kinesin family member 5A (KIF5A) - coding DNA reference sequence

(used for variant description)

(last modified June 15, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_004984.2 in the KIF5A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008155.1, covering KIF5A transcript NM_004984.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5028
                                 acgcccaggtcgcccgcatcccgctgcc       c.-181

 .         .         .         .         .         .                g.5088
 gcaggagagagacagcgcgccccggccctgctccccaggcttcgcccgggcgccctcaac       c.-121

 .         .         .         .         .         .                g.5148
 tctgtccccagagactgagcacctgtcctccgcctcggcctctgctgagagccctctcct       c.-61

 .         .         .         .         .         .                g.5208
 ctggagcacacaccacccctgcagcccaagaagagtcccagccccacgccggctaccacc       c.-1

          .         .         .         .         .         .       g.5268
 ATGGCGGAGACCAACAACGAATGTAGCATCAAGGTGCTCTGCCGATTCCGGCCCCTGAAC       c.60
 M  A  E  T  N  N  E  C  S  I  K  V  L  C  R  F  R  P  L  N         p.20

          .         .         .         .         .         .       g.5328
 CAGGCTGAGATTCTGCGGGGAGACAAGTTCATCCCCATTTTCCAAGGGGACGACAGCGTC       c.120
 Q  A  E  I  L  R  G  D  K  F  I  P  I  F  Q  G  D  D  S  V         p.40

           | 02        .         .         .         .         .    g.18426
 GTTATTGGG | GGGAAGCCATATGTTTTTGACCGTGTATTCCCCCCAAACACGACTCAAGAG    c.180
 V  I  G   | G  K  P  Y  V  F  D  R  V  F  P  P  N  T  T  Q  E      p.60

          .         .         .        | 03.         .         .    g.18579
 CAAGTTTATCATGCATGTGCCATGCAGATTGTCAAAG | ATGTCCTTGCTGGCTACAATGGC    c.240
 Q  V  Y  H  A  C  A  M  Q  I  V  K  D |   V  L  A  G  Y  N  G      p.80

          .         .         .         .         .  | 04      .    g.19053
 ACCATTTTTGCTTATGGACAGACATCCTCAGGGAAAACACATACCATGGAG | GGAAAGCTG    c.300
 T  I  F  A  Y  G  Q  T  S  S  G  K  T  H  T  M  E   | G  K  L      p.100

          .         .         .         .         .         .       g.19113
 CACGACCCTCAGCTGATGGGAATCATTCCTCGAATTGCCCGAGACATCTTCAACCACATC       c.360
 H  D  P  Q  L  M  G  I  I  P  R  I  A  R  D  I  F  N  H  I         p.120

          .         .         .       | 05 .         .         .    g.19420
 TACTCCATGGATGAGAACCTTGAGTTCCACATCAAG | GTTTCTTACTTTGAAATTTACCTG    c.420
 Y  S  M  D  E  N  L  E  F  H  I  K   | V  S  Y  F  E  I  Y  L      p.140

          .         .      | 06  .         .         .         .    g.19889
 GACAAAATTCGTGACCTTCTGGATG | TGACCAAGACAAATCTGTCCGTGCACGAGGACAAG    c.480
 D  K  I  R  D  L  L  D  V |   T  K  T  N  L  S  V  H  E  D  K      p.160

          .         .  | 07      .         .         .         .    g.22101
 AACCGGGTGCCATTTGTCAAG | GGTTGTACTGAACGCTTTGTGTCCAGCCCGGAGGAGATT    c.540
 N  R  V  P  F  V  K   | G  C  T  E  R  F  V  S  S  P  E  E  I      p.180

          .         .         .         .          | 08        .    g.22441
 CTGGATGTGATTGATGAAGGGAAATCAAATCGTCATGTGGCTGTCACCA | ACATGAATGAA    c.600
 L  D  V  I  D  E  G  K  S  N  R  H  V  A  V  T  N |   M  N  E      p.200

          .         .         .         .         .         .       g.22501
 CACAGCTCTCGGAGCCACAGCATCTTCCTCATCAACATCAAGCAGGAGAACATGGAAACG       c.660
 H  S  S  R  S  H  S  I  F  L  I  N  I  K  Q  E  N  M  E  T         p.220

          .         .         .         .         .     | 09   .    g.23905
 GAGCAGAAGCTCAGTGGGAAGCTGTATCTGGTGGACCTGGCAGGGAGTGAGAAG | GTCAGC    c.720
 E  Q  K  L  S  G  K  L  Y  L  V  D  L  A  G  S  E  K   | V  S      p.240

          .         .         .         .         .         .       g.23965
 AAGACTGGAGCAGAGGGAGCCGTGCTGGACGAGGCAAAGAATATCAACAAGTCACTGTCA       c.780
 K  T  G  A  E  G  A  V  L  D  E  A  K  N  I  N  K  S  L  S         p.260

