kinesin family member 22 (KIF22) - coding DNA reference sequence

(used for variant description)

(last modified October 30, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_007317.2 in the KIF22 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032055.1, covering KIF22 transcript NM_007317.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5047
              gcaccggggaattcgaatgggagaggcgggcccaaggagggagtgga       c.-1

          .         .         .         .         .         .       g.5107
 ATGGCCGCGGGCGGCTCGACGCAGCAGAGGCGACGCGAGATGGCGGCAGCTTCAGCGGCG       c.60
 M  A  A  G  G  S  T  Q  Q  R  R  R  E  M  A  A  A  S  A  A         p.20

          . | 02       .         .         .         .         .    g.11230
 GCGATCTCAG | GAGCTGGTCGCTGTCGGCTAAGCAAGATTGGAGCTACTCGTCGTCCACCT    c.120
 A  I  S  G |   A  G  R  C  R  L  S  K  I  G  A  T  R  R  P  P      p.40

          .         .         .         .         .         .       g.11290
 CCAGCTCGCGTAAGGGTGGCTGTGCGACTGCGGCCATTTGTGGATGGAACAGCGGGAGCA       c.180
 P  A  R  V  R  V  A  V  R  L  R  P  F  V  D  G  T  A  G  A         p.60

          .         .         .         .         .         .       g.11350
 AGTGATCCCCCCTGTGTGCGGGGCATGGACAGCTGCTCTCTAGAGATTGCTAACTGGAGG       c.240
 S  D  P  P  C  V  R  G  M  D  S  C  S  L  E  I  A  N  W  R         p.80

          .         .       | 03 .         .         .         .    g.12695
 AACCACCAGGAGACTCTCAAATACCA | GTTTGATGCCTTCTATGGGGAGAGGAGTACTCAG    c.300
 N  H  Q  E  T  L  K  Y  Q  |  F  D  A  F  Y  G  E  R  S  T  Q      p.100

          .         .         .         .         .         .       g.12755
 CAGGACATCTATGCAGGTTCAGTGCAGCCCATCCTAAGGCACTTGCTGGAAGGGCAGAAT       c.360
 Q  D  I  Y  A  G  S  V  Q  P  I  L  R  H  L  L  E  G  Q  N         p.120

          .         .         .     | 04   .         .         .    g.12906
 GCCAGTGTGCTTGCCTATGGACCCACAGGAGCTG | GGAAGACGCACACAATGCTGGGCAGC    c.420
 A  S  V  L  A  Y  G  P  T  G  A  G |   K  T  H  T  M  L  G  S      p.140

          .         .         .         .         .         .       g.12966
 CCAGAGCAACCTGGGGTGATCCCGCGGGCTCTCATGGACCTCCTGCAGCTCACAAGGGAG       c.480
 P  E  Q  P  G  V  I  P  R  A  L  M  D  L  L  Q  L  T  R  E         p.160

          .         .         .         .         .         .       g.13026
 GAGGGTGCCGAGGGCCGGCCATGGGCCCTTTCTGTCACCATGTCTTACCTAGAGATCTAC       c.540
 E  G  A  E  G  R  P  W  A  L  S  V  T  M  S  Y  L  E  I  Y         p.180

           | 05        .         .         .         .         .    g.13313
 CAGGAGAAG | GTATTAGACCTCCTGGACCCTGCTTCGGGAGACCTGGTAATCCGAGAAGAC    c.600
 Q  E  K   | V  L  D  L  L  D  P  A  S  G  D  L  V  I  R  E  D      p.200

          .         .         .         .         .         .       g.13373
 TGCCGGGGGAATATCCTGATTCCGGGTCTCTCCCAGAAGCCCATCAGTAGCTTTGCTGAT       c.660
 C  R  G  N  I  L  I  P  G  L  S  Q  K  P  I  S  S  F  A  D         p.220

          .         .         .         .         .         .       g.13433
 TTTGAGCGGCACTTCCTGCCAGCCAGTCGAAATCGGACTGTAGGAGCCACCCGGCTCAAC       c.720
 F  E  R  H  F  L  P  A  S  R  N  R  T  V  G  A  T  R  L  N         p.240

          .         .         .          | 06        .         .    g.13572
 CAGCGCTCCTCCCGCAGTCATGCTGTGCTCCTGGTCAAG | GTGGACCAGCGGGAACGTTTG    c.780
 Q  R  S  S  R  S  H  A  V  L  L  V  K   | V  D  Q  R  E  R  L      p.260

          .         .         .         .         .         .       g.13632
 GCCCCATTTCGCCAGCGAGAGGGAAAACTCTACCTGATTGACTTGGCTGGGTCAGAGGAC       c.840
 A  P  F  R  Q  R  E  G  K  L  Y  L  I  D  L  A  G  S  E  D         p.280

          .         .         .         .         .         .       g.13692
 AACCGGCGCACAGGCAACAAGGGCCTTCGGCTAAAAGAGAGTGGAGCCATCAACACCTCC       c.900
 N  R  R  T  G  N  K  G  L  R  L  K  E  S  G  A  I  N  T  S         p.300

          .         .         .         .         .         .       g.13752
 CTGTTTGTCCTGGGCAAAGTGGTAGATGCGCTGAATCAGGGCCTCCCTCGTGTACCTTAT       c.960
 L  F  V  L  G  K  V  V  D  A  L  N  Q  G  L  P  R  V  P  Y         p.320

          .         .         . | 07       .         .         .    g.13945
 CGGGACAGCAAGCTCACTCGCCTATTGCAG | GACTCTCTGGGTGGCTCAGCCCACAGTATC    c.1020
 R  D  S  K  L  T  R  L  L  Q   | D  S  L  G  G  S  A  H  S  I      p.340

