kinesin family member 3B (KIF3B) - coding DNA reference sequence

(used for variant description)

(last modified May 8, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_004798.3 in the KIF3B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000020.10, covering KIF3B transcript NM_004798.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5060
 actgtctctccccatccggggcagcggggaatggctgagccaggggttcgccgcccccgc       c.-121

 .         .         .         .         .         .     | 02       g.37067
 cgccgccgccgccgccgccgccgccgccgccgcccgctttcggctcgggcctcag | gaccg    c.-61

 .         .         .         .         .         .                g.37127
 tagcatcctgagacattttgaattgacacttctcaagatttgactggatcagagttcatc       c.-1

          .         .         .         .         .         .       g.37187
 ATGTCAAAGTTGAAAAGCTCAGAGTCAGTCAGGGTGGTGGTTCGCTGTCGGCCCATGAAT       c.60
 M  S  K  L  K  S  S  E  S  V  R  V  V  V  R  C  R  P  M  N         p.20

          .         .         .         .         .         .       g.37247
 GGCAAGGAAAAGGCTGCTTCGTATGACAAAGTGGTGGATGTGGATGTTAAGCTGGGGCAG       c.120
 G  K  E  K  A  A  S  Y  D  K  V  V  D  V  D  V  K  L  G  Q         p.40

          .         .         .         .         .         .       g.37307
 GTGTCTGTGAAGAACCCCAAAGGGACGGCCCATGAAATGCCCAAGACCTTCACCTTTGAT       c.180
 V  S  V  K  N  P  K  G  T  A  H  E  M  P  K  T  F  T  F  D         p.60

          .         .         .         .         .         .       g.37367
 GCCGTCTATGACTGGAATGCCAAGCAGTTTGAACTGTACGATGAGACGTTCCGACCACTT       c.240
 A  V  Y  D  W  N  A  K  Q  F  E  L  Y  D  E  T  F  R  P  L         p.80

          .         .         .         .         .         .       g.37427
 GTTGACTCTGTCCTGCAAGGTTTCAATGGAACCATTTTTGCCTATGGACAAACTGGGACA       c.300
 V  D  S  V  L  Q  G  F  N  G  T  I  F  A  Y  G  Q  T  G  T         p.100

          .         .         .         .         .         .       g.37487
 GGAAAAACCTACACCATGGAAGGAATCCGTGGTGACCCTGAAAAAAGAGGAGTCATTCCT       c.360
 G  K  T  Y  T  M  E  G  I  R  G  D  P  E  K  R  G  V  I  P         p.120

          .         .         .         .         .         .       g.37547
 AACTCATTTGACCATATCTTCACCCACATCTCTCGATCCCAGAATCAACAATACCTGGTC       c.420
 N  S  F  D  H  I  F  T  H  I  S  R  S  Q  N  Q  Q  Y  L  V         p.140

          .         .         .         .         .         .       g.37607
 AGGGCTTCTTACTTAGAGATCTACCAGGAGGAGATCCGAGATTTGCTCTCAAAGGATCAG       c.480
 R  A  S  Y  L  E  I  Y  Q  E  E  I  R  D  L  L  S  K  D  Q         p.160

          .         .         .         .         .         .       g.37667
 ACCAAAAGGCTTGAGCTCAAAGAGAGGCCTGACACAGGAGTGTATGTGAAAGACCTGTCT       c.540
 T  K  R  L  E  L  K  E  R  P  D  T  G  V  Y  V  K  D  L  S         p.180

          .         .         .         .         .         .       g.37727
 TCCTTTGTCACCAAGAGTGTGAAGGAGATAGAGCATGTGATGAATGTGGGGAACCAGAAC       c.600
 S  F  V  T  K  S  V  K  E  I  E  H  V  M  N  V  G  N  Q  N         p.200

          .         .         .         .         .         .       g.37787
 CGTTCTGTCGGTGCTACCAACATGAACGAGCACAGCTCGCGTTCTCATGCAATTTTCGTT       c.660
 R  S  V  G  A  T  N  M  N  E  H  S  S  R  S  H  A  I  F  V         p.220

          .         .         .         .         .         .       g.37847
 ATCACTATTGAGTGCAGCGAGGTGGGCCTCGATGGTGAAAACCACATCCGTGTAGGAAAA       c.720
 I  T  I  E  C  S  E  V  G  L  D  G  E  N  H  I  R  V  G  K         p.240

