lysine methyltransferase 2B (KMT2B) - coding DNA reference sequence

(used for variant description)

(last modified September 30, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_014727.1 in the KMT2B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_052906.1, covering KMT2B transcript NM_014727.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
          .         .         .         .         .         .       g.60
 ATGGCGGCGGCGGCGGGCGGCGGCAGTTGCCCCGGGCCTGGCTCCGCGCGGGGCCGCTTC       c.60
 M  A  A  A  A  G  G  G  S  C  P  G  P  G  S  A  R  G  R  F         p.20

          .         .         .         .         .         .       g.120
 CCGGGCCGGCCGCGGGGCGCCGGCGGGGGCGGGGGCCGCGGCGGACGGGGCAACGGGGCC       c.120
 P  G  R  P  R  G  A  G  G  G  G  G  R  G  G  R  G  N  G  A         p.40

          .         .         .         .         .         .       g.180
 GAAAGAGTGCGGGTAGCTCTGCGGCGCGGCGGTGGCGCGACGGGGCCGGGCGGAGCCGAG       c.180
 E  R  V  R  V  A  L  R  R  G  G  G  A  T  G  P  G  G  A  E         p.60

          .         .         .         .         .         .       g.240
 CCCGGGGAGGACACGGCCCTGCTCCGTTTGCTGGGGCTCCGCCGGGGCCTGCGCCGGCTC       c.240
 P  G  E  D  T  A  L  L  R  L  L  G  L  R  R  G  L  R  R  L         p.80

          .         .         .         .         .         .       g.300
 CGCCGCCTGTGGGCCGGCCCGCGGGTCCAGCGGGGCCGGGGACGGGGTCGGGGCCGGGGC       c.300
 R  R  L  W  A  G  P  R  V  Q  R  G  R  G  R  G  R  G  R  G         p.100

          .         .         .         .         .         .       g.360
 TGGGGCCCGAGTCGAGGCTGCGTGCCGGAGGAGGAGAGCAGTGACGGGGAATCCGACGAG       c.360
 W  G  P  S  R  G  C  V  P  E  E  E  S  S  D  G  E  S  D  E         p.120

     | 02    .         .         .         .         .         .    g.1507
 GAG | GAGTTTCAGGGTTTTCATTCAGATGAAGATGTGGCCCCCAGTTCCCTGCGCTCTGCG    c.420
 E   | E  F  Q  G  F  H  S  D  E  D  V  A  P  S  S  L  R  S  A      p.140

          .       | 03 .         .         .         .         .    g.1809
 CTCCGATCCCAGCGAG | GTCGAGCGCCCCGAGGTCGGGGTCGCAAGCATAAGACGACCCCC    c.480
 L  R  S  Q  R  G |   R  A  P  R  G  R  G  R  K  H  K  T  T  P      p.160

          .         .         .         .         .         .       g.1869
 CTTCCTCCTCCTCGCCTAGCAGATGTGGCTCCTACCCCCCCAAAGACCCCTGCCCGGAAA       c.540
 L  P  P  P  R  L  A  D  V  A  P  T  P  P  K  T  P  A  R  K         p.180

          .         .         .         .         .         .       g.1929
 CGGGGTGAGGAAGGCACAGAACGGATGGTGCAGGCACTGACTGAACTTCTCCGGCGGGCC       c.600
 R  G  E  E  G  T  E  R  M  V  Q  A  L  T  E  L  L  R  R  A         p.200

          .         .         .         .         .         .       g.1989
 CAGGCACCCCAAGCACCCCGGAGCCGGGCATGTGAGCCCTCCACCCCCCGGCGGTCTCGG       c.660
 Q  A  P  Q  A  P  R  S  R  A  C  E  P  S  T  P  R  R  S  R         p.220

          .         .         .         .         .         .       g.2049
 GGACGGCCCCCAGGACGGCCAGCAGGCCCCTGCAGGAGGAAGCAGCAAGCAGTAGTGGTG       c.720
 G  R  P  P  G  R  P  A  G  P  C  R  R  K  Q  Q  A  V  V  V         p.240

          .         .         .         .         .         .       g.2109
 GCAGAAGCAGCTGTGACAATCCCCAAACCTGAGCCCCCACCTCCTGTGGTTCCAGTGAAA       c.780
 A  E  A  A  V  T  I  P  K  P  E  P  P  P  P  V  V  P  V  K         p.260

          .         .         .         .         .         .       g.2169
 CATCAGACTGGCAGCTGGAAATGCAAGGAGGGGCCCGGTCCAGGACCTGGGACCCCCAGG       c.840
 H  Q  T  G  S  W  K  C  K  E  G  P  G  P  G  P  G  T  P  R         p.280

          .         .         .         .         .         .       g.2229
 CGTGGAGGACAGTCAAGCCGTGGAGGCCGTGGAGGCAGGGGCCGCGGCCGAGGTGGTGGG       c.900
 R  G  G  Q  S  S  R  G  G  R  G  G  R  G  R  G  R  G  G  G         p.300

          .         .         .         .         .         .       g.2289
 CTCCCCTTTGTGATCAAGTTTGTTTCAAGGGCCAAAAAAGTAAAGATGGGACAATTGTCC       c.960
 L  P  F  V  I  K  F  V  S  R  A  K  K  V  K  M  G  Q  L  S         p.320

          .         .         .         .         .         .       g.2349
 TTGGGACTCGAATCAGGTCAAGGTCAAGGTCAACATGAGGAAAGTTGGCAGGATGTCCCC       c.1020
 L  G  L  E  S  G  Q  G  Q  G  Q  H  E  E  S  W  Q  D  V  P         p.340