          .         .         .         .         .         .       g.14005
 CTTATTGCCAACATTGCCCCTGAGAGACGCTTCTACCTAGACACAGTCTCCGCACTCAAC       c.1080
 L  I  A  N  I  A  P  E  R  R  F  Y  L  D  T  V  S  A  L  N         p.360

          .         .         .         .         .         .       g.14065
 TTTGCTGCCAGGTCCAAGGAGGTGATCAATCGGCCTTTTACCAATGAGAGCCTGCAGCCT       c.1140
 F  A  A  R  S  K  E  V  I  N  R  P  F  T  N  E  S  L  Q  P         p.380

      | 08   .         .         .         .         .         .    g.14256
 CATG | CCTTGGGACCTGTTAAGCTGTCTCAGAAAGAATTGCTTGGTCCACCAGAGGCAAAG    c.1200
 H  A |   L  G  P  V  K  L  S  Q  K  E  L  L  G  P  P  E  A  K      p.400

          .         .         .         .         .         .       g.14316
 AGAGCCCGAGGCCCTGAGGAAGAGGAGATCGGGAGCCCTGAGCCCATGGCAGCTCCAGCC       c.1260
 R  A  R  G  P  E  E  E  E  I  G  S  P  E  P  M  A  A  P  A         p.420

          .         . | 09       .         .         .         .    g.17096
 TCTGCCTCCCAGAAACTCAG | CCCCCTACAGAAGCTAAGCAGCATGGACCCGGCCATGCTG    c.1320
 S  A  S  Q  K  L  S  |  P  L  Q  K  L  S  S  M  D  P  A  M  L      p.440

          .         .         .         .         .         .       g.17156
 GAGCGCCTCCTCAGCTTGGACCGTCTGCTTGCCTCCCAGGGGAGCCAGGGGGCCCCTCTG       c.1380
 E  R  L  L  S  L  D  R  L  L  A  S  Q  G  S  Q  G  A  P  L         p.460

          .         .         .         .         .         .       g.17216
 TTGAGTACCCCAAAGCGAGAGCGGATGGTGCTAATGAAGACAGTGGAAGAGAAGGACCTA       c.1440
 L  S  T  P  K  R  E  R  M  V  L  M  K  T  V  E  E  K  D  L         p.480

           | 10        .         .         .         .         .    g.17787
 GAGATTGAG | AGGCTTAAGACGAAGCAAAAAGAACTGGAGGCCAAGATGTTGGCCCAGAAG    c.1500
 E  I  E   | R  L  K  T  K  Q  K  E  L  E  A  K  M  L  A  Q  K      p.500

          .         .         .         .         .         .       g.17847
 GCTGAGGAAAAGGAGAACCATTGTCCCACAATGCTCCGGCCCCTTTCACATCGCACAGTC       c.1560
 A  E  E  K  E  N  H  C  P  T  M  L  R  P  L  S  H  R  T  V         p.520

          .         .         .         .          | 11        .    g.18296
 ACAGGGGCAAAGCCCCTGAAAAAGGCTGTGGTGATGCCCCTACAGCTAA | TTCAGGAGCAG    c.1620
 T  G  A  K  P  L  K  K  A  V  V  M  P  L  Q  L  I |   Q  E  Q      p.540

          .         .         .         .         .        | 12.    g.19104
 GCAGCATCCCCAAATGCCGAGATCCACATCCTGAAGAATAAAGGCCGGAAGAGAAAG | CTG    c.1680
 A  A  S  P  N  A  E  I  H  I  L  K  N  K  G  R  K  R  K   | L      p.560

          .         .         .         .         .         .       g.19164
 GAGTCCCTGGATGCCCTAGAGCCTGAGGAGAAGGCTGAGGACTGCTGGGAGCTACAGATC       c.1740
 E  S  L  D  A  L  E  P  E  E  K  A  E  D  C  W  E  L  Q  I         p.580

          .         .         .         .         .         .       g.19224
 AGCCCGGAGCTACTGGCTCATGGGCGCCAAAAAATACTGGATCTGCTGAACGAAGGCTCA       c.1800
 S  P  E  L  L  A  H  G  R  Q  K  I  L  D  L  L  N  E  G  S         p.600

          .         .         .         .         .         .       g.19284
 GCCCGAGATCTCCGCAGTCTTCAGCGCATTGGCCCGAAGAAGGCCCAGCTAATCGTGGGC       c.1860
 A  R  D  L  R  S  L  Q  R  I  G  P  K  K  A  Q  L  I  V  G         p.620

          .         .         . | 13       .         .         .    g.19432
 TGGCGGGAGCTCCACGGCCCCTTCAGCCAG | GTGGAGGACCTGGAACGCGTGGAGGGCATA    c.1920
 W  R  E  L  H  G  P  F  S  Q   | V  E  D  L  E  R  V  E  G  I      p.640

          .         .         . | 14       .         .         .    g.19580
 ACGGGGAAACAGATGGAGTCCTTCCTGAAG | GCAAACATCCTGGGTCTCGCCGCCGGCCAG    c.1980
 T  G  K  Q  M  E  S  F  L  K   | A  N  I  L  G  L  A  A  G  Q      p.660

          .                                                         g.19598
 CGCTGTGGCGCCTCCTGA                                                 c.1998
 R  C  G  A  S  X                                                   p.665

          .         .         .         .         .         .       g.19658
 ccgtcgtctcctcactccgccttttcaaatttttgtataaccccgtgttgtgtaaataca       c.*60

          .                                                         g.19673
 gtttttgctccggtg                                                    c.*75

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Kinesin family member 22 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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