kinesin family member 11 (KIF11) - coding DNA reference sequence

(used for variant description)

(last modified April 24, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_004523.3 in the KIF11 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000010.10, covering KIF11 transcript NM_004523.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5008
                                                     agcgcagc       c.-301

 .         .         .         .         .         .                g.5068
 cattggtccggctactctgtctctttttcaaattgaggcgccgagtcgttgcttagtttc       c.-241

 .         .         .         .         .         .                g.5128
 tggggattcgggcggagacgagattagtgatttggcggctccgactggcgcgggacaaac       c.-181

 .         .         .         .         .         .                g.5188
 gccacggccagagtaccgggtagagagcggggacgccgacctgcgtgcgtcggtcctcca       c.-121

 .         .         .         .         .         .                g.5248
 ggccacgccagcgcccgagagggaccagggagactccggcccctgtcggccgccaagccc       c.-61

 .         .         .         .         .         .                g.5308
 ctccgcccctcacagcgcccaggtccgcggccgggccttgattttttggcggggaccgtc       c.-1

          .         .         .         .         .         .       g.5368
 ATGGCGTCGCAGCCAAATTCGTCTGCGAAGAAGAAAGAGGAGAAGGGGAAGAACATCCAG       c.60
 M  A  S  Q  P  N  S  S  A  K  K  K  E  E  K  G  K  N  I  Q         p.20

          .        | 02.         .         .         .         .    g.18240
 GTGGTGGTGAGATGCAG | ACCATTTAATTTGGCAGAGCGGAAAGCTAGCGCCCATTCAATA    c.120
 V  V  V  R  C  R  |  P  F  N  L  A  E  R  K  A  S  A  H  S  I      p.40

          .         .         .         .         .         .       g.18300
 GTAGAATGTGATCCTGTACGAAAAGAAGTTAGTGTACGAACTGGAGGATTGGCTGACAAG       c.180
 V  E  C  D  P  V  R  K  E  V  S  V  R  T  G  G  L  A  D  K         p.60

          .         .         . | 03       .         .         .    g.18581
 AGCTCAAGGAAAACATACACTTTTGATATG | GTGTTTGGAGCATCTACTAAACAGATTGAT    c.240
 S  S  R  K  T  Y  T  F  D  M   | V  F  G  A  S  T  K  Q  I  D      p.80

          .         .         .         .         .         .       g.18641
 GTTTACCGAAGTGTTGTTTGTCCAATTCTGGATGAAGTTATTATGGGCTATAATTGCACT       c.300
 V  Y  R  S  V  V  C  P  I  L  D  E  V  I  M  G  Y  N  C  T         p.100

          | 04         .         .         .         .         .    g.19143
 ATCTTTGC | GTATGGCCAAACTGGCACTGGAAAAACTTTTACAATGGAAGGTGAAAGGTCA    c.360
 I  F  A  |  Y  G  Q  T  G  T  G  K  T  F  T  M  E  G  E  R  S      p.120

          .         .        | 05.         .         .         .    g.20985
 CCTAATGAAGAGTATACCTGGGAAGAG | GATCCCTTGGCTGGTATAATTCCACGTACCCTT    c.420
 P  N  E  E  Y  T  W  E  E   | D  P  L  A  G  I  I  P  R  T  L      p.140

          .         .         .         .         .         .       g.21045
 CATCAAATTTTTGAGAAACTTACTGATAATGGTACTGAATTTTCAGTCAAAGTGTCTCTG       c.480
 H  Q  I  F  E  K  L  T  D  N  G  T  E  F  S  V  K  V  S  L         p.160

          .         .         .         .         .         .       g.21105
 TTGGAGATCTATAATGAAGAGCTTTTTGATCTTCTTAATCCATCATCTGATGTTTCTGAG       c.540
 L  E  I  Y  N  E  E  L  F  D  L  L  N  P  S  S  D  V  S  E         p.180

          .         .         .    | 06    .         .         .    g.21344
 AGACTACAGATGTTTGATGATCCCCGTAACAAG | AGAGGAGTGATAATTAAAGGTTTAGAA    c.600
 R  L  Q  M  F  D  D  P  R  N  K   | R  G  V  I  I  K  G  L  E      p.200

          .         .         .         .         .         .       g.21404
 GAAATTACAGTACACAACAAGGATGAAGTCTATCAAATTTTAGAAAAGGGGGCAGCAAAA       c.660
 E  I  T  V  H  N  K  D  E  V  Y  Q  I  L  E  K  G  A  A  K         p.220

