KIAA1257 (KIAA1257) - coding DNA reference sequence

(used for variant description)

(last modified September 4, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_020741.2 in the KIAA1257 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering KIAA1257 transcript NM_020741.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5016
                                             agcaaccgccaaacgt       c.-181

 .         .         .         .         .         .                g.5076
 agctgagtggctgggcctgcggccctccctgcaccggcggacgctcctctcagtcttgga       c.-121

 .         .         .         .         .         .                g.5136
 gtctcttcgcccaggtggctgtggatccggtacgggagttgccgccgcggtccaactccc       c.-61

 .         .         .        | 02.         .         .             g.5839
 cgctgccgcccagcgcatccgctcgcag | gagcgccggcggccagcagtgcgctctgcagc    c.-1

          .         .         .         .         .         .       g.5899
 ATGTCGCTACATGCCTGGGAGTGGGAAGAGGACCCCGCAAGCATAGAGCCCATCTCCTCC       c.60
 M  S  L  H  A  W  E  W  E  E  D  P  A  S  I  E  P  I  S  S         p.20

          .         .         .         .         .         .       g.5959
 ATCACTAGCTTTTACCAGTCCACGAGCGAGTGTGACGTGGAGGAACACCTGAAGGCCAAG       c.120
 I  T  S  F  Y  Q  S  T  S  E  C  D  V  E  E  H  L  K  A  K         p.40

          .         .         .         .         .         .       g.6019
 GCCAGGGCCCAGGAGTCTGACTCTGACCGCCCGTGCAGCAGCATCGAGTCCTCATCTGAG       c.180
 A  R  A  Q  E  S  D  S  D  R  P  C  S  S  I  E  S  S  S  E         p.60

          .         .         .         .         .         .       g.6079
 CCTGCCAGCACTTTCAGCTCCGACGTGCCCCACGTGGTCCCCTGCAAATTCACCATCTCA       c.240
 P  A  S  T  F  S  S  D  V  P  H  V  V  P  C  K  F  T  I  S         p.80

          .         .   | 03     .         .         .         .    g.10263
 CTGGCCTTCCCTGTGAATATGG | GTCAGAAGGGAAAATATGCAAGTTTGATTGAAAAATAT    c.300
 L  A  F  P  V  N  M  G |   Q  K  G  K  Y  A  S  L  I  E  K  Y      p.100

          .         .         .         .         .         .       g.10323
 AAGAAACACCCTAAAACAGACAGTTCTGTTACAAAGATGCGTCGTTTTTACCACATTGAG       c.360
 K  K  H  P  K  T  D  S  S  V  T  K  M  R  R  F  Y  H  I  E         p.120

          .         .         .         .         .         .       g.10383
 TATTTCCTTCTGCCGGACGATGAAGAACCTAAAAAAGTTGACATATTGCTATTTCCAATG       c.420
 Y  F  L  L  P  D  D  E  E  P  K  K  V  D  I  L  L  F  P  M         p.140

          .         .         .    | 04    .         .         .    g.11341
 GTGGCCAAAGTATTCCTGGAGTCAGGAGTAAAG | ACTGTGAAGCCGTGGCACGAAGGTGAC    c.480
 V  A  K  V  F  L  E  S  G  V  K   | T  V  K  P  W  H  E  G  D      p.160

          .         .         .         .         .         .       g.11401
 AAAGCCTGGGTGTCGTGGGAGCAGACTTTTAATATCACTGTGACAAAGGAATTATTAAAG       c.540
 K  A  W  V  S  W  E  Q  T  F  N  I  T  V  T  K  E  L  L  K         p.180

          .         .         .         .         .         .       g.11461
 AAAATAAATTTCCACAAAATCACCTTGAGGCTCTGGAACACTAAAGACAAGATGTCAAGA       c.600
 K  I  N  F  H  K  I  T  L  R  L  W  N  T  K  D  K  M  S  R         p.200