          .         .         .         .         .         .       g.2409
 CAAAGAAGAGTTGGATCTGGACAGGGAGGGAGCCCTTGCTGGAAAAAGCAGGAACAGAAG       c.1080
 Q  R  R  V  G  S  G  Q  G  G  S  P  C  W  K  K  Q  E  Q  K         p.360

          .         .         .         .         .         .       g.2469
 CTGGATGACGAGGAAGAAGAGAAGAAAGAAGAAGAAGAAAAAGACAAGGAGGGAGAAGAG       c.1140
 L  D  D  E  E  E  E  K  K  E  E  E  E  K  D  K  E  G  E  E         p.380

          .         .         .         .         .         .       g.2529
 AAGGAAGAAAGAGCTGTAGCTGAGGAGATGATGCCAGCTGCGGAAAAGGAAGAGGCAAAG       c.1200
 K  E  E  R  A  V  A  E  E  M  M  P  A  A  E  K  E  E  A  K         p.400

          .         .         .         .         .         .       g.2589
 CTGCCACCACCGCCTCTGACTCCTCCAGCCCCTTCACCTCCTCCACCCCTCCCACCCCCT       c.1260
 L  P  P  P  P  L  T  P  P  A  P  S  P  P  P  P  L  P  P  P         p.420

          .         .         .         .         .         .       g.2649
 TCGACATCTCCTCCACCCCCACTCTGCCCTCCACCACCACCCCCAGTGTCCCCACCACCT       c.1320
 S  T  S  P  P  P  P  L  C  P  P  P  P  P  P  V  S  P  P  P         p.440

          .         .         .         .         .         .       g.2709
 CTACCATCCCCTCCACCGCCTCCTGCCCAAGAGGAGCAGGAGGAATCCCCTCCTCCTGTG       c.1380
 L  P  S  P  P  P  P  P  A  Q  E  E  Q  E  E  S  P  P  P  V         p.460

          .         .         .         .         .         .       g.2769
 GTCCCAGCTACGTGCTCCAGGAAGAGGGGCCGGCCTCCCCTGACTCCCAGCCAGCGGGCG       c.1440
 V  P  A  T  C  S  R  K  R  G  R  P  P  L  T  P  S  Q  R  A         p.480

          .         .         .         .         .         .       g.2829
 GAGCGGGAAGCTGCTCGGGCAGGGCCAGAGGGCACCTCTCCTCCCACTCCAACCCCCAGC       c.1500
 E  R  E  A  A  R  A  G  P  E  G  T  S  P  P  T  P  T  P  S         p.500

          .         .         .         .         .         .       g.2889
 ACCGCCACGGGAGGCCCTCCGGAAGACAGTCCCACCGTGGCCCCCAAAAGCACCACCTTC       c.1560
 T  A  T  G  G  P  P  E  D  S  P  T  V  A  P  K  S  T  T  F         p.520

          .         .         .         .         .         .       g.2949
 CTGAAGAATATCCGGCAGTTTATTATGCCTGTGGTGAGTGCCCGCTCCTCCCGTGTCATC       c.1620
 L  K  N  I  R  Q  F  I  M  P  V  V  S  A  R  S  S  R  V  I         p.540

          .         .         .         .         .         .       g.3009
 AAGACACCCCGGCGATTTATGGATGAAGACCCCCCCAAACCCCCAAAGGTGGAGGTCTCA       c.1680
 K  T  P  R  R  F  M  D  E  D  P  P  K  P  P  K  V  E  V  S         p.560

          .         .         .         .         .         .       g.3069
 CCTGTCCTGCGACCTCCCATTACCACCTCCCCACCTGTTCCCCAGGAGCCAGCACCAGTC       c.1740
 P  V  L  R  P  P  I  T  T  S  P  P  V  P  Q  E  P  A  P  V         p.580

          .         .         .         .         .         .       g.3129
 CCCTCTCCACCACGTGCCCCAACTCCTCCATCTACCCCAGTTCCACTCCCTGAGAAGAGA       c.1800
 P  S  P  P  R  A  P  T  P  P  S  T  P  V  P  L  P  E  K  R         p.600

          .         .         .         .         .         .       g.3189
 CGGTCCATCCTAAGGGAACCCACATTTCGCTGGACCTCACTGACCCGGGAGCTGCCCCCT       c.1860
 R  S  I  L  R  E  P  T  F  R  W  T  S  L  T  R  E  L  P  P         p.620

          .         .         .         .         .         .       g.3249
 CCTCCCCCAGCCCCTCCACCTCCCCCGGCCCCCTCCCCACCCCCTGCTCCTGCCACCTCC       c.1920
 P  P  P  A  P  P  P  P  P  A  P  S  P  P  P  A  P  A  T  S         p.640

          .         .         .         .         .         .       g.3309
 TCCCGGAGGCCCCTACTCCTTCGGGCCCCTCAGTTTACCCCAAGCGAAGCCCACCTGAAG       c.1980
 S  R  R  P  L  L  L  R  A  P  Q  F  T  P  S  E  A  H  L  K         p.660

          .         .         .         .         .         .       g.3369
 ATCTACGAATCGGTGCTTACTCCTCCTCCTCTTGGGGCTCCTGAAGCCCCTGAGCCAGAG       c.2040
 I  Y  E  S  V  L  T  P  P  P  L  G  A  P  E  A  P  E  P  E         p.680

          .         .         .         .         .         .       g.3429
 CCTCCTCCTGCCGATGACTCTCCAGCTGAGCCTGAGCCTCGGGCAGTGGGCCGCACCAAC       c.2100
 P  P  P  A  D  D  S  P  A  E  P  E  P  R  A  V  G  R  T  N         p.700

