kelch-like 15 (Drosophila) (KLHL15) - coding DNA reference sequence

(used for variant description)

(last modified January 12, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_030624.2 in the KLHL15 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012625.1, covering KLHL15 transcript NM_030624.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5016
                                             gtttcaactcttgctt       c.-241

 .         .         .         . | 02       .         .             g.7157
 gaatcaagaacagaagcctctctttagacag | gacttatccagagggggctgcaggcgagc    c.-181

 .         .         .         .         .         .                g.7217
 actctcgtgccccgccggagcgacccggctcgtgccgggagcggctgctcgtagacgtcc       c.-121

 .         .         .         .         .         .                g.7277
 gaggagcctgccgagtgccgtcccggcgcccgaccgcccacccatcggcccgctggcccg       c.-61

 .         .         .         .         .         .   | 03         g.25493
 gttcttcctgatgcagactgccgtccactagaggctggacaggaccccccgag | gtgattc    c.-1

          .         .         .         .         .         .       g.25553
 ATGGCAGGGGACGTGGAAGGATTCTGTTCCTCCATCCACGACACCAGTGTCTCTGCTGGG       c.60
 M  A  G  D  V  E  G  F  C  S  S  I  H  D  T  S  V  S  A  G         p.20

          .         .         .         .         .         .       g.25613
 TTCAGAGCACTGTATGAGGAGGGATTGCTTCTTGATGTCACTCTGGTTATTGAAGATCAT       c.120
 F  R  A  L  Y  E  E  G  L  L  L  D  V  T  L  V  I  E  D  H         p.40

          .         .         .         .         .         .       g.25673
 CAGTTCCAGGCCCATAAAGCACTCTTGGCCACCCAGAGTGATTACTTCAGAATTATGTTT       c.180
 Q  F  Q  A  H  K  A  L  L  A  T  Q  S  D  Y  F  R  I  M  F         p.60

          .         .         .         .         .         .       g.25733
 ACTGCAGACATGAGGGAACGAGATCAGGACAAAATTCATTTAAAAGGTCTAACAGCTACC       c.240
 T  A  D  M  R  E  R  D  Q  D  K  I  H  L  K  G  L  T  A  T         p.80

          .         .         .         .         .         .       g.25793
 GGTTTCAGCCATGTCCTGCAATTTATGTACTATGGAACTATAGAGCTGAGTATGAATACC       c.300
 G  F  S  H  V  L  Q  F  M  Y  Y  G  T  I  E  L  S  M  N  T         p.100

          .         .         .         .         .         .       g.25853
 GTTCATGAGATTCTTCAGGCTGCCATGTATGTTCAACTTATAGAAGTGGTGAAGTTCTGC       c.360
 V  H  E  I  L  Q  A  A  M  Y  V  Q  L  I  E  V  V  K  F  C         p.120

          .         .         .         .         .         .       g.25913
 TGCTCTTTTCTCTTAGCGAAGATCTGCCTAGAAAATTGTGCAGAAATTATGAGACTCTTA       c.420
 C  S  F  L  L  A  K  I  C  L  E  N  C  A  E  I  M  R  L  L         p.140

          .         .         .         .         .         .       g.25973
 GATGATTTCGGCGTAAACATCGAGGGAGTCAGGGAGAAGTTAGACACCTTTCTGCTAGAC       c.480
 D  D  F  G  V  N  I  E  G  V  R  E  K  L  D  T  F  L  L  D         p.160

          .         .         .         .         .         .       g.26033
 AACTTTGTGCCACTCATGTCTAGGCCTGACTTTCTGTCCTATCTGAGCTTTGAGAAGCTC       c.540
 N  F  V  P  L  M  S  R  P  D  F  L  S  Y  L  S  F  E  K  L         p.180

          .         .         .         .         .         .       g.26093
 ATGTCTTACTTGGATAATGATCATCTGAGCAGGTTCCCAGAGATAGAGCTGTACGAGGCT       c.600
 M  S  Y  L  D  N  D  H  L  S  R  F  P  E  I  E  L  Y  E  A         p.200

          .         .         .         .         .         .       g.26153
 GTGCAGTCTTGGCTGCGGCATGATAGAAGACGCTGGAGACATACCGATACCATCATTCAG       c.660
 V  Q  S  W  L  R  H  D  R  R  R  W  R  H  T  D  T  I  I  Q         p.220

