kinesin family member 5B (KIF5B) - coding DNA reference sequence

(used for variant description)

(last modified April 7, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_004521.2 in the KIF5B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000010.10, covering KIF5B transcript NM_004521.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5050
           ctcctcccgcaccgccctgtcgcccaacggcggcctcaggagtgatcggg       c.-421

 .         .         .         .         .         .                g.5110
 cagcagtcggccggccagcggacggcagagcgggcggacgggtaggcccggcctgctctt       c.-361

 .         .         .         .         .         .                g.5170
 cgcgaggaggaagaaggtggccactctcccggtccccagaacctccccagcccccgcagt       c.-301

 .         .         .         .         .         .                g.5230
 ccgcccagaccgtaaagggggacgctgaggagccgcggacgctctccccggtgccgccgc       c.-241

 .         .         .         .         .         .                g.5290
 cgctgccgccgccatggctgccatgatggatcggaagtgagcattagggttaacggctgc       c.-181

 .         .         .         .         .         .                g.5350
 cggcgccggctcttcaagtcccggctccccggccgcctccacccggggaagcgcagcgcg       c.-121

 .         .         .         .         .         .                g.5410
 gcgcagctgactgctgcctctcacggccctcgcgaccacaagccctcaggtccggcgcgt       c.-61

 .         .         .         .         .         .                g.5470
 tccctgcaagactgagcggcggggagtggctcccggccgccggccccggctgcgagaaag       c.-1

          .         .         .         .         .         .       g.5530
 ATGGCGGACCTGGCCGAGTGCAACATCAAAGTGATGTGTCGCTTCAGACCTCTCAACGAG       c.60
 M  A  D  L  A  E  C  N  I  K  V  M  C  R  F  R  P  L  N  E         p.20

          .         .         .         .         .         .       g.5590
 TCTGAAGTGAACCGCGGCGACAAGTACATCGCCAAGTTTCAGGGAGAAGACACGGTCGTG       c.120
 S  E  V  N  R  G  D  K  Y  I  A  K  F  Q  G  E  D  T  V  V         p.40

        | 02 .         .         .         .         .         .    g.12946
 ATCGCG | TCCAAGCCTTATGCATTTGATCGGGTGTTCCAGTCAAGCACATCTCAAGAGCAA    c.180
 I  A   | S  K  P  Y  A  F  D  R  V  F  Q  S  S  T  S  Q  E  Q      p.60

          .         .         .     | 03   .         .         .    g.21012
 GTGTATAATGACTGTGCAAAGAAGATTGTTAAAG | ATGTACTTGAAGGATATAATGGAACA    c.240
 V  Y  N  D  C  A  K  K  I  V  K  D |   V  L  E  G  Y  N  G  T      p.80

          .         .         .         .         | 04         .    g.22024
 ATATTTGCATATGGACAAACATCCTCTGGGAAGACACACACAATGGAG | GGTAAACTTCAT    c.300
 I  F  A  Y  G  Q  T  S  S  G  K  T  H  T  M  E   | G  K  L  H      p.100

          .         .         .         .         .         .       g.22084
 GATCCAGAAGGCATGGGAATTATTCCAAGAATAGTGCAAGATATTTTTAATTATATTTAC       c.360
 D  P  E  G  M  G  I  I  P  R  I  V  Q  D  I  F  N  Y  I  Y         p.120

          .         .         .    | 05    .         .         .    g.22644
 TCCATGGATGAAAATTTGGAATTTCATATTAAG | GTTTCATATTTTGAAATATATTTGGAT    c.420
 S  M  D  E  N  L  E  F  H  I  K   | V  S  Y  F  E  I  Y  L  D      p.140

          .         .   | 06     .         .         .         .    g.23263
 AAGATAAGGGACCTGTTAGATG | TTTCAAAGACCAACCTTTCAGTTCATGAAGACAAAAAC    c.480
 K  I  R  D  L  L  D  V |   S  K  T  N  L  S  V  H  E  D  K  N      p.160