          .         .         .         .         .         .       g.3489
 CACCTCAGCCTGCCTCGATTCGCCCCTGTGGTCACCACTCCTGTTAAGGCCGAGGTGTCC       c.2160
 H  L  S  L  P  R  F  A  P  V  V  T  T  P  V  K  A  E  V  S         p.720

          .         .         .         .         .         .       g.3549
 CCTCACGGGGCTCCAGCTCTGAGCAACGGGCCACAGACACAGGCTCAGCTACTGCAGCCC       c.2220
 P  H  G  A  P  A  L  S  N  G  P  Q  T  Q  A  Q  L  L  Q  P         p.740

          .         .         .         .         .         .       g.3609
 CTGCAGGCCTTGCAAACCCAGCTCCTGCCCCAGGCACTACCGCCACCACAGCCACAGCTG       c.2280
 L  Q  A  L  Q  T  Q  L  L  P  Q  A  L  P  P  P  Q  P  Q  L         p.760

          .         .         .         .         .         .       g.3669
 CAGCCACCGCCGTCACCACAGCAGATGCCTCCCCTGGAAAAAGCCCGGATTGCGGGCGTG       c.2340
 Q  P  P  P  S  P  Q  Q  M  P  P  L  E  K  A  R  I  A  G  V         p.780

          .         .         .         .         .         .       g.3729
 GGTTCCTTGCCGCTGTCTGGGGTAGAGGAGAAGATGTTCAGCCTCCTCAAGAGAGCCAAA       c.2400
 G  S  L  P  L  S  G  V  E  E  K  M  F  S  L  L  K  R  A  K         p.800

          .         .         .         .         .        | 04.    g.4343
 GTGCAGCTATTCAAGATCGATCAGCAGCAGCAGCAGAAGGTGGCAGCTTCCATGCCG | CTG    c.2460
 V  Q  L  F  K  I  D  Q  Q  Q  Q  Q  K  V  A  A  S  M  P   | L      p.820

          .         .         .         .         .         .       g.4403
 AGCCCTGGAGGGCAGATGGAGGAGGTGGCCGGGGCTGTCAAGCAGATCTCCGACAGAGGC       c.2520
 S  P  G  G  Q  M  E  E  V  A  G  A  V  K  Q  I  S  D  R  G         p.840

          .         .         .         .         .  | 05      .    g.4558
 CCTGTCCGGTCTGAAGATGAGTCGGTGGAAGCTAAGAGAGAGCGGCCCTCA | GGTCCCGAG    c.2580
 P  V  R  S  E  D  E  S  V  E  A  K  R  E  R  P  S   | G  P  E      p.860

          .         .         .         .         .         .       g.4618
 TCCCCTGTGCAAGGTCCCCGCATCAAACATGTCTGCCGTCATGCTGCTGTGGCCCTGGGT       c.2640
 S  P  V  Q  G  P  R  I  K  H  V  C  R  H  A  A  V  A  L  G         p.880

          .         .         .         .         .         .       g.4678
 CAGGCCCGGGCCATGGTGCCTGAAGATGTCCCTCGCCTCAGTGCCCTCCCTCTCCGGGAT       c.2700
 Q  A  R  A  M  V  P  E  D  V  P  R  L  S  A  L  P  L  R  D         p.900

          .         .   | 06     .         .         .         .    g.5014
 CGGCAGGACCTCGCCACAGAGG | ATACATCATCGGCGTCCGAGACTGAGAGTGTCCCGTCA    c.2760
 R  Q  D  L  A  T  E  D |   T  S  S  A  S  E  T  E  S  V  P  S      p.920

          .         .         .         .         .         .       g.5074
 CGGTCCCGGCGGGGAAAGGTGGAGGCAGCAGGCCCTGGGGGAGAATCAGAGCCCACAGGT       c.2820
 R  S  R  R  G  K  V  E  A  A  G  P  G  G  E  S  E  P  T  G         p.940

          .         .         .         .         .         .       g.5134
 TCTGGAGGGACCCTGGCCCACACACCCCGGCGCTCACTGCCCTCCCATCACGGCAAGAAG       c.2880
 S  G  G  T  L  A  H  T  P  R  R  S  L  P  S  H  H  G  K  K         p.960

          .         .         .         .         .         .       g.5194
 ATGCGCATGGCTCGATGTGGACACTGTCGGGGCTGCCTACGTGTGCAGGACTGTGGGTCC       c.2940
 M  R  M  A  R  C  G  H  C  R  G  C  L  R  V  Q  D  C  G  S         p.980

          .         .         .         .         .         .       g.5254
 TGTGTCAACTGCCTAGACAAGCCCAAGTTTGGGGGCCCTAACACCAAGAAGCAGTGCTGT       c.3000
 C  V  N  C  L  D  K  P  K  F  G  G  P  N  T  K  K  Q  C  C         p.1000

    | 07     .         .         .         .         .         | 08 g.5714
 GT | ATACCGGAAGTGTGACAAAATAGAGGCTCGGAAGATGGAACGACTGGCTAAAAAAG | GC c.3060
 V  |  Y  R  K  C  D  K  I  E  A  R  K  M  E  R  L  A  K  K  G |    p.1020

          .         .         .         .         .         .       g.5774
 CGGACGATAGTGAAGACGCTGTTGCCCTGGGATTCCGATGAATCTCCTGAGGCCTCCCCT       c.3120
 R  T  I  V  K  T  L  L  P  W  D  S  D  E  S  P  E  A  S  P         p.1040

