kelch-like ECH-associated protein 1 (KEAP1) - coding DNA reference sequence

(used for variant description)

(last modified April 1, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_203500.1 in the KEAP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering KEAP1 transcript NM_203500.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5005
                                                        ctttc       c.-181

 .         .         .         .         .         .                g.5065
 cgccctctccccgcctccttttcgggcgtcccgaggccgctccccaaccgacaaccaaga       c.-121

 .         .         .         .         .         .                g.5125
 ccccgcaggccacgcagccctggagccgaggccccccgacggcggaggcgcccgcgggtc       c.-61

 .         .   | 02     .         .         .         .             g.8345
 ccctacagccaag | gtccctgagtgccagaggtggtggtgttgcttatcttctggaacccc    c.-1

          .         .         .         .         .         .       g.8405
 ATGCAGCCAGATCCCAGGCCTAGCGGGGCTGGGGCCTGCTGCCGATTCCTGCCCCTGCAG       c.60
 M  Q  P  D  P  R  P  S  G  A  G  A  C  C  R  F  L  P  L  Q         p.20

          .         .         .         .         .         .       g.8465
 TCACAGTGCCCTGAGGGGGCAGGGGACGCGGTGATGTACGCCTCCACTGAGTGCAAGGCG       c.120
 S  Q  C  P  E  G  A  G  D  A  V  M  Y  A  S  T  E  C  K  A         p.40

          .         .         .         .         .         .       g.8525
 GAGGTGACGCCCTCCCAGCATGGCAACCGCACCTTCAGCTACACCCTGGAGGATCATACC       c.180
 E  V  T  P  S  Q  H  G  N  R  T  F  S  Y  T  L  E  D  H  T         p.60

          .         .         .         .         .         .       g.8585
 AAGCAGGCCTTTGGCATCATGAACGAGCTGCGGCTCAGCCAGCAGCTGTGTGACGTCACA       c.240
 K  Q  A  F  G  I  M  N  E  L  R  L  S  Q  Q  L  C  D  V  T         p.80

          .         .         .         .         .         .       g.8645
 CTGCAGGTCAAGTACCAGGATGCACCGGCCGCCCAGTTCATGGCCCACAAGGTGGTGCTG       c.300
 L  Q  V  K  Y  Q  D  A  P  A  A  Q  F  M  A  H  K  V  V  L         p.100

          .         .         .         .         .         .       g.8705
 GCCTCATCCAGCCCTGTCTTCAAGGCCATGTTCACCAACGGGCTGCGGGAGCAGGGCATG       c.360
 A  S  S  S  P  V  F  K  A  M  F  T  N  G  L  R  E  Q  G  M         p.120

          .         .         .         .         .         .       g.8765
 GAGGTGGTGTCCATTGAGGGTATCCACCCCAAGGTCATGGAGCGCCTCATTGAATTCGCC       c.420
 E  V  V  S  I  E  G  I  H  P  K  V  M  E  R  L  I  E  F  A         p.140

          .         .         .         .         .         .       g.8825
 TACACGGCCTCCATCTCCATGGGCGAGAAGTGTGTCCTCCACGTCATGAACGGTGCTGTC       c.480
 Y  T  A  S  I  S  M  G  E  K  C  V  L  H  V  M  N  G  A  V         p.160

          .         .         .         .         .         .       g.8885
 ATGTACCAGATCGACAGCGTTGTCCGTGCCTGCAGTGACTTCCTGGTGCAGCAGCTGGAC       c.540
 M  Y  Q  I  D  S  V  V  R  A  C  S  D  F  L  V  Q  Q  L  D         p.180

          .         .         .         .         .         .       g.8945
 CCCAGCAATGCCATCGGCATCGCCAACTTCGCTGAGCAGATTGGCTGTGTGGAGTTGCAC       c.600
 P  S  N  A  I  G  I  A  N  F  A  E  Q  I  G  C  V  E  L  H         p.200

