kelch-like family member 7 (KLHL7) - coding DNA reference sequence

(used for variant description)

(last modified November 13, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001031710.2 in the KLHL7 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016983.1, covering KLHL7 transcript NM_001031710.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5053
        atagtgcccccgcctccttgcgcgaagtgcgcaggctcctgggcagggctcgg       c.-241

 .         .         .         .         .         .                g.5113
 gttctgcccggggacgcagcccagttggtagcgtcgctccctgagcgtttctaagggggc       c.-181

 .         .         .         .         .         .                g.5173
 cgcccggccttgtctttcggcagtggccgagccaccgccgcctgccgcgcgttccagagc       c.-121

 .         .         .         .         .         .                g.5233
 tgggcgctgcagctgcactgccgatcgccgtgtttggtcgatagaatccccagtgtgccc       c.-61

 .         .         .         .         .         .                g.5293
 agagagtgcgacccctcgcccggcccggcgagccccgggcgtgaaccgagctgagggagg       c.-1

          .         .         .         .         .         .       g.5353
 ATGGCAGCCTCTGGGGTGGAGAAGAGCAGCAAGAAGAAGACCGAGAAGAAACTTGCTGCT       c.60
 M  A  A  S  G  V  E  K  S  S  K  K  K  T  E  K  K  L  A  A         p.20

          .         .         .         .         .         .       g.5413
 CGGGAAGAAGCTAAATTGTTGGCGGGTTTCATGGGCGTCATGAATAACATGCGGAAACAG       c.120
 R  E  E  A  K  L  L  A  G  F  M  G  V  M  N  N  M  R  K  Q         p.40

  | 02       .         .         .         .         .         .    g.23103
  | AAAACGTTGTGTGACGTGATCCTCATGGTCCAGGAAAGAAAGATACCTGCTCATCGTGTT    c.180
  | K  T  L  C  D  V  I  L  M  V  Q  E  R  K  I  P  A  H  R  V      p.60

          .         .         .         .    | 03    .         .    g.23971
 GTTCTTGCTGCAGCCAGTCATTTTTTTAACTTAATGTTCACAA | CTAACATGCTTGAATCA    c.240
 V  L  A  A  A  S  H  F  F  N  L  M  F  T  T |   N  M  L  E  S      p.80

          .         .         .         .         .         .       g.24031
 AAGTCCTTTGAAGTAGAACTCAAAGATGCTGAACCTGATATTATTGAACAACTGGTGGAA       c.300
 K  S  F  E  V  E  L  K  D  A  E  P  D  I  I  E  Q  L  V  E         p.100

          .        | 04.         .         .         .         .    g.24357
 TTTGCTTATACTGCTAG | AATTTCCGTGAATAGCAACAATGTTCAGTCTTTGCTGGATGCA    c.360
 F  A  Y  T  A  R  |  I  S  V  N  S  N  N  V  Q  S  L  L  D  A      p.120

          .         .         .         .         .         .       g.24417
 GCAAACCAATATCAGATTGAACCTGTGAAGAAAATGTGTGTTGATTTTTTGAAAGAACAA       c.420
 A  N  Q  Y  Q  I  E  P  V  K  K  M  C  V  D  F  L  K  E  Q         p.140

          .         .   | 05     .         .         .         .    g.40073
 GTTGATGCTTCAAATTGTCTTG | GTATAAGTGTGCTAGCGGAGTGTCTAGATTGTCCTGAA    c.480
 V  D  A  S  N  C  L  G |   I  S  V  L  A  E  C  L  D  C  P  E      p.160

          .         .         .         .         .         .       g.40133
 TTGAAAGCAACTGCAGATGACTTTATTCATCAGCACTTTACTGAAGTTTACAAAACTGAT       c.540
 L  K  A  T  A  D  D  F  I  H  Q  H  F  T  E  V  Y  K  T  D         p.180

          .         .         .         .         .         .       g.40193
 GAATTTCTTCAACTTGATGTCAAGCGAGTAACACATCTTCTCAACCAGGACACTCTGACT       c.600
 E  F  L  Q  L  D  V  K  R  V  T  H  L  L  N  Q  D  T  L  T         p.200

          .         | 06         .         .         .         .    g.43159
 GTGAGAGCAGAGGATCAG | GTTTATGATGCTGCAGTCAGGTGGTTGAAATACGATGAACCT    c.660
 V  R  A  E  D  Q   | V  Y  D  A  A  V  R  W  L  K  Y  D  E  P      p.220