          .         .         .          | 10        .         .    g.24213
 GCTCTGGGCAATGTGATCTCCGCACTGGCTGAGGGCACT | AAAAGCTATGTTCCATATCGT    c.840
 A  L  G  N  V  I  S  A  L  A  E  G  T   | K  S  Y  V  P  Y  R      p.280

          .         .         .         .         .         .       g.24273
 GACAGCAAAATGACAAGGATTCTCCAGGACTCTCTCGGGGGAAACTGCCGGACGACTATG       c.900
 D  S  K  M  T  R  I  L  Q  D  S  L  G  G  N  C  R  T  T  M         p.300

          .         .         .         .         .         .       g.24333
 TTCATCTGTTGCTCACCATCCAGTTATAATGATGCAGAGACCAAGTCCACCCTGATGTTT       c.960
 F  I  C  C  S  P  S  S  Y  N  D  A  E  T  K  S  T  L  M  F         p.320

          | 11         .         .         .         .         .    g.24523
 GGGCAGCG | GGCAAAGACCATTAAGAACACTGCCTCAGTAAATTTGGAGTTGACTGCTGAG    c.1020
 G  Q  R  |  A  K  T  I  K  N  T  A  S  V  N  L  E  L  T  A  E      p.340

          .         .         .         .         .         .       g.24583
 CAGTGGAAGAAGAAATATGAGAAGGAGAAGGAGAAGACAAAGGCCCAGAAGGAGACGATT       c.1080
 Q  W  K  K  K  Y  E  K  E  K  E  K  T  K  A  Q  K  E  T  I         p.360

          .         .         .        | 12.         .         .    g.24946
 GCGAAGCTGGAGGCTGAGCTGAGCCGGTGGCGCAATG | GAGAGAATGTGCCTGAGACAGAG    c.1140
 A  K  L  E  A  E  L  S  R  W  R  N  G |   E  N  V  P  E  T  E      p.380

          .         .         .         .         .         .       g.25006
 CGCCTGGCTGGGGAGGAGGCAGCCCTGGGAGCCGAGCTCTGTGAGGAGACCCCTGTGAAT       c.1200
 R  L  A  G  E  E  A  A  L  G  A  E  L  C  E  E  T  P  V  N         p.400

          .         .         .         .         .         .       g.25066
 GACAACTCATCCATCGTGGTGCGCATCGCGCCCGAGGAGCGGCAGAAATACGAGGAGGAG       c.1260
 D  N  S  S  I  V  V  R  I  A  P  E  E  R  Q  K  Y  E  E  E         p.420

          .         .         .    | 13    .         .         .    g.26284
 ATCCGCCGTCTCTATAAGCAGCTTGACGACAAG | GATGATGAAATCAACCAACAAAGCCAA    c.1320
 I  R  R  L  Y  K  Q  L  D  D  K   | D  D  E  I  N  Q  Q  S  Q      p.440

          .         .         .         .   | 14     .         .    g.27015
 CTCATAGAGAAGCTCAAGCAGCAAATGCTGGACCAGGAAGAG | CTGCTGGTGTCCACCCGA    c.1380
 L  I  E  K  L  K  Q  Q  M  L  D  Q  E  E   | L  L  V  S  T  R      p.460

          .         .         .         .         .         .       g.27075
 GGAGACAACGAGAAGGTCCAGCGGGAGCTGAGCCACCTGCAATCAGAGAACGATGCCGCT       c.1440
 G  D  N  E  K  V  Q  R  E  L  S  H  L  Q  S  E  N  D  A  A         p.480

          .         .         .         .         .         .       g.27135
 AAGGATGAGGTGAAGGAAGTGCTGCAGGCCCTGGAGGAGCTGGCTGTGAACTATGACCAG       c.1500
 K  D  E  V  K  E  V  L  Q  A  L  E  E  L  A  V  N  Y  D  Q         p.500

          .         .         .         .         .         .       g.27195
 AAGTCCCAGGAGGTGGAGGAGAAGAGCCAGCAGAACCAGCTTCTGGTGGATGAGCTGTCT       c.1560
 K  S  Q  E  V  E  E  K  S  Q  Q  N  Q  L  L  V  D  E  L  S         p.520

           | 15        .         .         .         .         .    g.27567
 CAGAAGGTG | GCCACCATGCTGTCCCTGGAGTCTGAGTTGCAGCGGCTACAGGAGGTCAGT    c.1620
 Q  K  V   | A  T  M  L  S  L  E  S  E  L  Q  R  L  Q  E  V  S      p.540