          .         .         .          | 03        .         .    g.16137
 CAGCGTGCCCGGGAGTACATCTACATGCATTTTGGGGAG | GTGGCCAAGCAAGAGGAGTTC    c.660
 Q  R  A  R  E  Y  I  Y  M  H  F  G  E   | V  A  K  Q  E  E  F      p.220

          .         .         .         .         .         .       g.16197
 TTCAACCTGTCCCACTGCCAACTGGTGACCCTCATCAGCCGGGACGACCTGAACGTGCGC       c.720
 F  N  L  S  H  C  Q  L  V  T  L  I  S  R  D  D  L  N  V  R         p.240

          .         .         .         .         .         .       g.16257
 TGCGAGTCCGAGGTCTTCCACGCCTGCATCAACTGGGTCAAGTACGACTGCGAACAGCGA       c.780
 C  E  S  E  V  F  H  A  C  I  N  W  V  K  Y  D  C  E  Q  R         p.260

          .         .         .         .         .         .       g.16317
 CGGTTCTACGTCCAGGCGCTGCTGCGGGCCGTGCGCTGCCACTCGTTGACGCCGAACTTC       c.840
 R  F  Y  V  Q  A  L  L  R  A  V  R  C  H  S  L  T  P  N  F         p.280

          .         .         .         .         .         .       g.16377
 CTGCAGATGCAGCTGCAGAAGTGCGAGATCCTGCAGTCCGACTCCCGCTGCAAGGACTAC       c.900
 L  Q  M  Q  L  Q  K  C  E  I  L  Q  S  D  S  R  C  K  D  Y         p.300

          .         .         .         .         .         .       g.16437
 CTGGTCAAGATCTTCGAGGAGCTCACCCTGCACAAGCCCACGCAGGTGATGCCCTGCCGG       c.960
 L  V  K  I  F  E  E  L  T  L  H  K  P  T  Q  V  M  P  C  R         p.320

          .         .         .         .         .         .       g.16497
 GCGCCCAAGGTGGGCCGCCTGATCTACACCGCGGGCGGCTACTTCCGACAGTCGCTCAGC       c.1020
 A  P  K  V  G  R  L  I  Y  T  A  G  G  Y  F  R  Q  S  L  S         p.340

          .         .         .         .         .         .       g.16557
 TACCTGGAGGCTTACAACCCCAGTGACGGCACCTGGCTCCGGTTGGCGGACCTGCAGGTG       c.1080
 Y  L  E  A  Y  N  P  S  D  G  T  W  L  R  L  A  D  L  Q  V         p.360

          .         .         .         .         .         .       g.16617
 CCGCGGAGCGGCCTGGCCGGCTGCGTGGTGGGCGGGCTGTTGTACGCCGTGGGCGGCAGG       c.1140
 P  R  S  G  L  A  G  C  V  V  G  G  L  L  Y  A  V  G  G  R         p.380

          .         .         .         .         .         .       g.16677
 AACAACTCGCCCGACGGCAACACCGACTCCAGCGCCCTGGACTGTTACAACCCCATGACC       c.1200
 N  N  S  P  D  G  N  T  D  S  S  A  L  D  C  Y  N  P  M  T         p.400

          .         .         .         .         .         .       g.16737
 AATCAGTGGTCGCCCTGCGCCCCCATGAGCGTGCCCCGTAACCGCATCGGGGTGGGGGTC       c.1260
 N  Q  W  S  P  C  A  P  M  S  V  P  R  N  R  I  G  V  G  V         p.420

          .         .         .         .         .         .       g.16797
 ATCGATGGCCACATCTATGCCGTCGGCGGCTCCCACGGCTGCATCCACCACAACAGTGTG       c.1320
 I  D  G  H  I  Y  A  V  G  G  S  H  G  C  I  H  H  N  S  V         p.440

       | 04  .         .         .         .         .         .    g.18580
 GAGAG | GTATGAGCCAGAGCGGGATGAGTGGCACTTGGTGGCCCCAATGCTGACACGAAGG    c.1380
 E  R  |  Y  E  P  E  R  D  E  W  H  L  V  A  P  M  L  T  R  R      p.460

