaggtaaaggaagggctgggtgagacacac       c.*1020

          .         .         .         .         .         .       g.16432
 agctatcctaggagccgtaggaagacaaaacttcccttttgttttactcctcactcctct       c.*1080

          .         .         .         .         .         .       g.16492
 atttttgttttactcacttctttatattttgttttactcctcactcctgtatattttggt       c.*1140

          .         .         .         .         .         .       g.16552
 ttacttactcctctatttcagaaattgaaaaagatccccaaggatctgttactactgcat       c.*1200

          .         .         .         .         .         .       g.16612
 ttccttcttgctctgtctacagcctaggccaactagtcagggtctggacatgcatctcct       c.*1260

          .         .         .         .         .         .       g.16672
 aaaggaagaactgtgtagcaccattgatcacaatgtaacatttccatgctgcattaaggg       c.*1320

          .         .         .         .         .         .       g.16732
 tgtctctctctaatcatgattgtacctgtctcttcctgggtaaagggagatttttttttt       c.*1380

          .         .         .         .         .         .       g.16792
 taatgtgtaaagaattgatgcgagccaggaacatgtctgtagtcccagctacttgggcac       c.*1440

          .         .         .         .         .         .       g.16852
 acgcctgtagtccaggccactcgagcacacacctgtagtaccagctactctggaggctga       c.*1500

          .         .         .         .         .         .       g.16912
 ggcaggaggatcacttgagcccaggagattaagactgtagtatactatgatcgtgcctgt       c.*1560

          .         .         .         .         .         .       g.16972
 ggctagccactgtgctccagcctgggcaacaccatcgtaaaaataaataaataaataaat       c.*1620

          .         .         .         .         .         .       g.17032
 aaattggggaggacagcctcactggtatcagacttacaggaccagatagacaagatgggt       c.*1680

          .         .         .         .         .         .       g.17092
 ataaggggagctgaagtctgtgttcatatgaggaagagaagaccaagccctgggactttg       c.*1740

          .         .         .         .         .         .       g.17152
 gctgaattcctccgtggggctggacggcagtgatctcctgttccctatgtgtaaacaaag       c.*1800

          .         .         .         .         .         .       g.17212
 attccagggcgtggttttgcactcctgttgtactcttttagaggtggaaaagaggtggat       c.*1860

          .         .         .         .         .         .       g.17272
 actgagatctaagaggaaaggatagtcattcacgttctgagatatgcgctctctctattg       c.*1920

          .         .         .         .         .         .       g.17332
 ttctcgtacacaaagggatagtctcttttctggagctgatgtccctgcttggaggttagc       c.*1980

          .         .         .         .         .         .       g.17392
 cccaaaacatggctcttgtattgttctaagagaaaaggctttcattttggttcttctgat       c.*2040

          .         .         .         .         .         .       g.17452
 tggtgttacctactgcctaatatgtgttcattttttgacagagaggcagactattgaaaa       c.*2100

          .         .         .         .         .         .       g.17512
 agtctgtgtgaacagagagcagttcattaagcccattgctttcagtaatgtggccttgac       c.*2160

          .         .         .         .         .         .       g.17572
 cccttctgcttcccccttctcccatggagcatggcagggcttggttatttagagtccata       c.*2220

          .         .         .         .         .         .       g.17632
 catgcaagccattgagagacttgtttgctcaaatgcaagtttgctcaaaaacaggtcctg       c.*2280

          .         .         .         .         .         .       g.17692
 aaggcttgcttaggattacagggatgctgggtaagaacaccgttcctctctctcgctgga       c.*2340

          .         .         .         .         .         .       g.17752
 gaaatccctgtttctctgactccctttgtgatcctcacagtaatgtattctgtgccactg       c.*2400

          .         .         .         .         .         .       g.17812
 taggacacaaggctctgggccagtagaacaggcagagaggtgacactgggcagcaagctg       c.*2460

          .         .         .         .         .         .       g.17872
 agagctctttctaaatggagtgaaggaattcagtggcctagtttcgccattctctaatga       c.*2520

