lysine (K)-specific demethylase 4C (KDM4C) - coding DNA reference sequence

(used for variant description)

(last modified June 27, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_015061.3 in the KDM4C gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000009.11, covering KDM4C transcript NM_015061.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.41818
                     gccataggtgcgcgtcggcgcccaggaggacgtgtggcgc       c.-541

 .         .         .         .         .         .                g.41878
 gtggactacatcaggtccagccctgcgggaccccagccagcgcttccgggcaaggttctg       c.-481

 .         .         .         .         .         .                g.41938
 tgcacctgttttctccttctacgcgagtatctttcccctccggaaagaatgggatatgcc       c.-421

 .         .         .         .         .         .                g.41998
 tgtgtccaaaggacaagaagatgcgcgccagcaagcctaagttaaccacagcgcggaagt       c.-361

 .         .         .         .         .         .                g.42058
 tgagcccaaagcaagagcgtgccgggcacctttaagctgtttgtaagcccacgtgactca       c.-301

 .         .         .         .         .         .                g.42118
 ccaagtgcgggccccagcggtcacgtgacggcgcgcgcgccctcgcgcagggagagccgg       c.-241

 .         .         .         .         .         .                g.42178
 cggtgcgcgcgccttcgccgctgcctcccacccaccccctcgacgggagggtgaggcgcg       c.-181

 .         .         .         .         .         .                g.42238
 gcgcagtgatcgggcggccggggtcctgtgcgcgtgcgcagcgaacagctgtcacctagt       c.-121

 .         .         .         .         .         .                g.42298
 gcggaacaagtctcccaaatttcccaaatctccctgggccggaggccactgtcttctctt       c.-61

 .         .         .         .         .   | 02     .             g.77126
 cctcctccaccgagtcgtgctctcgccccaacccgcgcgccag | acactgccctaaccatc    c.-1

          .         .         .         .         .         .       g.77186
 ATGGAGGTGGCCGAGGTGGAAAGTCCTCTGAACCCCAGCTGTAAGATAATGACCTTCAGA       c.60
 M  E  V  A  E  V  E  S  P  L  N  P  S  C  K  I  M  T  F  R         p.20

          .         .         .         .         .         .       g.77246
 CCCTCCATGGAGGAGTTCCGGGAGTTCAACAAATACCTTGCATACATGGAGTCTAAAGGA       c.120
 P  S  M  E  E  F  R  E  F  N  K  Y  L  A  Y  M  E  S  K  G         p.40

          .         .     | 03   .         .         .         .    g.89772
 GCCCATCGTGCGGGTCTTGCAAAG | GTGATTCCTCCTAAGGAGTGGAAGCCAAGACAGTGC    c.180
 A  H  R  A  G  L  A  K   | V  I  P  P  K  E  W  K  P  R  Q  C      p.60

          .         .         .         .         .         .       g.89832
 TATGATGACATTGATAATTTGCTCATTCCAGCACCAATTCAGCAGATGGTCACAGGGCAG       c.240
 Y  D  D  I  D  N  L  L  I  P  A  P  I  Q  Q  M  V  T  G  Q         p.80

          .         .         .         .         .         .       g.89892
 TCAGGACTGTTCACTCAGTACAACATCCAGAAAAAAGCGATGACTGTGAAGGAGTTCAGG       c.300
 S  G  L  F  T  Q  Y  N  I  Q  K  K  A  M  T  V  K  E  F  R         p.100

          .         . | 04       .         .         .         .    g.98808
 CAGCTGGCCAACAGTGGCAA | ATATTGTACTCCAAGATACTTGGATTACGAAGATTTGGAG    c.360
 Q  L  A  N  S  G  K  |  Y  C  T  P  R  Y  L  D  Y  E  D  L  E      p.120

          .         .         .         .         .         .       g.98868
 CGCAAGTACTGGAAGAACTTAACTTTTGTGGCACCTATCTATGGTGCAGATATTAATGGG       c.420
 R  K  Y  W  K  N  L  T  F  V  A  P  I  Y  G  A  D  I  N  G         p.140

          .      | 05  .         .         .         .         .    g.133689
 AGCATATATGATGAG | GGTGTGGATGAATGGAACATAGCTCGCCTCAATACAGTCTTGGAT    c.480
 S  I  Y  D  E   | G  V  D  E  W  N  I  A  R  L  N  T  V  L  D      p.160