          .         .         .         .         .         .       g.5834
 GGTCCTCCAGGCCCACGCCGGGGGGCGGGAGCTGGGGGGCCCCGGGAGGAGGTGGTGGCC       c.3180
 G  P  P  G  P  R  R  G  A  G  A  G  G  P  R  E  E  V  V  A         p.1060

          .         .         .         .         .         .       g.5894
 CACCCAGGGCCCGAGGAGCAGGACTCCCTCCTGCAGCGCAAGTCAGCTCGGCGCTGCGTC       c.3240
 H  P  G  P  E  E  Q  D  S  L  L  Q  R  K  S  A  R  R  C  V         p.1080

          .         .         .         .         .         .       g.5954
 AAACAGCGACCCTCCTATGATATCTTCGAGGATTCGGATGACTCGGAGCCCGGGGGCCCC       c.3300
 K  Q  R  P  S  Y  D  I  F  E  D  S  D  D  S  E  P  G  G  P         p.1100

          .         .         .     | 09   .         .         .    g.6643
 CCTGCTCCTCGGCGTCGGACCCCCCGAGAAAATG | AGCTGCCACTGCCAGAACCTGAGGAG    c.3360
 P  A  P  R  R  R  T  P  R  E  N  E |   L  P  L  P  E  P  E  E      p.1120

          .         .         .         .         .         .       g.6703
 CAGAGCCGGCCCCGCAAACCTACCCTGCAGCCTGTGTTGCAGCTCAAGGCCCGAAGGCGC       c.3420
 Q  S  R  P  R  K  P  T  L  Q  P  V  L  Q  L  K  A  R  R  R         p.1140

           | 10        .         .         .         .         .    g.7020
 CTGGACAAG | GATGCTTTGGCCCCTGGCCCCTTTGCTTCTTTTCCCAATGGCTGGACTGGA    c.3480
 L  D  K   | D  A  L  A  P  G  P  F  A  S  F  P  N  G  W  T  G      p.1160

          .         .         .         .         | 11         .    g.7212
 AAGCAGAAGTCTCCCGATGGTGTGCACCGCGTCCGTGTGGATTTTAAG | GAGGATTGTGAT    c.3540
 K  Q  K  S  P  D  G  V  H  R  V  R  V  D  F  K   | E  D  C  D      p.1180

          .         .         .         .         .         .       g.7272
 TTAGAGAACGTGTGGCTGATGGGGGGCCTGAGTGTGCTCACCTCTGTGCCAGGGGGCCCC       c.3600
 L  E  N  V  W  L  M  G  G  L  S  V  L  T  S  V  P  G  G  P         p.1200

          .         .         .         .   | 12     .         .    g.7477
 CCGATGGTGTGCTTGCTGTGTGCCAGCAAAGGACTCCACGAG | CTGGTGTTCTGTCAAGTC    c.3660
 P  M  V  C  L  L  C  A  S  K  G  L  H  E   | L  V  F  C  Q  V      p.1220

          .         .         .         .         .         .       g.7537
 TGCTGTGACCCATTCCACCCATTCTGCCTGGAGGAGGCCGAGCGGCCCCTGCCCCAGCAT       c.3720
 C  C  D  P  F  H  P  F  C  L  E  E  A  E  R  P  L  P  Q  H         p.1240

          .         .         .         .         .         .       g.7597
 CACGACACCTGGTGCTGCCGTCGCTGCAAATTCTGCCACGTCTGTGGACGCAAAGGTCGT       c.3780
 H  D  T  W  C  C  R  R  C  K  F  C  H  V  C  G  R  K  G  R         p.1260

           | 13        .         .         .         .         .    g.7754
 GGATCCAAG | CACCTCCTGGAGTGCGAGCGCTGCCGCCATGCATACCACCCGGCCTGTCTG    c.3840
 G  S  K   | H  L  L  E  C  E  R  C  R  H  A  Y  H  P  A  C  L      p.1280

          .         .         .         .      | 14  .         .    g.8231
 GGGCCCAGCTATCCAACCCGGGCCACGCGCAAACGGCGCCACTGG | ATCTGTTCAGCCTGT    c.3900
 G  P  S  Y  P  T  R  A  T  R  K  R  R  H  W   | I  C  S  A  C      p.1300

          .         .         .         .         .         .       g.8291
 GTGCGCTGTAAGAGCTGTGGGGCAACTCCAGGCAAGAACTGGGACGTCGAGTGGTCTGGA       c.3960
 V  R  C  K  S  C  G  A  T  P  G  K  N  W  D  V  E  W  S  G         p.1320

          .         .         .         .    | 15    .         .    g.9153
 GATTACAGCCTCTGCCCCAGGTGCACCCAGCTATATGAGAAAG | GAAACTACTGCCCGATC    c.4020
 D  Y  S  L  C  P  R  C  T  Q  L  Y  E  K  G |   N  Y  C  P  I      p.1340

          .         .         .         .         .         .       g.9213
 TGTACACGCTGCTATGAAGACAACGACTATGAGAGCAAGATGATGCAGTGCGCACAGTGC       c.4080
 C  T  R  C  Y  E  D  N  D  Y  E  S  K  M  M  Q  C  A  Q  C         p.1360

          .         .         .        | 16.         .         .    g.9441
 GATCACTGGGTGCATGCCAAGTGCGAGGGGCTCTCAG | ATGAAGACTACGAGATCCTTTCA    c.4140
 D  H  W  V  H  A  K  C  E  G  L  S  D |   E  D  Y  E  I  L  S      p.1380