          .         .         .         .         .         .       g.37907
 TTGAACCTTGTAGATCTTGCTGGCAGCGAACGGCAAGCCAAGACCGGCGCACAAGGGGAG       c.780
 L  N  L  V  D  L  A  G  S  E  R  Q  A  K  T  G  A  Q  G  E         p.260

          .         .         .         .         .         .       g.37967
 AGATTAAAAGAAGCTACCAAGATCAACCTCTCCCTTTCCGCTTTGGGTAATGTCATCTCT       c.840
 R  L  K  E  A  T  K  I  N  L  S  L  S  A  L  G  N  V  I  S         p.280

          .         .         .         .         .         .       g.38027
 GCTCTAGTGGACGGCAAAAGCACTCACATTCCATATCGGGACTCAAAGCTTACCAGGCTC       c.900
 A  L  V  D  G  K  S  T  H  I  P  Y  R  D  S  K  L  T  R  L         p.300

          .         .         .         .         .         .       g.38087
 CTCCAAGATTCCCTTGGTGGCAATGCCAAGACTGTGATGGTGGCCAACGTGGGGCCTGCC       c.960
 L  Q  D  S  L  G  G  N  A  K  T  V  M  V  A  N  V  G  P  A         p.320

          .         .         .         .         .         .       g.38147
 TCTTACAACGTAGAAGAGACTCTGACCACTCTGCGATATGCCAACCGTGCCAAAAACATT       c.1020
 S  Y  N  V  E  E  T  L  T  T  L  R  Y  A  N  R  A  K  N  I         p.340

          .         .         .         .         .         .       g.38207
 AAGAACAAACCAAGGGTCAATGAGGACCCCAAGGATGCCCTCCTTCGAGAATTCCAGGAA       c.1080
 K  N  K  P  R  V  N  E  D  P  K  D  A  L  L  R  E  F  Q  E         p.360

          .         .         .         .         .         .       g.38267
 GAGATTGCTCGGCTCAAGGCCCAGCTGGAAAAACGGTCCATTGGTAGGAGGAAGAGGCGA       c.1140
 E  I  A  R  L  K  A  Q  L  E  K  R  S  I  G  R  R  K  R  R         p.380

          .         .         .         .         .         .       g.38327
 GAGAAGCGGAGGGAAGGTGGTGGCAGTGGTGGGGGTGGGGAAGAGGAGGAGGAGGAGGGA       c.1200
 E  K  R  R  E  G  G  G  S  G  G  G  G  E  E  E  E  E  E  G         p.400

          .         .         .         .         .         .       g.38387
 GAAGAGGGTGAGGAGGAAGGGGATGATAAGGATGATTACTGGCGGGAACAGCAAGAAAAA       c.1260
 E  E  G  E  E  E  G  D  D  K  D  D  Y  W  R  E  Q  Q  E  K         p.420

          .         .         .         .         .         .       g.38447
 CTGGAGATTGAGAAGCGGGCCATTGTAGAGGATCACAGCTTGGTTGCAGAGGAGAAGATG       c.1320
 L  E  I  E  K  R  A  I  V  E  D  H  S  L  V  A  E  E  K  M         p.440

          .         .         .         .         .         .       g.38507
 AGGCTGCTGAAGGAGAAAGAGAAAAAGATGGAGGACCTGCGGCGGGAGAAGGATGCTGCC       c.1380
 R  L  L  K  E  K  E  K  K  M  E  D  L  R  R  E  K  D  A  A         p.460

          .         .     | 03   .         .         .         .    g.43603
 GAGATGCTGGGCGCCAAGATCAAG | GCCATGGAGAGTAAGTTGCTTGTTGGAGGAAAAAAT    c.1440
 E  M  L  G  A  K  I  K   | A  M  E  S  K  L  L  V  G  G  K  N      p.480

          .         .         .         .         .         .       g.43663
 ATAGTAGATCATACGAATGAACAGCAGAAAATCCTGGAGCAGAAACGACAGGAAATTGCA       c.1500
 I  V  D  H  T  N  E  Q  Q  K  I  L  E  Q  K  R  Q  E  I  A         p.500

        | 04 .         .         .         .         .         .    g.43930
 GAGCAG | AAACGTCGAGAAAGAGAAATCCAGCAACAGATGGAAAGTCGAGATGAGGAGACC    c.1560
 E  Q   | K  R  R  E  R  E  I  Q  Q  Q  M  E  S  R  D  E  E  T      p.520

