kinesin light chain 2 (KLC2) - coding DNA reference sequence

(used for variant description)

(last modified May 4, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_001134775.1 in the KLC2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering KLC2 transcript NM_001134775.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5003
                                                          gcg       c.-241

 .         .         .         .         .         .                g.5063
 agccagataacagcggcactcacttctcgggtcttcgtgagcattaagtcaatgaaccca       c.-181

 .         .         .         .         .         .                g.5123
 gggcaccaaagcgcgcaacacgcagtaggcgctcagttagtggcgcctcgctctgtactc       c.-121

 .         .         .         .         .         .                g.5183
 caggaagcccaaccttctccctgcgcctcagtttctcccgacgtcctcgatggcgccatg       c.-61

 .         .  | 02      .         .         .         .             g.6301
 gcgccacactag | gcccggcgcccgcctgcccgcaccctcgtcctcacagacgccacagcc    c.-1

          .         .         .         .         .         .       g.6361
 ATGGCCATGATGGTGTTTCCGCGGGAGGAGAAGCTGAGCCAGGATGAGATCGTGCTGGGC       c.60
 M  A  M  M  V  F  P  R  E  E  K  L  S  Q  D  E  I  V  L  G         p.20

          .         .         .         .         .         .       g.6421
 ACCAAGGCTGTCATCCAGGGACTGGAGACTCTGCGTGGGGAGCATCGTGCCCTGCTGGCT       c.120
 T  K  A  V  I  Q  G  L  E  T  L  R  G  E  H  R  A  L  L  A         p.40

          .         .         .         .         .         .       g.6481
 CCTCTGGTTGCACCTGAGGCCGGCGAAGCCGAGCCTGGCTCGCAGGAGCGCTGCATCCTC       c.180
 P  L  V  A  P  E  A  G  E  A  E  P  G  S  Q  E  R  C  I  L         p.60

          .         .         .         .         | 03         .    g.9460
 CTGCGTCGCTCCCTGGAAGCCATTGAGCTTGGGCTGGGGGAGGCCCAG | GTGATCTTGGCA    c.240
 L  R  R  S  L  E  A  I  E  L  G  L  G  E  A  Q   | V  I  L  A      p.80

          .         .         .         .         .         .       g.9520
 TTGTCGAGCCACCTGGGGGCTGTAGAATCAGAGAAGCAGAAGCTGCGGGCGCAGGTGCGG       c.300
 L  S  S  H  L  G  A  V  E  S  E  K  Q  K  L  R  A  Q  V  R         p.100

          .         .         .         .         .         .       g.9580
 CGTCTGGTGCAGGAGAACCAGTGGCTGCGTGAGGAGCTGGCGGGGACACAGCAGAAGCTG       c.360
 R  L  V  Q  E  N  Q  W  L  R  E  E  L  A  G  T  Q  Q  K  L         p.120

          .         .         .         .         .         .       g.9640
 CAGCGCAGTGAGCAGGCCGTGGCCCAGCTCGAGGAGGAGAAGCAGCACTTGCTGTTCATG       c.420
 Q  R  S  E  Q  A  V  A  Q  L  E  E  E  K  Q  H  L  L  F  M         p.140

          .         .         .          | 04        .         .    g.9850
 AGCCAGATCCGCAAGTTGGATGAAGACGCCTCCCCTAAC | GAGGAGAAGGGGGACGTCCCC    c.480
 S  Q  I  R  K  L  D  E  D  A  S  P  N   | E  E  K  G  D  V  P      p.160

          .         .         .         .          | 05        .    g.10531
 AAAGACACACTGGATGACCTGTTCCCCAATGAGGATGAGCAGAGCCCAG | CCCCTAGCCCA    c.540
 K  D  T  L  D  D  L  F  P  N  E  D  E  Q  S  P  A |   P  S  P      p.180

          .         .         .         .         .         .       g.10591
 GGAGGAGGGGATGTGTCTGGTCAGCATGGGGGCTACGAGATCCCGGCCCGGCTCCGCACC       c.600
 G  G  G  D  V  S  G  Q  H  G  G  Y  E  I  P  A  R  L  R  T         p.200

          .         .         .         .         .         .       g.10651
 CTGCACAACCTGGTGATCCAATACGCCTCACAGGGCCGCTACGAGGTAGCTGTGCCACTC       c.660
 L  H  N  L  V  I  Q  Y  A  S  Q  G  R  Y  E  V  A  V  P  L         p.220