          .         .         .         .      | 04  .         .    g.43171
 AATATCCGGTTTTGCTTGATGACCCCAACCAGCGTTTTTGAGAAG | GTTAAGACATCAGAA    c.720
 N  I  R  F  C  L  M  T  P  T  S  V  F  E  K   | V  K  T  S  E      p.240

          .         .         .         .         .         .       g.43231
 TTTTATAGATACTCCCGACAGCTCCGTTACGAAGTTGACCAAGCATTGAATTACTTTCAG       c.780
 F  Y  R  Y  S  R  Q  L  R  Y  E  V  D  Q  A  L  N  Y  F  Q         p.260

          .         .         .         .         .         .       g.43291
 AATGTTCACCAGCAGCCTTTGTTGGATATGAAGTCAAGCCGCATCCGTTCTGCAAAACCG       c.840
 N  V  H  Q  Q  P  L  L  D  M  K  S  S  R  I  R  S  A  K  P         p.280

          .         .         .         .         .         .       g.43351
 CAAACTACAGTATTTCGAGGAATGATTGGACATAGCATGGTTAACAGTAAAATACTTCTC       c.900
 Q  T  T  V  F  R  G  M  I  G  H  S  M  V  N  S  K  I  L  L         p.300

          .         .         .         .         .         .       g.43411
 TTAAAGAAACCAAGAGTCTGGTGGGAGCTAGAAGGCCCACAAGTACCTCTGCGACCTGAC       c.960
 L  K  K  P  R  V  W  W  E  L  E  G  P  Q  V  P  L  R  P  D         p.320

          .         .         .         .         .         .       g.43471
 TGCCTTGCTATCGTCAATAATTTTGTGTTCCTGTTAGGCGGGGAAGAGCTGGGCCCGGAT       c.1020
 C  L  A  I  V  N  N  F  V  F  L  L  G  G  E  E  L  G  P  D         p.340

          .         .         .         .         .         .       g.43531
 GGTGAATTCCATGCTTCTTCCAAAGTATTCAGGTATGACCCGAGACAGAACTCCTGGCTG       c.1080
 G  E  F  H  A  S  S  K  V  F  R  Y  D  P  R  Q  N  S  W  L         p.360

          .         .         .         .         .         .       g.43591
 CAGATGGCAGATATGTCTGTACCACGCTCTGAATTTGCTGTAGGTGTTATTGGGAAGTTT       c.1140
 Q  M  A  D  M  S  V  P  R  S  E  F  A  V  G  V  I  G  K  F         p.380

          .         .         .         .         .         .       g.43651
 ATTTACGCCGTAGCAGGCAGAACCAGAGATGAGACTTTCTATTCAACTGAGAGATATGAC       c.1200
 I  Y  A  V  A  G  R  T  R  D  E  T  F  Y  S  T  E  R  Y  D         p.400

          .         .         .         .         .         .       g.43711
 ATCACCAACGATAAATGGGAATTTGTGGATCCTTATCCAGTTAACAAATATGGACATGAG       c.1260
 I  T  N  D  K  W  E  F  V  D  P  Y  P  V  N  K  Y  G  H  E         p.420

          .         .         .         .         .         .       g.43771
 GGGACAGTGCTCAATAACAAATTGTTTATCACCGGTGGAATCACCTCATCTTCCACCTCC       c.1320
 G  T  V  L  N  N  K  L  F  I  T  G  G  I  T  S  S  S  T  S         p.440

          .         .         .         .         .         .       g.43831
 AAGCAAGTGTGCGTGTTTGACCCCAGCAAAGAAGGGACCATAGAACAACGGACCAGGAGA       c.1380
 K  Q  V  C  V  F  D  P  S  K  E  G  T  I  E  Q  R  T  R  R         p.460

          .         .         .         .         .         .       g.43891
 ACTCAAGTGGTTACCAACTGTTGGGAGAATAAGAGCAAGATGAATTACGCGAGATGCTTT       c.1440
 T  Q  V  V  T  N  C  W  E  N  K  S  K  M  N  Y  A  R  C  F         p.480

          .         .         .         .         .         .       g.43951
 CACAAGATGATTTCTTACAATGGCAAGCTTTATGTCTTCGGTGGTGTCTGTGTGATCTTG       c.1500
 H  K  M  I  S  Y  N  G  K  L  Y  V  F  G  G  V  C  V  I  L         p.500