          .         .         .         | 07         .         .    g.24994
 AGGACAACTGCAGCTACTCTGATGAATGCATACTCTAG | TCGTTCCCACTCAGTTTTCTCT    c.720
 R  T  T  A  A  T  L  M  N  A  Y  S  S  |  R  S  H  S  V  F  S      p.240

          .         .         .         .         .         .       g.25054
 GTTACAATACATATGAAAGAAACTACGATTGATGGAGAAGAGCTTGTTAAAATCGGAAAG       c.780
 V  T  I  H  M  K  E  T  T  I  D  G  E  E  L  V  K  I  G  K         p.260

           | 08        .         .         .         .         .    g.25360
 TTGAACTTG | GTTGATCTTGCAGGAAGTGAAAACATTGGCCGTTCTGGAGCTGTTGATAAG    c.840
 L  N  L   | V  D  L  A  G  S  E  N  I  G  R  S  G  A  V  D  K      p.280

          .         .         .         .         .         .       g.25420
 AGAGCTCGGGAAGCTGGAAATATAAATCAATCCCTGTTGACTTTGGGAAGGGTCATTACT       c.900
 R  A  R  E  A  G  N  I  N  Q  S  L  L  T  L  G  R  V  I  T         p.300

          .         .         .         .         .         .       g.25480
 GCCCTTGTAGAAAGAACACCTCATGTTCCTTATCGAGAATCTAAACTAACTAGAATCCTC       c.960
 A  L  V  E  R  T  P  H  V  P  Y  R  E  S  K  L  T  R  I  L         p.320

          .         .         .         .         .         .       g.25540
 CAGGATTCTCTTGGAGGGCGTACAAGAACATCTATAATTGCAACAATTTCTCCTGCATCT       c.1020
 Q  D  S  L  G  G  R  T  R  T  S  I  I  A  T  I  S  P  A  S         p.340

          .   | 09     .         .         .         .         .    g.28717
 CTCAATCTTGAG | GAAACTCTGAGTACATTGGAATATGCTCATAGAGCAAAGAACATATTG    c.1080
 L  N  L  E   | E  T  L  S  T  L  E  Y  A  H  R  A  K  N  I  L      p.360

          .         .         .         .         | 10         .    g.33329
 AATAAGCCTGAAGTGAATCAGAAACTCACCAAAAAAGCTCTTATTAAG | GAGTATACGGAG    c.1140
 N  K  P  E  V  N  Q  K  L  T  K  K  A  L  I  K   | E  Y  T  E      p.380

          .         .         .         .         .         .       g.33389
 GAGATAGAACGTTTAAAACGAGATCTTGCTGCAGCCCGTGAGAAAAATGGAGTGTATATT       c.1200
 E  I  E  R  L  K  R  D  L  A  A  A  R  E  K  N  G  V  Y  I         p.400

          .        | 11.         .         .         .         .    g.40783
 TCTGAAGAAAATTTTAG | AGTCATGAGTGGAAAATTAACTGTTCAAGAAGAGCAGATTGTA    c.1260
 S  E  E  N  F  R  |  V  M  S  G  K  L  T  V  Q  E  E  Q  I  V      p.420

          .         .         .         .      | 12  .         .    g.42123
 GAATTGATTGAAAAAATTGGTGCTGTTGAGGAGGAGCTGAATAGG | GTTACAGAGTTGTTT    c.1320
 E  L  I  E  K  I  G  A  V  E  E  E  L  N  R   | V  T  E  L  F      p.440

          .         .         .         .         .         .       g.42183
 ATGGATAATAAAAATGAACTTGACCAGTGTAAATCTGACCTGCAAAATAAAACACAAGAA       c.1380
 M  D  N  K  N  E  L  D  Q  C  K  S  D  L  Q  N  K  T  Q  E         p.460

          .         .         .         .         .         .       g.42243
 CTTGAAACCACTCAAAAACATTTGCAAGAAACTAAATTACAACTTGTTAAAGAAGAATAT       c.1440
 L  E  T  T  Q  K  H  L  Q  E  T  K  L  Q  L  V  K  E  E  Y         p.480

          .         .         .         .         .     | 13   .    g.44424
 ATCACATCAGCTTTGGAAAGTACTGAGGAGAAACTTCATGATGCTGCCAGCAAG | CTGCTT    c.1500
 I  T  S  A  L  E  S  T  E  E  K  L  H  D  A  A  S  K   | L  L      p.500