          .         .         .         .         .         .       g.17932
 gaaaccaaggccaggctgaaaagtgcaattagatgtggtggattgtggtaacggcctcca       c.*2580

          .         .         .         .         .         .       g.17992
 gataaaggggttatccctgtggaagtgacttttccccatttgatcccttttcaactctaa       c.*2640

          .         .         .         .         .         .       g.18052
 atggccaggcccagaacagaagaagggttgggtctggaaggaaggctccaaaggatgaaa       c.*2700

          .         .         .         .         .         .       g.18112
 gcttctccctgatcataaggaagtgcatctttatagaattgttgtgcataatgtcagtaa       c.*2760

          .         .         .         .         .         .       g.18172
 atccctctcacttgacaagggactggattcatcttgccttgagacgggccagtagttatc       c.*2820

          .         .         .         .         .         .       g.18232
 agtgagtcaaagcaaagtgaaagtttcaggagatgggaccaatggtgcaatgctcgccat       c.*2880

          .         .         .         .         .         .       g.18292
 aacaaaattccttaaaaataaaaaagctaatgttatagcaacaaaaaaagactgaagcaa       c.*2940

          .         .         .         .         .         .       g.18352
 aaccacactgaaatgcatcccactccaggagaggaattcttagcgtaacactctaaataa       c.*3000

          .         .         .         .         .         .       g.18412
 atggaaggaatcatcaccttccttattttacctctgccttgttcaccaggctgcccagtg       c.*3060

          .         .         .         .         .         .       g.18472
 cttaccatgcagaaagcagtcagctgtactctggaagtttctgttcttctttcctggggc       c.*3120

          .         .         .         .         .         .       g.18532
 ttaggatattctgggagctgtctgagccttgtgcctaaggcttatcaggtgatataatct       c.*3180

          .         .         .         .         .         .       g.18592
 tcctgttctgggctgcttgctggaggaataggaagtgacatttataagacacaggcggtg       c.*3240

          .         .         .         .         .         .       g.18652
 tgagcatccatgtgtggtcttggtctaaaccagctcttgaacaggttaaagcaaacagca       c.*3300

          .         .         .         .         .         .       g.18712
 ataacaaaacaaaaactactgatgctgagcgttttgatcctagtaatatttcaaatattg       c.*3360

          .         .         .         .         .         .       g.18772
 tccttctgcatatgttctatccatatttgattccaatatacattattaagctttcttggg       c.*3420

          .         .         .         .         .         .       g.18832
 tactattttgctggggctcttgcgtgaaggtggtacctgtctcatgatccttaaaagaga       c.*3480

          .         .         .         .         .         .       g.18892
 gaggcttttttcatccaaagctgtagtgttgggaactggggtgggagaggcactttttgg       c.*3540

          .         .         .         .         .         .       g.18952
 aattctgaaagaatcatatctgtgtatatacatactgagtggggaaggatgggggttggc       c.*3600

          .         .         .         .         .         .       g.19012
 aggggttgagggaggtgggaacaaacagtgagtatgggaacaggcagtcacctcgagtgt       c.*3660

          .         .         .         .         .         .       g.19072
 gggaggtcacctgggtccgtcgtcttccttctgtatggtgttgggtttatgtacacacta       c.*3720

          .         .         .         .         .         .       g.19132
 taacacttcctgtgtgagttcatgtacctgtctgtgagtgctttggtgtattgagcctca       c.*3780

          .         .         .         .         .         .       g.19192
 gtacactccaagggcattaaagtcaagaactagaacctgggtgctgtgcctttctttttt       c.*3840

          .         .         .         .         .         .       g.19252
 agagatgtgctctcatctcttctctgacccccactttgccagcaaatattttttatttct       c.*3900

          .         .         .         .         .         .       g.19312
 gcttaaaatgtggtgtgtttggggatgccccacacaacaagacaggcttttccctgagac       c.*3960

          .         .         .                                     g.19349
 cagcagctgaatttctgccctgaaagggaggtgggcc                              c.*3997

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Potassium channel tetramerisation domain containing 7 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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