          .         .         .         .         .         .       g.11521
 AAAGTCAGATATTACCGATTAAAGACTGCCGGCTTCACAGACGACGTGGGAGCTTTTCAT       c.660
 K  V  R  Y  Y  R  L  K  T  A  G  F  T  D  D  V  G  A  F  H         p.220

         | 05.         .         .         .         .         .    g.21011
 AAGTCAG | AAGTGAGACATTTGGTTTTAAATCAGAGAAAATTATCTGAACAGGGCATTGAG    c.720
 K  S  E |   V  R  H  L  V  L  N  Q  R  K  L  S  E  Q  G  I  E      p.240

          .         .         .         .         .         .       g.21071
 AATACCAACATTGTCAGAGAAGAGTCGAACCAGGAACATCCGCCAGGAAAACAAGAAAAA       c.780
 N  T  N  I  V  R  E  E  S  N  Q  E  H  P  P  G  K  Q  E  K         p.260

          .         .         | 06         .         .         .    g.22109
 ACAGAAAAACACCCAAAGTCTTTGCAAG | GTTCTCACCAAGCAGAGCCCGAAACTTCTTCC    c.840
 T  E  K  H  P  K  S  L  Q  G |   S  H  Q  A  E  P  E  T  S  S      p.280

          .         .         .         .         .       | 07 .    g.23244
 AAGAACAGTGAGGAATATGAGAAGTCCCTCAAAATGGACGATTCTTCCACGATTCA | ATGG    c.900
 K  N  S  E  E  Y  E  K  S  L  K  M  D  D  S  S  T  I  Q  |  W      p.300

          .         .         .         .         .         .       g.23304
 AGTGTTTCAAGAACACCAACCATTTCTTTGGCAGGAGCAAGCATGATGGAGATCAAGGAA       c.960
 S  V  S  R  T  P  T  I  S  L  A  G  A  S  M  M  E  I  K  E         p.320

          .         .         .         .         .         .       g.23364
 TTAATTGAGAGTGAATCACTTAGCAGCTTAACAAACATATTAGACAGACAAAGGTCTCAA       c.1020
 L  I  E  S  E  S  L  S  S  L  T  N  I  L  D  R  Q  R  S  Q         p.340

   | 08      .         .         .         .         .         .    g.27769
 A | TTAAAGGGAAAGATTCAGAGGGAAGAAGGAAAATCCAGAGGAGACATAAGAAGCCCCTG    c.1080
 I |   K  G  K  D  S  E  G  R  R  K  I  Q  R  R  H  K  K  P  L      p.360

          .         .         .         .         .         .       g.27829
 GCAGAAGAAGAGGCAGACCCCACGCTGACAGGCCCCAGGAAGCAGAGCGCTTTCTCCATC       c.1140
 A  E  E  E  A  D  P  T  L  T  G  P  R  K  Q  S  A  F  S  I         p.380

          .         .         .         .         .         .       g.27889
 CAGCTGGCCGTCATGCCGCTCCTTGCCGGTACCCACTGCTTGCCCTGTTCCCAGCAGCTC       c.1200
 Q  L  A  V  M  P  L  L  A  G  T  H  C  L  P  C  S  Q  Q  L         p.400

          .         .         .                                     g.27919
 CTGCTTGTCTTGTGGCCAGAACGGCCATAA                                     c.1230
 L  L  V  L  W  P  E  R  P  X                                       p.409

          .         .         .         .         .         .       g.27979
 gcggatgctcctaatgacaaccctgctgcgtgccacctcatttcatcctcacagccacct       c.*60

          .         .         .         .         .         .       g.28039
 caggaaactcaggggaattggcttcatagtacagggggaaacaaaggcccagagagggta       c.*120

          .         .         .         .         .         .       g.28099
 gctaccttgcctgagatcacacagctaggaaatgtgaagcctggacttgaacccagctct       c.*180

          .         .         .         .         .         .       g.28159
 gtttgattccaaaatccaaggaagcctatgggaatattaaatgtcatcattgtgtttgtt       c.*240

          .         .         .         .                           g.28208
 aagaagatgctgcttttaataaatgctttcctacagatttttacaaaaa                  c.*289

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The KIAA1257 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 16
©2004-2016 Leiden University Medical Center