          .         .         .         .         .         .       g.9501
 GGACTGCCAGACTCGGTGCTGTACACCTGCGGACCGTGTGCTGGGGCAGCGCAGCCCCGC       c.4200
 G  L  P  D  S  V  L  Y  T  C  G  P  C  A  G  A  A  Q  P  R         p.1400

          .         .         .         .         .         .       g.9561
 TGGCGAGAGGCCCTGAGCGGGGCCCTCCAGGGGGGCCTGCGCCAGGTGCTCCAGGGCCTG       c.4260
 W  R  E  A  L  S  G  A  L  Q  G  G  L  R  Q  V  L  Q  G  L         p.1420

          .         .         .         .   | 17     .         .    g.9696
 CTGAGCTCCAAGGTGGTGGGCCCACTGCTGCTCTGCACCCAG | TGTGGGCCAGATGGGAAG    c.4320
 L  S  S  K  V  V  G  P  L  L  L  C  T  Q   | C  G  P  D  G  K      p.1440

          .         .         .         .         .         .       g.9756
 CAACTGCACCCAGGACCCTGCGGCCTGCAAGCTGTGAGTCAGCGCTTCGAGGATGGCCAC       c.4380
 Q  L  H  P  G  P  C  G  L  Q  A  V  S  Q  R  F  E  D  G  H         p.1460

          .   | 18     .         .         .         .         .    g.9909
 TACAAGTCTGTG | CACAGCTTCATGGAGGACATGGTGGGCATCCTCATGCGGCACTCGGAG    c.4440
 Y  K  S  V   | H  S  F  M  E  D  M  V  G  I  L  M  R  H  S  E      p.1480

          .         .         .         .         .        | 19.    g.10081
 GAGGGAGAGACCCCGGACCGCCGGGCTGGAGGCCAGATGAAGGGGCTCCTGCTGAAG | CTG    c.4500
 E  G  E  T  P  D  R  R  A  G  G  Q  M  K  G  L  L  L  K   | L      p.1500

          .         .         .         .         .         .       g.10141
 CTAGAATCTGCGTTCGGCTGGTTCGACGCCCACGACCCCAAGTACTGGCGACGGAGTACC       c.4560
 L  E  S  A  F  G  W  F  D  A  H  D  P  K  Y  W  R  R  S  T         p.1520

          .  | 20      .         .         .         .         .    g.10803
 CGGCTGCCAAA | CGGAGTCCTTCCCAATGCGGTGTTGCCCCCATCCCTGGATCATGTCTAT    c.4620
 R  L  P  N  |  G  V  L  P  N  A  V  L  P  P  S  L  D  H  V  Y      p.1540

          .         .         .         .         .         .       g.10863
 GCGCAGTGGAGACAGCAGGAACCAGAGACCCCAGAATCAGGGCAGCCTCCAGGGGATCCC       c.4680
 A  Q  W  R  Q  Q  E  P  E  T  P  E  S  G  Q  P  P  G  D  P         p.1560

         | 21.         .         .         .         .         .    g.11018
 TCAGCAG | CATTCCAGGGCAAGGATCCGGCTGCCTTCTCACACCTGGAGGACCCCCGTCAG    c.4740
 S  A  A |   F  Q  G  K  D  P  A  A  F  S  H  L  E  D  P  R  Q      p.1580

          .         .         .          | 22        .         .    g.11160
 TGTGCACTCTGCCTCAAATACGGGGATGCAGACTCCAAG | GAGGCGGGGCGGCTCTTGTAC    c.4800
 C  A  L  C  L  K  Y  G  D  A  D  S  K   | E  A  G  R  L  L  Y      p.1600

          .         .         .         .         .         .       g.11220
 ATCGGGCAGAACGAGTGGACACACGTCAACTGTGCCATCTGGTCGGCGGAAGTCTTCGAG       c.4860
 I  G  Q  N  E  W  T  H  V  N  C  A  I  W  S  A  E  V  F  E         p.1620

          .         .         .         .         .        | 23.    g.11950
 GAGAACGACGGCTCCCTCAAGAATGTGCATGCTGCTGTGGCCCGAGGGAGGCAGATG | CGC    c.4920
 E  N  D  G  S  L  K  N  V  H  A  A  V  A  R  G  R  Q  M   | R      p.1640

          .         .         .         .         .         .       g.12010
 TGCGAGCTCTGCCTGAAGCCTGGCGCCACGGTGGGCTGCTGCCTGTCCTCCTGCCTCAGC       c.4980
 C  E  L  C  L  K  P  G  A  T  V  G  C  C  L  S  S  C  L  S         p.1660

          .         .         .         .         .         .       g.12070
 AACTTCCACTTCATGTGTGCCCGGGCCAGCTACTGCATCTTCCAGGATGACAAGAAAGTC       c.5040
 N  F  H  F  M  C  A  R  A  S  Y  C  I  F  Q  D  D  K  K  V         p.1680

          .         .         .       | 24 .         .         .    g.12346
 TTCTGCCAGAAACACACTGATCTCCTGGATGGCAAG | GAAATTGTGAACCCCGATGGTTTT    c.5100
 F  C  Q  K  H  T  D  L  L  D  G  K   | E  I  V  N  P  D  G  F      p.1700

          .         .         .         .         .         .       g.12406
 GATGTTCTCCGCCGAGTCTATGTGGACTTCGAGGGCATCAACTTCAAGCGGAAGTTCTTG       c.5160
 D  V  L  R  R  V  Y  V  D  F  E  G  I  N  F  K  R  K  F  L         p.1720

          .         .         .        | 25.         .         .    g.12541
 ACGGGGCTTGAACCCGATGCCATCAACGTGCTCATTG | GTTCCATCCGCATTGACTCCCTG    c.5220
 T  G  L  E  P  D  A  I  N  V  L  I  G |   S  I  R  I  D  S  L      p.1740