          .         .         .         .         .         .       g.44011
 AGGGCCTCTTTCGAATCTCAGGGATGCCCTTCTACAGAAGTATACAACCCAGAGACTGAT       c.1560
 R  A  S  F  E  S  Q  G  C  P  S  T  E  V  Y  N  P  E  T  D         p.520

          .         .         .         .         .         .       g.44071
 CAGTGGACCATCTTGGCATCCATGCCGATTGGTAGAAGTGGCCATGGTGTGACTGTGCTG       c.1620
 Q  W  T  I  L  A  S  M  P  I  G  R  S  G  H  G  V  T  V  L         p.540

          .         .         .         .         .         .       g.44131
 GACAAACAAATAATGGTTCTTGGAGGCCTTTGTTATAATGGTCATTACAGCGATTCCATC       c.1680
 D  K  Q  I  M  V  L  G  G  L  C  Y  N  G  H  Y  S  D  S  I         p.560

          .         .         .         .         .         .       g.44191
 CTCACTTTTGATCCGGATGAAAACAAGTGGAAGGAAGATGAGTACCCTCGGATGCCCTGC       c.1740
 L  T  F  D  P  D  E  N  K  W  K  E  D  E  Y  P  R  M  P  C         p.580

          .         .         .         .         .         .       g.44251
 AAGCTGGATGGTTTACAAGTATGCAACCTGCATTTTCCGGACTATGTACTGGATGAGGTC       c.1800
 K  L  D  G  L  Q  V  C  N  L  H  F  P  D  Y  V  L  D  E  V         p.600

          .                                                         g.44266
 AGGCGTTGCAACTAA                                                    c.1815
 R  R  C  N  X                                                      p.604

          .         .         .         .         .         .       g.44326
 tgacatcctcctccctaaaaaaagaggcaaacaaagtatttgtttgcacagagtaattaa       c.*60

          .         .         .         .         .         .       g.44386
 ttaaaacatataaagaaaaacctcaccagttttactatcaaagccattggtctaacattg       c.*120

          .         .         .         .         .         .       g.44446
 taagaatttttcattctgtgctagcatcctttttttcttttcagtggcctcaaactcatg       c.*180

          .         .         .         .         .         .       g.44506
 caataagttaattctaagtgctagctcttgaaactacttccagaagcagttgaatagaat       c.*240

          .         .         .         .         .         .       g.44566
 gctccacttatctgggatattgattttctgctttaaacatttctttcagatgttagcgta       c.*300

          .         .         .         .         .         .       g.44626
 ggagtcatgtgtcttctaagagaagacccgataagtgtcactggatgtgatttcagtctc       c.*360

          .         .         .         .         .         .       g.44686
 tgtctctatctgaaacctttttgaagatttatttcagtgtatttcagtctgttatacttt       c.*420

          .         .         .         .         .         .       g.44746
 ttagttttattatttaaaagtttaaaactcttgacctttttgcatggctttttgctgaaa       c.*480

          .         .         .         .         .         .       g.44806
 atgcaaaaatataaattttctacaaaattaactttttatattcaaaacactatttctaag       c.*540

          .         .         .         .         .         .       g.44866
 ctgccttctcttatccgcattgtgttagtgaaagcatattcatactcgcatacaacctat       c.*600

          .         .         .         .         .         .       g.44926
 aaatacacaaggcacatcccttttatgcgtggttaggattctatatttttaagctagtgc       c.*660

          .         .         .         .         .         .       g.44986
 acttacttgcacacacagttcgccatacttgttgaattttagatgtaacgtcttttcaca       c.*720

          .         .         .         .         .         .       g.45046
 tattaacatttttagaaagttgaaataactggagtcctcatttgctatcaaagtagccta       c.*780

          .         .         .         .         .         .       g.45106
 tcttcagtccatactgattcagtaatatttgaactccttatatttctgaaacatgtatgg       c.*840

          .         .         .         .         .         .       g.45166
 ttatgaaaactaacactttatattttattttcaaaagtaaatgttagtgttctttgtcga       c.*900

          .         .         .         .         .         .       g.45226
 tgtatgtcttttctttttgaaaatgtttttctttgcagtctgtttaacgttaccctgttt       c.*960