          .         .         .         .         .         .       g.18640
 ATCGGGGTGGGCGTGGCTGTCCTCAATCGTCTCCTTTATGCCGTGGGGGGCTTTGACGGG       c.1440
 I  G  V  G  V  A  V  L  N  R  L  L  Y  A  V  G  G  F  D  G         p.480

          .         .         .         .         .         .       g.18700
 ACAAACCGCCTTAATTCAGCTGAGTGTTACTACCCAGAGAGGAACGAGTGGCGAATGATC       c.1500
 T  N  R  L  N  S  A  E  C  Y  Y  P  E  R  N  E  W  R  M  I         p.500

          .         .         .  | 05      .         .         .    g.19039
 ACAGCAATGAACACCATCCGAAGCGGGGCAG | GCGTCTGCGTCCTGCACAACTGTATCTAT    c.1560
 T  A  M  N  T  I  R  S  G  A  G |   V  C  V  L  H  N  C  I  Y      p.520

          .         .         .         .         .         .       g.19099
 GCTGCTGGGGGCTATGATGGTCAGGACCAGCTGAACAGCGTGGAGCGCTACGATGTGGAA       c.1620
 A  A  G  G  Y  D  G  Q  D  Q  L  N  S  V  E  R  Y  D  V  E         p.540

          .         .         .         .         .         .       g.19159
 ACAGAGACGTGGACTTTCGTAGCCCCCATGAAGCACCGGCGAAGTGCCCTGGGGATCACT       c.1680
 T  E  T  W  T  F  V  A  P  M  K  H  R  R  S  A  L  G  I  T         p.560

          .         .         | 06         .         .         .    g.21592
 GTCCACCAGGGGAGAATCTACGTCCTTG | GAGGCTATGATGGTCACACGTTCCTGGACAGT    c.1740
 V  H  Q  G  R  I  Y  V  L  G |   G  Y  D  G  H  T  F  L  D  S      p.580

          .         .         .         .         .         .       g.21652
 GTGGAGTGTTACGACCCAGATACAGACACCTGGAGCGAGGTGACCCGAATGACATCGGGC       c.1800
 V  E  C  Y  D  P  D  T  D  T  W  S  E  V  T  R  M  T  S  G         p.600

          .         .         .         .         .         .       g.21712
 CGGAGTGGGGTGGGCGTGGCTGTCACCATGGAGCCCTGCCGGAAGCAGATTGACCAGCAG       c.1860
 R  S  G  V  G  V  A  V  T  M  E  P  C  R  K  Q  I  D  Q  Q         p.620

          .                                                         g.21727
 AACTGTACCTGTTGA                                                    c.1875
 N  C  T  C  X                                                      p.624

          .         .         .         .         .         .       g.21787
 ggcacttttgtttcttgggcaaaaatacagtccaatggggagtatcattgtttttgtaca       c.*60

          .         .         .         .         .         .       g.21847
 aaaaccgggactaaaagaaaagacagcactgcaaataacccatcttccgggaagggaggc       c.*120

          .         .         .         .         .         .       g.21907
 caggatgcctcagtgttaaaatgacatctcaaaagaagtccaaagcgggaatcatgtgcc       c.*180

          .         .         .         .         .         .       g.21967
 cctcagcggagccccgggagtgtccaagacagcctggctgggaaagggggtgtggaaaga       c.*240

          .         .         .         .         .         .       g.22027
 gcaggcttccaggagagaggcccccaaaccctctggccgggtaataggcctgggtcccac       c.*300

          .         .         .         .         .         .       g.22087
 tcacccatgccggcagctgtcaccatgtgatttattcttggatacctgggagggggccaa       c.*360

          .         .         .         .         .         .       g.22147
 tgggggcctcagggggaggccccctctggaaatgtggttcccagggatgggcctgtacat       c.*420

          .         .         .         .         .         .       g.22207
 agaagccaccggatggcacttccccaccggatggacagttattttgttgataagtaaccc       c.*480

          .         .         .         .         .                 g.22259
 tgtaattttccaaggaaaataaagaacagactaactagtgtctttcaccctg               c.*532

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Kelch-like ECH-associated protein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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