          .         .         .         .         .         .       g.27627
 GGACACCAGCGAAAACGAATTGCTGAGGTGCTGAACGGGCTGATGAAGGATCTGAGCGAG       c.1680
 G  H  Q  R  K  R  I  A  E  V  L  N  G  L  M  K  D  L  S  E         p.560

          .         .         .       | 16 .         .         .    g.30044
 TTCAGTGTCATTGTGGGCAACGGGGAGATTAAGCTG | CCAGTGGAGATCAGTGGGGCCATC    c.1740
 F  S  V  I  V  G  N  G  E  I  K  L   | P  V  E  I  S  G  A  I      p.580

          .         .         .         .         .         .       g.30104
 GAGGAGGAGTTCACTGTGGCCCGACTCTACATCAGCAAAATCAAATCAGAAGTCAAGTCT       c.1800
 E  E  E  F  T  V  A  R  L  Y  I  S  K  I  K  S  E  V  K  S         p.600

          .         .         .         .         .         .       g.30164
 GTGGTCAAGCGGTGCCGGCAGCTGGAGAACCTCCAGGTGGAGTGTCACCGCAAGATGGAA       c.1860
 V  V  K  R  C  R  Q  L  E  N  L  Q  V  E  C  H  R  K  M  E         p.620

          .         .         .         .      | 17  .         .    g.30591
 GTGACCGGGCGGGAGCTCTCATCCTGCCAGCTCCTCATCTCTCAG | CATGAGGCCAAGATC    c.1920
 V  T  G  R  E  L  S  S  C  Q  L  L  I  S  Q   | H  E  A  K  I      p.640

          .         .         .         .         .         .       g.30651
 CGCTCGCTTACGGAATACATGCAGAGCGTGGAGCTAAAGAAGCGGCACCTGGAAGAGTCC       c.1980
 R  S  L  T  E  Y  M  Q  S  V  E  L  K  K  R  H  L  E  E  S         p.660

          .         .         .         .    | 18    .         .    g.31040
 TATGACTCCTTGAGCGATGAGCTGGCCAAGCTCCAGGCCCAGG | AAACTGTGCATGAAGTG    c.2040
 Y  D  S  L  S  D  E  L  A  K  L  Q  A  Q  E |   T  V  H  E  V      p.680

          .         .         .         .         | 19         .    g.31217
 GCCCTGAAGGACAAGGAGCCTGACACTCAGGATGCAGATGAAGTGAAG | AAGGCTCTGGAG    c.2100
 A  L  K  D  K  E  P  D  T  Q  D  A  D  E  V  K   | K  A  L  E      p.700

          .         .         .         .         .         .       g.31277
 CTGCAGATGGAGAGTCACCGGGAGGCCCATCACCGGCAGCTGGCCCGGCTCCGGGACGAG       c.2160
 L  Q  M  E  S  H  R  E  A  H  H  R  Q  L  A  R  L  R  D  E         p.720

          .         .         .         | 20         .         .    g.31719
 ATCAACGAGAAGCAGAAGACCATTGATGAGCTCAAAGA | CCTAAATCAGAAGCTCCAGTTA    c.2220
 I  N  E  K  Q  K  T  I  D  E  L  K  D  |  L  N  Q  K  L  Q  L      p.740

          .         .         .         .         .         .       g.31779
 GAGCTAGAGAAGCTTCAGGCTGACTACGAGAAGCTGAAGAGCGAAGAACACGAGAAGAGC       c.2280
 E  L  E  K  L  Q  A  D  Y  E  K  L  K  S  E  E  H  E  K  S         p.760

          .         . | 21       .         .         .         .    g.32689
 ACCAAGCTGCAGGAGCTGAC | ATTTCTGTACGAGCGACATGAGCAGTCCAAGCAGGACCTC    c.2340
 T  K  L  Q  E  L  T  |  F  L  Y  E  R  H  E  Q  S  K  Q  D  L      p.780

          .         .  | 22      .         .         .         .    g.32984
 AAGGGTCTGGAGGAGACAGTT | GCCCGGGAACTCCAGACCCTCCACAACCTTCGCAAGCTG    c.2400
 K  G  L  E  E  T  V   | A  R  E  L  Q  T  L  H  N  L  R  K  L      p.800

          .         .         .    | 23    .         .         .    g.33201
 TTCGTTCAAGACGTCACGACTCGAGTCAAGAAA | AGTGCAGAAATGGAGCCCGAAGACAGT    c.2460
 F  V  Q  D  V  T  T  R  V  K  K   | S  A  E  M  E  P  E  D  S      p.820

          .         .         .         .         .         .       g.33261
 GGGGGGATTCACTCCCAAAAGCAGAAGATTTCCTTTCTTGAGAACAACCTGGAACAGCTT       c.2520
 G  G  I  H  S  Q  K  Q  K  I  S  F  L  E  N  N  L  E  Q  L         p.840