          .         .         .         .         .         .       g.43990
 TTGGAACTTAAAGAGACATACAGCTCATTGCAGCAAGAGGTGGACATCAAGACCAAAAAA       c.1620
 L  E  L  K  E  T  Y  S  S  L  Q  Q  E  V  D  I  K  T  K  K         p.540

           | 05        .         .         .         .         .    g.44156
 CTCAAAAAG | CTCTTCTCCAAGCTTCAGGCAGTGAAGGCTGAGATCCATGACCTCCAAGAA    c.1680
 L  K  K   | L  F  S  K  L  Q  A  V  K  A  E  I  H  D  L  Q  E      p.560

          .         .         .         .         .         .       g.44216
 GAACACATCAAGGAGCGCCAAGAGCTAGAGCAGACTCAGAATGAGCTCACCAGGGAGCTG       c.1740
 E  H  I  K  E  R  Q  E  L  E  Q  T  Q  N  E  L  T  R  E  L         p.580

          | 06         .         .         .         .         .    g.54172
 AAACTCAA | GCATCTTATTATAGAAAACTTTATCCCTCTGGAAGAAAAAAGTAAAATTATG    c.1800
 K  L  K  |  H  L  I  I  E  N  F  I  P  L  E  E  K  S  K  I  M      p.600

          .         .         .         .         .         .       g.54232
 AATAGAGCCTTCTTTGATGAAGAGGAAGATCATTGGAAACTACATCCTATAACCAGACTG       c.1860
 N  R  A  F  F  D  E  E  E  D  H  W  K  L  H  P  I  T  R  L         p.620

    | 07     .         .         .         .         .         .    g.54963
 GA | GAACCAGCAGATGATGAAGCGGCCAGTCTCAGCCGTGGGATATAAGAGACCATTGAGC    c.1920
 E  |  N  Q  Q  M  M  K  R  P  V  S  A  V  G  Y  K  R  P  L  S      p.640

          .         .         .         .         | 08         .    g.57502
 CAGCACGCAAGAATGTCCATGATGATTCGTCCAGAGGCCCGATATAGG | GCAGAAAACATT    c.1980
 Q  H  A  R  M  S  M  M  I  R  P  E  A  R  Y  R   | A  E  N  I      p.660

          .         .         .         .         .         .       g.57562
 GTGCTGTTAGAGCTGGACATGCCCAGCCGGACCACCAGAGACTATGAGGGTCCAGCCATT       c.2040
 V  L  L  E  L  D  M  P  S  R  T  T  R  D  Y  E  G  P  A  I         p.680

          .         .         .         .         .         .       g.57622
 GCCCCCAAGGTCCAGGCTGCATTGGATGCGGCTCTGCAGGATGAAGATGAGATACAGGTG       c.2100
 A  P  K  V  Q  A  A  L  D  A  A  L  Q  D  E  D  E  I  Q  V         p.700

          .         .         .         .        | 09.         .    g.58585
 GATGCATCATCATTTGAAAGCACTGCAAATAAGAAATCCAAGGCCAG | GCCTAAAAGTGGA    c.2160
 D  A  S  S  F  E  S  T  A  N  K  K  S  K  A  R  |  P  K  S  G      p.720

          .         .         .         .         .         .       g.58645
 AGGAAGTCGGGATCCTCCTCCTCTTCCTCAGGAACCCCTGCATCTCAGCTTTATCCACAG       c.2220
 R  K  S  G  S  S  S  S  S  S  G  T  P  A  S  Q  L  Y  P  Q         p.740

          .         .                                               g.58669
 TCTCGGGGGCTGGTTCCAAAGTAA                                           c.2244
 S  R  G  L  V  P  K  X                                             p.747

          .         .         .         .         .         .       g.58729
 agccagcttctcctctcccagggcggaaacagcatttgccttctgagagaagagactagc       c.*60

          .         .         .         .         .         .       g.58789
 aaaaagctgcagagaggattcggcccaaactcagaactgttcccctgaggagaagcggtg       c.*120

          .         .         .         .         .         .       g.58849
 gcctctttgcagatcaaccaacttaatctggttgaacgtgctgttcctaatctggcactc       c.*180

          .         .         .         .         .         .       g.58909
 agcccctctgggaaacatcttttaattagcatctcagaaatgcatgggtaaggtaaagtg       c.*240

          .         .         .         .         .         .       g.58969
 cgatagttcaagtggaaagcaagagaatgaccagtgaccttgcttccttcccccttgcct       c.*300

          .         .         .         .         .         .       g.59029
 tcttctcccccttcccctgtgctccctttctctcctctctccttttctagcctgttcttt       c.*360