          .         .         .         .         .         .       g.45286
 ttagtgagaatcggagtggtatatgacaagttctggccctgcagcatgcaagcactttta       c.*1020

          .         .         .         .         .         .       g.45346
 aagagcatttaggtaataccagactcctaaatcaaggccccttaaaagtaagtgcaactc       c.*1080

          .         .         .         .         .         .       g.45406
 ccattttttacattcagtaaggctgctgcatttgttattgaatggaaggtagaaactctt       c.*1140

          .         .         .         .         .         .       g.45466
 agaaaatttgacctcagttttgacttagaggtaagaaatagaattataatgttactggtt       c.*1200

          .         .         .         .         .         .       g.45526
 ttatctacttgtttattttgtacaaaatacccagcgacactagggatgtaagccctcagt       c.*1260

          .         .         .         .         .         .       g.45586
 ttttgttttatttactgaaagctattagcatgaaggatagtaaccacaaagttcagaatg       c.*1320

          .         .         .         .         .         .       g.45646
 gatcaagaatagctgtttaaaagcatttataataagtgttttaggattagctgcaccttt       c.*1380

          .         .         .         .         .         .       g.45706
 caactctttaaatgcagaggaaaaaacatagttgacaaagttaagcaagaataacctggg       c.*1440

          .         .         .         .         .         .       g.45766
 agtggatcattgaaattgatgccatttgcgcatgagtagtctatatctgatacagactag       c.*1500

          .         .         .         .         .         .       g.45826
 atctatactggcaaaacttgccagatcttagaatattggtgcaatattgcaatgccttct       c.*1560

          .         .         .         .         .         .       g.45886
 atatggctgctgatgtataaattttctagtttcactttgtttggtgttttttgttttttt       c.*1620

          .         .         .         .         .         .       g.45946
 gtttgtttgtttgtttttttgctgctgccaccattgaacataaaatggaagtgtgaagtc       c.*1680

          .         .         .         .         .         .       g.46006
 atggaaatgtgaagactttggtttttgggggttttttgggcagttattagacatactatg       c.*1740

          .         .         .         .         .         .       g.46066
 agattaaacctgatcttcaaactccagaattggaggcatttgggtttaagaaaccaggta       c.*1800

          .         .         .         .         .         .       g.46126
 cataagtagcttttgaaaaaaccattggcattgatttcaaaaatcaataataatcttatt       c.*1860

          .         .         .         .         .         .       g.46186
 ttatatatgagacttatattttcattaactagtcctgtcatttacttacagtttccaaac       c.*1920

          .         .         .         .         .         .       g.46246
 atgaaatttggtatcttgtttcccatggtaatatgggtaaaagtctttttctacatttaa       c.*1980

          .         .         .         .         .         .       g.46306
 aaaatacattattttatttttgaaagttaggaataagttagccatttaatttttttctac       c.*2040

          .         .         .         .         .         .       g.46366
 attagtttagtggctttgtatgtgtgctattttgctttaaagaaaataacgtcttcatta       c.*2100

          .         .         .         .         .         .       g.46426
 ttttcctcattgatgtcttttgctagaaaagaccaagaaagagccatcaggccaggtatc       c.*2160

          .         .         .         .         .         .       g.46486
 cacatcaaagcctttacactatagtggtggttctctttaattgcttagatatgacttcat       c.*2220

          .         .         .         .         .         .       g.46546
 gaccctagtcagggtgacatctgggcaaacatttgagtattcttggtcttccattttaaa       c.*2280

          .         .         .         .         .         .       g.46606
 gacagaggccaagatcaaagttcatgttttgtaaaattcgtaaaatcttaacttgaacta       c.*2340

          .         .         .         .         .         .       g.46666
 actctgggttcagctttacgtaagtcacgtcggacctgatgttagctgtaatcagttttg       c.*2400

          .         .         .         .         .         .       g.46726
 agctttaaggatagttgctgttgcttgggttctgaatgtatgagaaaactccctgtttat       c.*2460

          .         .         .         .         .         .       g.46786
 atgtagttctaatttaggttattttaaatccatgattaacttacattcccttttaaaatt       c.*2520

          .         .         .         .         .         .       g.46846
 atggttttattgctgcaagagatttatttttgttatactaaactatggaaaagtttttca       c.*2580