          .         .         .         .         .         .       g.43219
 AATCGCCAGCCATTTATGGTTGATATCCTTGCTAAAGTCAGGTTTCCTCTTATATCAAAG       c.720
 N  R  Q  P  F  M  V  D  I  L  A  K  V  R  F  P  L  I  S  K         p.240

          .         .         .         .         .         .       g.43279
 AATTTCTTAAGTAAAACGGTACAAGCTGAACCACTTATTCAAGACAATCCTGAATGCCTT       c.780
 N  F  L  S  K  T  V  Q  A  E  P  L  I  Q  D  N  P  E  C  L         p.260

          .    | 07    .         .         .         .         .    g.51380
 AAGATGGTGATAA | GTGGAATGAGGTACCATCTACTGTCTCCAGAGGACCGAGAAGAACTT    c.840
 K  M  V  I  S |   G  M  R  Y  H  L  L  S  P  E  D  R  E  E  L      p.280

          .         .         .         .         .         .       g.51440
 GTAGATGGCACAAGACCTAGAAGAAAGAAACATGACTACCGCATAGCCCTATTTGGAGGC       c.900
 V  D  G  T  R  P  R  R  K  K  H  D  Y  R  I  A  L  F  G  G         p.300

          .         .         .       | 08 .         .         .    g.64988
 TCTCAACCACAGTCTTGTAGATATTTTAACCCAAAG | GATTATAGCTGGACAGACATCCGC    c.960
 S  Q  P  Q  S  C  R  Y  F  N  P  K   | D  Y  S  W  T  D  I  R      p.320

          .         .         .         .         .         .       g.65048
 TGCCCCTTTGAAAAACGAAGAGATGCAGCATGCGTGTTTTGGGACAATGTAGTATACATT       c.1020
 C  P  F  E  K  R  R  D  A  A  C  V  F  W  D  N  V  V  Y  I         p.340

          .         .         .         .         .         .       g.65108
 TTGGGAGGCTCTCAGCTTTTCCCAATAAAGCGAATGGACTGCTATAATGTAGTGAAGGAT       c.1080
 L  G  G  S  Q  L  F  P  I  K  R  M  D  C  Y  N  V  V  K  D         p.360

          .         .         .         .         .         .       g.65168
 AGCTGGTATTCGAAACTGGGTCCTCCGACACCTCGAGACAGCCTTGCTGCATGTGCTGCA       c.1140
 S  W  Y  S  K  L  G  P  P  T  P  R  D  S  L  A  A  C  A  A         p.380

          .         .         .        | 09.         .         .    g.67125
 GAAGGCAAAATTTATACATCTGGAGGTTCAGAAGTAG | GAAACTCAGCTCTGTATTTATTT    c.1200
 E  G  K  I  Y  T  S  G  G  S  E  V  G |   N  S  A  L  Y  L  F      p.400

          .         .         .         .         .         .       g.67185
 GAGTGCTATGATACGAGAACTGAAAGCTGGCACACAAAGCCCAGCATGCTGACCCAGCGC       c.1260
 E  C  Y  D  T  R  T  E  S  W  H  T  K  P  S  M  L  T  Q  R         p.420

          .         .         .         .         .         .       g.67245
 TGCAGCCATGGGATGGTGGAAGCCAATGGCCTAATCTATGTTTGTGGTGGAAGTTTAGGA       c.1320
 C  S  H  G  M  V  E  A  N  G  L  I  Y  V  C  G  G  S  L  G         p.440

          .         .         .         .         .          | 10    g.72215
 AACAATGTTTCTGGGAGAGTGCTTAATTCCTGTGAAGTTTATGATCCTGCCACAGAAAC | A    c.1380
 N  N  V  S  G  R  V  L  N  S  C  E  V  Y  D  P  A  T  E  T  |      p.460

          .         .         .         .         .         .       g.72275
 TGGACTGAGCTGTGTCCAATGATTGAAGCCAGGAAGAATCATGGGCTGGTATTTGTAAAA       c.1440
 W  T  E  L  C  P  M  I  E  A  R  K  N  H  G  L  V  F  V  K         p.480

          .         .         .        | 11.         .         .    g.73304
 GACAAGATATTTGCTGTGGGTGGTCAGAATGGTTTAG | GTGGTCTGGACAATGTGGAATAT    c.1500
 D  K  I  F  A  V  G  G  Q  N  G  L  G |   G  L  D  N  V  E  Y      p.500