          .         .         .         .         .         .       g.59089
 acatggggctcccttcttgttgaacaatagggcagaatcaggagtcaccttagcaggacc       c.*420

          .         .         .         .         .         .       g.59149
 acatctttggagcctcgggataaaatgacagtgaggttgaaaagtgaaaaccctagaact       c.*480

          .         .         .         .         .         .       g.59209
 tgaataggtgcctgttcttgtagggagaaatgagaaatcgcatttggatccaggccccag       c.*540

          .         .         .         .         .         .       g.59269
 gtgggcaccatcagcagtcttgcttccatgcacctcagtaagaagtggatctgcctttgg       c.*600

          .         .         .         .         .         .       g.59329
 gacctgctcagtgaggaaatctcttccaatttctgcttctgaatgattcaatgttgggag       c.*660

          .         .         .         .         .         .       g.59389
 caatagaaataacattccctttgccttctctgagtgtttagggaaatagcttctttaaaa       c.*720

          .         .         .         .         .         .       g.59449
 cctcaaaaccatgaccatcctgtcaaagacctaagtctgtaagctggtgccatgtccata       c.*780

          .         .         .         .         .         .       g.59509
 caccatgtcactttactcttcatttgtcaccatcttttcccatgcacgcatactctgaac       c.*840

          .         .         .         .         .         .       g.59569
 atccttgtgtgggcccatcctctgcatccagagcatgctctgcagtgggcctgttttgtg       c.*900

          .         .         .         .         .         .       g.59629
 gaagaaaggaggctgtctctgccttctctgatgggactggagttgagggaaggagctgta       c.*960

          .         .         .         .         .         .       g.59689
 ttgtggcacttctgaattccccgttttgttccatattggtatagagagcagaagagtagc       c.*1020

          .         .         .         .         .         .       g.59749
 taggcagatgcagagatggagacatgagactcagtgcagtgggcagggaagacataacag       c.*1080

          .         .         .         .         .         .       g.59809
 atggaagcaaaggaatcctgcctgccttcagcagagaattcaccgaatcctagaactgtg       c.*1140

          .         .         .         .         .         .       g.59869
 gctccctccaggcagagcctaagatgctggtgaagaatagctgtgtgattgaataggctc       c.*1200

          .         .         .         .         .         .       g.59929
 aaaggagagttcagaattcccatttacatattactagtttggtttgtaagttttagttcc       c.*1260

          .         .         .         .         .         .       g.59989
 ttgtattattgagattcagagcttcattttatgttggtcattaggtgaatattactcatt       c.*1320

          .         .         .         .         .         .       g.60049
 ttccctcaagagaagctcataagtgtgtgtgggtgtgagagcacgatggtgcctgtgttc       c.*1380

          .         .         .         .         .         .       g.60109
 tgtgaatgtgtccatatgtgtctgtaagagagacagagaccaagaacttgcccaatttta       c.*1440

          .         .         .         .         .         .       g.60169
 gaaatacactaatgtgcagttgttgccttttgtctgtattgaaggcccattgaatgacta       c.*1500

          .         .         .         .         .         .       g.60229
 atccaggctggaagcattcccatgtgggtgtctgagtccatgagccaagcctgaggggac       c.*1560

          .         .         .         .         .         .       g.60289
 agtgagtctccaggtctgccacactggtgcaccttgctggcacggtgcctcaggaaggtg       c.*1620

          .         .         .         .         .         .       g.60349
 gcgactcaggtgggccttgagttatattttaactcagctgctcagttcccagggcacatt       c.*1680

          .         .         .         .         .         .       g.60409
 tctggatcagaacccatgggaaacaggaggtactaagtgcaatgtcttagcattctgcaa       c.*1740

          .         .         .         .         .         .       g.60469
 aatggagatctgttgtccagcggcttatctcctttttagtaacccttctttctgaaccca       c.*1800

          .         .         .         .         .         .       g.60529
 gggcccttttcagccttccctcatattttcttgagatcaaactttacttctttcttattt       c.*1860

          .         .         .         .         .         .       g.60589
 actaagaatttgcctgtttgaataagaacaaaacgctaaggtgggtagcctaagctgatt       c.*1920

          .         .         .         .         .         .       g.60649
 ttctgctggttacacgtgtctctcacaccacatttcctcaaagctaatctgaattctgta       c.*1980

          .         .         .         .         .         .       g.60709
 ggctaaaaatattcatgtagcaaatctgagaattgaaaactgcagataaccggccgggta       c.*2040