          .         .         .         .         .         .       g.133749
 GTGGTTGAAGAAGAGTGTGGCATTTCTATTGAGGGTGTAAATACCCCATATCTCTATTTT       c.540
 V  V  E  E  E  C  G  I  S  I  E  G  V  N  T  P  Y  L  Y  F         p.180

          .         .         .         .         .         .       g.133809
 GGCATGTGGAAGACCACGTTTGCATGGCACACCGAAGACATGGACCTCTATAGCATTAAT       c.600
 G  M  W  K  T  T  F  A  W  H  T  E  D  M  D  L  Y  S  I  N         p.200

          .         .          | 06        .         .         .    g.164180
 TATCTCCACTTTGGAGAGCCCAAGTCTTG | GTATGCTATACCTCCGGAGCATGGAAAACGA    c.660
 Y  L  H  F  G  E  P  K  S  W  |  Y  A  I  P  P  E  H  G  K  R      p.220

          .          | 07        .         .         .         .    g.172138
 CTTGAAAGACTAGCTCAAG | GTTTTTTCCCAAGCAGCTCCCAAGGGTGTGATGCATTTCTT    c.720
 L  E  R  L  A  Q  G |   F  F  P  S  S  S  Q  G  C  D  A  F  L      p.240

          .         .         .         .         .         .       g.172198
 CGCCACAAGATGACATTGATTTCTCCATCAGTATTGAAGAAATATGGTATTCCCTTTGAC       c.780
 R  H  K  M  T  L  I  S  P  S  V  L  K  K  Y  G  I  P  F  D         p.260

     | 08    .         .         .         .         .         .    g.177289
 AAG | ATAACCCAGGAGGCTGGAGAATTCATGATCACTTTCCCATATGGCTACCATGCTGGT    c.840
 K   | I  T  Q  E  A  G  E  F  M  I  T  F  P  Y  G  Y  H  A  G      p.280

          .         .         .         .         .         .       g.177349
 TTTAATCATGGTTTCAACTGTGCAGAATCTACAAATTTTGCTACTGTCAGATGGATTGAC       c.900
 F  N  H  G  F  N  C  A  E  S  T  N  F  A  T  V  R  W  I  D         p.300

          .         .  | 09      .         .         .         .    g.265101
 TATGGAAAAGTTGCCAAATTG | TGCACTTGCAGGAAAGACATGGTGAAGATTTCAATGGAT    c.960
 Y  G  K  V  A  K  L   | C  T  C  R  K  D  M  V  K  I  S  M  D      p.320

          .         .         .         .         .         .       g.265161
 ATCTTTGTGAGGAAATTTCAGCCAGACAGATATCAGCTTTGGAAACAAGGAAAGGATATA       c.1020
 I  F  V  R  K  F  Q  P  D  R  Y  Q  L  W  K  Q  G  K  D  I         p.340

          .         .         .         .         .         .       g.265221
 TACACCATTGATCACACGAAGCCTACTCCAGCATCCACCCCTGAAGTAAAAGCATGGCTG       c.1080
 Y  T  I  D  H  T  K  P  T  P  A  S  T  P  E  V  K  A  W  L         p.360

          .         .         .      | 10  .         .         .    g.268328
 CAGAGGAGGAGGAAAGTAAGAAAAGCATCCCGAAG | CTTCCAGTGTGCTAGGTCTACCTCT    c.1140
 Q  R  R  R  K  V  R  K  A  S  R  S  |  F  Q  C  A  R  S  T  S      p.380

          .         .         .         .         .         .       g.268388
 AAAAGGCCTAAGGCTGATGAGGAAGAGGAAGTGTCAGATGAAGTCGATGGGGCAGAGGTC       c.1200
 K  R  P  K  A  D  E  E  E  E  V  S  D  E  V  D  G  A  E  V         p.400

          .         .         .         .         .         .       g.268448
 CCTAACCCCGACTCAGTCACAGATGACCTCAAGGTCAGTGAAAAGTCAGAAGCAGCAGTG       c.1260
 P  N  P  D  S  V  T  D  D  L  K  V  S  E  K  S  E  A  A  V         p.420

