kelch-like family member 41 (KLHL41) - coding DNA reference sequence

(used for variant description)

(last modified December 22, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_006063.2 in the KLHL41 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.12, covering KLHL41 transcript NM_006063.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5017
                                            ctttttacagctagacc       c.-61

 .         .         .         .         .         .                g.5077
 tgtgtgctgcaaggagctaaggccttcagtgtccccttccttacccaggtttctcacaga       c.-1

          .         .         .         .         .         .       g.5137
 ATGGATTCCCAGCGGGAACTTGCAGAGGAACTGCGGCTTTACCAATCCACCCTTCTTCAG       c.60
 M  D  S  Q  R  E  L  A  E  E  L  R  L  Y  Q  S  T  L  L  Q         p.20

          .         .         .         .         .         .       g.5197
 GATGGTCTAAAAGATCTCCTGGATGAGAAAAAATTCATCGATTGCACCCTAAAAGCAGGT       c.120
 D  G  L  K  D  L  L  D  E  K  K  F  I  D  C  T  L  K  A  G         p.40

          .         .         .         .         .         .       g.5257
 GACAAAAGTCTTCCTTGCCACAGATTGATTTTGTCAGCTTGTAGTCCTTACTTCCGTGAG       c.180
 D  K  S  L  P  C  H  R  L  I  L  S  A  C  S  P  Y  F  R  E         p.60

          .         .         .         .         .         .       g.5317
 TACTTTTTATCTGAAATTGATGAGGCGAAAAAAAAGGAGGTAGTGCTAGACAATGTGGAT       c.240
 Y  F  L  S  E  I  D  E  A  K  K  K  E  V  V  L  D  N  V  D         p.80

          .         .         .         .         .         .       g.5377
 CCTGCTATACTTGATTTAATCATCAAATACCTGTACTCTGCCAGTATTGATCTCAATGAC       c.300
 P  A  I  L  D  L  I  I  K  Y  L  Y  S  A  S  I  D  L  N  D         p.100

          .         .         .         .         .         .       g.5437
 GGAAATGTGCAAGATATTTTTGCATTGGCCAGCCGCTTTCAGATCCCCTCAGTGTTTACT       c.360
 G  N  V  Q  D  I  F  A  L  A  S  R  F  Q  I  P  S  V  F  T         p.120

          .         .         .         .         .         .       g.5497
 GTCTGCGTTTCTTATCTTCAGAAAAGACTTGCTCCTGGTAACTGTCTAGCCATCCTAAGA       c.420
 V  C  V  S  Y  L  Q  K  R  L  A  P  G  N  C  L  A  I  L  R         p.140

          .         .         .         .         .         .       g.5557
 TTAGGACTTCTTCTTGACTGCCCGAGACTCGCCATTTCTGCCCGTGAATTTGTGTCTGAT       c.480
 L  G  L  L  L  D  C  P  R  L  A  I  S  A  R  E  F  V  S  D         p.160

          .         .         .         .         .         .       g.5617
 CGCTTTGTACAGATTTGTAAGGAAGAGGACTTTATGCAACTGTCTCCACAGGAACTGATC       c.540
 R  F  V  Q  I  C  K  E  E  D  F  M  Q  L  S  P  Q  E  L  I         p.180

          .         .         .         .         .         .       g.5677
 TCAGTCATTTCAAATGACAGCCTAAATGTAGAAAAAGAAGAAGCAGTATTTGAGGCAGTG       c.600
 S  V  I  S  N  D  S  L  N  V  E  K  E  E  A  V  F  E  A  V         p.200

          .         .         .         .         .         .       g.5737
 ATGAAATGGGTGCGAACAGACAAGGAAAACAGGGTTAAAAACCTTAGTGAAGTGTTTGAT       c.660
 M  K  W  V  R  T  D  K  E  N  R  V  K  N  L  S  E  V  F  D         p.220

          .         .         .         .         .         .       g.5797
 TGTATCCGTTTTCGCCTTATGACAGAAAAATATTTTAAGGATCATGTTGAGAAAGATGAT       c.720
 C  I  R  F  R  L  M  T  E  K  Y  F  K  D  H  V  E  K  D  D         p.240

          .         .         .         .         .         .       g.5857
 ATAATTAAAAGCAACCCAGACCTCCAGAAAAAAATCAAAGTTCTAAAAGATGCTTTCGCA       c.780
 I  I  K  S  N  P  D  L  Q  K  K  I  K  V  L  K  D  A  F  A         p.260

          .         .         .         .         .         .       g.5917
 GGCAAACTCCCAGAACCTAGCAAAAATGCCGCGAAGACTGGGGCTGGTGAGGTGAATGGT       c.840
 G  K  L  P  E  P  S  K  N  A  A  K  T  G  A  G  E  V  N  G         p.280

          .         .         .         .         .         .       g.5977
 GATGTTGGTGATGAAGATTTACTTCCTGGTTACCTGAATGACATTCCCAGGCATGGAATG       c.900
 D  V  G  D  E  D  L  L  P  G  Y  L  N  D  I  P  R  H  G  M         p.300

          .         .         .         .         .         .       g.6037
 TTTGTAAAAGACCTCATCCTCTTGGTTAATGACACAGCAGCAGTGGCTTATGACCCCACG       c.960
 F  V  K  D  L  I  L  L  V  N  D  T  A  A  V  A  Y  D  P  T         p.320

          .         .         .         .         .         .       g.6097
 GAAAATGAATGCTACCTTACTGCACTGGCTGAGCAGATTCCCAGAAATCATTCCAGCATT       c.1020
 E  N  E  C  Y  L  T  A  L  A  E  Q  I  P  R  N  H  S  S  I         p.340