          .         | 07         .         .         .         .    g.23878
 CGAGTTCCCTATGTAAAG | GGGTGCACAGAGCGTTTTGTATGTAGTCCAGATGAAGTTATG    c.540
 R  V  P  Y  V  K   | G  C  T  E  R  F  V  C  S  P  D  E  V  M      p.180

          .         .         .         .       | 08 .         .    g.24079
 GATACCATAGATGAAGGAAAATCCAACAGACATGTAGCAGTTACAA | ATATGAATGAACAT    c.600
 D  T  I  D  E  G  K  S  N  R  H  V  A  V  T  N |   M  N  E  H      p.200

          .         .         .         .         .         .       g.24139
 AGCTCTAGGAGTCACAGTATATTTCTTATTAATGTCAAACAAGAGAACACACAAACGGAA       c.660
 S  S  R  S  H  S  I  F  L  I  N  V  K  Q  E  N  T  Q  T  E         p.220

          .         .         .         .         .  | 09      .    g.25458
 CAAAAGCTGAGTGGAAAACTTTATCTGGTTGATTTAGCTGGTAGTGAAAAG | GTTAGTAAA    c.720
 Q  K  L  S  G  K  L  Y  L  V  D  L  A  G  S  E  K   | V  S  K      p.240

          .         .         .         .         .         .       g.25518
 ACTGGAGCTGAAGGTGCTGTGCTGGATGAAGCTAAAAACATCAACAAGTCACTTTCTGCT       c.780
 T  G  A  E  G  A  V  L  D  E  A  K  N  I  N  K  S  L  S  A         p.260

          .         .         .       | 10 .         .         .    g.25800
 CTTGGAAATGTTATTTCTGCTTTGGCTGAGGGTAGT | ACATATGTTCCATATCGAGATAGT    c.840
 L  G  N  V  I  S  A  L  A  E  G  S   | T  Y  V  P  Y  R  D  S      p.280

          .         .         .         .         .         .       g.25860
 AAAATGACAAGAATCCTTCAAGATTCATTAGGTGGCAACTGTAGAACCACTATTGTAATT       c.900
 K  M  T  R  I  L  Q  D  S  L  G  G  N  C  R  T  T  I  V  I         p.300

          .         .         .         .         .         .       g.25920
 TGCTGCTCTCCATCATCATACAATGAGTCTGAAACAAAATCTACACTCTTATTTGGCCAA       c.960
 C  C  S  P  S  S  Y  N  E  S  E  T  K  S  T  L  L  F  G  Q         p.320

    | 11     .         .         .         .         .         .    g.26663
 AG | GGCCAAAACAATTAAGAACACAGTTTGTGTCAATGTGGAGTTAACTGCAGAACAGTGG    c.1020
 R  |  A  K  T  I  K  N  T  V  C  V  N  V  E  L  T  A  E  Q  W      p.340

          .         .         .         .         .         .       g.26723
 AAAAAGAAGTATGAAAAAGAAAAAGAAAAAAATAAGATCCTGCGGAACACTATTCAGTGG       c.1080
 K  K  K  Y  E  K  E  K  E  K  N  K  I  L  R  N  T  I  Q  W         p.360

          .         .         .  | 12      .         .         .    g.27434
 CTTGAAAATGAGCTCAACAGATGGCGTAATG | GGGAGACGGTGCCTATTGATGAACAGTTT    c.1140
 L  E  N  E  L  N  R  W  R  N  G |   E  T  V  P  I  D  E  Q  F      p.380

          .         .         .         .         .         .       g.27494
 GACAAAGAGAAAGCCAACTTGGAAGCTTTCACAGTGGATAAAGATATTACTCTTACCAAT       c.1200
 D  K  E  K  A  N  L  E  A  F  T  V  D  K  D  I  T  L  T  N         p.400