          .         .         .         .         .         .       g.44484
 AACACAGTTGAAGAAACTACAAAAGATGTATCTGGTCTCCATTCCAAACTGGATCGTAAG       c.1560
 N  T  V  E  E  T  T  K  D  V  S  G  L  H  S  K  L  D  R  K         p.520

          .         .         .         .         .         .       g.44544
 AAGGCAGTTGACCAACACAATGCAGAAGCTCAGGATATTTTTGGCAAAAACCTGAATAGT       c.1620
 K  A  V  D  Q  H  N  A  E  A  Q  D  I  F  G  K  N  L  N  S         p.540

          .         .         .         .         .         .       g.44604
 CTGTTTAATAATATGGAAGAATTAATTAAGGATGGCAGCTCAAAGCAAAAGGCCATGCTA       c.1680
 L  F  N  N  M  E  E  L  I  K  D  G  S  S  K  Q  K  A  M  L         p.560

          .         .   | 14     .         .         .         .    g.45593
 GAAGTACATAAGACCTTATTTG | GTAATCTGCTGTCTTCCAGTGTCTCTGCATTAGATACC    c.1740
 E  V  H  K  T  L  F  G |   N  L  L  S  S  S  V  S  A  L  D  T      p.580

          .         .         .         .         .         .       g.45653
 ATTACTACAGTAGCACTTGGATCTCTCACATCTATTCCAGAAAATGTGTCTACTCATGTT       c.1800
 I  T  T  V  A  L  G  S  L  T  S  I  P  E  N  V  S  T  H  V         p.600

          .         .         .         .         .         .       g.45713
 TCTCAGATTTTTAATATGATACTAAAAGAACAATCATTAGCAGCAGAAAGTAAAACTGTA       c.1860
 S  Q  I  F  N  M  I  L  K  E  Q  S  L  A  A  E  S  K  T  V         p.620

          .      | 15  .         .         .         .         .    g.49161
 CTACAGGAATTGATT | AATGTACTCAAGACTGATCTTCTAAGTTCACTGGAAATGATTTTA    c.1920
 L  Q  E  L  I   | N  V  L  K  T  D  L  L  S  S  L  E  M  I  L      p.640

          .         .         .         .         .         .       g.49221
 TCCCCAACTGTGGTGTCTATACTGAAAATCAATAGTCAACTAAAGCATATTTTCAAGACT       c.1980
 S  P  T  V  V  S  I  L  K  I  N  S  Q  L  K  H  I  F  K  T         p.660

          .         .  | 16      .         .         .         .    g.49358
 TCATTGACAGTGGCCGATAAG | ATAGAAGATCAAAAAAAGGAACTAGATGGCTTTCTCAGT    c.2040
 S  L  T  V  A  D  K   | I  E  D  Q  K  K  E  L  D  G  F  L  S      p.680

          .         .         .         .         .         .       g.49418
 ATACTGTGTAACAATCTACATGAACTACAAGAAAATACCATTTGTTCCTTGGTTGAGTCA       c.2100
 I  L  C  N  N  L  H  E  L  Q  E  N  T  I  C  S  L  V  E  S         p.700

          .         .         .         .         .         .       g.49478
 CAAAAGCAATGTGGAAACCTAACTGAAGACCTGAAGACAATAAAGCAGACCCATTCCCAG       c.2160
 Q  K  Q  C  G  N  L  T  E  D  L  K  T  I  K  Q  T  H  S  Q         p.720

  | 17       .         .         .         .         .         .    g.51786
  | GAACTTTGCAAGTTAATGAATCTTTGGACAGAGAGATTCTGTGCTTTGGAGGAAAAGTGT    c.2220
  | E  L  C  K  L  M  N  L  W  T  E  R  F  C  A  L  E  E  K  C      p.740

          .         .         .         .        | 18.         .    g.57308
 GAAAATATACAGAAACCACTTAGTAGTGTCCAGGAAAATATACAGCA | GAAATCTAAGGAT    c.2280
 E  N  I  Q  K  P  L  S  S  V  Q  E  N  I  Q  Q  |  K  S  K  D      p.760