          .         .         .         .         .         .       g.268508
 AAGCTGAGGAACACAGAAGCATCTTCAGAAGAAGAGTCATCTGCTAGCAGGATGCAGGTG       c.1320
 K  L  R  N  T  E  A  S  S  E  E  E  S  S  A  S  R  M  Q  V         p.440

          .         .         .     | 11   .         .         .    g.270507
 GAGCAGAATTTATCAGATCATATCAAACTCTCAG | GAAACAGCTGCTTAAGTACATCTGTA    c.1380
 E  Q  N  L  S  D  H  I  K  L  S  G |   N  S  C  L  S  T  S  V      p.460

          .         .         .         .         .         .       g.270567
 ACAGAAGACATAAAAACTGAGGATGACAAAGCTTATGCATATAGAAGTGTACCTTCTATA       c.1440
 T  E  D  I  K  T  E  D  D  K  A  Y  A  Y  R  S  V  P  S  I         p.480

          .         .         .         .         .         .       g.270627
 TCCAGTGAGGCTGATGATTCCATTCCATTGTCTAGTGGCTATGAGAAGCCCGAGAAATCA       c.1500
 S  S  E  A  D  D  S  I  P  L  S  S  G  Y  E  K  P  E  K  S         p.500

          .         .         .         .         .         .       g.270687
 GACCCATCCGAGCTTTCATGGCCAAAGTCACCTGAGTCATGCTCATCAGTGGCAGAGAGT       c.1560
 D  P  S  E  L  S  W  P  K  S  P  E  S  C  S  S  V  A  E  S         p.520

          .         .         .         .         .         .       g.270747
 AATGGTGTGTTAACAGAGGGAGAAGAGAGTGATGTGGAGAGCCATGGGAATGGCCTTGAA       c.1620
 N  G  V  L  T  E  G  E  E  S  D  V  E  S  H  G  N  G  L  E         p.540

          .         .         .         .         .        | 12.    g.274556
 CCTGGGGAAATCCCAGCGGTCCCCAGTGGAGAGAGAAATAGCTTCAAAGTCCCCAGT | ATA    c.1680
 P  G  E  I  P  A  V  P  S  G  E  R  N  S  F  K  V  P  S   | I      p.560

          .         .         .         .         .         .       g.274616
 GCAGAGGGAGAGAACAAAACCTCTAAGAGTTGGCGCCATCCACTTAGCAGGCCTCCAGCA       c.1740
 A  E  G  E  N  K  T  S  K  S  W  R  H  P  L  S  R  P  P  A         p.580

          .         .         .         .       | 13 .         .    g.295849
 AGATCTCCGATGACTCTTGTGAAGCAGCAGGCGCCAAGTGATGAAG | AATTGCCTGAGGTT    c.1800
 R  S  P  M  T  L  V  K  Q  Q  A  P  S  D  E  E |   L  P  E  V      p.600

          .         .         .         .         .         .       g.295909
 CTGTCCATTGAGGAGGAAGTGGAAGAAACAGAGTCTTGGGCGAAACCTCTCATCCACCTT       c.1860
 L  S  I  E  E  E  V  E  E  T  E  S  W  A  K  P  L  I  H  L         p.620

          .         .         .         .         .         .       g.295969
 TGGCAGACGAAGTCCCCTAACTTCGCAGCTGAGCAAGAGTATAATGCAACAGTGGCCAGG       c.1920
 W  Q  T  K  S  P  N  F  A  A  E  Q  E  Y  N  A  T  V  A  R         p.640

          .         .         .         .         | 14         .    g.297937
 ATGAAGCCACACTGTGCCATCTGCACTCTGCTCATGCCGTACCACAAG | CCAGATAGCAGC    c.1980
 M  K  P  H  C  A  I  C  T  L  L  M  P  Y  H  K   | P  D  S  S      p.660

          .         .         .         .         .         .       g.297997
 AATGAAGAAAATGATGCTAGATGGGAGACAAAATTAGATGAAGTCGTTACATCGGAGGGA       c.2040
 N  E  E  N  D  A  R  W  E  T  K  L  D  E  V  V  T  S  E  G         p.680