          .         .         .         .         .         .       g.6157
 GTTACCCAGCAAAATCAGATATATGTGGTAGGAGGACTATATGTGGATGAAGAAAATAAG       c.1080
 V  T  Q  Q  N  Q  I  Y  V  V  G  G  L  Y  V  D  E  E  N  K         p.360

          .         .         . | 02       .         .         .    g.9902
 GATCAACCTCTACAGTCATACTTCTTCCAG | CTCGATAGCATAGCATCTGAATGGGTTGGA    c.1140
 D  Q  P  L  Q  S  Y  F  F  Q   | L  D  S  I  A  S  E  W  V  G      p.380

          .         .         .         .         .         .       g.9962
 CTTCCACCTCTGCCTTCAGCCAGGTGTCTCTTCGGTCTGGGAGAGGTGGATGATAAAATC       c.1200
 L  P  P  L  P  S  A  R  C  L  F  G  L  G  E  V  D  D  K  I         p.400

          .         .         .         .         .         .       g.10022
 TATGTAGTTGCAGGCAAAGACCTTCAAACAGAGGCTTCGCTGGATTCAGTATTATGCTAT       c.1260
 Y  V  V  A  G  K  D  L  Q  T  E  A  S  L  D  S  V  L  C  Y         p.420

          | 03         .         .         .         .         .    g.10204
 GATCCTGT | GGCTGCAAAATGGAACGAAGTAAAAAAACTCCCTATCAAAGTCTATGGCCAT    c.1320
 D  P  V  |  A  A  K  W  N  E  V  K  K  L  P  I  K  V  Y  G  H      p.440

          .         .         .         .         .       | 04 .    g.13492
 AATGTGATTTCACATAAAGGGATGATATATTGTCTAGGAGGAAAGACAGATGACAA | AAAA    c.1380
 N  V  I  S  H  K  G  M  I  Y  C  L  G  G  K  T  D  D  K  |  K      p.460

          .         .         .         .         .         .       g.13552
 TGTACAAACAGGGTGTTTATCTTCAACCCCAAAAAAGGAGATTGGAAAGATCTGGCTCCA       c.1440
 C  T  N  R  V  F  I  F  N  P  K  K  G  D  W  K  D  L  A  P         p.480

          .         .         .         .         .         .       g.13612
 ATGAAAATTCCTCGTTCCATGTTTGGAGTAGCAGTCCATAAAGGCAAAATTGTGATTGCA       c.1500
 M  K  I  P  R  S  M  F  G  V  A  V  H  K  G  K  I  V  I  A         p.500

          .         .         .         .         .         .       g.13672
 GGAGGTGTCACTGAAGATGGTCTTTCAGCTTCAGTTGAAGCTTTTGACCTTACAACAAAT       c.1560
 G  G  V  T  E  D  G  L  S  A  S  V  E  A  F  D  L  T  T  N         p.520

    | 05     .         .         .         .         .         .    g.16217
 AA | ATGGGATGTAATGACCGAATTTCCCCAAGAAAGAAGCTCCATCAGTTTGGTCAGCCTG    c.1620
 K  |  W  D  V  M  T  E  F  P  Q  E  R  S  S  I  S  L  V  S  L      p.540

          .         .         .         .         .         .       g.16277
 GCTGGATCTCTGTATGCAATTGGTGGTTTTGCTATGATTCAACTGGAGTCTAAAGAATTT       c.1680
 A  G  S  L  Y  A  I  G  G  F  A  M  I  Q  L  E  S  K  E  F         p.560

          .         .          | 06        .         .         .    g.20914
 GCACCCACTGAAGTCAATGACATATGGAA | GTATGAAGATGATAAAAAAGAATGGGCTGGG    c.1740
 A  P  T  E  V  N  D  I  W  K  |  Y  E  D  D  K  K  E  W  A  G      p.580

          .         .         .         .         .         .       g.20974
 ATGTTGAAGGAAATACGTTATGCTTCAGGAGCTAGTTGCCTAGCAACACGTTTAAATCTC       c.1800
 M  L  K  E  I  R  Y  A  S  G  A  S  C  L  A  T  R  L  N  L         p.600

          .         .                                               g.20995
 TTCAAACTGTCTAAACTGTGA                                              c.1821
 F  K  L  S  K  L  X                                                p.606

          .         .         .         .         .         .       g.21055
 acaaggtgacaaaacataatagattgggaggtggtttgtttggtgaatggggctttaatt       c.*60

          .         .         .         .         .         .       g.21115
 tattctgttttttaaaagcttgtacagacactcatgtagaaattattcaagaagttattg       c.*120

          .         .         .         .         .         .       g.21175
 tctaagagatgagcagtaggtaagaaaacctcagtcattgactcttcaatgtaatgatca       c.*180

          .         .         .         .         .         .       g.21235
 gagtttaaaaccattttctaataataaattaaatcttcagttgaacaaattattttgtga       c.*240

          .         .         .         .         .         .       g.21295
 atctgtttcactcaatggattgtaaagaaggctcctaaatttgagttgtttgctaatcat       c.*300

          .         .         .         .         .         .       g.21355
 ttcatttgcatcattagggtatccttaaactgattttctattacaattggaagtggagaa       c.*360

          .         .         .         .         .         .       g.21415
 tatgtgcatctacactaaaaaaatgtttaagatatcaaaaacctctcctcgtgcttcaaa       c.*420

          .         .         .         .         .         .       g.21475
 atgacaggaatcctgtgcattatactaagaattacatgccataagatgacttcagaaatc       c.*480

          .         .         .         .         .         .       g.21535
 ctacttcagaagtgtaataaatggatggggaaatcgtttgatggggaaaagtctcttgta       c.*540

          .         .                                               g.21561
 agtaaaagtagtcaaattcaaatggc                                         c.*566

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Kelch-like family member 41 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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