          .         .         .         .         .         .       g.57368
 ATAGTCAACAAAATGACTTTTCACAGTCAAAAATTTTGTGCTGATTCTGATGGCTTCTCA       c.2340
 I  V  N  K  M  T  F  H  S  Q  K  F  C  A  D  S  D  G  F  S         p.780

          .         .         .         .         .         .       g.57428
 CAGGAACTCAGAAATTTTAACCAAGAAGGTACAAAATTGGTTGAAGAATCTGTGAAACAC       c.2400
 Q  E  L  R  N  F  N  Q  E  G  T  K  L  V  E  E  S  V  K  H         p.800

          .         .         .         .         .         .       g.57488
 TCTGATAAACTCAATGGCAACCTGGAAAAAATATCTCAAGAGACTGAACAGAGATGTGAA       c.2460
 S  D  K  L  N  G  N  L  E  K  I  S  Q  E  T  E  Q  R  C  E         p.820

          .         .         .         .         .         .       g.57548
 TCTCTGAACACAAGAACAGTTTATTTTTCTGAACAGTGGGTATCTTCCTTAAATGAAAGG       c.2520
 S  L  N  T  R  T  V  Y  F  S  E  Q  W  V  S  S  L  N  E  R         p.840

          .         .        | 19.         .         .         .    g.60177
 GAACAGGAACTTCACAACTTATTGGAG | GTTGTAAGCCAATGTTGTGAGGCTTCAAGTTCA    c.2580
 E  Q  E  L  H  N  L  L  E   | V  V  S  Q  C  C  E  A  S  S  S      p.860

          .         .         .         .         .         .       g.60237
 GACATCACTGAGAAATCAGATGGACGTAAGGCAGCTCATGAGAAACAGCATAACATTTTT       c.2640
 D  I  T  E  K  S  D  G  R  K  A  A  H  E  K  Q  H  N  I  F         p.880

          .         .         .         .         .         .       g.60297
 CTTGATCAGATGACTATTGATGAAGATAAATTGATAGCACAAAATCTAGAACTTAATGAA       c.2700
 L  D  Q  M  T  I  D  E  D  K  L  I  A  Q  N  L  E  L  N  E         p.900

          .         .         .         .         .         .       g.60357
 ACCATAAAAATTGGTTTGACTAAGCTTAATTGCTTTCTGGAACAGGATCTGAAACTGGAT       c.2760
 T  I  K  I  G  L  T  K  L  N  C  F  L  E  Q  D  L  K  L  D         p.920

          . | 20       .         .         .         .         .    g.61817
 ATCCCAACAG | GTACGACACCACAGAGGAAAAGTTATTTATACCCATCAACACTGGTAAGA    c.2820
 I  P  T  G |   T  T  P  Q  R  K  S  Y  L  Y  P  S  T  L  V  R      p.940

          .         .         .         .         .         .       g.61877
 ACTGAACCACGTGAACATCTCCTTGATCAGCTGAAAAGGAAACAGCCTGAGCTGTTAATG       c.2880
 T  E  P  R  E  H  L  L  D  Q  L  K  R  K  Q  P  E  L  L  M         p.960

          .         .         .         .   | 21     .         .    g.62351
 ATGCTAAACTGTTCAGAAAACAACAAAGAAGAGACAATTCCG | GATGTGGATGTAGAAGAG    c.2940
 M  L  N  C  S  E  N  N  K  E  E  T  I  P   | D  V  D  V  E  E      p.980

          .         .         .         .         .         .       g.62411
 GCAGTTCTGGGGCAGTATACTGAAGAACCTCTAAGTCAAGAGCCATCTGTAGATGCTGGT       c.3000
 A  V  L  G  Q  Y  T  E  E  P  L  S  Q  E  P  S  V  D  A  G         p.1000

          .         .         .          | 22        .         .    g.65618
 GTGGATTGTTCATCAATTGGCGGGGTTCCATTTTTCCAG | CATAAAAAATCACATGGAAAA    c.3060
 V  D  C  S  S  I  G  G  V  P  F  F  Q   | H  K  K  S  H  G  K      p.1020

          .         .         .         .         .         .       g.65678
 GACAAAGAAAACAGAGGCATTAACACACTGGAGAGGTCTAAAGTGGAAGAAACTACAGAG       c.3120
 D  K  E  N  R  G  I  N  T  L  E  R  S  K  V  E  E  T  T  E         p.1040

          .         .         .         .         .                 g.65729
 CACTTGGTTACAAAGAGCAGATTACCTCTGCGAGCCCAGATCAACCTTTAA                c.3171
 H  L  V  T  K  S  R  L  P  L  R  A  Q  I  N  L  X                  p.1056