          .         .         .         .         .         .       g.298057
 AAGACTAAGCCCCTCATACCAGAGATGTGTTTTATTTATAGTGAAGAAAATATAGAATAT       c.2100
 K  T  K  P  L  I  P  E  M  C  F  I  Y  S  E  E  N  I  E  Y         p.700

          .         .         .         .         .         .       g.298117
 TCTCCACCCAATGCCTTCCTTGAAGAGGATGGAACAAGTCTCCTTATTTCCTGTGCAAAG       c.2160
 S  P  P  N  A  F  L  E  E  D  G  T  S  L  L  I  S  C  A  K         p.720

          .         .   | 15     .         .         .         .    g.300028
 TGCTGCGTACGGGTTCATGCAA | GTTGTTATGGTATTCCTTCTCATGAGATCTGTGATGGA    c.2220
 C  C  V  R  V  H  A  S |   C  Y  G  I  P  S  H  E  I  C  D  G      p.740

          .         .         .          | 16        .         .    g.331020
 TGGCTGTGTGCCCGGTGCAAAAGAAATGCGTGGACAGCA | GAATGCTGTCTCTGCAATTTG    c.2280
 W  L  C  A  R  C  K  R  N  A  W  T  A   | E  C  C  L  C  N  L      p.760

          .         .         .      | 17  .         .         .    g.333254
 AGAGGAGGTGCTCTTAAGCAAACGAAGAACAATAA | GTGGGCCCATGTCATGTGCGCCGTT    c.2340
 R  G  G  A  L  K  Q  T  K  N  N  K  |  W  A  H  V  M  C  A  V      p.780

          .         .         .         .         .         .       g.333314
 GCGGTCCCAGAAGTTCGATTCACTAATGTCCCAGAAAGGACACAAATAGATGTAGGCAGA       c.2400
 A  V  P  E  V  R  F  T  N  V  P  E  R  T  Q  I  D  V  G  R         p.800

          .         .     | 18   .         .         .         .    g.387858
 ATACCTTTACAGAGGTTAAAATTG | AAATGCATCTTCTGCAGACACCGGGTTAAGAGGGTC    c.2460
 I  P  L  Q  R  L  K  L   | K  C  I  F  C  R  H  R  V  K  R  V      p.820

          .         .         .         .         .         .       g.387918
 TCTGGAGCCTGCATCCAGTGTTCCTACGGTCGCTGCCCGGCCTCCTTCCATGTCACTTGT       c.2520
 S  G  A  C  I  Q  C  S  Y  G  R  C  P  A  S  F  H  V  T  C         p.840

          .         .         .         .         .         .       g.387978
 GCCCATGCTGCTGGGGTACTGATGGAGCCTGATGACTGGCCTTATGTGGTGAACATTACA       c.2580
 A  H  A  A  G  V  L  M  E  P  D  D  W  P  Y  V  V  N  I  T         p.860

          .         .         . | 19       .         .         .    g.412233
 TGCTTTCGACATAAGGTCAACCCCAACGTG | AAGTCCAAGGCTTGCGAGAAGGTCATTTCC    c.2640
 C  F  R  H  K  V  N  P  N  V   | K  S  K  A  C  E  K  V  I  S      p.880

          .         .         .         .         .         .       g.412293
 GTGGGTCAAACGGTCATCACGAAGCATCGGAACACCCGGTATTACAGTTGCAGAGTGATG       c.2700
 V  G  Q  T  V  I  T  K  H  R  N  T  R  Y  Y  S  C  R  V  M         p.900

          .         .         .         .         .         .       g.412353
 GCTGTGACATCGCAGACCTTCTATGAGGTCATGTTTGATGATGGCTCCTTTAGCAGAGAC       c.2760
 A  V  T  S  Q  T  F  Y  E  V  M  F  D  D  G  S  F  S  R  D         p.920

          .         .  | 20      .         .         .         .    g.449414
 ACATTTCCTGAGGATATCGTG | AGCCGAGACTGTCTGAAGCTGGGCCCACCTGCTGAGGGA    c.2820
 T  F  P  E  D  I  V   | S  R  D  C  L  K  L  G  P  P  A  E  G      p.940

          .         .         .         .         .         .       g.449474
 GAAGTCGTCCAAGTCAAGTGGCCCGATGGCAAACTCTATGGAGCAAAATATTTTGGATCA       c.2880
 E  V  V  Q  V  K  W  P  D  G  K  L  Y  G  A  K  Y  F  G  S         p.960

