keratin 10 (KRT10) - coding DNA reference sequence

(used for variant description)

(last modified December 2, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_000421.3 in the KRT10 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008405.1, covering KRT10 transcript NM_000421.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5026
                                   cactccctgggctaaacagcatcacc       c.-1

          .         .         .         .         .         .       g.5086
 ATGTCTGTTCGATACAGCTCAAGCAAGCACTACTCTTCCTCCCGCAGTGGAGGAGGAGGA       c.60
 M  S  V  R  Y  S  S  S  K  H  Y  S  S  S  R  S  G  G  G  G         p.20

          .         .         .         .         .         .       g.5146
 GGAGGAGGAGGATGTGGAGGAGGAGGAGGAGTGTCATCCCTAAGAATTTCTAGCAGCAAA       c.120
 G  G  G  G  C  G  G  G  G  G  V  S  S  L  R  I  S  S  S  K         p.40

          .         .         .         .         .         .       g.5206
 GGCTCCCTTGGTGGAGGATTTAGCTCAGGGGGGTTCAGTGGTGGCTCTTTTAGCCGTGGG       c.180
 G  S  L  G  G  G  F  S  S  G  G  F  S  G  G  S  F  S  R  G         p.60

          .         .         .         .         .         .       g.5266
 AGCTCTGGTGGGGGCTGCTTTGGGGGCTCATCAGGTGGCTATGGAGGATTAGGAGGTTTT       c.240
 S  S  G  G  G  C  F  G  G  S  S  G  G  Y  G  G  L  G  G  F         p.80

          .         .         .         .         .         .       g.5326
 GGTGGAGGTAGCTTTCGTGGAAGCTATGGAAGTAGCAGCTTTGGTGGGAGTTATGGAGGC       c.300
 G  G  G  S  F  R  G  S  Y  G  S  S  S  F  G  G  S  Y  G  G         p.100

          .         .         .         .         .         .       g.5386
 AGCTTTGGAGGGGGCAGTTTCGGAGGTGGCAGCTTTGGTGGGGGCAGCTTTGGTGGAGGC       c.360
 S  F  G  G  G  S  F  G  G  G  S  F  G  G  G  S  F  G  G  G         p.120

          .         .         .         .         .         .       g.5446
 GGCTTTGGTGGAGGCGGCTTTGGAGGAGGCTTTGGTGGTGGATTTGGAGGAGATGGTGGC       c.420
 G  F  G  G  G  G  F  G  G  G  F  G  G  G  F  G  G  D  G  G         p.140

          .         .         .         .         .         .       g.5506
 CTTCTCTCTGGAAATGAAAAAGTAACCATGCAGAATCTGAATGACCGCCTGGCTTCCTAC       c.480
 L  L  S  G  N  E  K  V  T  M  Q  N  L  N  D  R  L  A  S  Y         p.160

          .         .         .         .         .         .       g.5566
 TTGGACAAAGTTCGGGCTCTGGAAGAATCAAACTATGAGCTGGAAGGCAAAATCAAGGAG       c.540
 L  D  K  V  R  A  L  E  E  S  N  Y  E  L  E  G  K  I  K  E         p.180

          .         .         .         .         .         .       g.5626
 TGGTATGAAAAGCATGGCAACTCACATCAGGGGGAGCCTCGTGACTACAGCAAATACTAC       c.600
 W  Y  E  K  H  G  N  S  H  Q  G  E  P  R  D  Y  S  K  Y  Y         p.200

          .         .        | 02.         .         .         .    g.6527
 AAAACCATCGATGACCTTAAAAATCAG | ATTCTCAACCTAACAACTGATAATGCCAACATC    c.660
 K  T  I  D  D  L  K  N  Q   | I  L  N  L  T  T  D  N  A  N  I      p.220

          .         .         .         .         . | 03       .    g.6954
 CTGCTTCAGATCGACAATGCCAGGCTGGCAGCTGATGACTTCAGGCTGAA | GTATGAGAAT    c.720
 L  L  Q  I  D  N  A  R  L  A  A  D  D  F  R  L  K  |  Y  E  N      p.240

          .         .         .         .         .         .       g.7014
 GAGGTAGCTCTGCGCCAGAGCGTGGAGGCTGACATCAACGGCCTGCGTAGGGTGCTGGAT       c.780
 E  V  A  L  R  Q  S  V  E  A  D  I  N  G  L  R  R  V  L  D         p.260

          .         .         .         .         .         .       g.7074
 GAGCTGACCCTGACCAAGGCTGACCTGGAGATGCAAATTGAGAGCCTGACTGAAGAGCTG       c.840
 E  L  T  L  T  K  A  D  L  E  M  Q  I  E  S  L  T  E  E  L         p.280

          .         .        | 04.         .         .         .    g.7221
 GCCTATCTGAAGAAGAACCACGAGGAG | GAAATGAAAGACCTTCGAAATGTGTCCACTGGT    c.900
 A  Y  L  K  K  N  H  E  E   | E  M  K  D  L  R  N  V  S  T  G      p.300

          .         .         .         .         .         .       g.7281
 GATGTGAATGTGGAAATGAATGCTGCCCCGGGTGTTGATCTGACTCAACTTCTGAATAAC       c.960
 D  V  N  V  E  M  N  A  A  P  G  V  D  L  T  Q  L  L  N  N         p.320

