kizuna centrosomal protein (KIZ) - coding DNA reference sequence

(used for variant description)

(last modified June 19, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_018474.4 in the KIZ gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033122.1, covering KIZ transcript NM_018474.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5013
                                                ggcgtcttgcccc       c.-121

 .         .         .         .         .         .                g.5073
 gcctcctgcaggcggcccggcgcggtgtttacccgcggtgcatggtggggcggtctcctt       c.-61

 .         .         .         .         .         .                g.5133
 cggcaaccccggccgaacggccacccagaggctgtgctgagctggcgcagcggcagcagc       c.-1

          .         .         .         .         .         .       g.5193
 ATGAGCCGGACCCTCGCATCGGCCGTGCCCCTGTCGAGTCCCGACTACTACGAGAGGCTG       c.60
 M  S  R  T  L  A  S  A  V  P  L  S  S  P  D  Y  Y  E  R  L         p.20

          .         .          | 02        .         .         .    g.11145
 GGCCAACTCCAGCACGGGCTGCGGGACAG | TGAAAAGAAGAGATTGGACCTGGAAAAGAAA    c.120
 G  Q  L  Q  H  G  L  R  D  S  |  E  K  K  R  L  D  L  E  K  K      p.40

          .         .         .   | 03     .         .         .    g.15435
 CTTTATGAATATAATCAGTCTGATACATGCAG | AGTTAAGCTGAAATATGTAAAACTAAAG    c.180
 L  Y  E  Y  N  Q  S  D  T  C  R  |  V  K  L  K  Y  V  K  L  K      p.60

          .         .         .         .         .         .       g.15495
 AATTATCTGAAGGAAATATGTGAATCTGAAAAGAAGGCTCATACTCGAAACCAAGAATAT       c.240
 N  Y  L  K  E  I  C  E  S  E  K  K  A  H  T  R  N  Q  E  Y         p.80

          .         .         .         .         .         .       g.15555
 TTAAAGCGATTTGAGCGTGTCCAAGCTCATGTTGTACACTTCACCACAAATACAGAGAAG       c.300
 L  K  R  F  E  R  V  Q  A  H  V  V  H  F  T  T  N  T  E  K         p.100

          .      | 04  .         .         .         .         .    g.24627
 CTTCAAAAACTGAAG | CTCGAATATGAGACTCAAATTAAGAAGATGCTATGCTCAAAAGAT    c.360
 L  Q  K  L  K   | L  E  Y  E  T  Q  I  K  K  M  L  C  S  K  D      p.120

          .         .         .         .      | 05  .         .    g.40903
 AGCCTGGGACTAAAAGAGGAACTGACAGATGAAGACAGAGAAAAG | GTTGCAGTGCACGAG    c.420
 S  L  G  L  K  E  E  L  T  D  E  D  R  E  K   | V  A  V  H  E      p.140

          .         .         .         .         .         .       g.40963
 GGGATTAACTCAGGAACAGCCATGTCAAGAGGATTGTATCAACCAGCAACAATCTTTATG       c.480
 G  I  N  S  G  T  A  M  S  R  G  L  Y  Q  P  A  T  I  F  M         p.160

          .         .         .         .         .         .       g.41023
 GGCCGCCAAATGTCAGCCATCTTAAGCATGAGAGATTTCAGTACAGAGCACAAATCTCCC       c.540
 G  R  Q  M  S  A  I  L  S  M  R  D  F  S  T  E  H  K  S  P         p.180

          .         .         .         .         .         .       g.41083
 CAGCCCACAAAGAACTTTTCAATTCCTGACCCACATTCACACCGACAGACAGCCCAGAGC       c.600
 Q  P  T  K  N  F  S  I  P  D  P  H  S  H  R  Q  T  A  Q  S         p.200

          .         .         .         .         .         .       g.41143
 AGTAATGTGACAGACAGCTGTGTAGTACAAACTAGTAATGACACACAGTGCTTAAATAAG       c.660
 S  N  V  T  D  S  C  V  V  Q  T  S  N  D  T  Q  C  L  N  K         p.220

          .         .         .         .         .         .       g.41203
 TCTGACAACATAGATGGAAAGGCATCTCTTCAGATTGGTGAGAAAATGCCAGTCACAGCC       c.720
 S  D  N  I  D  G  K  A  S  L  Q  I  G  E  K  M  P  V  T  A         p.240

          .         .         .         .         .         .       g.41263
 AGTGTATTGTCTGAGGAGGAACAAACTCATTGCTTGGAGATAGGAAGTAACACACGTCAT       c.780
 S  V  L  S  E  E  E  Q  T  H  C  L  E  I  G  S  N  T  R  H         p.260

          .         .         .         .         .         .       g.41323
 GGCAAGAGTAATTTATCTGAAGGCAAAAAGTCTGCTGAACTCAATTCCCCGTTACGGGAA       c.840
 G  K  S  N  L  S  E  G  K  K  S  A  E  L  N  S  P  L  R  E         p.280

          .         .         .         .         .         .       g.41383
 AGATTAAGTCCAGAGAACAGAACCACTGATTTAAAGTGTGACAGTTCCAGCGGATCAGAG       c.900
 R  L  S  P  E  N  R  T  T  D  L  K  C  D  S  S  S  G  S  E         p.300

          .         .         .         .         .         .       g.41443
 GGAGAAATACTGACACGGGAACATATTGAAGTTGAGGAAAAAAGAGCCAGCCCGCCAGTC       c.960
 G  E  I  L  T  R  E  H  I  E  V  E  E  K  R  A  S  P  P  V         p.320