          .         .         .         .         .         .       g.46906
 tagcatttttttcaagtttattttttgtgtgcttcatttggagtttttgtttatatacat       c.*2640

          .         .         .         .         .         .       g.46966
 tgcgctcaaaaaagtagttttttgaaaaattcagtaagatttgaatctatacagtttaac       c.*2700

          .         .         .         .         .         .       g.47026
 tgttatgacctttatgcgtgttgttttcactttatatctcaaatgccagagttcacaaaa       c.*2760

          .         .         .         .         .         .       g.47086
 atagctgatcttcattaattacatcttaattagaaccatttgttctcttccgtgtctttg       c.*2820

          .         .         .         .         .         .       g.47146
 accttctaagttttgattttaaagaaattccttgcactacagccttttcttaaaatgcaa       c.*2880

          .         .         .         .         .         .       g.47206
 gattctcactttgaaggttttgtgttggaagaaatgctactggtttttaaaaagcaaagc       c.*2940

          .         .         .         .         .         .       g.47266
 ttaactaatagaattattagcttttcttgagacagctttctgtgtcctcattactctgct       c.*3000

          .         .         .         .         .         .       g.47326
 ctgtgtgagtgttactagaatttgtgaaatactgactgagcccttcacttatcttttcta       c.*3060

          .         .         .         .         .         .       g.47386
 aagcagcacctttggacacctcattctgggaagcctgctcgagtcatagtaaaggacaca       c.*3120

          .         .         .         .         .         .       g.47446
 cgctttatgtggggagaagtggtaaaaatggagttttgtcttaattacatgaaactaagc       c.*3180

          .         .         .         .         .         .       g.47506
 tttaaaatattttataacagattatttgagctgcataatctaaacatgtcaaacgttcag       c.*3240

          .         .         .         .         .         .       g.47566
 tgggactatttttatatatgtatatgtgggtgtaggtcataacatttcagtttataatat       c.*3300

          .         .         .         .         .         .       g.47626
 aaattgttatttcagtttataagctatctctcagaggagactagctcttttgagaattca       c.*3360

          .         .         .         .         .         .       g.47686
 taatttaaagttttagactgaagtaaaatgcaacatagataatagtgtaaatcagatata       c.*3420

          .         .         .         .         .         .       g.47746
 attgagggctatatggcagtaaaactgctagtgccagttttcttgtttgcctgttataca       c.*3480

          .         .         .         .         .         .       g.47806
 tttttgatttttgtttttgtattctgaacattttgagagatcatatgtttgttcaattac       c.*3540

          .         .         .         .         .         .       g.47866
 atttagagttggtttgggaataaatatcttctaaaaagagatttatcttaaaaatggaag       c.*3600

          .         .         .         .         .         .       g.47926
 tcctaaaaattagtttatccagagtttataaagtcaaatattcagtaggcatagactgga       c.*3660

          .         .         .         .         .         .       g.47986
 atagataaattcatggaaatcatatcctttcagtacaccgtataacttcaatattacaca       c.*3720

          .         .         .         .         .         .       g.48046
 agtaacattgaggagaatgccatcagctttgttctcccttaaattctttggttttctttt       c.*3780

          .         .         .         .         .         .       g.48106
 tacattttgggaacaactgcatttaaaatgttattagtcagtatatagtaaggattaggt       c.*3840

          .         .         .         .         .         .       g.48166
 gtttgctttctgaaggaatggtccagtgaggtgattgggagaggttattttctacctaac       c.*3900

          .         .         .         .         .         .       g.48226
 ttgtatatgccctatacctcttgggcatactttgtctatagaaaaatattttgaccttta       c.*3960

          .         .         .         .         .         .       g.48286
 ggtacattttgggccagtagtcaaataatcctagggccgatataaaaatcttagaataat       c.*4020

          .         .         .         .         .         .       g.48346
 ttaaggtttgccttttatacctgttttgaaagcctttacatttttgtcaggtaatttttc       c.*4080

          .         .         .         .         .         .       g.48406
 ccaagccgtggatataatctattcaaacatgtttatgctatccattctgtttttaaattg       c.*4140

          .         .         .         .         .         .       g.48466
 aaaaaaatgttaaaagtgtttatgaagaaaagtttaaataaaatatttttaatctttaaa       c.*4200

                                                                    g.48471
 atata                                                              c.*4205

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Kelch-like 15 (Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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