          .         .         .         .         .       | 26 .    g.12691
 GGTACTCTGTCTGATCTCTCGGACTGCGAGGGACGGCTCTTCCCCATTGGCTACCA | GTGC    c.5280
 G  T  L  S  D  L  S  D  C  E  G  R  L  F  P  I  G  Y  Q  |  C      p.1760

          .         .         .         .         .         .       g.12751
 TCCCGTCTGTACTGGAGCACAGTGGATGCTCGGAGGCGCTGCTGGTATCGGTGCCGAATT       c.5340
 S  R  L  Y  W  S  T  V  D  A  R  R  R  C  W  Y  R  C  R  I         p.1780

          .         .         .         .         .         .       g.12811
 CTGGAGTATCGGCCATGGGGGCCGAGGGAAGAGCCAGCTCACCTGGAGGCTGCAGAGGAG       c.5400
 L  E  Y  R  P  W  G  P  R  E  E  P  A  H  L  E  A  A  E  E         p.1800

          .         .         .        | 27.         .         .    g.13911
 AACCAGACCATTGTGCACAGCCCCGCCCCTTCCTCAG | AGCCCCCAGGTGGTGAGGACCCC    c.5460
 N  Q  T  I  V  H  S  P  A  P  S  S  E |   P  P  G  G  E  D  P      p.1820

          .         .         .         .         .         .       g.13971
 CCACTGGACACAGATGTTCTTGTCCCTGGAGCTCCTGAGCGCCACTCGCCCATTCAGAAC       c.5520
 P  L  D  T  D  V  L  V  P  G  A  P  E  R  H  S  P  I  Q  N         p.1840

          .         .         .         .         .         .       g.14031
 CTGGACCCTCCACTGCGGCCAGATTCAGGCAGCGCCCCTCCTCCAGCCCCCCGTTCTTTT       c.5580
 L  D  P  P  L  R  P  D  S  G  S  A  P  P  P  A  P  R  S  F         p.1860

          .         .         .         .         .         .       g.14091
 TCGGGGGCTCGAATCAAAGTGCCCAACTACTCGCCATCCCGGAGGCCCTTGGGGGGTGTC       c.5640
 S  G  A  R  I  K  V  P  N  Y  S  P  S  R  R  P  L  G  G  V         p.1880

          .         .      | 28  .         .         .         .    g.14230
 TCCTTTGGCCCCCTGCCCTCCCCTG | GAAGTCCATCTTCACTGACCCACCACATCCCCACA    c.5700
 S  F  G  P  L  P  S  P  G |   S  P  S  S  L  T  H  H  I  P  T      p.1900

          .         .         .         .         .         .       g.14290
 GTGGGAGACCCGGACTTCCCAGCTCCCCCCAGACGTTCCCGTCGTCCCAGCCCTTTGGCT       c.5760
 V  G  D  P  D  F  P  A  P  P  R  R  S  R  R  P  S  P  L  A         p.1920

          .         .         .         .         .         .       g.14350
 CCCAGGCCGCCTCCATCACGGTGGGCCTCCCCTCCTCTAAAAACCTCCCCTCAGCTCAGG       c.5820
 P  R  P  P  P  S  R  W  A  S  P  P  L  K  T  S  P  Q  L  R         p.1940

          .         .         .         .         .         .       g.14410
 GTGCCCCCTCCTACCTCAGTCGTCACAGCCCTCACACCTACCTCAGGGGAGCTGGCTCCC       c.5880
 V  P  P  P  T  S  V  V  T  A  L  T  P  T  S  G  E  L  A  P         p.1960

          .         .         .         .         .         .       g.14470
 CCTGGCCCGGCCCCATCTCCACCACCCCCTGAAGACCTGGGCCCAGACTTCGAGGACATG       c.5940
 P  G  P  A  P  S  P  P  P  P  E  D  L  G  P  D  F  E  D  M         p.1980

          .         .         .         .         .         .       g.14530
 GAGGTGGTGTCAGGACTGAGTGCTGCTGACCTGGACTTCGCGGCCAGCCTGCTGGGGACT       c.6000
 E  V  V  S  G  L  S  A  A  D  L  D  F  A  A  S  L  L  G  T         p.2000

          .         .         .         .         .         .       g.14590
 GAGCCCTTCCAGGAAGAGATTGTAGCCGCTGGGGCCATGGGGAGCAGCCACGGGGGCCCG       c.6060
 E  P  F  Q  E  E  I  V  A  A  G  A  M  G  S  S  H  G  G  P         p.2020

          .         .         .         .         .         .       g.14650
 GGGGACAGCTCCGAGGAGGAGTCCAGCCCCACCTCCCGCTACATCCACTTCCCTGTGACT       c.6120
 G  D  S  S  E  E  E  S  S  P  T  S  R  Y  I  H  F  P  V  T         p.2040

          .         .         .         .         .         .       g.14710
 GTGGTGTCCGCCCCTGGTCTGGCCCCCAGCGCTACCCCTGGAGCCCCCCGCATTGAACAG       c.6180
 V  V  S  A  P  G  L  A  P  S  A  T  P  G  A  P  R  I  E  Q         p.2060

          .         .         .         .         .         .       g.14770
 CTGGACGGCGTGGACGACGGCACTGACAGTGAGGCTGAGGCGGTGCAGCAGCCTCGGGGC       c.6240
 L  D  G  V  D  D  G  T  D  S  E  A  E  A  V  Q  Q  P  R  G         p.2080