          .         .         .         .         .         .       g.41503
 TCTCCGATACCAGTTTCAGAATACTGTGAATCTGAAAATAAGTGGTCTCAAGAGAAGCAT       c.1020
 S  P  I  P  V  S  E  Y  C  E  S  E  N  K  W  S  Q  E  K  H         p.340

          .         .   | 06     .         .         .         .    g.41905
 TCTCCTTGGGAAGGTGTTTCAG | ATCATCTTGCTCACAGGGAACCAAAGTCACAAAAGCCC    c.1080
 S  P  W  E  G  V  S  D |   H  L  A  H  R  E  P  K  S  Q  K  P      p.360

          .         .         .         .         .         .       g.41965
 TTCAGAAAAATGCAGGAAGAGGAGGAGGAAAGTTGGAGCACCAGCAGTGACCTTACCATT       c.1140
 F  R  K  M  Q  E  E  E  E  E  S  W  S  T  S  S  D  L  T  I         p.380

          .         .         .         .         .         .       g.42025
 TCAATAAGTGAAGATGATCTGATTTTAGAGAGCCCAGAACCACAGCCAAATCCAGGTGGC       c.1200
 S  I  S  E  D  D  L  I  L  E  S  P  E  P  Q  P  N  P  G  G         p.400

          .         .         .         .         .         .       g.42085
 AAGATGGAGGGAGAAGATGGAATAGAGGCCTTAAAATTAATCCATGCTGAGCAAGAAAGA       c.1260
 K  M  E  G  E  D  G  I  E  A  L  K  L  I  H  A  E  Q  E  R         p.420

          .         .         .         .         .         .       g.42145
 GTTGCCCTATCCACTGAAAAAAATTGTATTTTGCAAACCCTAAGCTCTCCTGATTCAGAA       c.1320
 V  A  L  S  T  E  K  N  C  I  L  Q  T  L  S  S  P  D  S  E         p.440

          .         .         .   | 07     .         .         .    g.84534
 AAGGAATCCTCCACTAACGCACCAACAAGAGA | ACCTGGACAAACACCAGACTCAGACGTA    c.1380
 K  E  S  S  T  N  A  P  T  R  E  |  P  G  Q  T  P  D  S  D  V      p.460

          .         .         .         .         .         .       g.84594
 CCGAGGGCACAGGTGGGTCAGCATGTTGCCACCTTGAAAGAACATGATAATTCTGTCAAA       c.1440
 P  R  A  Q  V  G  Q  H  V  A  T  L  K  E  H  D  N  S  V  K         p.480

        | 08 .         .         .         .         .         .    g.93604
 GAAGAG | GCAACAGCATTATTGAGAAAAGCCCTTACAGAAGAGTGTGGCCGTAGGTCAGCT    c.1500
 E  E   | A  T  A  L  L  R  K  A  L  T  E  E  C  G  R  R  S  A      p.500

          .         .         .         .         .         .       g.93664
 ATTCACAGTAGTGAATCATCTTGCAGCTTGCCATCTATTCTGAATGACAATAGTGGAATA       c.1560
 I  H  S  S  E  S  S  C  S  L  P  S  I  L  N  D  N  S  G  I         p.520

          .         .         .         .         .   | 09     .    g.94606
 AAGGAAGCCAAACCTGCTGTATGGCTCAACAGTGTTCCTACAAGGGAACAAG | AAGTTTCA    c.1620
 K  E  A  K  P  A  V  W  L  N  S  V  P  T  R  E  Q  E |   V  S      p.540

          .         .         .         .         .         | 10    g.108028
 AGTGGCTGTGGAGACAAGAGCAAGAAAGAAAATGTGGCTGCAGATATCCCAATCACAG | AA    c.1680
 S  G  C  G  D  K  S  K  K  E  N  V  A  A  D  I  P  I  T  E |       p.560

          .         .         .         .         .         .       g.108088
 ACAGAAGCCTATCAGTTGCTGAAGAAGGCCACCCTTCAGGATAATACAAATCAAACTGAA       c.1740
 T  E  A  Y  Q  L  L  K  K  A  T  L  Q  D  N  T  N  Q  T  E         p.580

          .         .         .         .    | 11    .         .    g.111766
 AACAGGTTTCAAAAGACAGATGCTTCTGTGTCACACTTGTCAG | GTTTGAATATTGGCAGC    c.1800
 N  R  F  Q  K  T  D  A  S  V  S  H  L  S  G |   L  N  I  G  S      p.600

          .         .         .         .         .         .       g.111826
 GGTGCATTCGAGACAAAGACAGCTAACAAAATTGCTTCGGAAGCTAGTTTTTCATCTAGT       c.1860
 G  A  F  E  T  K  T  A  N  K  I  A  S  E  A  S  F  S  S  S         p.620

          .         . | 12       .         .         .         .    g.123300
 GAAGGAAGTCCTTTGTCAAG | GCATGAAAACAAAAAGAAACCCGTGATCAATTTAAAATCT    c.1920
 E  G  S  P  L  S  R  |  H  E  N  K  K  K  P  V  I  N  L  K  S      p.640

      | 13   .         .         .         .         .         .    g.125550
 AATG | CCCTCTGGGATGAGTCTGATGACAGTAACTCAGAAATTGAGGCTGCTTTACGCCCC    c.1980
 N  A |   L  W  D  E  S  D  D  S  N  S  E  I  E  A  A  L  R  P      p.660

          .         .         .         .                           g.125592
 AGAAACCATAACACCGATGATTCTGATGATTTTTATGACTAA                         c.2022
 R  N  H  N  T  D  D  S  D  D  F  Y  D  X                           p.673

          .         .         .         .                           g.125638
 cgtgctgtgacattggtttcaaataaagtctttaaacaaactaaaa                     c.*46

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Kizuna centrosomal protein protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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