          .         .         .         .         .         .       g.10711
 TGCAAGCAGGCACTCGAAGACCTGGAGAAGACGTCAGGCCACGACCACCCTGACGTTGCC       c.720
 C  K  Q  A  L  E  D  L  E  K  T  S  G  H  D  H  P  D  V  A         p.240

          .         .         .   | 06     .         .         .    g.11394
 ACCATGCTGAACATCCTGGCACTGGTCTATCG | GGATCAGAACAAGTACAAGGAGGCTGCC    c.780
 T  M  L  N  I  L  A  L  V  Y  R  |  D  Q  N  K  Y  K  E  A  A      p.260

          .         .         .         .         .         .       g.11454
 CACCTGCTCAATGATGCTCTGGCCATCCGGGAGAAAACACTGGGCAAGGACCACCCAGCC       c.840
 H  L  L  N  D  A  L  A  I  R  E  K  T  L  G  K  D  H  P  A         p.280

  | 07       .         .         .         .         .         .    g.11617
  | GTGGCTGCGACACTAAACAACCTGGCAGTCCTGTATGGCAAGAGGGGCAAGTACAAGGAG    c.900
  | V  A  A  T  L  N  N  L  A  V  L  Y  G  K  R  G  K  Y  K  E      p.300

          .         .         .         .   | 08     .         .    g.11770
 GCTGAGCCATTGTGCAAGCGGGCACTGGAGATCCGGGAGAAG | GTCCTGGGCAAGTTTCAC    c.960
 A  E  P  L  C  K  R  A  L  E  I  R  E  K   | V  L  G  K  F  H      p.320

          .         .         .         .         .         .       g.11830
 CCAGATGTGGCCAAGCAGCTCAGCAACCTGGCCCTGCTGTGCCAGAACCAGGGCAAAGCT       c.1020
 P  D  V  A  K  Q  L  S  N  L  A  L  L  C  Q  N  Q  G  K  A         p.340

          .         .         .         .         .         .       g.11890
 GAGGAGGTGGAATATTACTATCGGCGGGCACTGGAGATCTATGCTACACGCCTCGGGCCC       c.1080
 E  E  V  E  Y  Y  Y  R  R  A  L  E  I  Y  A  T  R  L  G  P         p.360

          .         .         .       | 09 .         .         .    g.12075
 GATGACCCCAATGTGGCCAAGACCAAGAACAACCTG | GCTTCCTGCTACCTGAAGCAGGGC    c.1140
 D  D  P  N  V  A  K  T  K  N  N  L   | A  S  C  Y  L  K  Q  G      p.380

          .         .         .         .         .         .       g.12135
 AAGTACCAGGATGCGGAGACCTTGTACAAGGAGATCCTCACCCGCGCTCATGAGAAAGAG       c.1200
 K  Y  Q  D  A  E  T  L  Y  K  E  I  L  T  R  A  H  E  K  E         p.400

          .       | 10 .         .         .         .         .    g.12773
 TTTGGCTCTGTCAATG | GGGACAACAAGCCCATCTGGATGCACGCAGAGGAGCGGGAGGAA    c.1260
 F  G  S  V  N  G |   D  N  K  P  I  W  M  H  A  E  E  R  E  E      p.420

        | 11 .         .         .         .         .         .    g.12928
 AGCAAG | GATAAGCGCCGGGACAGCGCCCCCTATGGGGAATACGGCAGCTGGTACAAGGCC    c.1320
 S  K   | D  K  R  R  D  S  A  P  Y  G  E  Y  G  S  W  Y  K  A      p.440

          .     | 12   .         .         .         .         .    g.13407
 TGTAAAGTAGACAG | CCCCACAGTCAACACCACCCTGCGCAGCTTGGGGGCCCTATACCGG    c.1380
 C  K  V  D  S  |  P  T  V  N  T  T  L  R  S  L  G  A  L  Y  R      p.460

          .         .         .         .         .         .       g.13467
 CGCCAGGGCAAGCTGGAAGCCGCGCACACACTAGAGGACTGTGCCAGCCGTAACCGCAAG       c.1440
 R  Q  G  K  L  E  A  A  H  T  L  E  D  C  A  S  R  N  R  K         p.480

     | 13    .         .         .         .         .         .    g.13617
 CAG | GGTTTGGACCCCGCAAGCCAGACCAAGGTGGTAGAACTGCTGAAAGATGGCAGTGGC    c.1500
 Q   | G  L  D  P  A  S  Q  T  K  V  V  E  L  L  K  D  G  S  G      p.500