          .         .         .         .         .         .       g.14830
 CAGGGCACGCCTCCTTCGGGGCCAGGAGTAGTCCGGGCAGGGGTCCTTGGGGCTGCAGGG       c.6300
 Q  G  T  P  P  S  G  P  G  V  V  R  A  G  V  L  G  A  A  G         p.2100

          .         .         .         .         .         .       g.14890
 GACAGGGCCCGGCCTCCTGAGGACCTGCCATCGGAAATTGTGGATTTTGTGTTGAAGAAC       c.6360
 D  R  A  R  P  P  E  D  L  P  S  E  I  V  D  F  V  L  K  N         p.2120

          .         .         .         .         .         .       g.14950
 CTAGGGGGTCCTGGGGATGGAGGTGCTGGCCCTAGAGAGGAGTCACTCCCCCCGGCGCCT       c.6420
 L  G  G  P  G  D  G  G  A  G  P  R  E  E  S  L  P  P  A  P         p.2140

          .         .         .         .         .         .       g.15010
 CCCCTGGCTAATGGCAGCCAGCCCTCCCAAGGCCTGACCGCCAGCCCAGCTGACCCCACC       c.6480
 P  L  A  N  G  S  Q  P  S  Q  G  L  T  A  S  P  A  D  P  T         p.2160

          .         .         .         .         .         .       g.15070
 CGCACATTTGCCTGGCTCCCAGGGGCCCCAGGGGTCCGGGTGTTAAGCCTTGGCCCTGCC       c.6540
 R  T  F  A  W  L  P  G  A  P  G  V  R  V  L  S  L  G  P  A         p.2180

          .         .         .         .         .         .       g.15130
 CCTGAGCCCCCCAAACCCGCCACATCCAAAATCATACTTGTCAACAAGCTGGGGCAAGTA       c.6600
 P  E  P  P  K  P  A  T  S  K  I  I  L  V  N  K  L  G  Q  V         p.2200

          .         .         .         .         .         .       g.15190
 TTTGTGAAGATGGCTGGGGAGGGTGAACCTGTCCCACCCCCAGTGAAGCAGCCACCTTTG       c.6660
 F  V  K  M  A  G  E  G  E  P  V  P  P  P  V  K  Q  P  P  L         p.2220

          .         .         .         .         .         .       g.15250
 CCCCCCACCATTTCCCCCACGGCTCCCACCTCCTGGACTCTGCCCCCAGGCCCCCTCCTC       c.6720
 P  P  T  I  S  P  T  A  P  T  S  W  T  L  P  P  G  P  L  L         p.2240

          .         .         .         .         .         .       g.15310
 GGCGTGCTGCCCGTGGTCGGAGTGGTCCGCCCTGCCCCGCCCCCGCCACCCCCTCCCCTG       c.6780
 G  V  L  P  V  V  G  V  V  R  P  A  P  P  P  P  P  P  P  L         p.2260

          .         .         .         .         .         .       g.15370
 ACGCTGGTGCTGAGCAGTGGGCCAGCCAGCCCGCCCCGCCAGGCCATCCGCGTCAAGAGG       c.6840
 T  L  V  L  S  S  G  P  A  S  P  P  R  Q  A  I  R  V  K  R         p.2280

          .         .         .         .         .         .       g.15430
 GTGTCCACTTTCTCCGGCCGGTCCCCGCCAGCACCTCCCCCATACAAAGCCCCCCGGCTG       c.6900
 V  S  T  F  S  G  R  S  P  P  A  P  P  P  Y  K  A  P  R  L         p.2300

          .         .         .         .         .          | 29    g.15578
 GATGAAGATGGAGAGGCCTCAGAGGATACCCCTCAGGTTCCAGGGCTTGGCAGTGGCGG | G    c.6960
 D  E  D  G  E  A  S  E  D  T  P  Q  V  P  G  L  G  S  G  G  |      p.2320

          .         .         .         .         .         .       g.15638
 TTTAGCCGTGTGAGGATGAAAACCCCCACAGTGCGTGGGGTCCTTGACCTGGATCGGCCT       c.7020
 F  S  R  V  R  M  K  T  P  T  V  R  G  V  L  D  L  D  R  P         p.2340

          .         .          | 30        .         .         .    g.15774
 GGGGAGCCCGCTGGGGAAGAAAGTCCTGG | GCCCCTCCAGGAACGGTCCCCTTTGCTGCCA    c.7080
 G  E  P  A  G  E  E  S  P  G  |  P  L  Q  E  R  S  P  L  L  P      p.2360

          .         .         .         .         .         .       g.15834
 CTTCCGGAAGATGGTCCTCCCCAGGTCCCCGATGGTCCCCCAGACCTGCTGCTTGAGTCC       c.7140
 L  P  E  D  G  P  P  Q  V  P  D  G  P  P  D  L  L  L  E  S         p.2380

          .          | 31        .         .         .         .    g.18711
 CAGTGGCACCACTATTCAG | GTGAGGCTTCGAGCTCTGAGGAAGAGCCTCCATCCCCAGAT    c.7200
 Q  W  H  H  Y  S  G |   E  A  S  S  S  E  E  E  P  P  S  P  D      p.2400

          .         .         .         .         .         .       g.18771
 GATAAAGAGAACCAGGCCCCAAAACGGACTGGCCCACATCTGCGCTTCGAGATCAGCAGT       c.7260
 D  K  E  N  Q  A  P  K  R  T  G  P  H  L  R  F  E  I  S  S         p.2420