          .         .         .         .         .         .       g.27554
 GATAAACCAGCAACCGCAATTGGAGTTATAGGAAATTTTACTGATGCTGAAAGAAGAAAG       c.1260
 D  K  P  A  T  A  I  G  V  I  G  N  F  T  D  A  E  R  R  K         p.420

          .         .         .         .      | 13  .         .    g.28684
 TGTGAAGAAGAAATTGCTAAATTATACAAACAGCTTGATGACAAG | GATGAAGAAATTAAC    c.1320
 C  E  E  E  I  A  K  L  Y  K  Q  L  D  D  K   | D  E  E  I  N      p.440

          .         .         .         .         .     | 14   .    g.30170
 CAGCAAAGTCAACTGGTAGAGAAACTGAAGACGCAAATGTTGGATCAGGAGGAG | CTTTTG    c.1380
 Q  Q  S  Q  L  V  E  K  L  K  T  Q  M  L  D  Q  E  E   | L  L      p.460

          .         .         .         .         .         .       g.30230
 GCATCTACCAGAAGGGATCAAGACAATATGCAAGCTGAGCTGAATCGCCTTCAAGCAGAA       c.1440
 A  S  T  R  R  D  Q  D  N  M  Q  A  E  L  N  R  L  Q  A  E         p.480

          .         .         .         .         .         .       g.30290
 AATGATGCCTCTAAAGAAGAAGTGAAAGAAGTTTTACAGGCCCTAGAAGAACTTGCTGTC       c.1500
 N  D  A  S  K  E  E  V  K  E  V  L  Q  A  L  E  E  L  A  V         p.500

          .         .         .         .         .         .       g.30350
 AATTATGATCAGAAGTCTCAGGAAGTTGAAGACAAAACTAAGGAATATGAATTGCTTAGT       c.1560
 N  Y  D  Q  K  S  Q  E  V  E  D  K  T  K  E  Y  E  L  L  S         p.520

          .         .  | 15      .         .         .         .    g.32911
 GATGAATTGAATCAGAAATCG | GCAACTTTAGCGAGTATAGATGCTGAGCTTCAGAAACTT    c.1620
 D  E  L  N  Q  K  S   | A  T  L  A  S  I  D  A  E  L  Q  K  L      p.540

          .         .         .         .         .         .       g.32971
 AAGGAAATGACCAACCACCAGAAAAAACGAGCAGCTGAGATGATGGCATCTTTACTAAAA       c.1680
 K  E  M  T  N  H  Q  K  K  R  A  A  E  M  M  A  S  L  L  K         p.560

          .         .         .         .      | 16  .         .    g.38422
 GACCTTGCAGAAATAGGAATTGCTGTGGGAAATAATGATGTAAAG | CAGCCTGAGGGAACT    c.1740
 D  L  A  E  I  G  I  A  V  G  N  N  D  V  K   | Q  P  E  G  T      p.580

          .         .         .         .         .         .       g.38482
 GGCATGATAGATGAAGAGTTCACTGTTGCAAGACTCTACATTAGCAAAATGAAGTCAGAA       c.1800
 G  M  I  D  E  E  F  T  V  A  R  L  Y  I  S  K  M  K  S  E         p.600

          .         .         .         .         .         .       g.38542
 GTAAAAACCATGGTGAAACGTTGCAAGCAGTTAGAAAGCACACAAACTGAGAGCAACAAA       c.1860
 V  K  T  M  V  K  R  C  K  Q  L  E  S  T  Q  T  E  S  N  K         p.620

          .         .         .         .         .     | 17   .    g.39192
 AAAATGGAAGAAAATGAAAAGGAGTTAGCAGCATGTCAGCTTCGTATCTCTCAA | CATGAA    c.1920
 K  M  E  E  N  E  K  E  L  A  A  C  Q  L  R  I  S  Q   | H  E      p.640

          .         .         .         .         .         .       g.39252
 GCCAAAATCAAGTCATTGACTGAATACCTTCAAAATGTGGAACAAAAGAAAAGACAGTTG       c.1980
 A  K  I  K  S  L  T  E  Y  L  Q  N  V  E  Q  K  K  R  Q  L         p.660