          .         .         .         .         .         .       g.13677
 AGGCGGGGAGACCGCCGCAGCAGCCGAGACATGGCTGGGGGTGCCGGGCCTCGGTCTGAG       c.1560
 R  R  G  D  R  R  S  S  R  D  M  A  G  G  A  G  P  R  S  E         p.520

          .         .         .         .   | 14     .         .    g.13817
 TCTGACCTCGAGGACGTGGGACCTACAGCTGAGTGGAATGGG | GATGGCAGTGGCTCCTTG    c.1620
 S  D  L  E  D  V  G  P  T  A  E  W  N  G   | D  G  S  G  S  L      p.540

          .         .         .         .         .         .       g.13877
 AGGCGCAGCGGTTCCTTTGGGAAACTCCGGGATGCCCTGAGGCGCAGCAGTGAGATGCTG       c.1680
 R  R  S  G  S  F  G  K  L  R  D  A  L  R  R  S  S  E  M  L         p.560

          .         .         .         .        | 15.         .    g.14152
 GTAAAGAAGCTGCAGGGGGGCACCCCCCAGGAGCCCCCTAACCCCAG | GATGAAGCGGGCC    c.1740
 V  K  K  L  Q  G  G  T  P  Q  E  P  P  N  P  R  |  M  K  R  A      p.580

          .         .         .         .      | 16  .         .    g.14594
 AGTTCCCTCAACTTCCTCAACAAGAGCGTGGAAGAGCCGACCCAG | CCTGGAGGCACAGGT    c.1800
 S  S  L  N  F  L  N  K  S  V  E  E  P  T  Q   | P  G  G  T  G      p.600

          .         .         .         .         .         .       g.14654
 CTCTCTGACAGCCGCACTCTCAGCTCCAGCTCCATGGACCTCTCCCGACGAAGCTCCCTG       c.1860
 L  S  D  S  R  T  L  S  S  S  S  M  D  L  S  R  R  S  S  L         p.620

                                                                    g.14663
 GTGGGCTAA                                                          c.1869
 V  G  X                                                            p.622

          .         .         .         .         .         .       g.14723
 tgctgaaggggcagccagtcaccagagcgcccacctggcacacccccctcaccccagccc       c.*60

          .         .         .         .         .         .       g.14783
 tgcgcatgggcctgctgcttgtcccgcctgtctctcccacagcccctgtcttttctgttc       c.*120

          .         .         .         .         .         .       g.14843
 aatctcagggtaaccttctcccttgtcatctcagcctgagccctggaggctgggcctgcc       c.*180

          .         .         .         .         .         .       g.14903
 cactccagctccatcccttatttattccttccagcagggccctcttccctaggttcgggc       c.*240

          .         .         .         .         .         .       g.14963
 cagcaggaggtgccggctggagtctccaccatagactcagtggcctggcctccccagacc       c.*300

          .         .         .         .         .         .       g.15023
 ccagagccaagaacactaagcactcgccggcccttcggcaccctcgccctccctcccgac       c.*360

          .         .         .         .         .         .       g.15083
 tcaacccggccgttgcttctgtatatagagaaataagttattggccgcgcgcctcccttc       c.*420

          .         .         .         .         .         .       g.15143
 agtccacggtactacccgggcctcccctcgtccctcttctagtggtaccgcccaggcctt       c.*480

          .         .         .         .         .         .       g.15203
 aatcacccccattccgtgcggtggtatctcccaggctctacattctcgggagcggcgcct       c.*540

          .         .         .         .         .         .       g.15263
 cccaagggggtcctgggaccttctcgcgctcctcctggcctctgagggatgcgtcctacc       c.*600

          .         .         .         .         .         .       g.15323
 cgcgccatcgccccgtggcccaggacggggacctccccttagtccgtcctcccaccgccg       c.*660

          .         .         .         .         .         .       g.15383
 ggccctgccccgcatcccggccttatgcactgcccctcccacccggccccgcccaggcac       c.*720

          .         .         .         .         .         .       g.15443
 ggccgaccccgccccgggcaccgcccaccgagccatcctgcctcgcctccccccacgcct       c.*780

          .         .         .         .         .         .       g.15503
 gcagcttctcgcgaggggcggcgacggtcccctggtggcaggaggggctccccctgttgc       c.*840

          .         .         .         .         .         .       g.15563
 gggtgaggcggctgctctcatattttcagatgttgctgtagaaataaagacggtttaaat       c.*900

                                                                    g.15567
 ctga                                                               c.*904

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Kinesin light chain 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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