          .         .         .        | 32.         .         .    g.18915
 GAGGATGGGTTCAGCGTTGAGGCAGAGAGCTTGGAGG | GGGCGTGGAGAACTCTGATCGAG    c.7320
 E  D  G  F  S  V  E  A  E  S  L  E  G |   A  W  R  T  L  I  E      p.2440

          .         .         .         .         .   | 33     .    g.19074
 AAAGTGCAAGAGGCCCGAGGGCATGCCCGACTCAGACATCTCTCCTTTAGTG | GAATGAGT    c.7380
 K  V  Q  E  A  R  G  H  A  R  L  R  H  L  S  F  S  G |   M  S      p.2460

          .         .         .         .         .         .       g.19134
 GGGGCGAGACTCCTGGGCATCCACCATGATGCTGTCATCTTCCTGGCCGAGCAGCTCCCC       c.7440
 G  A  R  L  L  G  I  H  H  D  A  V  I  F  L  A  E  Q  L  P         p.2480

          .         .         .         .         .         .       g.19194
 GGAGCCCAGCGTTGCCAGCACTATAAGTTCCGTTACCACCAGCAGGGAGAGGGCCAGGAG       c.7500
 G  A  Q  R  C  Q  H  Y  K  F  R  Y  H  Q  Q  G  E  G  Q  E         p.2500

          .         .         .         .         . | 34       .    g.19626
 GAGCCGCCCCTGAATCCCCATGGGGCTGCTCGGGCAGAGGTCTATCTCCG | GAAGTGCACC    c.7560
 E  P  P  L  N  P  H  G  A  A  R  A  E  V  Y  L  R  |  K  C  T      p.2520

          .         .         .         .         .         .       g.19686
 TTTGACATGTTCAACTTCCTGGCCTCCCAGCACCGGGTGCTCCCTGAGGGGGCCACCTGT       c.7620
 F  D  M  F  N  F  L  A  S  Q  H  R  V  L  P  E  G  A  T  C         p.2540

          .         .         .         | 35         .         .    g.19861
 GATGAGGAAGAGGATGAGGTGCAGCTCAGGTCAACCAG | ACGTGCCACCAGCCTGGAGCTG    c.7680
 D  E  E  E  D  E  V  Q  L  R  S  T  R  |  R  A  T  S  L  E  L      p.2560

          .         .         .         .         .         .       g.19921
 CCCATGGCCATGCGTTTTCGTCACCTTAAGAAGACGTCCAAAGAAGCTGTGGGTGTCTAC       c.7740
 P  M  A  M  R  F  R  H  L  K  K  T  S  K  E  A  V  G  V  Y         p.2580

    | 36     .         .         .         .         .         .    g.20100
 AG | ATCAGCCATCCACGGGCGAGGCCTGTTCTGTAAGCGCAACATCGACGCGGGGGAGATG    c.7800
 R  |  S  A  I  H  G  R  G  L  F  C  K  R  N  I  D  A  G  E  M      p.2600

          .         .         .         .         .         .       g.20160
 GTCATCGAGTACTCTGGCATTGTCATCCGCTCGGTGTTGACTGACAAGCGGGAGAAGTTC       c.7860
 V  I  E  Y  S  G  I  V  I  R  S  V  L  T  D  K  R  E  K  F         p.2620

          .   | 37     .         .         .         .         .    g.20310
 TACGATGGGAAG | GGCATCGGGTGCTATATGTTCCGCATGGATGACTTTGATGTAGTGGAC    c.7920
 Y  D  G  K   | G  I  G  C  Y  M  F  R  M  D  D  F  D  V  V  D      p.2640

          .         .         .         .         .         .       g.20370
 GCCACGATGCATGGCAATGCCGCCCGCTTCATCAACCACTCCTGTGAGCCCAACTGCTTC       c.7980
 A  T  M  H  G  N  A  A  R  F  I  N  H  S  C  E  P  N  C  F         p.2660

          .         .         .         .         .         .       g.20430
 TCTCGGGTCATCCACGTGGAGGGCCAGAAACACATTGTTATCTTCGCCCTGCGCCGCATC       c.8040
 S  R  V  I  H  V  E  G  Q  K  H  I  V  I  F  A  L  R  R  I         p.2680

          .         .         .         .         .         .       g.20490
 CTGCGTGGTGAGGAGCTCACCTACGACTACAAGTTCCCCATCGAGGATGCCAGCAACAAG       c.8100
 L  R  G  E  E  L  T  Y  D  Y  K  F  P  I  E  D  A  S  N  K         p.2700

          .         .         .         .                           g.20538
 CTGCCCTGCAACTGTGGCGCCAAGCGCTGCCGTCGGTTCCTTAACTGA                   c.8148
 L  P  C  N  C  G  A  K  R  C  R  R  F  L  N  X                     p.2715

          .         .         .         .         .         .       g.20598
 ggccgtggctgcccaccacgacccctcacacctcctgctgccgtcgctgccatcttgccc       c.*60

          .         .         .         .         .         .       g.20658
 ctagcctgggggctccctagcccctcccagagcatctcacccccaccctcatgttcaggg       c.*120

          .         .         .         .         .         .       g.20718
 tggatgtgggcatgcaggtgacaagggccctgcctccacccctccagcccatccagcaat       c.*180

          .         .         .         .         .         .       g.20778
 cgccccctttctgccctgggggcccaggatgtagatattgtacaaaggtttctaaatccc       c.*240

          .         .         .         .         .         .       g.20838
 ttcttttctatgcacttttttatttaagaggtggggtcccaggtgggaacccccccacaa       c.*300

          .         .                                               g.20859
 taaagtctgtcaatgtttgga                                              c.*321

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Lysine methyltransferase 2B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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