          .         .         .         .         .   | 18     .    g.40164
 GAGGAATCTGTCGATGCCCTCAGTGAAGAACTAGTCCAGCTTCGAGCACAAG | AGAAAGTC    c.2040
 E  E  S  V  D  A  L  S  E  E  L  V  Q  L  R  A  Q  E |   K  V      p.680

          .         .         .         .         .     | 19   .    g.40318
 CATGAAATGGAAAAGGAGCACTTAAATAAGGTTCAGACTGCAAATGAAGTTAAG | CAAGCT    c.2100
 H  E  M  E  K  E  H  L  N  K  V  Q  T  A  N  E  V  K   | Q  A      p.700

          .         .         .         .         .         .       g.40378
 GTTGAACAGCAGATCCAGAGCCATAGAGAAACTCATCAAAAACAGATCAGTAGTTTGAGA       c.2160
 V  E  Q  Q  I  Q  S  H  R  E  T  H  Q  K  Q  I  S  S  L  R         p.720

          .         .         .         .     | 20   .         .    g.41500
 GATGAAGTAGAAGCAAAAGCAAAACTTATTACTGATCTTCAAGA | CCAAAACCAGAAAATG    c.2220
 D  E  V  E  A  K  A  K  L  I  T  D  L  Q  D  |  Q  N  Q  K  M      p.740

          .         .         .         .         .         .       g.41560
 ATGTTAGAGCAGGAACGTCTAAGAGTAGAACATGAGAAGTTGAAAGCCACAGATCAGGAA       c.2280
 M  L  E  Q  E  R  L  R  V  E  H  E  K  L  K  A  T  D  Q  E         p.760

          .         .       | 21 .         .         .         .    g.42915
 AAGAGCAGAAAACTACATGAACTTAC | GGTTATGCAAGATAGACGAGAACAAGCAAGACAA    c.2340
 K  S  R  K  L  H  E  L  T  |  V  M  Q  D  R  R  E  Q  A  R  Q      p.780

          .         .        | 22.         .         .         .    g.43089
 GACTTGAAGGGTTTGGAAGAGACAGTG | GCAAAAGAACTTCAGACTTTACACAACCTGCGC    c.2400
 D  L  K  G  L  E  E  T  V   | A  K  E  L  Q  T  L  H  N  L  R      p.800

          .         .         .          | 23        .         .    g.43308
 AAACTCTTTGTTCAGGACCTGGCTACAAGAGTTAAAAAG | AGTGCTGAGATTGATTCTGAT    c.2460
 K  L  F  V  Q  D  L  A  T  R  V  K  K   | S  A  E  I  D  S  D      p.820

          .         .         .         .         .         .       g.43368
 GACACCGGAGGCAGCGCTGCTCAGAAGCAAAAAATCTCCTTTCTTGAAAATAATCTTGAA       c.2520
 D  T  G  G  S  A  A  Q  K  Q  K  I  S  F  L  E  N  N  L  E         p.840

          .         .     | 24   .         .         .         .    g.44120
 CAGCTCACTAAAGTGCACAAACAG | TTGGTACGTGATAATGCAGATCTCCGCTGTGAACTT    c.2580
 Q  L  T  K  V  H  K  Q   | L  V  R  D  N  A  D  L  R  C  E  L      p.860

          .         .         .         .         .         .       g.44180
 CCTAAGTTGGAAAAGCGACTTCGAGCTACAGCTGAGAGAGTGAAAGCTTTGGAATCAGCA       c.2640
 P  K  L  E  K  R  L  R  A  T  A  E  R  V  K  A  L  E  S  A         p.880

          .         .         .         .         .         .       g.44240
 CTGAAAGAAGCTAAAGAAAATGCATCTCGTGATCGCAAACGCTATCAGCAAGAAGTAGAT       c.2700
 L  K  E  A  K  E  N  A  S  R  D  R  K  R  Y  Q  Q  E  V  D         p.900