          .         .         .         .         .         .       g.60769
 tggtgactcatgcctgtaatcctagcactttgggaggccgaggtgggtggaccacctgag       c.*2100

          .         .         .         .         .         .       g.60829
 gttaggacttcaagaccagcctggccaacatggtgaaaccccatctgtactaaaaataca       c.*2160

          .         .         .         .         .         .       g.60889
 aaaatttgcctggtgtggtggtgcatgcctctagtcctagctactcgggaggctgaggca       c.*2220

          .         .         .         .         .         .       g.60949
 cgagaatcacttgaacctgggaggcggaggttgcagtgagtcgagataacactactgcat       c.*2280

          .         .         .         .         .         .       g.61009
 tccagcctgggtgacagagtgagactccccctcaaaaaaaaaaaaaaaaaaaaaaaaaac       c.*2340

          .         .         .         .         .         .       g.61069
 agaaagaaagaaaaagaaaactgcagataaccctatacattaatactggtatctcgaggt       c.*2400

          .         .         .         .         .         .       g.61129
 gactcttctgaccaagggtggttaagtgacacatagaacttttctaagagaagacagaca       c.*2460

          .         .         .         .         .         .       g.61189
 agttgacaggcatgccttgtactcagctgtgttcatgtggtggtctgtggaaagaaaaga       c.*2520

          .         .         .         .         .         .       g.61249
 agactcatttggaaatgaagctgtccctttccaagcagtctctggtgcttttcttctctc       c.*2580

          .         .         .         .         .         .       g.61309
 aaaatggatccgataaatatttgaatagagcagattgtagaatgtcgtgctgtcaccaga       c.*2640

          .         .         .         .         .         .       g.61369
 aagctgctgttttgggttctgcattgagccaaatatgtagaggacctaccaagcccactg       c.*2700

          .         .         .         .         .         .       g.61429
 agggactaggttttcatgtctctagtcatacctagaatgttctgagccgtctgagggcct       c.*2760

          .         .         .         .         .         .       g.61489
 tcatgccggcagcagctagcaaagccagaaagcaagtctaacaggatctaagatgaccat       c.*2820

          .         .         .         .         .         .       g.61549
 caggagaaggagtttgagactgtgtatgcaacccccaatagacccccttttactctgatc       c.*2880

          .         .         .         .         .         .       g.61609
 tggagaatgtatctggcttcatattttcaagtcacatgtctctcagacccctggattcag       c.*2940

          .         .         .         .         .         .       g.61669
 aacccaaggccacaaatcataggcatgaagcactttcttaagactgacctaacgctggat       c.*3000

          .         .         .         .         .         .       g.61729
 tatttcccgtccaatgcctgcatgctgcttgaattgctccacccacacctccatgaccaa       c.*3060

          .         .         .         .         .         .       g.61789
 gggcgccagagtgctgcaactggggcgtgggccgctctctgcttttcctgtctgactctg       c.*3120

          .         .         .         .         .         .       g.61849
 acaagtcctccctcactgaatgtagaatcgttgccaagtttctgagaagtgtcgattccc       c.*3180

          .         .         .         .         .         .       g.61909
 tgttaacatggatatcagttctgcctcacatttcccacttgaggttgaggcgtactggag       c.*3240

          .         .         .         .         .         .       g.61969
 acaacacctcagaccatctgaaccccatcagtggacgaaaatggggctgttaatatactc       c.*3300

          .         .         .         .         .         .       g.62029
 taaaagccatactaaaaatgctctgagggaactggctaagaatagtgggcctggtgattg       c.*3360

          .         .         .         .         .         .       g.62089
 tctatcacgcaaggctttgttttgtactgttcagaaatctgtcacctttctgcctgccct       c.*3420

          .         .         .         .         .         .       g.62149
 tgtttcctgaatgaaatgcttctggggttatttatgaaaggagtgatcctggggcaggca       c.*3480

          .         .         .         .         .         .       g.62209
 ggaggcagtgggcttcatggctccttgaagttattactgatcttgaccttctctttggct       c.*3540

          .         .         .         .         .         .       g.62269
 acctttagacaaagaatacgccaatcaatacttggggctctaagttttacaattgatatt       c.*3600

          .         .         .         .         .         .       g.62329
 tatttgtatcatctctttgtctaggaatgtaaaagtgattctaaactaagatgtgtaata       c.*3660

          .         .         .                                     g.62361
 aaaatcaatcagatttattgtacctacaaaaa                                   c.*3692

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Kinesin family member 3B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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