          .         | 24         .         .         .         .    g.35934
 ACAAAGGTTCACAAACAG | CTGGTACGTGACAATGCAGATCTGCGTTGTGAGCTTCCTAAA    c.2580
 T  K  V  H  K  Q   | L  V  R  D  N  A  D  L  R  C  E  L  P  K      p.860

          .         .         .         .         .         .       g.35994
 TTGGAAAAACGACTTAGGGCTACGGCTGAGAGAGTTAAGGCCCTGGAGGGTGCACTGAAG       c.2640
 L  E  K  R  L  R  A  T  A  E  R  V  K  A  L  E  G  A  L  K         p.880

          .         .         .         .         .         .       g.36054
 GAGGCCAAGGAGGGCGCCATGAAGGACAAGCGCCGGTACCAGCAGGAGGTGGACCGCATC       c.2700
 E  A  K  E  G  A  M  K  D  K  R  R  Y  Q  Q  E  V  D  R  I         p.900

          .         .         .         .         .      | 25  .    g.36356
 AAGGAGGCCGTTCGCTACAAGAGCTCGGGCAAACGGGGCCATTCTGCCCAGATTG | CCAAA    c.2760
 K  E  A  V  R  Y  K  S  S  G  K  R  G  H  S  A  Q  I  A |   K      p.920

          .         .         .         .         .         .       g.36416
 CCCGTCCGGCCTGGCCACTACCCAGCATCCTCACCCACCAACCCCTATGGCACCCGGAGC       c.2820
 P  V  R  P  G  H  Y  P  A  S  S  P  T  N  P  Y  G  T  R  S         p.940

          .         .         .         .         .         .       g.36476
 CCTGAGTGCATCAGTTACACCAACAGCCTCTTCCAGAACTACCAGAATCTCTACCTGCAG       c.2880
 P  E  C  I  S  Y  T  N  S  L  F  Q  N  Y  Q  N  L  Y  L  Q         p.960

          .         .          | 26        .         .         .    g.36837
 GCCACACCCAGCTCCACCTCAGATATGTA | CTTTGCAAACTCCTGTACCAGCAGTGGAGCC    c.2940
 A  T  P  S  S  T  S  D  M  Y  |  F  A  N  S  C  T  S  S  G  A      p.980

          .         .         .         .         .   | 27     .    g.37546
 ACATCTTCTGGCGGCCCCTTGGCTTCCTACCAGAAGGCCAACATGGACAATG | GAAATGCC    c.3000
 T  S  S  G  G  P  L  A  S  Y  Q  K  A  N  M  D  N  G |   N  A      p.1000

          .         . | 28       .         .         .         .    g.38077
 ACAGATATCAATGACAATAG | GAGTGACCTGCCGTGTGGCTATGAGGCTGAGGACCAGGCC    c.3060
 T  D  I  N  D  N  R  |  S  D  L  P  C  G  Y  E  A  E  D  Q  A      p.1020

          .         .         .                                     g.38116
 AAGCTTTTCCCTCTCCACCAAGAGACAGCAGCCAGCTAA                            c.3099
 K  L  F  P  L  H  Q  E  T  A  A  S  X                              p.1032

          .         .         .       | 29 .         .         .    g.39178
 tctcccacacccacggctgcatacctgcactttcag | tttctaagagggactgaggcctct    c.*60

          .         .         .         .         .         .       g.39238
 tctcagcatgctgcaaacctgtggtctctgatactaactccctccccaacccctgttgtt       c.*120

          .         .         .         .         .         .       g.39298
 ggactgtactatgtttgatgtcttctcttacttactctgtatctctttgtactctgtatc       c.*180

          .         .         .         .         .         .       g.39358
 tatatatcaaaagctgctgctatgtctctcttctgtcttattctcaagtatctactgatg       c.*240

          .         .         .         .         .         .       g.39418
 tatttagcaatttcaaagcatagtctaccttccttatttggggcaatagggaggagggtg       c.*300

          .         .         .         .         .         .       g.39478
 aatgtttcttctttctcatctactcgtctcacactgagtggtgttagtcactgagtagag       c.*360

          .         .         .         .         .         .       g.39538
 gtcacagagatgacaaaaggaaaaatgggagctagagggttgtgacccttcatacacaca       c.*420

          .         .         .         .         .         .       g.39598
 cgcacgcacgcacacaaacatgcacacacgcatgcacacacacaaagccttaagcagaag       c.*480

          .         .         .         .         .         .       g.39658
 aatgtcttagcatcatgagacagagaaatagactcttcctccctcctctttcacatatag       c.*540

          .         .         .         .         .                 g.39708
 cacaggggaaggtaaaatggaagggctgctaattgagacatataattttc                 c.*590

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Kinesin family member 5A protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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