          .         .         .         .         .         .       g.44300
 CGCATAAAGGAAGCAGTCAGGTCAAAGAATATGGCCAGAAGAGGGCATTCTGCACAGATT       c.2760
 R  I  K  E  A  V  R  S  K  N  M  A  R  R  G  H  S  A  Q  I         p.920

   | 25      .         .         .         .         .         .    g.45843
 G | CTAAACCTATTCGTCCCGGGCAACATCCAGCAGCTTCTCCAACTCACCCAAGTGCAATT    c.2820
 A |   K  P  I  R  P  G  Q  H  P  A  A  S  P  T  H  P  S  A  I      p.940

          .         .         .         .         .         .       g.45903
 CGTGGAGGAGGTGCATTTGTTCAGAACAGCCAGCCAGTGGCAGTGCGAGGTGGAGGAGGC       c.2880
 R  G  G  G  A  F  V  Q  N  S  Q  P  V  A  V  R  G  G  G  G         p.960

          .                                                     g.45915
 AAACAAGTGTAA |                                                    c.2893
 K  Q  V  X                                                      p.963

          .         . | 26       .         .         .         .    g.49967
 tcgtttatacatacccacag | gtgttaaaaagtaatcgaagtacgaagaggacatggtatc    c.*60

          .         .         .         .         .         .       g.50027
 aagcagtcattcaatgactataacctctactcccttgggattgtagaattataactttta       c.*120

          .         .         .         .         .         .       g.50087
 aaaaaaatgtataaattatacctggcctgtacagctgtttcctacctactcttcttgtaa       c.*180

          .         .         .         .         .         .       g.50147
 actctgctgcttcccaacacaactagagtgcaattttggcatcttaggagggaaaaagga       c.*240

          .         .         .         .         .         .       g.50207
 cagtttacaactgtggccctatttattacacagtttgtctatcgtgtcttaaatttagtc       c.*300

          .         .         .         .         .         .       g.50267
 tttactgtgccaagctaactgtaccttataggactgtactttttgtattttttgtgtatg       c.*360

          .         .         .         .         .         .       g.50327
 tttattttttaatctcagtttaaattacctagctgctactgcttcttgtttttcttttcc       c.*420

          .         .         .         .         .         .       g.50387
 tattaaaacgtcttcctttttttttcttaagagaaaatggaacatttaggttaaatgtct       c.*480

          .         .         .         .         .         .       g.50447
 ttaaattttaccacttaacaacactacatgcccataaaatatatccagtcagtactgtat       c.*540

          .         .         .         .         .         .       g.50507
 tttaaaatcccttgaaatgatgatatcagggttaaaattacttgtattgtttctgaagtt       c.*600

          .         .         .         .         .         .       g.50567
 tgctcctgaaaactactgtttgagcactgaaacgttacaaatgcctaataggcatttgag       c.*660

          .         .         .         .         .         .       g.50627
 actgagcaaggctacttgttatctcatgaaatgcctgttgccgagttattttgaatagaa       c.*720

          .         .         .         .         .         .       g.50687
 atattttaaagtatcaaaagcagatcttagtttaagggagtttggaaaaggaattatatt       c.*780

          .         .         .         .         .         .       g.50747
 tctctttttcctgattctgtactcaacaagtcttgatggaattaaaatactctgctttat       c.*840

          .         .         .         .         .         .       g.50807
 tctggtgagcctgctagctaatataagtattggacaggtaataatttgtcatctttaata       c.*900

          .         .         .         .         .         .       g.50867
 ttagtaaaatgaattaagatattataggattaaacataattttatacggttagtacttta       c.*960

          .         .         .         .         .         .       g.50927
 ttggccgacctaaatttatagcgtgtggaaattgagaaaaatgaagaaacaggacagata       c.*1020

          .         .         .         .         .         .       g.50987
 tatgatgaattaaaaatatatataggtcaattttggtctgaaatccctgaggtgttttta       c.*1080