          .         .         .         .         .         .       g.65789
 ttcacttgggggttggcaattttatttttaaagaaaacttaaaaataaaacctgaaaccc       c.*60

          .         .         .         .         .         .       g.65849
 cagaacttgagccttgtgtatagattttaaaagaatatatatatcagccgggcgcggtgg       c.*120

          .         .         .         .         .         .       g.65909
 ctcatgcctgtaatcccagcactttgggaggctgaggcgggtggattgcttgagcccagg       c.*180

          .         .         .         .         .         .       g.65969
 agtttgagaccagcctggccaacgtggcaaaacctcgtctctgttaaaaattagccgggc       c.*240

          .         .         .         .         .         .       g.66029
 gtggtggcacactcctgtaatcccagctactggggaggctgaggcacgagaatcacttga       c.*300

          .         .         .         .         .         .       g.66089
 acccaggaagcggggttgcagtgagccaaaggtacaccactacactccagcctgggcaac       c.*360

          .         .         .         .         .         .       g.66149
 agagcaagactcggtctcaaaaacaaaatttaaaaaagatataaggcagtactgtaaatt       c.*420

          .         .         .         .         .         .       g.66209
 cagttgaattttgatatctacccatttttctgtcatccctatagttcactttgtattaaa       c.*480

          .         .         .         .         .         .       g.66269
 ttgggtttcatttgggatttgcaatgtaaatacgtatttctagttttcatataaagtagt       c.*540

          .         .         .         .         .         .       g.66329
 tcttttataacaaatgaaaagtatttttcttgtatattattaagtaatgaatatataaga       c.*600

          .         .         .         .         .         .       g.66389
 actgtactcttctcagcttgagcttacataggtaaatatcaccaacatctgtccttagaa       c.*660

          .         .         .         .         .         .       g.66449
 aggaccatctcatgttttttttcttgctatgacttgtgtattttcttgcatcctccctag       c.*720

          .         .         .         .         .         .       g.66509
 acttccctatttcgctttctcctcggctcactttctccctttttatttttcaccaaacca       c.*780

          .         .         .         .         .         .       g.66569
 tttgtagagctacaaaaggtatcctttcttattttcagtagtcagaattttatctagaaa       c.*840

          .         .         .         .         .         .       g.66629
 tcttttaacacctttttagtggttatttctaaaatcactgtcaacaataaatctaaccct       c.*900

          .         .         .         .         .         .       g.66689
 agttgtatccctcctttcagtatttttcacttgttgccccaaatgtgaaagcatttcatt       c.*960

          .         .         .         .         .         .       g.66749
 cctttaagaggcctaactcattcaccctgacagagttcacaaaaagcccacttaagagta       c.*1020

          .         .         .         .         .         .       g.66809
 tacattgctattatgggagaccacccagacatctgactaatggctctgtgcccacactcc       c.*1080

          .         .         .         .         .         .       g.66869
 aagacctgtgccttttagagaagctcacaatgatttaaggactgtttgaaacttccaatt       c.*1140

          .         .         .         .         .         .       g.66929
 atgtctataatttatattcttttgtttacatgatgaaactttttgttgttgcttgtttgt       c.*1200

          .         .         .         .         .         .       g.66989
 atataatacaatgtgtacatgtatctttttctcgattcaaatcttaacccttaggactct       c.*1260

          .         .         .         .         .         .       g.67049
 ggtatttttgatctggcaaccatatttctggaagttgagatgtttcagcttgaagaacca       c.*1320

          .         .         .         .         .         .       g.67109
 aaacagaaggaatatgtacaaagaataaattttctgctcacgatgagtttagtgtgtaaa       c.*1380

          .         .         .         .         .         .       g.67169
 gtttagagacatctgactttgatagctaaattaaaccaaaccctattgaagaattgaata       c.*1440

          .         .         .         .         .         .       g.67229
 tatgctacttcaagaaactaaattgatctcgtagaattatcttaataaaataatggctat       c.*1500

          .         .         .         .         .         .       g.67289
 aatttctctgcaaaatcagatgtcagcataagcgatggataatacctaataaactgccct       c.*1560

          .         .         .                                     g.67328
 cagtaaatccatggttaataaatgtggtttctacattaa                            c.*1599

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Kinesin family member 11 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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