          .         .         .         .         .         .       g.73364
 TACGATATTAAGTTGAACGAATGGAAGATGGTCTCACCAATGCCATGGAAGGGTGTAACA       c.1560
 Y  D  I  K  L  N  E  W  K  M  V  S  P  M  P  W  K  G  V  T         p.520

          .         .         .         .         .         .       g.73424
 GTGAAATGTGCAGCAGTTGGCTCTATAGTTTATGTCTTGGCTGGTTTTCAGGGTGTTGGT       c.1620
 V  K  C  A  A  V  G  S  I  V  Y  V  L  A  G  F  Q  G  V  G         p.540

          .         .         .         .         .         .       g.73484
 CGATTAGGACACATTCTCGAATATAATACCGAAACAGACAAATGGGTTGCCAACTCCAAA       c.1680
 R  L  G  H  I  L  E  Y  N  T  E  T  D  K  W  V  A  N  S  K         p.560

          .         .         .         .         .         .       g.73544
 GTTCGTGCTTTTCCAGTCACAAGTTGTTTAATTTGTGTTGTCGATACTTGTGGAGCAAAT       c.1740
 V  R  A  F  P  V  T  S  C  L  I  C  V  V  D  T  C  G  A  N         p.580

          .         .                                               g.73565
 GAAGAGACCCTTGAAACATGA                                              c.1761
 E  E  T  L  E  T  X                                                p.586

          .         .         .         .         .         .       g.73625
 aaaatgagtggacttcagactcatcagagactctaaaatatagccaccagtgctttgttc       c.*60

          .         .         .         .         .         .       g.73685
 caggagtttggtgacaaagttttggtttggtgttttggtaaagaaagtttcaagtgaaat       c.*120

          .         .         .         .         .         .       g.73745
 gaggttcctataaaatagatgtttcttttatatggatttccttaattcaaagatcatatt       c.*180

          .         .         .         .         .         .       g.73805
 ttagctggccacaaaaccaagaacatatctagcaagaaaacttgaaaaagtataagcatt       c.*240

          .         .         .         .         .         .       g.73865
 tgttaaaaatgtgaatttcttgaatgaatttcacatttgtaactatgattttggcagaat       c.*300

          .         .         .         .         .         .       g.73925
 agaagattggctcatcagtgaagcgcagtatcttagctctagattctattttcatgcatc       c.*360

          .         .         .         .         .         .       g.73985
 acagaagtgctatacggttaggtctgtttgtgctcagtcaagaactaagaaatagtatga       c.*420

          .         .         .         .         .         .       g.74045
 attgtaagtcaagatgggcaactcagatggagcagcttagtctcacagtttgcttgtcta       c.*480

          .         .         .         .         .         .       g.74105
 tttattttatttagtgccaaatgtattccattttaaaagtaagccagagtgagtcaaggc       c.*540

          .         .         .         .         .         .       g.74165
 atatacacactttctcacaaaacttcctaaacagatttgggggtttaatatgtccaactc       c.*600

          .         .         .         .         .         .       g.74225
 ctcatgaaatatattcaatccacttaaatatattccatctttttaacataaaatgtaaag       c.*660

          .         .         .         .         .         .       g.74285
 cttagcacccatcattaatttatgtctctgttttatccagtggttaaaaaaggattctgc       c.*720

          .         .         .         .         .         .       g.74345
 ctctttagtcctcactgttaaataaaacccaatcatagtaagtgattaactagcaaaaag       c.*780

          .         .         .         .         .         .       g.74405
 taaagctatttatagcaaatttctagatcattagaaaagcactggtagttgtacaatatc       c.*840

          .         .         .         .         .         .       g.74465
 agtgttgactttgaacttctttaacgagatcatgaattcttttcccttagccaaaacatg       c.*900

          .         .         .         .         .         .       g.74525
 aaatatttaacctagttgtctctaaaagttttgtaatcatgagttagatatatgtcatct       c.*960

          .         .         .         .         .         .       g.74585
 cctattcattgcttttatgtgatcaataaatcttttacaaacccaactactcatttcctt       c.*1020

          .         .         .         .         .         .       g.74645
 cctagtaatactttgcctttttcactgtgtatggaatgaaacatgtaaagctgtcacaat       c.*1080

          .         .         .         .                           g.74688
 caatgtttttatctgataatattaaatattttttaacttaaaa                        c.*1123

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Kelch-like family member 7 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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