          .         .         .         .         .         .       g.51047
 acctgctacactaatttgtacactaatttatttctttagtctagaaatagtaaattgttt       c.*1140

          .         .         .         .         .         .       g.51107
 gcaagtcactaataatcattagataaattattttcttggccatagccgataattttgtaa       c.*1200

          .         .         .         .         .         .       g.51167
 tcagtactaagtgtatacgtatttttgccactttttcctcagatgattaaagtaagtcaa       c.*1260

          .         .         .         .         .         .       g.51227
 cagcttattttaggaaactgtaaaagtaatagggaaagagatttcactatttgcttcatc       c.*1320

          .         .         .         .         .         .       g.51287
 agtggtaggggggcggtgactgcaactgtgttagcagaaattcacagagaatggggattt       c.*1380

          .         .         .         .         .         .       g.51347
 aaggttagcagagaaacttggaaagttctgtgttaggatcttgctggcagaattaacttt       c.*1440

          .         .         .         .         .         .       g.51407
 ttgcaaaagttttatacacagatatttgtattaaatttggagccatagtcagaagactca       c.*1500

          .         .         .         .         .         .       g.51467
 gatcataattggcttatttttctatttccgtaactattgtaatttccacttttgtaataa       c.*1560

          .         .         .         .         .         .       g.51527
 ttttgatttaaaatataaatttatttatttatttttttaatagtcaaaaatctttgctgt       c.*1620

          .         .         .         .         .         .       g.51587
 tgtagtctgcaacctctaaaatgattgtgttgcttttaggattgatcagaagaaacactc       c.*1680

          .         .         .         .         .         .       g.51647
 caaaaattgagatgaaatgttggtgcagccagttataagtaatatagttaacaagcaaaa       c.*1740

          .         .         .         .         .         .       g.51707
 aaagtgctgccaccttttatgatgattttctaaatggagaaacatttggctgcatccaca       c.*1800

          .         .         .         .         .         .       g.51767
 tagacctttatgttttgttttcagttgaaaacttgcctcctttggcaacattcgtaaatg       c.*1860

          .         .         .         .         .         .       g.51827
 aagcagaatttttttttctcttttttccaaatatgttagttttgttcttgtaagatgtat       c.*1920

          .         .         .         .         .         .       g.51887
 catgggtattggtgctgtgtaatgaacaacgaattttaattagcatgtggttcagaatat       c.*1980

          .         .         .         .         .         .       g.51947
 acaatgttaggtttttaaaaagtatcttgatggttcttttctatttataatttcagactt       c.*2040

          .         .         .         .         .         .       g.52007
 tcataaagtgtaccaagaatttcataaatttgttttcagtgaactgctttttgctatggt       c.*2100

          .         .         .         .         .         .       g.52067
 aggtcattaaacacagcacttactcttaaaaatgaaaatttctgatcatctaggatattg       c.*2160

          .         .         .         .         .         .       g.52127
 acacatttcaatttgcagtgtctttttgactggatatattaacgttcctctgaatggcat       c.*2220

          .         .         .         .         .         .       g.52187
 tgatagatggttcagaagagaaactcaatgaaataaagagaatatttattcatggcgatt       c.*2280

          .         .         .         .         .         .       g.52247
 aattaaattatttgcctaacttaagaaaactactgtgcgtaactctcagtttgtgcttaa       c.*2340

          .         .         .         .         .         .       g.52307
 ctccatttgacatgaggtgacagaagagagtctgagtctacctgtggaatatgttggttt       c.*2400

          .         .         .         .         .         .       g.52367
 attttcagtgcttgaagatacattcacaaatacttggtttgggaagacaccgtttaattt       c.*2460

          .         .         .         .         .         .       g.52427
 taagttaacttgcatgttgtaaatgcgttttatgtttaaataaagaggaaaattttttga       c.*2520

                                                                    g.52434
 aatgtaa                                                            c.*2527

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Kinesin family member 5B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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