          .         .         .         .         .         .       g.7341
 ATGAGAAGCCAATATGAACAACTTGCTGAACAAAACCGCAAAGATGCTGAAGCCTGGTTC       c.1020
 M  R  S  Q  Y  E  Q  L  A  E  Q  N  R  K  D  A  E  A  W  F         p.340

           | 05        .         .         .         .         .    g.7488
 AATGAAAAG | AGCAAGGAACTGACTACAGAAATTGATAATAACATTGAACAGATATCCAGC    c.1080
 N  E  K   | S  K  E  L  T  T  E  I  D  N  N  I  E  Q  I  S  S      p.360

          .         .         .         .         .         .       g.7548
 TATAAATCTGAGATTACTGAATTGAGACGTAATGTACAAGCTCTGGAGATAGAACTACAG       c.1140
 Y  K  S  E  I  T  E  L  R  R  N  V  Q  A  L  E  I  E  L  Q         p.380

          .      | 06  .         .         .         .         .    g.7922
 TCCCAACTGGCCTTG | AAACAATCCCTGGAAGCCTCCTTGGCAGAAACAGAAGGTCGCTAC    c.1200
 S  Q  L  A  L   | K  Q  S  L  E  A  S  L  A  E  T  E  G  R  Y      p.400

          .         .         .         .         .         .       g.7982
 TGTGTGCAGCTCTCACAGATTCAGGCCCAGATATCCGCTCTGGAAGAACAGTTGCAACAG       c.1260
 C  V  Q  L  S  Q  I  Q  A  Q  I  S  A  L  E  E  Q  L  Q  Q         p.420

          .         .         .         .         .         .       g.8042
 ATTCGAGCTGAAACCGAGTGCCAGAATACTGAATACCAACAACTCCTGGATATTAAGATC       c.1320
 I  R  A  E  T  E  C  Q  N  T  E  Y  Q  Q  L  L  D  I  K  I         p.440

          .         .         .         .         .    | 07    .    g.8457
 CGACTGGAGAATGAAATTCAAACCTACCGCAGCCTGCTAGAAGGAGAGGGAAG | TTCCGGA    c.1380
 R  L  E  N  E  I  Q  T  Y  R  S  L  L  E  G  E  G  S  |  S  G      p.460

          .         .         .         .         .         .       g.8517
 GGCGGCGGACGCGGCGGCGGAAGTTTCGGCGGCGGCTACGGCGGCGGAAGCTCCGGCGGC       c.1440
 G  G  G  R  G  G  G  S  F  G  G  G  Y  G  G  G  S  S  G  G         p.480

          .         .         .         .         .         .       g.8577
 GGAAGCTCCGGCGGCGGCCACGGCGGCGGCCACGGCGGCAGTTCCGGCGGCGGCTACGGA       c.1500
 G  S  S  G  G  G  H  G  G  G  H  G  G  S  S  G  G  G  Y  G         p.500

          .         .         .         .         .         .       g.8637
 GGCGGAAGCTCCGGCGGCGGAAGCTCCGGCGGCGGCTACGGGGGCGGAAGCTCCAGCGGC       c.1560
 G  G  S  S  G  G  G  S  S  G  G  G  Y  G  G  G  S  S  S  G         p.520

          .         .         .         .         .         .       g.8697
 GGCCACGGCGGCAGTTCCAGCGGCGGCTACGGTGGTGGCAGTTCCGGCGGCGGCGGCGGC       c.1620
 G  H  G  G  S  S  S  G  G  Y  G  G  G  S  S  G  G  G  G  G         p.540

          .         .         .         .         .         .       g.8757
 GGCTACGGGGGCGGCAGCTCCGGCGGCGGCAGCAGCTCCGGCGGCGGATACGGCGGCGGC       c.1680
 G  Y  G  G  G  S  S  G  G  G  S  S  S  G  G  G  Y  G  G  G         p.560

          .         .         .         .         .         .       g.8817
 AGCTCCAGCGGAGGCCACAAGTCCTCCTCTTCCGGGTCCGTGGGCGAGTCTTCATCTAAG       c.1740
 S  S  S  G  G  H  K  S  S  S  S  G  S  V  G  E  S  S  S  K         p.580

          | 08                                                      g.9181
 GGACCAAG | ATACTAA                                                 c.1755
 G  P  R  |  Y  X                                                   p.584

          .         .         .         .         .         .       g.9241
 caaaaccagagtaatcaagacaattattgaagaggtggcgcccgacggtagagttctttc       c.*60

          .         .         .         .         .         .       g.9301
 atctatggttgaatcagaaaccaagaaacactactattaaactgcatcaagaggaaagag       c.*120

          .         .         .         .         .         .       g.9361
 tctcccttcacacagaccattatttacagatgcatggaaaacaaagtctccaagaaaaca       c.*180

          .         .         .         .         .         .       g.9421
 cttctgtcttgatggtctatggaaatagaccttgaaaataaggtgtctacaaggtgtttt       c.*240

          .         .         .         .         .         .       g.9481
 gtggtttctgtatttcttcttttcactttaccagaaagtgttctttaatggaaagaaaaa       c.*300

          .         .         .         .         .                 g.9540
 caactttctgttctcatttactaatgaatttcaataaactttcttactgatgcaaacta        c.*359

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Keratin 10 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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