          .         .  | 21      .         .         .         .    g.453974
 AATATTGCCCACATGTACCAG | GTTGAGTTTGAAGATGGATCCCAGATAGCAATGAAGAGA    c.2940
 N  I  A  H  M  Y  Q   | V  E  F  E  D  G  S  Q  I  A  M  K  R      p.980

          .         .         .         .         .     | 22   .    g.458696
 GAGGACATCTACACTTTAGATGAAGAGTTACCCAAGAGAGTGAAAGCTCGATTT | TCCACA    c.3000
 E  D  I  Y  T  L  D  E  E  L  P  K  R  V  K  A  R  F   | S  T      p.1000

          .         .         .         .         .         .       g.458756
 GCCTCTGACATGCGATTTGAAGACACGTTTTATGGAGCAGACATTATCCAAGGGGAGAGA       c.3060
 A  S  D  M  R  F  E  D  T  F  Y  G  A  D  I  I  Q  G  E  R         p.1020

          .         .         .         .         .         .       g.458816
 AAGAGACAAAGAGTGCTGAGCTCCAGGTTTAAGAATGAATATGTGGCCGACCCTGTATAC       c.3120
 K  R  Q  R  V  L  S  S  R  F  K  N  E  Y  V  A  D  P  V  Y         p.1040

          .         .         .         .         .                 g.458867
 CGCACTTTTTTGAAGAGCTCTTTCCAGAAGAAGTGCCAGAAGAGACAGTAG                c.3171
 R  T  F  L  K  S  S  F  Q  K  K  C  Q  K  R  Q  X                  p.1056

          .         .         .         .         .         .       g.458927
 tctgcatacatcgctgcaggccacagagcagcttgggttggaagagagaagatgaaggga       c.*60

          .         .         .         .         .         .       g.458987
 catccttggggctgtgccgtgagttttgctggcataggtgacagggtgtgtctctgacag       c.*120

          .         .         .         .         .         .       g.459047
 tggtaaatcgggtttccagagtttggtcaccaaaaatacaaaatacacccaatgaattgg       c.*180

          .         .         .         .         .         .       g.459107
 acgcagcaatctgaaatcatctctagtcttgctttcacttgtgagcagttgtcttctatg       c.*240

          .         .         .         .         .         .       g.459167
 atcccaaagaagttttctaagtgaaaggaaatactagtgaatcacccacaaggaaaagcc       c.*300

          .         .         .         .         .         .       g.459227
 actgccacagaggaggcgggtccccttgtgcggcttagggccctgtcaggaaacacacgg       c.*360

          .         .         .         .         .         .       g.459287
 ggacctctctctctagctccagcaggtggcacctcggtacccagcgggtagggcgataat       c.*420

          .         .         .         .         .         .       g.459347
 ttatatattttccacagtcagggaaggactctcacttatttgtttcaaattgcagttttt       c.*480

          .         .         .         .         .         .       g.459407
 ataaaacatttttaaaacacaaatggcatgtatgctaatgagatttacccgtgtgctatc       c.*540

          .         .         .         .         .         .       g.459467
 tgtatttcccttgtacagaacttttacatttttgaatattcctattacttttgattgtgt       c.*600

          .         .         .         .         .         .       g.459527
 ctgatgggaactgagttgttggcctttgtgaaatgaaatttttggctcttgagaaagaat       c.*660

          .         .         .         .         .         .       g.459587
 tcttatgaattgttatgcgaattttatatatttaaagagggagatctggggctgttattt       c.*720

          .         .         .         .         .         .       g.459647
 ttaaacactttttttcataatacatattccgagtagatatttataaaatatatgtttctt       c.*780

          .         .         .         .         .         .       g.459707
 tcattatgtgtttgtaaaattagagtttaaataaatatgctttgatgcatagttttgaac       c.*840

          .         .         .         .         .         .       g.459767
 taatgtaacatgatttttcttttttaaaacagcctgaaaatgtactagtgtttaaaaata       c.*900

          .                                                         g.459786
 aagatttccattttctcca                                                c.*919

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Lysine (K)-specific demethylase 4C protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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